Cytotoxic esterified diterpenoid alkaloid derivatives with increased selectivity against a drug-resistant cancer cell line

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 249-252

  Wada, Koji ^a,b   Ohkoshi, Emika ^a   Morris Natschke, Susan L ^a   Bastow, Kenneth F ^a   Lee, Kuo Hsiung ^a,c  

^a UNC Hamner Institute for Drug Safety Sciences   (United States)

^b HOKKAIDO INSTITUTE OF TECHNOLOGY   (Japan)

^c CHINA MEDICAL UNIVERSITY   (Taiwan)

Author keywords

C 19 Diterpenoid alkaloid; Cytotoxicity; Delpheline

Indexed keywords

6 (3 TRIFLUOROMETHYLCINNAMOYL)DELPHELINE; 6 (4 BENZYLOXYBENZOYL)DELPHELINE; 6 (4 FLUORO 3 METHYLBENZOYL)DELPHELINE; 7,8 DEMETHYLENE 6 (3 TRIFLUOROMETHYLBENZOYL)DELPHELINE; 7,8 DEMETHYLENEDELPHELINE; CYTOTOXIC AGENT; DELPHELINE; DITERPENOID; PACININE; PACLITAXEL; UNCLASSIFIED DRUG; VINCRISTINE; YUNNADELPHININE;

ACYLATION; ARTICLE; CANCER RESISTANCE; CYTOTOXICITY; ESTERIFICATION; HUMAN; HUMAN CELL; LUNG CARCINOMA; MALE; NASOPHARYNX CANCER; PROSTATE CARCINOMA;

ALKALOIDS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CHEMISTRY, PHARMACEUTICAL; DITERPENES; DRUG DESIGN; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; NEOPLASMS; PACLITAXEL; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84655176669     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2011.11.026     Document Type: Article

References (15)

1. D.J. Newman, and G.M. Cragg J. Nat. Prod. 70 2007 461
2. F.P. Wang, Q.H. Chen, and X.Y. Liu Nat. Prod. Rep. 27 2010 570
3. F.P. Wang, and Q.H. Chen G.A. Cordell, The Alkaloids Vol. 69 2010 Elsevier Science New York 1 623
4. F.P. Wang, Q.H. Chen, and X.T. Liang G.A. Cordell, The Alkaloids Vol. 67 2007 Elsevier Science New York 1 78
5. T. Amiya, and H. Bando A. Brossi, The Alkaloids Vol. 34 1988 Academic Press San Diego 95 179
6. B.S. Joshi, and S.W. Pelletier S.W. Pelletier, Alkaloids: Chemical and Biological Perspectives Vol. 13 1999 Pergamon Amesterdam 289 370
7. A. Chdoeva, J.-J. Bosc, J. Guillon, A. Decendit, M. Petraud, C. Absalon, C. Vitry, C. Jarry, and J. Robert Bioorg. Med. Chem. 13 2005 6493
8. C. de Ines, M. Reina, J.A. Gavin, and A.Z. Gonzalez-Coloma Naturforsch, C 61 2006 11
9. K. Wada, M. Hazawa, K. Takahashi, T. Mori, N. Kawahara, and I. Kashiwakura J. Nat. Prod. 70 2007 1854
10. M. Hazawa, K. Wada, K. Takahashi, T. Mori, N. Kawahara, and I. Kashiwakura Invest. New Drugs 27 2009 111
11. M. Hazawa, K. Wada, K. Takahashi, T. Mori, N. Kawahara, and I. Kashiwakura Invest. New Drugs 29 2011 1
12. K. Wada, M. Hazawa, K. Takahashi, T. Mori, N. Kawahara, and I. Kashiwakura J. Nat. Med. 65 2011 43
13. H. Bando, K. Wada, J. Tanaka, S. Kimura, E. Hasegawa, and T. Amiya Heterocycles 29 1989 1293
14. K. Wada, T. Yamamoto, H. Bando, and N. Kawahara Phytochemistry 31 1992 2135
15. A.S. Narzullaev, M.S. Yunusov, and S.S. Sabirov Chem. Nat. Compd. 25 1989 43