Long-circulating non-toxic blood pool imaging agent based on hyperbranched polyglycerols

International Journal of Pharmaceutics

Volumn 422, Issue 1-2, 2012, Pages 418-427

  Saatchi, Katayoun ^a   Gelder, Nikolaus ^a   Gershkovich, Pavel ^a   Sivak, Olena ^a   Wasan, Kishor M ^a   Kainthan, Rajesh K ^a   Brooks, Donald E ^a   Häfeli, Urs O ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

Biocompatibility; Blood pharmacokinetics and biodistribution; Blood pool imaging; Cardiac imaging; Gallium 67; Gallium 68; PET imaging; Plasma lipoprotein distribution; Polymer; Radiolabelling; Stability

Indexed keywords

EDETIC ACID; GALLIUM 67; GALLIUM 68; GLYCEROL; POLYGLYCEROL; TECHNETIUM 99M; TRANSFERRIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BLOOD COMPATIBILITY; BLOOD POOL IMAGING; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG HALF LIFE; DRUG STABILITY; ERYTHROCYTE; IN VITRO STUDY; IN VIVO STUDY; ISOTOPE LABELING; MACROMOLECULE; MALE; MOLECULAR WEIGHT; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RAT; ROOM TEMPERATURE; THERMOSTABILITY; THROMBOCYTE ACTIVATION;

ANIMALS; BLOOD COAGULATION; CELL SURVIVAL; CELLS, CULTURED; COMPLEMENT ACTIVATION; ERYTHROCYTE AGGREGATION; GALLIUM RADIOISOTOPES; GATED BLOOD-POOL IMAGING; GLYCEROL; HALF-LIFE; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; INJECTIONS, INTRAVENOUS; MOLECULAR STRUCTURE; MOLECULAR WEIGHT; PARTIAL THROMBOPLASTIN TIME; PLATELET ACTIVATION; POLYMERS; POSITRON-EMISSION TOMOGRAPHY; PROTHROMBIN TIME; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; THROMBELASTOGRAPHY; TISSUE DISTRIBUTION;

EID: 84655169988     PISSN: 03785173     EISSN: 18733476     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2011.10.036     Document Type: Article

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