Rapamycin decreases survivin expression to induce NSCLC cell apoptosis under hypoxia through inhibiting HIF-1α induction

Molecular Biology Reports

Volumn 39, Issue 1, 2012, Pages 185-191

  Chen, Bin ^a   Yuping, Sun ^a   Ni, Jian ^a  

^a TONGJI UNIVERSITY   (China)

Author keywords

Apoptosis; HIF 1 ; mTOR; NSCLC; Rapamycin; Survivin

Indexed keywords

HYPOXIA INDUCIBLE FACTOR 1ALPHA; MAMMALIAN TARGET OF RAPAMYCIN; MESSENGER RNA; RAPAMYCIN; SMALL INTERFERING RNA; SURVIVIN;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; GENE; GENE EXPRESSION REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; HYPOXIA; LUNG NON SMALL CELL CANCER; PROMOTER REGION; PROTEIN DEGRADATION; PROTEIN DNA BINDING; PROTEIN EXPRESSION; PROTEIN INDUCTION; SURVIVIN GENE; TRANSCRIPTION INITIATION;

APOPTOSIS; BLOTTING, WESTERN; CARCINOMA, NON-SMALL-CELL LUNG; CELL HYPOXIA; CELL LINE, TUMOR; CHROMATIN IMMUNOPRECIPITATION; DNA PRIMERS; HUMANS; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; INHIBITOR OF APOPTOSIS PROTEINS; REAL-TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, SMALL INTERFERING; SIROLIMUS; TRANSCRIPTIONAL ACTIVATION;

EID: 84855202611     PISSN: 03014851     EISSN: 15734978     Source Type: Journal    
DOI: 10.1007/s11033-011-0724-3     Document Type: Article

References (26)

1. JR Molina AA Adjei JR Jett 2006 Advances in chemotherapy of non-small cell lung cancer Chest 130 1211 1219 17035458 10.1378/chest.130.4.1211 1:CAS:528:DC%2BD28Xht1Sgt7bE (Pubitemid 44583755)
2. MY Koh TR Spivak-Kroizman G Powis 2010 HIF-1alpha and cancer therapy Recent Results Cancer Res 180 15 34 20033376 10.1007/978-3-540-78281-0-3 1:CAS:528:DC%2BC3cXovVCru7g%3D
3. M Volm R Koomagi 2000 Hypoxia-inducible factor (HIF-1) and its relationship to apoptosis and proliferation in lung cancer Anticancer Res 20 881 890
4. A Giatromanolaki MI Koukourakis E Sivridis H Turley K Talks F Pezzella KC Gatter AL Harris 2001 Relation of hypoxia inducible factor 1 alpha and 2 alpha in operable non-small cell lung cancer to angiogenic/molecular profile of tumors and survival Br J Cancer 85 881 890 11556841 10.1054/bjoc.2001.2018 1:CAS:528:DC%2BD3MXpt1Kisbs%3D (Pubitemid 33010557)
5. DE Swinson JL Jones G Cox D Richardson AL Harris KJ O'Byrne 2004 Hypoxia-inducible factor-1 alpha in non small cell lung cancer: relation to growth factor, protease and apoptosis pathway Int J Cancer 111 43 50 15185341 10.1002/ijc.20052 1:CAS:528:DC%2BD2cXlsFWrtLw%3D (Pubitemid 38859281)
6. A Unruh A Ressel HG Mohamed RS Johnson R Nadrowitz E Richter DM Katschinski RH Wenger 2003 The hypoxa-inducible factor-1 alpha is a negative factor for tumor therapy Oncogene 22 3213 3220 12761491 10.1038/sj.onc.1206385 1:CAS:528:DC%2BD3sXjvFaksL8%3D (Pubitemid 36712933)
7. CC Hudson M Liu GG Chiang DM Otterness DC Loomis F Kaper AJ Giaccia RT Abraham 2002 Regulation of hypoxia-inducible factor 1 expression and function by the mammalian target of rapamycin Mol Cell Biol 22 7004 7014 12242281 10.1128/MCB.22.20.7004-7014.2002 1:CAS:528:DC%2BD38XnsFKitrk%3D
8. N Hay 2005 The Akt-mTOR tango and its relevance to cancer Cancer Cell 8 179 183 16169463 10.1016/j.ccr.2005.08.008 1:CAS:528:DC%2BD2MXhtV2gt7rL (Pubitemid 41317589)
9. RM Memmott PA Dennis 2009 Akt-dependent and -independent mechanisms of mTOR regulation in cancer Cell Signal 21 656 664 19166931 10.1016/j.cellsig. 2009.01.004 1:CAS:528:DC%2BD1MXisFWjs7c%3D
10. RJ Phillips J Mestas M Gharaee-Kermani MD Burdick A Sica JA Belperio MP Keane RM Strieter 2005 Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha J Biol Chem 280 22473 22481 15802268 10.1074/jbc.M500963200 1:CAS:528:DC%2BD2MXksl2htb4%3D (Pubitemid 40827903)
11. RJ Dowling M Pollak N Sonenberg 2009 Current status and challenges associated with targeting mTOR for cancer therapy BioDrugs 23 77 91 19489650 10.2165/00063030-200923020-00002 1:CAS:528:DC%2BD1MXovFSnsbo%3D
12. EC LaCasse S Baird RG Komeluk AE Mackenzie 1998 The inhibitors of apoptosis (IAPs) and their emerging role in cancer Oncogene 17 3247 3259 9916987 10.1038/sj.onc.1202569 (Pubitemid 29043977)
13. DC Altieri 2008 Survivin, cancer networks and pathway-directed drug discovery Nat Rev Cancer 8 61 70 18075512 10.1038/nrc2293 1:CAS:528: DC%2BD2sXhsVKku73M
14. T Strömberg A Dimberg A Hammarberg K Carlson A Osterborg K Nilsson H Jernberg-Wiklund 2004 Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone Blood 103 3138 3147 15070696 10.1182/blood-2003-05-1543 (Pubitemid 38451692)
15. SH Oh Q Jin ES Kim FR Khuri HY Lee 2008 Insulin-like growth factor-I receptor signaling pathway induces resistance to the apoptotic activities of SCH66336 (lonafarnib) through Akt/mammalian target of rapamycin-mediated increases in survivin expression Clin Cancer Res 14 1581 1589 18316583 10.1158/1078-0432.CCR-07-0952 1:CAS:528:DC%2BD1cXislSrtr8%3D (Pubitemid 351413943)
16. R Xu P Zhang J Huang SF Ge J Lu GX Qian 2007 Sp1 and Sp3 regulate basal transcription of the survivin gene Biochem Biophys Res Commun 356 229 286 10.1016/j.bbrc.2007.02.140 (Pubitemid 46413162)
17. XR Luo JS Li Y Niu L Miao 2010 Targeted killing effects of double CD and TK suicide genes controlled by survivin promoter on gastric cancer cell Mol Biol Rep 38 1201 1207 20574710 10.1007/s11033-010-0218-8
18. YQ Chen CL Zhao W Li 2009 Effect of hypoxia-inducible factor-1α on transcription of survivin in non-small cell lung cancer J Exp Clin Cancer Res 28 29 19245702 10.1186/1756-9966-28-29
19. X Zhang A Chang 2008 Molecular predictors of EGFR-TKI sensitivity in advanced non-small cell lung cancer Int J Med Sci 5 209 217 18645621 1:CAS:528:DC%2BD1cXht1amu7rP
20. E Conde B Angulo M Tang M Morente J Torres-Lanzas A Lopez-Encuentra F Lopez-Rios M Sanchez-Cespedes 2006 Molecular context of the EGFR mutations: evidence for the activation of mTOR/S6K signaling Clin Cancer Res 12 710 717 16467080 10.1158/1078-0432.CCR-05-1362 1:CAS:528:DC%2BD28XhtFeitbw%3D (Pubitemid 43259849)
21. F Morgillo JK Woo ES Kim WK Hong HY Lee 2006 Heterodimerization of insulin-like growth factor receptor/epidermal growth factor receptor and induction of survivin expression counteract the antitumor action of erlotinib Cancer Res 66 10100 10111 17047074 10.1158/0008-5472.CAN-06-1684 1:CAS:528:DC%2BD28XhtVyiur7F (Pubitemid 44672064)
22. D Derin HO Soydinç N Guney F Tas H Camlica D Duranyildiz V Yasasever E Topuz 2008 Serum levels of apoptosis biomarkers, survivin and TNF-alpha in nonsmall cell lung cancer Lung Cancer 59 240 245 17875341 10.1016/j.lungcan.2007.08.005 (Pubitemid 351173407)
23. AE Greijer E van der Wall 2004 The role of hypoxia inducible factor 1 (HIF-1) in hypoxia induced apoptosis J Clin Pathol 57 1009 1014 15452150 10.1136/jcp.2003.015032 1:CAS:528:DC%2BD2cXps1Kls78%3D (Pubitemid 39331346)
24. V Vaira CW Lee HL Goel S Bosari LR Languino DC Altieri 2007 Regulation of survivin expression by IGF-1/mTOR signaling Oncogene 26 2678 2684 17072337 10.1038/sj.onc.1210094 1:CAS:528:DC%2BD2sXksF2rsbo%3D (Pubitemid 46663841)
25. XH Peng P Karna Z Cao BH Jiang M Zhou L Yang 2006 Cross-talk between epidermal growth factor receptor and hypoxia-inducible factor-1alpha signal pathways increases resistance to apoptosis by up-regulating survivin gene expression J Biol Chem 281 25114 25903
26. RJ Giordano JK Edwards RM Tuder W Arap R Pasqualini 2009 Combinatorial ligand-directed lung targeting Proc Am Thorac Soc 6 411 415 19687212 10.1513/pats.200903-014AW 1:CAS:528:DC%2BD1MXhtFWrt7jF