The association of inherited thrombophilia and intrauterine fetal death: A case-control study

Blood Coagulation and Fibrinolysis

Volumn 22, Issue 8, 2011, Pages 651-656

  Helgadottir, Linda B ^a,b   Skjeldestad, Finn E ^c   Jacobsen, Anne F ^a   Sandset, Per M ^a,b   Jacobsen, Eva Marie ^a,b  

^a ULLEVÅL UNIVERSITY HOSPITAL   (Norway)

^b UNIVERSITY OF OSLO   (Norway)

^c UNIVERSITY OF TROMSØ   (Norway)

Author keywords

Antithrombin deficiency; Factor V Leiden polymorphism; Inherited thrombophilia; Intrauterine fetal death; Protein C deficiency; Protein S deficiency; Prothrombin G20210A polymorphism; Stillbirth

Indexed keywords

BLOOD CLOTTING FACTOR 5 LEIDEN; PROTEIN C; PROTEIN S; PROTHROMBIN;

ADULT; ANTITHROMBIN DEFICIENCY; ARTICLE; CASE CONTROL STUDY; CONFIDENCE INTERVAL; CONTROLLED STUDY; DISEASE CARRIER; DNA POLYMORPHISM; FEMALE; FETUS; GENETIC ASSOCIATION; GESTATIONAL AGE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; LIVE BIRTH; NORMAL HUMAN; PRENATAL MORTALITY; PREVALENCE; PRIORITY JOURNAL; PROTEIN C DEFICIENCY; PROTEIN S DEFICIENCY; RISK; THROMBOPHILIA;

ADULT; ANTITHROMBINS; BLOOD COAGULATION DISORDERS, INHERITED; CASE-CONTROL STUDIES; FACTOR V; FEMALE; FETAL DEATH; FETUS; HUMANS; NORWAY; ODDS RATIO; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; PREGNANCY COMPLICATIONS, HEMATOLOGIC; PRENATAL DIAGNOSIS; PREVALENCE; PROTEIN C; PROTEIN S; PROTHROMBIN; THROMBOPHILIA; UTERUS;

EID: 84855161515     PISSN: 09575235     EISSN: 14735733     Source Type: Journal    
DOI: 10.1097/MBC.0b013e32834a614c     Document Type: Article

References (31)

1. Kupferminc MJ, Eldor A, Steinman N, Many A, Bar-Am A, Jaffa A, et al. Increased frequency of genetic thrombophilia in women with complications of pregnancy. N Engl J Med 1999; 340:9-13. (Pubitemid 29024678)
2. Dizon-Townson DS, Nelson LM, Easton K, Ward K. The factor V Leiden mutation may predispose women to severe preeclampsia. Am J Obstet Gynecol 1996; 175:902-905. (Pubitemid 26357952)
3. Wiener-Megnagi Z, Ben-Shlomo I, Goldberg Y, Shalev E. Resistance to activated protein C and the Leiden mutation: high prevalence in patients with abruptio placentae. Am J Obstet Gynecol 1998; 179:1565-1567. (Pubitemid 29028401)
4. Jacobsen AF, Skjeldestad FE, Sandset PM Incidence and risk patterns of venous thromboembolism in pregnancy and puerperium: a register-based case-control study. Am J Obstet Gynecol 2008; 198:233
5. Brenner B. Inherited thrombophilia and fetal loss. Curr Opin Hematol 2000; 7:290-295. (Pubitemid 30637668)
6. Rodger MA, Paidas M, Claire M, Middeldorp S, Kahn S, Martinelli I, et al. Inherited thrombophilia and pregnancy complications revisited. Obstet Gynecol 2008; 112:320-324.
7. Arias F, Romero R, Joist H, Kraus FT. Thrombophilia: a mechanism of disease in women with adverse pregnancy outcome and thrombotic lesions in the placenta. J Matern Fetal Med 1998; 7:277-286.
8. Sood R, Zogg M, Westrick RJ, Guo YH, Kerschen EJ, Girardi G, et al. Fetal gene defects precipitate platelet-mediated pregnancy failure in factor V Leiden mothers. J Exp Med 2007; 204:1049-1056. (Pubitemid 46798149)
9. Isermann B, Sood R, Pawlinski R, Zogg M, Kalloway S, Degen JL, et al. The thrombomodulin-protein C system is essential for the maintenance of pregnancy. Nat Med 2003; 9:331-337. (Pubitemid 36362789)
10. Wu O, Robertson L, Twaddle S, LoweG, Clark P,Walker I, et al., Thrombosis: Risk and Economic Assessment of Thrombophilia Screening (TREATS) Study. Screening for thrombophilia in high-risk situations: a meta-analysis and cost-effectiveness analysis. Br J Haematol 2005; 131:80-90. (Pubitemid 43899712)
11. Howley HE, Walker M, Rodger MA. A systematic review of the association between factor V Leiden or prothrombin gene variant and intrauterine growth restriction. Am J Obstet Gynecol 2005; 192:694-708. (Pubitemid 40311258)
12. Rey E, Kahn SR, David M, Shrier I. Thrombophilic disorders and fetal loss: a meta-analysis. Lancet 2003; 361:901-908. (Pubitemid 36335814)
13. Preston FE, Rosendaal FR, Walker ID, Briet E, Berntorp E, Conard J, et al. Increased fetal loss in women with heritable thrombophilia. Lancet 1996; 348:913-916. (Pubitemid 26333847)
14. Brenner B. Thrombophilia and pregnancy loss. Thromb Res 2002; 108:197-202. (Pubitemid 36263136)
15. Brenner B, Sarig G, Weiner Z, Younis J, Blumenfeld Z, Lanir N. Thrombophilic polymorphisms are common in women with fetal loss without apparent cause. Thromb Haemost 1999; 82:6-9. (Pubitemid 29368764)
16. Robertson L, Wu O, Langhorne P, Twaddle S, Clark P, Lowe GD, et al. Thrombophilia in pregnancy: a systematic review. Br J Haematol 2006; 132:171-196. (Pubitemid 43381552)
17. Helgadottir LB, Skjeldestad FE, Jacobsen AF, Sandset PM, Jacobsen EM. Incidence and risk factors of fetal death in Norway: a case-control study. Acta Obstet Gynecol Scand 2011; 90:390-397.
18. Bergrem A, Jacobsen EM, Skjeldestad FE, Jacobsen AF, Skogstad M, Sandset PM. The association of antiphospholipid antibodies with pregnancy-related first time venous thrombosis: a population-based case-control study. Thromb Res 2010; 125:e222-e227.
19. Jacobsen AF, Dahm A, Bergrem A, Jacobsen EM, Sandset PM. Risk of venous thrombosis in pregnancy among carriers of the factor V Leiden and the prothrombin gene G20210A polymorphisms. J Thromb Haemost 2010; 8:2443-2449.
20. Jacobsen AF, Skjeldestad FE, Sandset PM. Ante-and postnatal risk factors of venous thrombosis: a hospital-based case-control study. J Thromb Haemost 2008; 6:905-912. (Pubitemid 351689910)
21. Kujovich JL. Thrombophilia and pregnancy complications. Am J Obstet Gynecol 2004; 191:412-424. (Pubitemid 39178692)
22. Said JM, Higgins JR, Moses EK, Walker SP, Borg AJ, Monagle PT, et al. Inherited thrombophilia polymorphisms and pregnancy outcomes in nulliparous women. Obstet Gynecol 2010; 115:5-13.
23. Rodger MA, Betancourt MT, Clark P, Lindqvist PG, Dizon-Townson D, Said J, et al. The association of factor V Leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: a systematic review and metaanalysis of prospective cohort studies. PLoS Med 2010; 7:e1000292.
24. Dudding TE, Attia J. The association between adverse pregnancy outcomes and maternal factor V Leiden genotype: a meta-analysis. Thromb Haemost 2004; 91:700-711. (Pubitemid 38477450)
25. Gris JC, Quere I, Monpeyroux F, Mercier E, Ripart-Neveu S, Tailland ML, et al. Case-control study of the frequency of thrombophilic disorders in couples with late foetal loss and no thrombotic antecedent: the Nimes Obstetricians and Haematologists Study5 (NOHA5). Thromb Haemost 1999; 81:891-899. (Pubitemid 29312703)
26. Gonen R, Lavi N, Attias D, Schliamser L, Borochowitz Z, Toubi E, et al. Absence of association of inherited thrombophilia with unexplained thirdtrimester intrauterine fetal death. Am J Obstet Gynecol 2005; 192:742-746. (Pubitemid 40311264)
27. Pasquier E, Bohec C, Mottier D, Jaffuel S, Mercier B, Ferec C, et al. Inherited thrombophilias and unexplained pregnancy loss: an incident case-control study. J Thromb Haemost 2009; 7:306-311.
28. Sarig G, Younis JS, Hoffman R, Lanir N, Blumenfeld Z, Brenner B. Thrombophilia is common in women with idiopathic pregnancy loss and is associated with late pregnancy wastage. Fertil Steril 2002; 77:342-347. (Pubitemid 34086913)
29. Mulder R, Ten Kate MK, Kluin-Nelemans HC, Mulder AB. Low cut-off values increase diagnostic performance of protein S assays. Thromb Haemost 2010; 104:618-625.
30. Greer IA. Thrombophilia: implications for pregnancy outcome. Thromb Res 2003; 109:73-81. (Pubitemid 36428756)
31. Bates SM, Greer IA, Pabinger I, Sofaer S, Hirsh J, American College of Chest Physicians. Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest 2008; 133 (Suppl):886S.