Resistance to activated protein C and the Leiden mutation: High prevalence in patients with abruptio placentae

American Journal of Obstetrics and Gynecology

Volumn 179, Issue 6 I, 1998, Pages 1565-1567

  Wiener Megnagi, Z ^a   Ben Shlomo, I ^a   Goldberg, Y ^a   Shalev, E ^a  

^a HAEMEK MEDICAL CENTER   (Israel)

Author keywords

Abruptio placentae; Activated protein C resistance; Factor V Leiden mutation; Thrombophilia

Indexed keywords

BLOOD CLOTTING FACTOR; PROTEIN C;

ADULT; CLINICAL ARTICLE; CONFERENCE PAPER; CONTROLLED STUDY; FEMALE; HUMAN; POINT MUTATION; PREGNANCY COMPLICATION; PRIORITY JOURNAL; RISK FACTOR; SOLUTIO PLACENTAE; THROMBOEMBOLISM;

EID: 0032441447     PISSN: 00029378     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0002-9378(98)70025-0     Document Type: Conference Paper

References (16)

1. 19th ed FG Cunningham PC MacDonald NF Gant KJ Leveno LC Gilstrap Williams obstetrics 1993 Appleton & Lange Norwalk (CT) 827 828
2. FB Rigby TE Nolan Inherited disorders of coagulation in pregnancy Clin Obstet Gynecol 38 1995 497 513
3. JP Vandenbroucke T Koster E Briët PH Reitsma RM Bertina FR Rosendaal Increased risk of venous thrombosis in oral-contraceptive users who are carriers of factor V Leiden mutation Lancet 344 1994 1453 1457
4. KW Bloemenkamp FR Rosendaal FM Helmerhorst HR Büller JP Vandenbroecke Enhancement by factor V Leiden mutation of risk of deep-vein thrombosis associated with oral contraceptives containing a third-generation progestogen Lancet 346 1995 1593 1596
5. T Koster FR Rosendaal H de Ronde E Briët JP Vandenbroucke MR Bertina Venous thrombosis due to poor anticoagulant response to activated protein C: Leiden thrombophilia study Lancet 342 1993 1503 1506
6. PJ Svensson B Dahlbäck Resistance to activated protein C as a basis for venous thrombosis N Engl J Med 330 1994 517 522
7. MR Bertina BP Koeleman T Koster FR Rosendaal RJ Dirven H de Ronde Mutation in blood coagulation factor V associated with resistance to activated protein C Nature 369 1994 64 67
8. PM Ridker CH Hennekens K Lindpaintner MJ Stampfer PR Eisenberg JP Miletich Mutation in the gene coding for coagulation factor V and the risk of myocardial infarction, stroke, and venous thrombosis in apparently healthy men N Engl J Med 332 1995 912 917
9. J Voorberg J Roelse R Koopman H Büller F Berends JW ten Cate Association of idiopathic venous thromboembolism with single point-mutation at Arg 506 of factor V Lancet 343 1994 1534 1535
10. MR Aboud DD Ma A comparison between two activated protein C resistance methods as routine diagnostic tests for factor V Leiden mutation Br J Haematol 97 1997 798 803
11. DS Dizon-Townson LM Nelson K Easton K Ward The factor V Leiden mutation may predispose women to severe preeclampsia Am J Obstet Gynecol 175 1996 902 905
12. B Brenner N Lanir I Thaler HELLP syndrome associated with factor V R506Q mutation Br J Haemetol 92 1996 999 1001
13. C Lindoff I Ingemarsson G Martinsson M Segelmark H Thysell B Astedt Preeclampsia is associated with a reduced response to activated protein C Am J Obstet Gynecol 176 1997 457 460
14. S Rotmensch M Liberati M Mittlemann Z Ben-Rafael Activated protein C resistance and adverse pregnancy outcome Am J Obstet Gynecol 177 1997 170 173
15. JH Rand XX Wu HA Andree CJ Lockwood S Guller J Scher Pregnancy loss in the antiphospholipid-antibody syndrome: a possible thrombogenic mechanism N Engl J Med 337 1997 148 153
16. MC Walker PR Garner JK Erin AR Gail DR Marchiano Changes in activated protein C resistance in normal pregnancy Am J Obstet Gynecol 177 1997 162 169