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Volumn 125, Issue 1, 2012, Pages 196-208

Delayed reduction of hippocampal synaptic transmission and spines following exposure to repeated subclinical doses of organophosphorus pesticide in adult mice

Author keywords

Acetylcholinesterase; Chlorpyrifos; Gulf war illness; Gulf war syndrome; Synapse

Indexed keywords

CHLORPYRIFOS;

EID: 84555178188     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfr253     Document Type: Article
Times cited : (49)

References (71)
  • 2
    • 33747057459 scopus 로고    scopus 로고
    • In utero exposure to nicotine and chlorpyrifos alone, and in combination produces persistent sensorimotor deficits and Purkinje neuron loss in the cerebellum of adult offspring rats
    • Abou-Donia, M. B., Khan, W. A., Dechkovskaia, A. M., Goldstein, L. B., Bullman, S. L., and Abdel-Rahman, A. (2006). In utero exposure to nicotine and chlorpyrifos alone, and in combination produces persistent sensorimotor deficits and Purkinje neuron loss in the cerebellum of adult offspring rats. Arch. Toxicol. 80, 620-631.
    • (2006) Arch. Toxicol. , vol.80 , pp. 620-631
    • Abou-Donia, M.B.1    Khan, W.A.2    Dechkovskaia, A.M.3    Goldstein, L.B.4    Bullman, S.L.5    Abdel-Rahman, A.6
  • 3
    • 80855148211 scopus 로고    scopus 로고
    • Comparative effects of chlorpyrifos in wild-type and cannabinoid Cb1 receptor knockout mice
    • Baireddy, P., Liu, J., Hinsdale, M., and Pope, C. (2011). Comparative effects of chlorpyrifos in wild-type and cannabinoid Cb1 receptor knockout mice. Toxicol. Appl. Pharmacol. 256, 324-329.
    • (2011) Toxicol. Appl. Pharmacol. , vol.256 , pp. 324-329
    • Baireddy, P.1    Liu, J.2    Hinsdale, M.3    Pope, C.4
  • 4
    • 36248997070 scopus 로고    scopus 로고
    • Alteration of neurotrophins in the hippocampus and cerebral cortex of young rats exposed to chlorpyrifos and methyl parathion
    • Betancourt, A. M., Filipov, N. M., and Carr, R. L. (2007). Alteration of neurotrophins in the hippocampus and cerebral cortex of young rats exposed to chlorpyrifos and methyl parathion. Toxicol. Sci. 100, 445-455.
    • (2007) Toxicol. Sci. , vol.100 , pp. 445-455
    • Betancourt, A.M.1    Filipov, N.M.2    Carr, R.L.3
  • 5
    • 42749100518 scopus 로고    scopus 로고
    • Cholinesterase inhibitors for Alzheimer's disease
    • Birks, J. (2006). Cholinesterase inhibitors for Alzheimer's disease. Cochrane Database Syst. Rev. 1, CD005593.
    • (2006) Cochrane Database Syst. Rev. , vol.1
    • Birks, J.1
  • 6
    • 0031754195 scopus 로고    scopus 로고
    • Review of health consequences from high-, intermediate- and low-level exposure to organophosphorus nerve agents
    • Brown, M. A., and Brix, K. A. (1998). Review of health consequences from high-, intermediate- and low-level exposure to organophosphorus nerve agents. J. Appl. Toxicol. 18, 393-408.
    • (1998) J. Appl. Toxicol. , vol.18 , pp. 393-408
    • Brown, M.A.1    Brix, K.A.2
  • 7
    • 0028291114 scopus 로고
    • Repeated inhibition of cholinesterase by chlorpyrifos in rats: Behavioral, neurochemical and pharmacological indices of tolerance
    • Bushnell, P. J., Kelly, K. L., and Ward, T. R. (1994). Repeated inhibition of cholinesterase by chlorpyrifos in rats: Behavioral, neurochemical and pharmacological indices of tolerance. J. Pharmacol. Exp. Ther. 270, 15-25.
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , pp. 15-25
    • Bushnell, P.J.1    Kelly, K.L.2    Ward, T.R.3
  • 8
    • 20544476429 scopus 로고    scopus 로고
    • Longterm neurotoxicity of chlorpyrifos: Spatial learning impairment on repeated acquisition in a water maze
    • Canãdas, F., Cardona, D., Davila, E., and Sánchez-Santed, F. (2005). Longterm neurotoxicity of chlorpyrifos: Spatial learning impairment on repeated acquisition in a water maze. Toxicol. Sci. 85, 944-951.
    • (2005) Toxicol. Sci. , vol.85 , pp. 944-951
    • Canãdas, F.1    Cardona, D.2    Davila, E.3    Sánchez-Santed, F.4
  • 9
    • 54349095416 scopus 로고    scopus 로고
    • Effect of different administration paradigms on cholinesterase inhibition following repeated chlorpyrifos exposure in late preweaning rats
    • Carr, R. L., and Nail, C. A. (2008). Effect of different administration paradigms on cholinesterase inhibition following repeated chlorpyrifos exposure in late preweaning rats. Toxicol. Sci. 106, 186-192.
    • (2008) Toxicol. Sci. , vol.106 , pp. 186-192
    • Carr, R.L.1    Nail, C.A.2
  • 10
    • 13444288245 scopus 로고    scopus 로고
    • Cholinergic modulation of hippocampal cells and circuits
    • Cobb, S. R., and Davies, C. H. (2005). Cholinergic modulation of hippocampal cells and circuits. J. Physiol. 562, 81-88.
    • (2005) J. Physiol. , vol.562 , pp. 81-88
    • Cobb, S.R.1    Davies, C.H.2
  • 11
    • 0030826606 scopus 로고    scopus 로고
    • Chlorpyrifos produces selective learning deficits in rats working under a schedule of repeated acquisition and performance
    • Cohn, J., and MacPhail, R. C. (1997). Chlorpyrifos produces selective learning deficits in rats working under a schedule of repeated acquisition and performance. J. Pharmacol. Exp. Ther. 283, 312-320.
    • (1997) J. Pharmacol. Exp. Ther. , vol.283 , pp. 312-320
    • Cohn, J.1    MacPhail, R.C.2
  • 12
    • 33745795738 scopus 로고    scopus 로고
    • Organophosphate pesticide exposure and work in pome fruit: Evidence for the take-home pesticide pathway
    • Coronado, G. D., Vigoren, E. M., Thompson, B., Griffith, W. C., and Faustman, E. M. (2006). Organophosphate pesticide exposure and work in pome fruit: Evidence for the take-home pesticide pathway. Environ. Health Perspect. 114, 999-1006.
    • (2006) Environ. Health Perspect. , vol.114 , pp. 999-1006
    • Coronado, G.D.1    Vigoren, E.M.2    Thompson, B.3    Griffith, W.C.4    Faustman, E.M.5
  • 13
    • 0037704264 scopus 로고    scopus 로고
    • Paraoxonase PON 1 as a biomarker of susceptibility for organophosphate toxicity
    • Costa, L. G., Richter, R. J., Li, W. F., Cole, T., Guizzetti, M., and Furlong, C. E. (2003). Paraoxonase (PON 1) as a biomarker of susceptibility for organophosphate toxicity. Biomarkers 8, 1-12.
    • (2003) Biomarkers , vol.8 , pp. 1-12
    • Costa, L.G.1    Richter, R.J.2    Li, W.F.3    Cole, T.4    Guizzetti, M.5    Furlong, C.E.6
  • 17
    • 0029670738 scopus 로고    scopus 로고
    • Paired-pulse facilitation and depression at unitary synapses in rat hippocampus: Quantal fluctuation affects subsequent release
    • Debanne, D., Guerineau, N. C., Gahwiler, B. H., and Thompson, S. M. (1996). Paired-pulse facilitation and depression at unitary synapses in rat hippocampus: Quantal fluctuation affects subsequent release. J. Physiol. 491(Pt 1), 163-176.
    • (1996) J. Physiol. , vol.491 , Issue.PART 1 , pp. 163-176
    • Debanne, D.1    Guerineau, N.C.2    Gahwiler, B.H.3    Thompson, S.M.4
  • 18
    • 0035986863 scopus 로고    scopus 로고
    • Release probability is regulated by the size of the readily releasable vesicle pool at excitatory synapses in hippocampus
    • Dobrunz, L. E. (2002). Release probability is regulated by the size of the readily releasable vesicle pool at excitatory synapses in hippocampus. Int. J. Dev. Neurosci. 20, 225-236.
    • (2002) Int. J. Dev. Neurosci. , vol.20 , pp. 225-236
    • Dobrunz, L.E.1
  • 19
    • 0030919664 scopus 로고    scopus 로고
    • Heterogeneity of release probability, facilitation, and depletion at central synapses
    • Dobrunz, L. E., and Stevens, C. F. (1997). Heterogeneity of release probability, facilitation, and depletion at central synapses. Neuron 18, 995-1008.
    • (1997) Neuron , vol.18 , pp. 995-1008
    • Dobrunz, L.E.1    Stevens, C.F.2
  • 20
    • 79955744677 scopus 로고    scopus 로고
    • The cholinergic system and hippocampal plasticity. Behav
    • Drever, B. D., Riedel, G., and Platt, B. (2010). The cholinergic system and hippocampal plasticity. Behav. Brain Res. 221, 505-514.
    • (2010) Brain Res , vol.221 , pp. 505-514
    • Drever, B.D.1    Riedel, G.2    Platt, B.3
  • 22
    • 79960699408 scopus 로고    scopus 로고
    • Pharmacokinetics and pharmacodynamics of chlorpyrifos in adult male Long-Evans rats following repeated subcutaneous exposure to chlorpyrifos
    • Ellison, C. A., Smith, J. N., Lein, P. J., and Olson, J. R. (2011). Pharmacokinetics and pharmacodynamics of chlorpyrifos in adult male Long-Evans rats following repeated subcutaneous exposure to chlorpyrifos. Toxicology 287, 137-144.
    • (2011) Toxicology , vol.287 , pp. 137-144
    • Ellison, C.A.1    Smith, J.N.2    Lein, P.J.3    Olson, J.R.4
  • 23
    • 0032852717 scopus 로고    scopus 로고
    • Acute and chronic nicotine exposure differentially facilitate the induction of LTP
    • Fujii, S., Ji, Z., Morita, N., and Sumikawa, K. (1999). Acute and chronic nicotine exposure differentially facilitate the induction of LTP. Brain Res. 846, 137-143.
    • (1999) Brain Res. , vol.846 , pp. 137-143
    • Fujii, S.1    Ji, Z.2    Morita, N.3    Sumikawa, K.4
  • 24
    • 0034595443 scopus 로고    scopus 로고
    • Inactivation of alpha7 ACh receptors and activation of non-alpha7 ACh receptors both contribute to long term potentiation induction in the hippocampal CA1 region
    • Fujii, S., Ji, Z., and Sumikawa, K. (2000a). Inactivation of alpha7 ACh receptors and activation of non-alpha7 ACh receptors both contribute to long term potentiation induction in the hippocampal CA1 region. Neurosci. Lett. 286, 134-138.
    • (2000) Neurosci. Lett. , vol.286 , pp. 134-138
    • Fujii, S.1    Ji, Z.2    Sumikawa, K.3
  • 25
    • 0034724994 scopus 로고    scopus 로고
    • Nicotine reverses GABAergic inhibition of long-term potentiation induction in the hippocampal CA1 region
    • Fujii, S., Jia, Y., Yang, A., and Sumikawa, K. (2000b). Nicotine reverses GABAergic inhibition of long-term potentiation induction in the hippocampal CA1 region. Brain Res. 863, 259-265.
    • (2000) Brain Res. , vol.863 , pp. 259-265
    • Fujii, S.1    Jia, Y.2    Yang, A.3    Sumikawa, K.4
  • 26
    • 41949132813 scopus 로고    scopus 로고
    • Acetylcholinesterase inhibitors and Gulf War illnesses
    • Golomb, B. A. (2008). Acetylcholinesterase inhibitors and Gulf War illnesses. Proc. Natl. Acad. Sci. U. S. A. 105, 4295-4300.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 4295-4300
    • Golomb, B.A.1
  • 27
    • 79960193224 scopus 로고    scopus 로고
    • Timing-dependent septal cholinergic induction of dynamic hippocampal synaptic plasticity
    • Gu, Z., and Yakel, J. L. (2011). Timing-dependent septal cholinergic induction of dynamic hippocampal synaptic plasticity. Neuron 71, 155-165.
    • (2011) Neuron , vol.71 , pp. 155-165
    • Gu, Z.1    Yakel, J.L.2
  • 28
    • 0042512300 scopus 로고    scopus 로고
    • Gulf war syndrome: Narrowing the possibilities
    • Haley, R. W. (2003a). Gulf war syndrome: Narrowing the possibilities. Lancet Neurol. 2, 272-273.
    • (2003) Lancet Neurol. , vol.2 , pp. 272-273
    • Haley, R.W.1
  • 29
    • 0141860155 scopus 로고    scopus 로고
    • Excess incidence of ALS in young Gulf War veterans
    • Haley, R. W. (2003b). Excess incidence of ALS in young Gulf War veterans. Neurology 61, 750-756.
    • (2003) Neurology , vol.61 , pp. 750-756
    • Haley, R.W.1
  • 30
    • 0031030843 scopus 로고    scopus 로고
    • Self-reported exposure to neurotoxic chemical combinations in the Gulf War A cross-sectional epidemiologic study
    • Haley, R. W., and Kurt, T. L. (1997). Self-reported exposure to neurotoxic chemical combinations in the Gulf War. A cross-sectional epidemiologic study. JAMA 277, 231-237.
    • (1997) JAMA , vol.277 , pp. 231-237
    • Haley, R.W.1    Kurt, T.L.2
  • 31
    • 33751235837 scopus 로고    scopus 로고
    • The role of acetylcholine in learning and memory
    • Hasselmo, M. E. (2006). The role of acetylcholine in learning and memory. Curr. Opin. Neurobiol. 16, 710-715.
    • (2006) Curr. Opin. Neurobiol. , vol.16 , pp. 710-715
    • Hasselmo, M.E.1
  • 33
    • 23744456959 scopus 로고    scopus 로고
    • Chlorpyrifos exerts opposing effects on axonal and dendritic growth in primary neuronal cultures
    • Howard, A. S., Bucelli, R., Jett, D. A., Bruun, D., Yang, D., and Lein, P. J. (2005). Chlorpyrifos exerts opposing effects on axonal and dendritic growth in primary neuronal cultures. Toxicol. Appl. Pharmacol. 207, 112-124.
    • (2005) Toxicol. Appl. Pharmacol. , vol.207 , pp. 112-124
    • Howard, A.S.1    Bucelli, R.2    Jett, D.A.3    Bruun, D.4    Yang, D.5    Lein, P.J.6
  • 34
    • 0031778449 scopus 로고    scopus 로고
    • Gulf War syndrome-A model for the complexity of biological and environmental interaction with human health
    • Jamal, G. A. (1998). Gulf War syndrome-A model for the complexity of biological and environmental interaction with human health. Adverse Drug React. Toxicol. Rev. 17, 1-17.
    • (1998) Adverse Drug React. Toxicol. Rev. , vol.17 , pp. 1-17
    • Jamal, G.A.1
  • 35
    • 0037184874 scopus 로고    scopus 로고
    • Low level exposures to organophosphorus esters may cause neurotoxicity
    • Jamal, G. A., Hansen, S., and Julu, P. O. (2002a). Low level exposures to organophosphorus esters may cause neurotoxicity. Toxicology 181-182, 23-33.
    • (2002) Toxicology , vol.181-182 , pp. 23-33
    • Jamal, G.A.1    Hansen, S.2    Julu, P.O.3
  • 37
    • 50049083073 scopus 로고    scopus 로고
    • Prenatal and childhood exposure to pesticides and neurobehavioral development: Review of epidemiological studies
    • Jurewicz, J., and Hanke, W. (2008). Prenatal and childhood exposure to pesticides and neurobehavioral development: Review of epidemiological studies. Int. J. Occup. Med. Environ. Health 21, 121-132.
    • (2008) Int. J. Occup. Med. Environ. Health , vol.21 , pp. 121-132
    • Jurewicz, J.1    Hanke, W.2
  • 38
    • 3142781649 scopus 로고    scopus 로고
    • Association of pesticide exposure with neurologic dysfunction and disease
    • Kamel, F., and Hoppin, J. A. (2004). Association of pesticide exposure with neurologic dysfunction and disease. Environ. Health Perspect. 112, 950-958.
    • (2004) Environ. Health Perspect. , vol.112 , pp. 950-958
    • Kamel, F.1    Hoppin, J.A.2
  • 39
    • 0027515689 scopus 로고
    • Sensory neuropathy associated with Dursban chlorpyrifos exposure
    • Kaplan, J. G., Kessler, J., Rosenberg, N., Pack, D., and Schaumburg, H. H. (1993). Sensory neuropathy associated with Dursban (chlorpyrifos) exposure. Neurology 43, 2193-2196.
    • (1993) Neurology , vol.43 , pp. 2193-2196
    • Kaplan, J.G.1    Kessler, J.2    Rosenberg, N.3    Pack, D.4    Schaumburg, H.H.5
  • 40
    • 84855824953 scopus 로고    scopus 로고
    • A rising dose toxicology study to determine the no-observable-effect levels NOEL for erythrocyte acetyl-cholinesterase AChE inhibition and cholinergic signs and symptoms of chlorpyrifos at three dose levels. Lincoln, Neb: MDS Harris; April 19, 1999. Project 21438
    • Lockwood, A. H. Am J Public Health, 94/11/1908 [pii]
    • Kisicki JC, Seip CW, Combs ML. A rising dose toxicology study to determine the no-observable-effect levels (NOEL) for erythrocyte acetyl-cholinesterase (AChE) inhibition and cholinergic signs and symptoms of chlorpyrifos at three dose levels. Lincoln, Neb: MDS Harris; April 19, 1999. Project 21438.In Lockwood, A. H. (2004). Human testing of pesticides: ethical and scientific considerations. Am J Public Health 94, 1908-1916, 94/11/1908 [pii]. http://www.ncbi.nlm.nih.gov/pubmed/15514226?dopt=Citation
    • (2004) Human testing of pesticides: ethical and scientific considerations , vol.94 , pp. 1908-1916
    • Kisicki, J.C.1    Seip, C.W.2    Combs, M.L.3
  • 41
    • 24044433269 scopus 로고    scopus 로고
    • Organophosphate-induced delayed polyneuropathy
    • Lotti, M., and Moretto, A. (2005). Organophosphate-induced delayed polyneuropathy. Toxicol. Rev. 24, 37-49.
    • (2005) Toxicol. Rev. , vol.24 , pp. 37-49
    • Lotti, M.1    Moretto, A.2
  • 42
    • 57449088041 scopus 로고    scopus 로고
    • Presynaptic and postsynaptic NMDA receptors mediate distinct effects of brain-derived neurotrophic factor on synaptic transmission
    • Madara, J. C., and Levine, E. S. (2008). Presynaptic and postsynaptic NMDA receptors mediate distinct effects of brain-derived neurotrophic factor on synaptic transmission. J. Neurophysiol. 100, 3175-3184.
    • (2008) J. Neurophysiol. , vol.100 , pp. 3175-3184
    • Madara, J.C.1    Levine, E.S.2
  • 43
    • 0034791120 scopus 로고    scopus 로고
    • A normative construction of Gulf War syndrome
    • Mahoney, D. B. (2001). A normative construction of Gulf War syndrome. Perspect. Biol. Med. 44, 575-583.
    • (2001) Perspect. Biol. Med. , vol.44 , pp. 575-583
    • Mahoney, D.B.1
  • 44
    • 0027368451 scopus 로고
    • Modulation of synaptic transmission and long-term potentiation: Effects on paired pulse facilitation and EPSC variance in the CA1 region of the hippocampus
    • Manabe, T., Wyllie, D. J., Perkel, D. J., and Nicoll, R. A. (1993). Modulation of synaptic transmission and long-term potentiation: Effects on paired pulse facilitation and EPSC variance in the CA1 region of the hippocampus. J. Neurophysiol. 70, 1451-1459.
    • (1993) J. Neurophysiol. , vol.70 , pp. 1451-1459
    • Manabe, T.1    Wyllie, D.J.2    Perkel, D.J.3    Nicoll, R.A.4
  • 46
    • 36248964687 scopus 로고    scopus 로고
    • The effect of route, vehicle, and divided doses on the pharmacokinetics of chlorpyrifos and its metabolite trichloropyridinol in neonatal Sprague-Dawley rats
    • Marty, M. S., Domoradzki, J. Y., Hansen, S. C., Timchalk, C., Bartels, M. J., and Mattsson, J. L. (2007). The effect of route, vehicle, and divided doses on the pharmacokinetics of chlorpyrifos and its metabolite trichloropyridinol in neonatal Sprague-Dawley rats. Toxicol. Sci. 100, 360-373.
    • (2007) Toxicol. Sci. , vol.100 , pp. 360-373
    • Marty, M.S.1    Domoradzki, J.Y.2    Hansen, S.C.3    Timchalk, C.4    Bartels, M.J.5    Mattsson, J.L.6
  • 47
    • 77953026873 scopus 로고    scopus 로고
    • Repeated exposures to low-level chlorpyrifos results in impairments in sustained attention and increased impulsivity in rats
    • Middlemore-Risher, M. L., Buccafusco, J. J., and Terry, A. V., Jr. (2010). Repeated exposures to low-level chlorpyrifos results in impairments in sustained attention and increased impulsivity in rats. Neurotoxicol. Teratol. 32, 415-424.
    • (2010) Neurotoxicol. Teratol. , vol.32 , pp. 415-424
    • Middlemore-Risher, M.L.1    Buccafusco, J.J.2    Terry Jr., A.V.3
  • 48
    • 34249734238 scopus 로고    scopus 로고
    • A geneenvironment study of the paraoxonase 1 gene and pesticides in amyotrophic lateral sclerosis
    • Morahan, J. M., Yu, B., Trent, R. J., and Pamphlett, R. (2007). A geneenvironment study of the paraoxonase 1 gene and pesticides in amyotrophic lateral sclerosis. Neurotoxicology 28, 532-540.
    • (2007) Neurotoxicology , vol.28 , pp. 532-540
    • Morahan, J.M.1    Yu, B.2    Trent, R.J.3    Pamphlett, R.4
  • 49
    • 0029561808 scopus 로고
    • Comparisons of the acute effects of cholinesterase inhibitors using a neurobehavioral screening battery in rats
    • Moser, V. C. (1995). Comparisons of the acute effects of cholinesterase inhibitors using a neurobehavioral screening battery in rats. Neurotoxicol. Teratol. 17, 617-625.
    • (1995) Neurotoxicol. Teratol. , vol.17 , pp. 617-625
    • Moser, V.C.1
  • 50
    • 0030687921 scopus 로고    scopus 로고
    • Asymptomatic sequelae to acute sarin poisoning in the central and autonomic nervous system 6 months after the Tokyo subway attack
    • Murata, K., Araki, S., Yokoyama, K., Okumura, T., Ishimatsu, S., Takasu, N., and White, R. F. (1997). Asymptomatic sequelae to acute sarin poisoning in the central and autonomic nervous system 6 months after the Tokyo subway attack. J. Neurol. 244, 601-606.
    • (1997) J. Neurol. , vol.244 , pp. 601-606
    • Murata, K.1    Araki, S.2    Yokoyama, K.3    Okumura, T.4    Ishimatsu, S.5    Takasu, N.6    White, R.F.7
  • 51
    • 79951826784 scopus 로고    scopus 로고
    • Short- and long-lasting consequences of in vivo nicotine treatment on hippocampal excitability
    • Penton, R. E., Quick, M. W., and Lester, R. A. (2011). Short- and long-lasting consequences of in vivo nicotine treatment on hippocampal excitability. J. Neurosci. 31, 2584-2594.
    • (2011) J. Neurosci. , vol.31 , pp. 2584-2594
    • Penton, R.E.1    Quick, M.W.2    Lester, R.A.3
  • 52
    • 0034771255 scopus 로고    scopus 로고
    • An epidemiological study of the relations between exposure to organophosphate pesticides and indices of chronic peripheral neuropathy and neuropsychological abnormalities in sheep farmers and dippers
    • Pilkington, A., Buchanan, D., Jamal, G. A., Gillham, R., Hansen, S., Kidd, M., Hurley, J. F., and Soutar, C. A. (2001). An epidemiological study of the relations between exposure to organophosphate pesticides and indices of chronic peripheral neuropathy and neuropsychological abnormalities in sheep farmers and dippers. Occup. Environ. Med. 58, 702-710.
    • (2001) Occup. Environ. Med. , vol.58 , pp. 702-710
    • Pilkington, A.1    Buchanan, D.2    Jamal, G.A.3    Gillham, R.4    Hansen, S.5    Kidd, M.6    Hurley, J.F.7    Soutar, C.A.8
  • 53
    • 0033369584 scopus 로고    scopus 로고
    • Organophosphorus pesticides: Do they all have the same mechanism of toxicity?
    • Pope, C. N. (1999). Organophosphorus pesticides: Do they all have the same mechanism of toxicity? J. Toxicol. Environ. Health B Crit. Rev. 2, 161-181.
    • (1999) J. Toxicol. Environ. Health B Crit. Rev. , vol.2 , pp. 161-181
    • Pope, C.N.1
  • 54
    • 0031957438 scopus 로고    scopus 로고
    • Effects of chronic, low-level organophosphate exposure on delayed recall, discrimination, and spatial learning in monkeys and rats
    • Prendergast, M. A., Terry, A. V., Jr., and Buccafusco, J. J. (1998). Effects of chronic, low-level organophosphate exposure on delayed recall, discrimination, and spatial learning in monkeys and rats. Neurotoxicol. Teratol. 20, 115-122.
    • (1998) Neurotoxicol. Teratol. , vol.20 , pp. 115-122
    • Prendergast, M.A.1    Terry Jr., A.V.2    Buccafusco, J.J.3
  • 55
    • 79961050803 scopus 로고    scopus 로고
    • Seven-year neurodevelopmental scores and prenatal exposure to chlorpyrifos, a common agricultural pesticide
    • Rauh, V., Arunajadai, S., Horton, M., Perera, F., Hoepner, L., Barr, D. B., and Whyatt, R. (2011). Seven-year neurodevelopmental scores and prenatal exposure to chlorpyrifos, a common agricultural pesticide. Environ. Health Perspect. 119, 1196-1201.
    • (2011) Environ. Health Perspect. , vol.119 , pp. 1196-1201
    • Rauh, V.1    Arunajadai, S.2    Horton, M.3    Perera, F.4    Hoepner, L.5    Barr, D.B.6    Whyatt, R.7
  • 57
    • 77956904245 scopus 로고    scopus 로고
    • Dose-related gene expression changes in forebrain following acute, low-level chlorpyrifos exposure in neonatal rats
    • Ray, A., Liu, J., Ayoubi, P., and Pope, C. (2010). Dose-related gene expression changes in forebrain following acute, low-level chlorpyrifos exposure in neonatal rats. Toxicol. Appl. Pharmacol. 248, 144-155.
    • (2010) Toxicol. Appl. Pharmacol. , vol.248 , pp. 144-155
    • Ray, A.1    Liu, J.2    Ayoubi, P.3    Pope, C.4
  • 58
    • 77249099731 scopus 로고    scopus 로고
    • Mechanisms of chlorpyrifos and diazinon induced neurotoxicity in cortical culture
    • Rush, T., Liu, X. Q., Hjelmhaug, J., and Lobner, D. (2010). Mechanisms of chlorpyrifos and diazinon induced neurotoxicity in cortical culture. Neuroscience 166, 899-906.
    • (2010) Neuroscience , vol.166 , pp. 899-906
    • Rush, T.1    Liu, X.Q.2    Hjelmhaug, J.3    Lobner, D.4
  • 60
    • 1542298283 scopus 로고    scopus 로고
    • Long-term functional neurotoxicity of paraoxon and chlorpyrifos: Behavioural and pharmacological evidence
    • Sánchez-Santed, F., Canãdas, F., Flores, P., López-Grancha, M., and Cardona, D. (2004). Long-term functional neurotoxicity of paraoxon and chlorpyrifos: Behavioural and pharmacological evidence. Neurotoxicol. Teratol. 26, 305-317.
    • (2004) Neurotoxicol. Teratol. , vol.26 , pp. 305-317
    • Sánchez-Santed, F.1    Canãdas, F.2    Flores, P.3    López-Grancha, M.4    Cardona, D.5
  • 61
    • 0036353211 scopus 로고    scopus 로고
    • Noncholinesterase mechanisms of chlorpyrifos neurotoxicity: Altered phosphorylation of Ca2+/cAMP response element binding protein in cultured neurons
    • Schuh, R. A., Lein, P. J., Beckles, R. A., and Jett, D. A. (2002). Noncholinesterase mechanisms of chlorpyrifos neurotoxicity: Altered phosphorylation of Ca2+/cAMP response element binding protein in cultured neurons. Toxicol. Appl. Pharmacol. 182, 176-185.
    • (2002) Toxicol. Appl. Pharmacol. , vol.182 , pp. 176-185
    • Schuh, R.A.1    Lein, P.J.2    Beckles, R.A.3    Jett, D.A.4
  • 62
    • 61849176478 scopus 로고    scopus 로고
    • Protein kinase C is a target for diverse developmental neurotoxicants: Transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells
    • Slotkin, T. A., and Seidler, F. J. (2009). Protein kinase C is a target for diverse developmental neurotoxicants: Transcriptional responses to chlorpyrifos, diazinon, dieldrin and divalent nickel in PC12 cells. Brain Res. 1263, 23-32.
    • (2009) Brain Res. , vol.1263 , pp. 23-32
    • Slotkin, T.A.1    Seidler, F.J.2
  • 63
    • 66049098146 scopus 로고    scopus 로고
    • Comparative chlorpyrifos pharmacokinetics via multiple routes of exposure and vehicles of administration in the adult rat
    • Smith, J. N., Campbell, J. A., Busby-Hjerpe, A. L., Lee, S., Poet, T. S., Barr, D. B., and Timchalk, C. (2009). Comparative chlorpyrifos pharmacokinetics via multiple routes of exposure and vehicles of administration in the adult rat. Toxicology 261, 47-58.
    • (2009) Toxicology , vol.261 , pp. 47-58
    • Smith, J.N.1    Campbell, J.A.2    Busby-Hjerpe, A.L.3    Lee, S.4    Poet, T.S.5    Barr, D.B.6    Timchalk, C.7
  • 64
    • 0031194056 scopus 로고    scopus 로고
    • Cellular mechanisms for developmental toxicity of chlorpyrifos: Targeting the adenylyl cyclase signaling cascade
    • Song, X., Seidler, F. J., Saleh, J. L., Zhang, J., Padilla, S., and Slotkin, T. A. (1997). Cellular mechanisms for developmental toxicity of chlorpyrifos: Targeting the adenylyl cyclase signaling cascade. Toxicol. Appl. Pharmacol. 145, 158-174.
    • (1997) Toxicol. Appl. Pharmacol. , vol.145 , pp. 158-174
    • Song, X.1    Seidler, F.J.2    Saleh, J.L.3    Zhang, J.4    Padilla, S.5    Slotkin, T.A.6
  • 65
    • 42149109203 scopus 로고    scopus 로고
    • The effect of nicotine on spiking activity and Ca2+ dynamics of dendritic spines in rat CA1 pyramidal neurons
    • Szabo, S. I., Zelles, T., Vizi, E. S., and Lendvai, B. (2008). The effect of nicotine on spiking activity and Ca2+ dynamics of dendritic spines in rat CA1 pyramidal neurons. Hippocampus 18, 376-385.
    • (2008) Hippocampus , vol.18 , pp. 376-385
    • Szabo, S.I.1    Zelles, T.2    Vizi, E.S.3    Lendvai, B.4
  • 66
    • 70349952318 scopus 로고    scopus 로고
    • Chlorpyrifos induces delayed cytotoxicity after withdrawal in primary hippocampal neurons through extracellular signalregulated kinase inhibition
    • Tan, D.H., Peng, S. Q., Wu, Y. L., Wang, Y. M., Lu, C. F., Ding, W., Wang, Q.X., and Yan, C. H. (2009). Chlorpyrifos induces delayed cytotoxicity after withdrawal in primary hippocampal neurons through extracellular signalregulated kinase inhibition. Biol. Pharm. Bull. 32, 1649-1655.
    • (2009) Biol. Pharm. Bull. , vol.32 , pp. 1649-1655
    • Tan, D.H.1    Peng, S.Q.2    Wu, Y.L.3    Wang, Y.M.4    Lu, C.F.5    Ding, W.6    Wang, Q.X.7    Yan, C.H.8
  • 68
    • 0037379972 scopus 로고    scopus 로고
    • Repeated exposures to subthreshold doses of chlorpyrifos in rats: Hippocampal damage, impaired axonal transport, and deficits in spatial learning
    • Terry, A. V., Jr., Stone, J. D., Buccafusco, J. J., Sickles, D. W., Sood, A., and Prendergast, M. A. (2003). Repeated exposures to subthreshold doses of chlorpyrifos in rats: Hippocampal damage, impaired axonal transport, and deficits in spatial learning. J. Pharmacol. Exp. Ther. 305, 375-384.
    • (2003) J. Pharmacol. Exp. Ther. , vol.305 , pp. 375-384
    • Terry Jr., A.V.1    Stone, J.D.2    Buccafusco, J.J.3    Sickles, D.W.4    Sood, A.5    Prendergast, M.A.6
  • 70
    • 40849142446 scopus 로고    scopus 로고
    • Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase
    • Yang, D., Howard, A., Bruun, D., Ajua-Alemanj, M., Pickart, C., and Lein, P. J. (2008). Chlorpyrifos and chlorpyrifos-oxon inhibit axonal growth by interfering with the morphogenic activity of acetylcholinesterase. Toxicol. Appl. Pharmacol. 228, 32-41.
    • (2008) Toxicol. Appl. Pharmacol. , vol.228 , pp. 32-41
    • Yang, D.1    Howard, A.2    Bruun, D.3    Ajua-Alemanj, M.4    Pickart, C.5    Lein, P.J.6


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