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Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 1, 2012, Pages 363-366

Discovery and characterization of a potent and selective antagonist of melanin-concentrating hormone receptor 2

(12) Chen, Xiaoqi a Mihalic, Jeff a Fan, Pingchen a Liang, Lingming a Lindstrom, Michelle a Wong, Sylvia a Ye, Qiuping a Fu, Ying a Jaen, Juan a Chen, Jin Long a Dai, Kang a Li, Leping a

a AMGEN INC (United States)

Author keywords

Antagonist; MCH; MCHR2

Indexed keywords

CARBAZOLE DERIVATIVE; MELANIN CONCENTRATING HORMONE RECEPTOR; MELANIN CONCENTRATING HORMONE RECEPTOR 2; MELANIN CONCENTRATING HORMONE RECEPTOR 2 ANTAGONIST; PEPTIDE HORMONE RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHO CELL; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DOG; DRUG BIOAVAILABILITY; DRUG CLEARANCE; DRUG DETERMINATION; DRUG HYDROXYLATION; DRUG POTENCY; DRUG SYNTHESIS; HIGH THROUGHPUT SCREENING; IC 50; MEAN RESIDENCE TIME; NONHUMAN; PROTEIN FUNCTION; RACEMIC MIXTURE; RAT; RHESUS MONKEY; STRUCTURE ACTIVITY RELATION;

ANIMALS; CARBAZOLES; CELL LINE; CHEMISTRY, PHARMACEUTICAL; CHO CELLS; CRICETINAE; DOGS; DRUG DESIGN; HUMANS; INHIBITORY CONCENTRATION 50; MACACA MULATTA; MODELS, CHEMICAL; PIPERIDINES; RATS; RECEPTORS, G-PROTEIN-COUPLED; RECEPTORS, PITUITARY HORMONE; STRUCTURE-ACTIVITY RELATIONSHIP;

CANIS FAMILIARIS; MACACA MULATTA; RATTUS;

EID: 84655162796 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2011.10.125 Document Type: Article

Times cited : (14)

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