Human type 2 17beta-hydroxysteroid dehydrogenase in umbilical vein and artery endothelial cells: Differential inactivation of sex steroids according to the vessel type

Endocrine

Volumn 40, Issue 2, 2011, Pages 203-211

  Simard, Marc ^a,b   Drolet, Renée ^a,b   Blomquist, Charles H ^c   Tremblay, Yves ^a,b,d  

^a Université Laval   (Canada)

^b LAVAL UNIVERSITY   (Canada)

^c UNIVERSITY OF MINNESOTA   (United States)

^d UNIVERSITÉ LAVAL   (Canada)

Author keywords

Estradiol; Estrogen receptors; HUAEC; HUVEC; Placenta

Indexed keywords

ESTROGEN RECEPTOR ALPHA; ESTROGEN RECEPTOR BETA; MESSENGER RNA; SEX HORMONE; TESTOSTERONE 17BETA DEHYDROGENASE; TESTOSTERONE 17BETA DEHYDROGENASE TYPE 2; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; ENDOTHELIUM CELL; ENZYME ACTIVITY; GENE EXPRESSION; HORMONAL REGULATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; HUMAN TISSUE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; STEROID METABOLISM; UMBILICAL ARTERY; UMBILICAL VEIN; WESTERN BLOTTING;

EID: 84855199974     PISSN: 1355008X     EISSN: 15590100     Source Type: Journal    
DOI: 10.1007/s12020-011-9519-5     Document Type: Article

References (44)

1. E.D. Albrecht, G.J. Pepe, Placental steroid hormone biosynthesis in primate pregnancy. Endocr. Rev. 11(1), 124-150 (1990) (Pubitemid 20101341)
2. G.J. Pepe, E.D. Albrecht, Regulation of the primate fetal adrenal cortex. Endocr. Rev. 11(1), 151-176 (1990) (Pubitemid 20101342)
3. Y. Tremblay, G.E. Ringler, Y. Morel, T.K. Mohandas, F. Labrie, J.F. Strauss III, W.L. Miller, Regulation of the gene for estrogenic 17-ketosteroid reductase lying on chromosome 17cen-q25. J. Biol. Chem. 264(34), 20458-20462 (1989) (Pubitemid 20009232)
4. C. Beaudoin, C.H. Blomquist, Y. Tremblay, Gene expression of 17 beta-hydroxysteroid dehydrogenase type 2 isozyme in primary cultures of human trophoblasts predicts different mechanisms regulating type 1 and type 2 enzymes. Endocrinology 136(9), 3807-3814 (1995)
5. L. Wu, M. Einstein, W.M. Geissler, H.K. Chan, K.O. Elliston, S. Andersson, Expression cloning and characterization of human 17 beta-hydroxysteroid dehydrogenase type 2, a microsomal enzyme possessing 20 alpha-hydroxysteroid dehydrogenase activity. J. Biol. Chem. 268(17), 12964-12969 (1993) (Pubitemid 23182471)
6. M.L. Casey, P.C. MacDonald, S. Andersson, 17 beta-Hydroxysteroid dehydrogenase type 2: chromosomal assignment and progestin regulation of gene expression in human endometrium. J. Clin. Invest. 94(5), 2135-2141 (1994)
7. M. Bonenfant, P.R. Provost, R. Drolet, Y. Tremblay, Localization of type 1 17beta-hydroxysteroid dehydrogenase mRNA and protein in syncytiotrophoblasts and invasive cytotrophoblasts in the human term villi. J. Endocrinol. 165(2), 217-222 (2000) (Pubitemid 30341070)
8. J. Takeyama, T. Suzuki, G. Hirasawa, Y. Muramatsu, H. Nagura, K. Iinuma, J. Nakamura, K.I. Kimura, M. Yoshihama, N. Harada, S. Andersson, H. Sasano, 17beta-hydroxysteroid dehydrogenase type 1 and 2 expression in the human fetus. J. Clin. Endocrinol. Metab. 85(1), 410-416 (2000) (Pubitemid 32268844)
9. M. Bonenfant, C.H. Blomquist, P.R. Provost, R. Drolet, P. D'Ascoli, Y. Tremblay, Tissue- and site-specific gene expression of type 2 17beta-hydroxysteroid dehydrogenase: in situ hybridization and specificenzymatic activity studies in human placental endothelial cells of the arterial system. J. Clin. Endocrinol. Metab. 85(12), 4841-4850 (2000) (Pubitemid 32157676)
10. R. Drolet, M. Simard, J. Plante, P. Laberge, Y. Tremblay, Human type 2 17 beta-hydroxysteroid dehydrogenase mRNA and protein distribution in placental villi at mid and term pregnancy. Reprod. Biol. Endocrinol. 5, 30 (2007)
11. J.D. Boyd, W.J. Hamilton, Development and structure of the human placenta from the end of the 3rd month of gestation. J. Obstet. Gynaecol. Br. Commonw. 74(2), 161-226 (1967)
12. M.E. Mendelsohn, R.H. Karas, The protective effects of estrogen on the cardiovascular system. N. Engl. J. Med. 340(23), 1801-1811 (1999) (Pubitemid 29266405)
13. H.P. Kim, J.Y. Lee, J.K. Jeong, S.W. Bae, H.K. Lee, I. Jo, Nongenomic stimulation of nitric oxide release by estrogen is mediated by estrogen receptor alpha localized in caveolae. Biochem. Biophys. Res. Commun. 263(1), 257-262 (1999) (Pubitemid 29443672)
14. K.H. Kim, K. Moriarty, J.R. Bender, Vascular cell signaling by membrane estrogen receptors. Steroids 73(9-10), 864-869 (2008)
15. T. Hayashi, K. Yamada, T. Esaki, M. Kuzuya, S. Satake, T. Ishikawa, H. Hidaka, A. Iguchi, Estrogen increases endothelial nitric oxide by a receptor-mediated system. Biochem. Biophys. Res. Commun. 214(3), 847-855 (1995)
16. M. Akishita, K. Kozaki, M. Eto, M. Yoshizumi, M. Ishikawa, K. Toba, H. Orimo, Y. Ouchi, Estrogen attenuates endothelin-1 production by bovine endothelial cells via estrogen receptor. Biochem. Biophys. Res. Commun. 251(1), 17-21 (1998) (Pubitemid 28498056)
17. M.A. Herve, G. Meduri, F.G. Petit, T.S. Domet, G. Lazennec, S. Mourah, M. Perrot-Applanat, Regulation of the vascular endothelial growth factor (VEGF) receptor Flk-1/KDR by estradiol through VEGF in uterus. J. Endocrinol. 188(1), 91-99 (2006) (Pubitemid 43159813)
18. B. Toth, G. Saadat, A. Geller, C. Scholz, S. Schulze, K. Friese, U. Jeschke, Human umbilical vascular endothelial cells express estrogen receptor beta (ERbeta) and progesterone receptor A (PRA), but not ERalpha and PR-B. Histochem. Cell Biol. 130(2), 399-405 (2008)
19. A.H. Wagner, M.R. Schroeter, M. Hecker, 17beta-estradiol inhibition of NADPH oxidase expression in human endothelial cells. FASEB J. 15(12), 2121-2130 (2001) (Pubitemid 32927929)
20. A. Sobrino, M. Mata, A. Laguna-Fernandez, S. Novella, P.J. Oviedo, M.A. Garcia-Perez, J.J. Tarin, A. Cano, C. Hermenegildo, Estradiol stimulates vasodilatory and metabolic pathways in cultured human endothelial cells. PLoS One 4(12), e8242 (2009)
21. W. Tschugguel, W. Dietrich, Z. Zhegu, F. Stonek, A. Kolbus, J.C. Huber, Differential regulation of proteasome-dependent estrogen receptor alpha and beta turnover in cultured human uterine artery endothelial cells. J. Clin. Endocrinol. Metab. 88(5), 2281-2287 (2003) (Pubitemid 36549909)
22. E.A. Jaffe, R.L. Nachman, C.G. Becker, C.R. Minick, Culture of human endothelial cells derived from umbilical veins Identification by morphologic and immunologic criteria. J. Clin. Invest. 52(11), 2745-2756 (1973)
23. R.T. Hinegardner, An improved fluorometric assay for DNA. Anal. Biochem. 39(1), 197-201 (1971)
24. B. Fiszer-Szafarz, D. Szafarz, A. Guevara de Murillo, A general, fast, and sensitive micromethod for DNA determination application to rat and mouse liver, rat hepatoma, human leukocytes, chicken fibroblasts, and yeast cells. Anal. Biochem. 110(1), 165-170 (1981) (Pubitemid 11157566)
25. C.H. Blomquist, H.C. Hensleigh, D.L. Block, L.A. Feeney, Placental 17 beta-hydroxysteroid oxidoreductase, lactate dehydrogenase and malate dehydrogenase during the latter half of pregnancy in the mouse. J. Steroid Biochem. Mol. Biol. 46(1), 61-67 (1993) (Pubitemid 23219626)
26. M. Simard, J. Plante, M. Boucher, P.R. Provost, Y. Tremblay, Type 2 and 5 17beta-hydroxysteroid dehydrogenases and androgen receptor in human fetal lungs. Mol. Cell. Endocrinol. 319(1-2), 79-87 (2010)
27. M. Simard, E. Boucher, P.R. Provost, Y. Tremblay, Minimization of PCR efficiency differences between standards and samples through dilution of PCR amplicons in reverse transcription buffer. Anal. Biochem. 362(1), 142-144 (2007) (Pubitemid 46201960)
28. J. Vandesompele, K. De Preter, F. Pattyn, B. Poppe, N. Van Roy, A. De Paepe, F. Speleman, Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol. 3(7), RESEARCH0034 (2002)
29. C.H. Blomquist, D.G. Bealka, H.C. Hensleigh, G.E. Tagatz, A comparison of 17 beta-hydroxysteroid oxidoreductase type 1 and type 2 activity of cytosol and microsomes from human term placenta, ovarian stroma and granulosa-luteal cells. J. Steroid Biochem. Mol. Biol. 49(2-3), 183-189 (1994)
30. S.S. Khosla, S.A. Rooney, Stimulation of fetal lung surfactant production by administration of 17beta-estradiol to the maternal rabbit. Am. J. Obstet. Gynecol. 133(2), 213-216 (1979) (Pubitemid 9098635)
31. S.S. Khosla, G.J. Smith, P.A. Parks, S.A. Rooney, Effects of estrogen on fetal rabbit lung maturation: morphological and biochemical studies. Pediatr. Res. 15(9), 1274-1281 (1981) (Pubitemid 11054581)
32. K. Hanley, U. Rassner, Y. Jiang, D. Vansomphone, D. Crumrine, L. Komuves, P.M. Elias, K.R. Feingold, M.L. Williams, Hormonal basis for the gender difference in epidermal barrier formation in the fetal rat. Acceleration by estrogen and delay by testosterone. J. Clin. Invest. 97(11), 2576-2584 (1996)
33. M.L. Williams, K. Hanley, P.M. Elias, K.R. Feingold, Ontogeny of the epidermal permeability barrier. J. Investig. Dermatol. Symp. Proc. 3(2), 75-79 (1998) (Pubitemid 29135199)
34. J.A. Visser, A. McLuskey, M. Verhoef-Post, P. Kramer, J.A. Grootegoed, A.P. Themmen, Effect of prenatal exposure to diethylstilbestrol on Mullerian duct development in fetal male mice. Endocrinology 139(10), 4244-4251 (1998) (Pubitemid 28513712)
35. J.R. Palmer, E.E. Hatch, R.S. Rao, R.H. Kaufman, A.L. Herbst, K.L. Noller, L. Titus-Ernstoff, R.N. Hoover, Infertility among women exposed prenatally to diethylstilbestrol. Am. J. Epidemiol. 154(4), 316-321 (2001) (Pubitemid 32756627)
36. H.W. Horne Jr., Evidence of improved pregnancy outcome with diethylstilbestrol (DES) treatment of women with previous pregnancy failures: a retrospective analysis. J. Chronic Dis. 38(10), 873-880 (1985) (Pubitemid 15233762)
37. H.W. Horne Jr., R.B. Kundsin, Results of infertility studies on DES-exposed and non DES-exposed consecutive patients. Int. J. Fertil. 30(1), 46-49 (1001). (1985) (Pubitemid 16216935)
38. R.M. Giusti, K. Iwamoto, E.E. Hatch, Diethylstilbestrol revisited: a review of the long-term health effects. Ann. Intern. Med. 122(10), 778-788 (1995)
39. G. Delbes, C. Levacher, R. Habert, Estrogen effects on fetal and neonatal testicular development. Reproduction 132(4), 527-538 (2006) (Pubitemid 44660527)
40. L.J. Guillette Jr., B.C. Moore, Environmental contaminants, fertility, and multioocytic follicles: a lesson from wildlife? Semin. Reprod. Med. 24(3), 134-141 (2006)
41. M. Mustonen, M. Poutanen, A. Chotteau-Lelievre, Y. de Launoit, V. Isomaa, S. Vainio, R. Vihko, P. Vihko, Ontogeny of 17betahydroxysteroid dehydrogenase type 2 mRNA expression in the developing mouse placenta and fetus. Mol. Cell. Endocrinol. 134(1), 33-40 (1997) (Pubitemid 27490286)
42. M. Mustonen, V.V.T. Isomaa, J. Tapanainen, M. Poutanen, F. Stenbäck, R. Vihko, P. Vihko, Human 17beta-hydroxysteroid dehydrogenase type 2 messenger ribonucleic acid expression and localization in term placenta and in endometrium during the menstrual cycle. J. Clin. Endocrinol. Metab. 83(4), 1319-1324 (1998) (Pubitemid 28496415)
43. A. Bukovsky, M.R. Caudle, M. Cekanova, R.I. Fernando, J. Wimalasena, J.S. Foster, D.C. Henley, R.F. Elder, Placental expression of estrogen receptor beta and its hormone binding variant-comparison with estrogen receptor alpha and a role for estrogen receptors in asymmetric division and differentiation of estrogen-dependent cells. Reprod. Biol. Endocrinol. 1, 36 (2003)
44. B. Schiessl, I. Mylonas, C. Kuhn, S. Kunze, S. Schulze, K. Friese, U. Jeschke, Expression of estrogen receptor-alpha, estrogen receptor-beta and placental endothelial and inducible NO synthase in intrauterine growth-restricted and normal placentals. Arch. Med. Res. 37(8), 967-975 (2006) (Pubitemid 44540235)