Intravital imaging of thrombus formation in small and large mouse arteries: Experimentally induced vascular damage and plaque rupture in vivo

Methods in Molecular Biology

Volumn 788, Issue , 2012, Pages 3-19

  Kuijpers, Marijke J E ^a   Heemskerk, Johan W M ^a  

^a MAASTRICHT UNIVERSITY   (Netherlands)

Author keywords

Animal models; Arterial thrombus formation; Atherosclerosis; Coagulation; Plaque rupture; Platelet activation; Two photon microscopy

Indexed keywords

APOLIPOPROTEIN E;

ANIMAL; ARTICLE; ATHEROSCLEROTIC PLAQUE; C57BL MOUSE; CAROTID ARTERY; DISEASE MODEL; FEMALE; FLUORESCENCE MICROSCOPY; GENETICS; IMAGE PROCESSING; MALE; METHODOLOGY; MOUSE; PATHOLOGY; THROMBOSIS;

ANIMALS; APOLIPOPROTEINS E; CAROTID ARTERIES; DISEASE MODELS, ANIMAL; FEMALE; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; MICE; MICE, INBRED C57BL; MICROSCOPY, FLUORESCENCE; PLAQUE, ATHEROSCLEROTIC; THROMBOSIS;

ANIMALIA; MUS;

EID: 84555191653     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-61779-307-3_1     Document Type: Article

References (15)

1. Virmani R, Burke AP, Farb A, Kolodgie FD (2006) Pathology of the vulnerable plaque. J Am Coll Cardiol 47: C13-18.
2. Falati S, Gross P, Merrill-Skoloff G, Furie BC, Furie B (2002) Real-time in vivo imaging of platelets, tissue factor and fibrin during arterial thrombus formation in the mouse. Nat Med 8: 1175-1181.
3. Westrick RJ, Winn ME, Eitzman DT (2007) Murine models of vascular thrombosis (Eitzman series). Arterioscler Thromb Vasc Biol 27: 2079-2093. (Pubitemid 350287234)
4. oude Egbrink MGA, van Gestel MA, Broeders MD, Tangelder GJ, Heemskerk JWM, et al. (2005) Regulation of microvascular thromboembolism in vivo. Microcirculation 12: 287-300. (Pubitemid 40691824)
5. Kuijpers MJE, Gilio K, Reitsma S, Nergiz-Unal R, Prinzen L, et al. (2009) Complementary roles of platelets and coagulation in thrombus formation on plaques acutely ruptured by targeted ultrasound treatment: a novel intravital model. J Thromb Haemost 7: 152-161.
6. Hechler B, Eckly A, Magnenat S, Freund M, Cazenave JP, et al. (2009) Localized arterial thrombosis on ruptured atherosclerotic plaques of ApoE-/-mice after vascular injury with ultrasound. J Thromb Haemost 7: Abstract OC-TH-033.
7. Nergiz-Unal R, Cosemans JMEM, Feijge MAH, van der Meijden PEJ, Storey RF, et al. (2010) Stabilizing role of platelet P2Y 12 receptors in shear-dependent thrombus formation on ruptured plaques. PLoS One 2010; 5: e10130.
8. Munnix IC, Kuijpers MJ, Auger J, Thomassen CM, Panizzi P, et al. (2007) Segregation of platelet aggregatory and procoagulant microdomains in thrombus formation: regulation by transient integrin activation. Arterioscler Thromb Vasc Biol 27: 2484-2490. (Pubitemid 350203968)
9. Kuijpers MJ, Pozgajova M, Cosemans JM, Munnix IC, Eckes B, et al. (2007) Role of murine integrin alpha2beta1 in thrombus stabilization and embolization: Contribution of thromboxane A(2). Thromb Haemost 98: 1072-1080. (Pubitemid 350091137)
10. Kuijpers MJE, Munnix ICA, Cosemans JMEM, Van Vlijmen BJ, Reutelingsperger CPM, et al. (2008) Key role of platelet procoagulant activity in tissue factor-and collagen-dependent thrombus formation in arterioles and venules in vivo. Differential sensitivity to thrombin inhibition. Microcirculation 15: 269-282. (Pubitemid 351903343)
11. Megens RT, Oude Egbrink MG, Cleutjens JP, Kuijpers MJ, Schiffers PH, et al. (2007) Imaging collagen in intact viable healthy and atherosclerotic arteries using fluorescently labeled CNA35 and two-photon laser scanning microscopy. Mol Imaging 6: 247-260. (Pubitemid 47509829)
12. Denis C, Methia N, Frenette PS, Rayburn H, Ullman Cullere M, et al. (1998) A mouse model of severe von Willebrand disease: defects in hemostasis and thrombosis. Proc Natl Acad Sci USA 95: 9524-9529. (Pubitemid 28506264)
13. Massberg S, Gawaz M, Gruner S, Schulte V, Konrad I, et al. (2003) A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo. J Exp Med 197: 41-49. (Pubitemid 36110256)
14. van Zandvoort M, Engels W, Douma K, Beckers L, Oude Egbrink M, et al. (2004) Two-photon microscopy for imaging of the (atherosclerotic) vascular wall: a proof of concept study. J Vasc Res 41: 54-63. (Pubitemid 38296300)
15. Jirouskova M, Shet AS, Johnson GJ (2007) A guide to murine platelet structure, function, assays, and genetic alterations. J Thromb Haemost 5: 661-669. (Pubitemid 46563562)