Losartan inhibits conventional dendritic cell maturation and Th1 and Th17 polarization responses: Novel mechanisms of preventive effects on lipopolysaccharide-induced acute lung injury

International Journal of Molecular Medicine

Volumn 29, Issue 2, 2012, Pages 269-276

  Liu, Jun ^a   Zhang, Peng Shu ^a   Yu, Qing ^a   Liu, Ling ^a   Yang, Yi ^a   Guo, Feng Mei ^a   Qiu, Hai Bo ^a  

^a MEDICAL SCHOOL OF SOUTHEAST UNIVERSITY   (China)

Author keywords

Acute respiratory distress syndrome; Angiotensin II; Dendritic cells; Inflammation

Indexed keywords

B7 ANTIGEN; GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 4; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; LOSARTAN;

ACUTE LUNG INJURY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN EXPRESSION; ARTICLE; CELL MATURATION; CONTROLLED STUDY; DENDRITIC CELL; DRUG EFFECT; HISTOPATHOLOGY; IMMUNE RESPONSE; LUNG; LUNG ALVEOLUS CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; TH17 CELL;

ACUTE LUNG INJURY; ANIMALS; CYTOKINES; DENDRITIC CELLS; LIPOPOLYSACCHARIDES; LOSARTAN; MALE; MICE; MODELS, BIOLOGICAL; TH1 CELLS; TH17 CELLS;

EID: 84855167533     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2011.818     Document Type: Article

References (35)

1. Zhang H and Slutsky AS: Year in review 2008: critical care - respirology. Crit Care 13: 225, 2009.
2. Imai Y, Kuba K, Rao S, et al.: Angiotensin-converting enzyme 2 protects from severe acute lung failure. Nature 436: 112-116, 2005. (Pubitemid 40966195)
3. Kuba K, Imai Y, Rao S, et al.: A crucial role of angiotensin converting enzyme 2 (ACE2) in SARS coronavirus-induced lung injury. Nat Med 11: 875-879, 2005. (Pubitemid 41161120)
4. Hagiwara S, Iwasaka H, Matumoto S, Hidaka S and Noguchi T: Effects of an angiotensin-converting enzyme inhibitor on the inflammatory response in in vivo and in vitro models. Crit Care Med 37: 626-633, 2009.
5. Liu L, Qiu HB, Yang Y, Wang L, Ding HM and Li HP: Losartan, an antagonist of AT1 receptor for angiotensin II, attenuates lipopolysaccharide-induced acute lung injury in rat. Arch Biochem Biophys 481: 131-136, 2009.
6. Heath WR and Carbone FR: Dendritic cell subsets in primary and secondary T cell responses at body surfaces. Nat Immunol 10: 1237-1244, 2009.
7. Vermaelen K and Pauwels R: Pulmonary dendritic cells. Am J Respir Crit Care Med 172: 530-551, 2005. (Pubitemid 41232964)
8. Cosio M G, Saetta M and Agusti A: Immunologic aspects of chronic obstructive pulmonary disease. N Engl J Med 360: 2445-2454, 2009.
9. Shinohara ML and Cantor H: The bridge between dendritic cells and asthma. Nat Med 13: 536-538, 2007. (Pubitemid 46828473)
10. Bantsimba-Malanda C, Marchal-Somme J, Goven D, Freynet O, Michel L, Crestani B and Soler P: A role for dendritic cells in bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med 182: 385-395, 2010.
11. Zhu J, Yamane H and Paul WE: Differentiation of effector CD4 T cell populations. Annu Rev Immunol 28: 445-489, 2010.
12. Bermejo-Martin JF, de Lejarazu RO, Pumarola T, et al.: Th1 and Th17 hypercytokinemia as early host response signature in severe pandemic influenza. Crit Care 13: R201, 2009.
13. Hagau N, Slavcovici A, Gonganau DN, et al.: Clinical aspects and cytokine response in severe H1N1 influenza A virus infection. Crit Care 14: R203, 2010.
14. Nahmod KA, Vermeulen ME, Raiden S, et al.: Control of dendritic cell differentiation by angiotensin II. FASEB J 17: 491-493, 2003.
15. Jurewicz M, McDermott DH, Sechler JM, et al.: Human T and natural killer cells possess a functional renin-angiotensin system: further mechanisms of angiotensin II-induced inflammation. J Am Soc Nephrol 18: 1093-1102, 2007. (Pubitemid 46536895)
16. Hoch NE, Guzik TJ, Chen W, et al.: Regulation of T-cell function by endogenously produced angiotensin II. Am J Physiol Regul Integr Comp Physiol 296: R208-R216, 2009.
17. Stegbauer J, Lee DH, Seubert S, et al.: Role of the renin-angiotensin system in autoimmune inflammation of the central nervous system. Proc Natl Acad Sci USA 106: 14942-14947, 2009.
18. Platten M, Youssef S, Hur EM, et al.: Blocking angiotensin-converting enzyme induces potent regulatory T cells and modulates TH1- and TH17-mediated autoimmunity. Proc Natl Acad Sci USA 106: 14948-14953, 2009.
19. Taooka Y, Maeda A, Hiyama K, Ishioka S and Yamakido M: Effects of neutrophil elastase inhibitor on bleomycin-induced pulmonary fibrosis in mice. Am J Respir Crit Care Med 156: 260-265, 1997. (Pubitemid 27293199)
20. Smith KM, Mrozek JD, Simonton SC, Bing DR, Meyers PA, Connett JE and Mammel MC: Prolonged partial liquid ventilation using conventional and high-frequency ventilatory techniques: gas exchange and lung pathology in an animal model of respiratory distress syndrome. Crit Care Med 25: 1888-1897, 1997. (Pubitemid 27483972)
21. Koya T, Kodama T, Takeda K, et al.: Importance of myeloid dendritic cells in persistent airway disease after repeated allergen exposure. Am J Respir Crit Care Med 173: 42-55, 2006. (Pubitemid 43069787)
22. Cleret A, Quesnel-Hellmann A, Vallon-Eberhard A, et al.: Lung dendritic cells rapidly mediate anthrax spore entry through the pulmonary route. J Immunol 178: 7994-8001, 2007. (Pubitemid 46898070)
23. Kiwamoto T, Ishii Y, Morishima Y, et al.: Transcription factors T-bet and GATA-3 regulate development of airway remodeling. Am J Respir Crit Care Med 174: 142-151, 2006. (Pubitemid 44015387)
24. Matute-Bello G, Frevert CW and Martin TR: Animal models of acute lung injury. Am J Physiol Lung Cell Mol Physiol 295: L379-L399, 2008.
25. von Wulffen W, Steinmueller M, Herold S, et al.: Lung dendritic cells elicited by Fms-like tyrosine 3-kinase ligand amplify the lung inflammatory response to lipopolysaccharide. Am J Respir Crit Care Med 176: 892-901, 2007. (Pubitemid 350097079)
26. de Heer HJ, Hammad H, Kool M and Lambrecht BN: Dendritic cell subsets and immune regulation in the lung. Semin Immunol 17: 295-303, 2005. (Pubitemid 40981934)
27. high dendritic cells in homeostasis and in allergic lung inflammation. J Immunol 178: 1882-1895, 2007.
28. McWilliam AS, Nelson D, Thomas JA and Holt PG: Rapid dendritic cell recruitment is a hallmark of the acute inflammatory response at mucosal surfaces. J Exp Med 179: 1331-1336, 1994. (Pubitemid 24091791)
29. Osterholzer JJ, Ames T, Polak T, et al.: CCR2 and CCR6, but not endothelial selectins, mediate the accumulation of immature dendritic cells within the lungs of mice in response to particulate antigen. J Immunol 175: 874-883, 2005. (Pubitemid 41094970)
30. Grayson MH, Ramos MS, Rohlfing MM, et al.: Controls for lung dendritic cell maturation and migration during respiratory viral infection. J Immunol 179: 1438-1448, 2007.
31. Kabir K, Gelinas JP, Chen M, et al.: Characterization of a murine model of endotoxin-induced acute lung injury. Shock 17: 300-303, 2002.
32. Venet F, Huang X, Chung CS, Chen Y and Ayala A: Plasmacytoid dendritic cells control lung inflammation and monocyte recruitment in indirect acute lung injury in mice. Am J Pathol 176: 764-773, 2010.
33. + T cells and the Th1/Th2 imbalance are implicated in the pathogenesis of Graves' ophthalmopathy. Int J Mol Med 17: 911-916, 2006.
34. + T cells in indirect pulmonary lung injury. J Immunol 183: 3472-3480, 2009.
35. Nelms K, Keegan AD, Zamorano J, Ryan JJ and Paul WE: The IL-4 receptor: signaling mechanisms and biologic functions. Annu Rev Immunol 17: 701-738, 1999. (Pubitemid 29241138)