Synchronicity of systolic deformation in healthy pediatric and young adult subjects: A two-dimensional strain echocardiography study

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 302, Issue 1, 2012, Pages

  Marcus, Karen A ^a   Janoušek, Jan ^b   Barends, Marlieke E ^a   Weijers, Gert ^a   de Korte, Chris L ^a   Kapusta, Livia ^a,c  

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b UNIVERSITY HOSPITAL MOTOL   (Czech Republic)

^c WOLFSON MEDICAL CENTER   (Israel)

Author keywords

Child; Reference value

Indexed keywords

ADULT; ANTHROPOMETRY; ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; HUMAN; MALE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SYSTOLE; TRANSTHORACIC ECHOCARDIOGRAPHY; TWO DIMENSIONAL ECHOCARDIOGRAPHY;

ADOLESCENT; ADULT; AGE FACTORS; AGING; ANALYSIS OF VARIANCE; CHILD; CHILD, PRESCHOOL; ECHOCARDIOGRAPHY, DOPPLER; ECHOCARDIOGRAPHY, DOPPLER, PULSED; ELECTROCARDIOGRAPHY; HEART RATE; HEART VENTRICLES; HUMANS; INFANT; INFANT, NEWBORN; NETHERLANDS; PERIODICITY; PREDICTIVE VALUE OF TESTS; REFERENCE VALUES; RETROSPECTIVE STUDIES; SYSTOLE; TIME FACTORS; VENTRICULAR FUNCTION, LEFT; YOUNG ADULT;

EID: 84455208788     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00740.2011     Document Type: Article

References (71)

1. Abd EI Rahman MY, Hui W, Yigitbasi, Dsebissowa F, Schubert S, Hetzer R, Lange PE, Abdul-Khaliq H. Detection of left ventricular asynchrony in patients with right bundle branch block after repair of tetralogy of Fallot using tissue-Doppler imaging-derived strain. J Am Coll Cardiol 45: 915-921, 2005.
2. Abraham WT, Fisher WG, Smith AL, Delurgio DB, Leon AR, Loh E, Kocovic DZ, Packer M, Clavell AL, Hayes DL, Ellestad M, Trupp RJ, Underwood J, Pickering F, Truex C, McAtee P, Messenger J; MIRACLE Study Group. Multicenter InSync Randomized Clinical Evaluation. Cardiac resynchronization in chronic heart failure. N Engl J Med 346: 1845-1853, 2002.
3. Achilli A, Sassara M, Ficili S, Pontillo D, Achilli P, Alessi C, De Spirito S, Guerra R, Patruno N, Serra F. Long-term effectiveness of cardiac resynchronization therapy in patients with refractory heart failure and "narrow" QRS. J Am Coll Cardiol 42: 2117-2124, 2003.
4. American College of Cardiology, American Heart Association. A Report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines ACC/AHA 2005 guideline update for the diagnosis and management of chronic heart failure in the adult-summary article. J Am Coll Cardiol 46: 1116-1143, 2005.
5. Amundsen BH, Helle-Valle T, Edvardsen T, Torp H, Crosby J, Lyseggen E, Støylen A, Ihlen H, Lima JA, Smiseth OA, Slørdahl SA. Noninvasive myocardial strain measurement by speckle tracking echocar-diography: validation against sonomicrometry and tagged magnetic resonance imaging. J Am Coll Cardiol 47: 789-793, 2006.
6. Ansalone G, Giannantoni P, Ricci R, Trambaiolo P, Fedele F, Santini M. Doppler myocardial imaging to evaluate the effectiveness of pacing sites in patients receiving biventricular pacing. J Am Coll Cardiol 39: 489-499, 2002.
7. Bazett HC. An analysis of the time-relations of electrocardiograms. Heart 7: 353-370, 1920.
8. Becker M, Bilke E, Kuhl H, Katoh M, Kramann R, Franke A, Bücker A, Hanrath P, Hoffmann R. Analysis of myocardial deformation based on pixel tracking in two dimensional echocardiographic images enables quantitative assessment of regional left ventricular function. Heart 92: 1102-1108, 2006.
9. Berne RM, Levy MN. Physiology (3rd ed.). St. Louis, IL: Mosby, 1993.
10. Bleeker GB, Bax JJ, Fung JW, van der Wall EE, Zhang Q, Schalij MJ, Chan JY, Yu CM. Clinical versus echocardiographic parameters to assess response to cardiac resynchronization therapy. Am J Cardiol 97: 260-263, 2006.
11. Boettler P, Hartmann M, Watzl K, Maroula E, Schulte-Moenting J, Knirsch W, Dittrich S, Kececioglu D. Heart rate effects on strain and strain rate in healthy children. J Am Soc Echocardiogr 18: 1121-1130, 2005.
12. Bradley DJ, Bradley EA, Baughman KL, Berger RD, Calkins H, Goodman SN, Kass DA, Powe NR. Cardiac resynchronization and death from progressive heart failure: a meta-analysis of randomized controlled trials. JAMA 289: 730-740, 2003.
13. Breithardt OA, Stellbrink C, Kramer AP, Sinha AM, Franke A, Salo R, Schiffgens B, Huvelle E, Auricchio A; PATH-CHF Study Group. Pacing Therapies for Congestive Heart Failure. Echocardiographic quantification of left ventricular asynchrony predicts an acute hemody-namic benefit of cardiac resynchronization therapy. J Am Coll Cardiol 40: 536-545, 2002.
14. Bristow MR, Saxon LA, Boehmer J, Krueger S, Kass DA, De Marco T, Carson P, DiCarlo L, DeMets D, White BG, DeVries DW, Feldman AM; Comparison of Medical Therapy, Pacing, and Defibrillation in Heart Failure (COMPANION) Investigators. Cardiac-resynchroniza-tion therapy with or without an implantable defibrillator in advanced chronic heart failure. N Engl J Med 350: 2140-2150, 2004.
15. Cecchin F, Frangini PA, Brown DW, Fynn-Thompson F, Alexander ME, Triedman JK, Gauvreau K, Walsh EP, Berul CI. Cardiac resyn-chronization therapy (and multisite pacing) in pediatrics and congenital heart disease: five years' experience in a single institution. J Cardiovasc Electrophysiol 20: 58-65, 2009.
16. Cerqueira MD, Weissman NJ, Dilsizian V, Jacobs AK, Kaul S, Laskey WK, Pennell DJ, Rumberger JA, Ryan T, Verani MS; American Heart Association Writing Group on Myocardial Segmentation and Registration for Cardiac Imaging. Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart. A statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association. Int J Cardiovasc Imaging 18: 539-542, 2002.
17. Chan PS, Khumri T, Chung ES, Ghio S, Reid KJ, Gerritse B, Nallamothu BK, Spertus JA. Echocardiographic dyssynchrony and health status outcomes from cardiac resynchronization therapy. Insights from the PROSPECT trial. JACC Cardiovasc Imaging 3: 451-460, 2010.
18. Chattopadhyay S, Alamgir MF, Nikitin NP, Fraser AG, Clark AL, Cleland JG. The effect of pharmacological stress on intraventricular dyssynchrony in left ventricular systolic dysfunction. Eur J Heart Fail 10: 412-420, 2008.
19. Cho GY, Chan J, Leano R, Strudwick M, Marwick TH. Comparison of two dimensional speckle and tissue velocity based strain and validation with harmonic phase magnetic resonance imaging. Am J Cardiol 97: 1661-1666, 2006.
20. Chung ES, Leon AR, Tavazzi L, Sun JP, Nihoyannopoulos P, Merlino J, Abraham WT, Ghio S, Leclercq C, Bax JJ, Yu CM, Gorcsan J, St John Sutton M, De Sutter J, Murillo J. Results of the Predictors of response to CRT (PROSPECT) trial. Circulation 117: 2608-2616, 2008.
21. Cleland JG, Daubert JC, Erdmann E, Freemantle N, Gras D, Kap-penberger L, Tavazzi L; Cardiac Resynchronization-Heart Failure (CARE-HF) Study Investigators. The effect of cardiac resynchroniza-tion on morbidity and mortality in heart failure. N Engl J Med 352: 1539-1549, 2005.
22. Colan SD, Borow KM, Neumann A. Left ventricular end-systolic wall stress-velocity of fiber shortening relation: a load-independent index of myocardial contractility. J Am Coll Cardiol 4: 715-724, 1984.
23. Delgado V, Tops LF, van Bommel RJ, van der Kley F, Marsan NA, Klautz RJ, Versteegh MI, Holman ER, Schalij MJ, Bax JJ. Strain analysis in patients with severe aortic stenosis and preserved left ventricular ejection fraction undergoing surgical valve replacement. Eur Heart J 30: 3037-3047, 2009.
24. Devereux RB, Reichek N. Echocardiographic determination of left ventricular mass in man. Anatomic validation of the method. Circulation 55: 613-618, 1977.
25. Dickstein K, Vardas PE, Auricchio A, Daubert JC, Linde C, McMurray J, Ponikowski P, Priori SG, Sutton R, van Veldhuisen DJ; ESC Committee for Practice Guidelines, Vahanian A, Auricchio A, Bax J, Ceconi C, Dean V, Filippatos G, Funck-Brentano C, Hobbs R, Kearney P, McDonagh T, Popescu BA, Reiner Z, Sechtem U, Sirnes PA, Tendera M, Vardas P, Widimsky P, Tendera M, Anker SD, Blanc JJ, Gasparini M, Hoes AW, Israel CW, Kalarus Z, Merkely B, Swedberg K, Camm AJ. 2010 Focused Update of ESC Guidelines on device therapy in heart failure: an update of the 2008 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure and the 2007 ESC Guidelines for cardiac and resynchronization therapy. Developed with the special contribution of the Heart Failure Association and the European Heart Rhythm Association. Europace 12: 1526-1536, 2010.
26. Dubin AM, Janousek J, Rhee E, Strieper MJ, Cecchin F, Law IH, Shannon KM, Temple J, Rosenthal E, Zimmerman FJ, Davis A, Karpawich PP, Al Ahmad A, Vetter VL, Kertesz NJ, Shah M, Snyder C, Stephenson E, Emmel M, Sanatani S, Kanter R, Batra A, Collins KK. Resynchronization therapy in pediatric and congenital heart disease patients: an international multicenter study. J Am Coll Cardiol 46: 2277- 2283, 2005.
27. Fonseca CG, Oxenham HC, Cowan BR, Occleshaw CJ, Young AA. Aging alters patterns of regional nonuniformity in LV strain relaxation: a 3-D MR tissue tagging study. Am J Physiol Heart Circ Physiol 285: H621-H630, 2003.
28. Ganame J, Mertens L, Eidem BW, Claus P, D'hooge J, Havemann LM, McMahon CJ, Elayda MA, Vaughn WK, Towbin JA, Ayres NA, Pignatelli RH. Regional myocardial deformation in children with hyper-trophic cardiomyopathy: morphological and clinical correlations. Eur Heart J 28: 2886-2894, 2007.
29. Janousek J, Gebauer RA. Cardiac resynchronization therapy in pediatric and congenital heart disease. Pacing Clin Electrophysiol 31, Suppl 1: S21-23, 2008.
30. Janousek J. Cardiac resynchronisation in congenital heart disease. Heart 95: 940-947, 2009.
31. Janousek J, Gebauer RA, Abdul-Khaliq H, Turner M, Kornyei L, Grollmuss O, Rosenthal E, Villain E, Früh A, Paul T, Blom NA, Happonen JM, Bauersfeld U, Jacobsen JR, van den Heuvel F, Delhaas T, Papagiannis J, Trigo C; Working Group for Cardiac Dysrhythmias and Electrophysiology of the Association for European Paediatric Cardiology. Cardiac resynchronisation therapy in paediatric and congenital heart disease: differential effects in various anatomical and functional substrates. Heart 95: 1165-1171, 2009.
32. Kalogeropoulos AP, Georgiopoulou VV, Howell S, Pernetz MA, Fisher MR, Lerakis S, Martin RP. Evaluation of right intraventricular dyssynchrony by two-dimensional strain echocardiography in patients with pulmonary arterial hypertension. J Am Soc Echocardiogr 21: 1028- 1034, 2008.
33. Kass DA, Chen CH, Curry C, Talbot M, Berger R, Fetics B, Nevo E. Improved left ventricular mechanics from acute VDD pacing in patients with dilated cardiomyopathy and ventricular conduction delay. Circulation 99: 1567-1573, 1999.
34. Kligfield P, Gettes LS, Bailey JJ, Childers R, Deal BJ, Hancock EW, van Herpen G, Kors JA, Macfarlane P, Mirvis DM, Pahlm O, Rau-taharju P, Wagner GS; American Heart Association Electrocardiog-raphy and Arrhythmias Committee, Council on Clinical Cardiology; American College of Cardiology Foundation; Heart Rhythm Society. Recommendations for the standardization and interpretation of the electrocardiogram Part I: The electrocardiogram and its technology A scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society. Heart Rhythm 4: 394-412, 2007.
35. Kitzman DW, Sheikh KH, Beere PA, Philips JL, Higginbotham MB. Age-related alterations of Doppler left ventricular filling indexes in normal subjects are independent of left ventricular mass, heart rate, contractility and loading conditions. J Am Coll Cardiol 18: 1243-1250, 1991.
36. Korinek J, Wang J, Sengupta PP, Miyazaki C, Kjaergaard J, McMahon E, Abraham TP, Belohlavek M. Two-dimensional strain-a Doppler-independent ultrasound method for quantitation of regional deformation: validation in vitro and in vivo. J Am Soc Echocardiogr 18: 1247-1253, 2005.
37. Kuroda T, Seward JB, Rumberger JA, Yanagi H, Tajik AJ. Left ventricular volume and mass: comparative study of two-dimensional echocardiography and ultrafast computed tomography. Echocardiography 11: 1-9, 1994.
38. Lakatta EG, Gerstenblith G, Angell CS, Shock NW, Weisfeldt ML. Prolonged contraction duration in aged myocardium. J Clin Invest 55: 61-68, 1975.
39. Lang RM, Bierig M, Devereux RB, Flachskampf FA, Foster E, Pellikka PA, Picard MH, Roman MJ, Seward J, Shanewise JS, Solomon SD, Spencer KT, Sutton MS, Stewart WJ; Chamber Quantification Writing Group; American Society of Echocardiography's Guidelines and Standards Committee; European Association of Echo-cardiography. Recommendations for chamber quantification: a report from the American Society of Echocardiography's Guidelines and Standards Committee and the Chamber Quantification Writing Group, developed in conjunction with the European Association of Echocardiography, a branch of the European Society of Cardiology. J Am Soc Echocardiogr 18: 1440-1463, 2005.
40. Leitman M, Lysyansky P, Sidenko S, Shir V, Peleg E, Binenbaum M, Kaluski E, Krakover R, Vered Z. Two-dimensional strain-A novel software for real-time quantitative echocardiographic assessment of myo-cardial function. J Am Soc Echocardiogr 17: 1021-1029, 2004.
41. Linde C, Leclercq C, Rex S, Garrigue S, Lavergne T, Cazeau S, McKenna W, Fitzgerald M, Deharo JC, Alonso C, Walker S, Braunschweig F, Bailleul C, Daubert JC. Long-term benefits of biventricular pacing in congestive heart failure: results from the Multisite STimulation in cardiomyopathy (MUSTIC) study. J Am Coll Cardiol 40: 111-118, 2002.
42. López B, González A, Querejeta R, Díez J. The use of collagen-derived serum peptides for the clinical assessment of hypertensive heart disease. J Hypertens 23: 1445-1451, 2005.
43. Marcus KA, Mavinkurve-Groothuis AM, Barends ME, van Dijk A, Feuth T, de Korte C, Kapusta L. Reference values for myocardial two dimensional strain echocardiography in a healthy pediatric and young adult cohort. J Am Soc Echocardiogr 24: 625-636, 2011.
44. Marcus KA, de Korte CL, Feuth T, Thijssen JM, Kapusta L. Abnormal two-dimensional strain echocardiography findings in children with congenital valvar aortic stenosis. Ultraschall Med 2011 Mar 17 [Epub ahead of print].
45. Mehra MR, Greenberg BH. Cardiac resynchronization therapy: caveat medicus. J Am Coll Cardiol 43: 1145-1148, 2004.
46. Mollema SA, Bleeker GB, van der Wall EE, Schalij MJ, Bax JJ. Usefulness of QRS duration to predict response to cardiac resynchroniza-tion therapy in patients with end-stage heart failure. Am J Cardiol 100: 1665-1670, 2007.
47. Moiduddin N, Texter KM, Zaidi AN, Hershenson JA, Stefaniak C, Hayes J, Cua CL. Two-dimensional speckle strain and dyssynchrony in single left ventricles vs. normal left ventricles. Congenit Heart Dis 5: 579-586, 2010.
48. Mueller M, Rentzsch A, Hoetzer K, Raedle-Hurst T, Boettler P, Stiller B, Lemmer J, Sarikouch S, Beerbaum P, Peters B, Vogt M, Vogel M, Abdul-Khaliq H. Assessment of interventricular and right-intraventricu-lar dyssynchrony in patients with surgically repaired tetralogy of Fallot by two-dimensional speckle tracking. Eur J Echocardiogr 11: 786-792, 2010.
49. Nelson GS, Berger RD, Fetics BJ, Talbot M, Spinelli JC, Hare JM, Kass DA. Left ventricular or biventricular pacing improves cardiac function at diminished energy cost in patients with dilated cardiomyopathy and left bundle-branch block. Circulation 102: 3053-3059, 2000.
50. Nelson GS, Curry CW, Wyman BT, Kramer A, Declerck J, Talbot M, Douglas MR, Berger RD, McVeigh ER, Kass DA. Predictors of systolic augmentation from left ventricular preexcitation in patients with dilated cardiomyopathy and intraventricular conduction delay. Circulation 101: 2703-2709, 2000.
51. Ng AC, Tran da T, Newman M, Allman C, Vidaic J, Lo ST, Hopkins AP, Leung DY. Left ventricular longitudinal and radial synchrony and their determinants in healthy subjects. J Am Soc Echocardiogr 21: 1042- 1048, 2008.
52. van Oosterhout MF, Prinzen FW, Arts T, Schreuder JJ, Vanagt WY, Cleutjens JP, Reneman RS. Asynchronous electrical activation induces asymmetrical hypertrophy of the left ventricular wall. Circulation 98: 588-595, 1998.
53. Poerner TC, Goebel B, Geiger T, Haghi D, Borggrefe M, Haase KK. Physiological range of mechanical synchronicity of the human heart: comparison between different echocardiographic assessment modalities. Ultrasound Med Biol 31: 1163-1172, 2005.
54. Prinzen FW, Augustijn CH, Arts T, Allessie MA, Reneman RS. Redistribution of myocardial fiber strain and blood flow by asynchronous activation. Am J Physiol Heart Circ Physiol 259: H300-H308, 1990.
55. Prinzen FW, Hunter WC, Wyman BT, McVeigh ER. Mapping of regional myocardial strain and work during ventricular pacing: experimental study using magnetic resonance imaging tagging. J Am Coll Cardiol 33: 1735-1742, 1999.
56. Rijnbeek PR, Witsenburg M, Schrama E, Hess J, Kors JA. New normal limits for the paediatric electrocardiogram. Eur Heart J 22: 702-711, 2001.
57. Rosen BD, Fernandes VR, Nasir K, Helle-Valle T, Jerosch-Herold M, Bluemke DA, Lima JA. Age, increased left ventricular mass, and lower regional myocardial perfusion are related to greater extent of myocardial dyssynchrony in asymptomatic individuals: the multi-ethnic study of atherosclerosis. Circulation 120: 859-866, 2009.
58. Rowland DG, Gutgesell HP. Use of mean arterial pressure for noninva-sive determination of left ventricular end-systolic wall stress in infants and children. Am J Cardiol 74: 98-99, 1994.
59. Sarubbi B, Ducceschi V, Santangelo L, Iacono A. Arrhythmias in patients with mechanical ventricular dysfunction and myocardial stretch: role of mechano-electric feedback. Can J Cardiol 14: 245-252, 1998.
60. Saxon LA, Ellenbogen KA. Resynchronization therapy for the treatment of heart failure. Circulation 108: 1044-1048, 2003.
61. Shi H, Shu X, Wang F, Cui J, Chen H, Sun B, Liu S. Longitudinal two-dimensional strain rate imaging: a potential approach to predict the response to cardiac resynchronization therapy. Int J Cardiovasc Imaging 25: 677-687, 2009.
62. Skulstad H, Edvardsen T, Urheim S, Lyseggen E, Rodevand O, Smiseth OA. Postsystolic shortening in ischemic myocardium: active contraction or passive recoil? Circulation 106: 718-724, 2002.
63. Suffoletto MS, Dohi K, Cannesson M, Saba S, Gorcsan J. Novel speckle-tracking radial strain from routine black-and-white echocardio-graphic images to quantify dyssynchrony and predict response to cardiac resynchronization therapy. Circulation 113: 960-968, 2006.
64. Surawicz B, Childers R, Deal BJ, Gettes LS, Bailey JJ, Gorgels A, Hancock EW, Josephson M, Kligfield P, Kors JA, Macfarlane P, Mason JW, Mirvis DM, Okin P, Pahlm O, Rautaharju PM, van Herpen G, Wagner GS, Wellens H; American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; American College of Cardiology Foundation; Heart Rhythm Society. AHA/ACCF/HRS recommendations for the standardization and interpretation of the electrocardiogram: part III: intraventric-ular conduction disturbances: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society: endorsed by the International Society for Computerized Electrocardiology. Circulation 119: e235-240, 2009.
65. Swedberg K, Cleland J, Dargie H, Drexler H, Follath F, Komajda M, Tavazzi L, Smiseth OA, Gavazzi A, Haverich A, Hoes A, Jaarsma T, Korewicki J, Lévy S, Linde C, Lopez-Sendon JL, Nieminen MS, Piérard L, Remme WJ; Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology. Guidelines for the diagnosis and treatment of chronic heart failure: executive summary (update 2005): the Task Force for the Diagnosis and Treatment of Chronic Heart Failure of the European Society of Cardiology. Eur Heart J 26: 1115-1140, 2005.
66. Takemoto Y, Hozumi T, Sugioka K, Takagi Y, Matsumura Y, Yo-shiyama M, Abraham TP, Yoshikawa J. Beta-blocker therapy induces ventricular resynchronization in dilated cardiomyopathy with narrow QRS complex. J Am Coll Cardiol 49: 778-783, 2007.
67. Tei C, Ling LH, Hodge DO, Bailey KR, Oh JK, Rodeheffer RJ, Tajik AJ, Seward JB. New index of combined systolic and diastolic myocardial performance: a simple and reproducible measure of cardiac function-a study in normals and dilated cardiomyopathy. J Cardiol 26: 357-366, 1995.
68. Templeton GH, Platt MR, Willerson JT, Weisfeldt ML. Influence of aging on left ventricular hemodynamics and stiffness in beagles. Circ Res 44: 189-194, 1979.
69. Urheim S, Edvardsen T, Torp H, Angelsen B, Smiseth OA. Myocardial strain by Doppler echocardiography. Validation of a new method to quantify regional myocardial function. Circulation 102: 1158-1164, 2000.
70. Yu CM, Lin H, Zhang Q, Sanderson JE. High prevalence of left ventricular systolic and diastolic asynchrony in patients with congestive heart failure and normal QRS duration. Heart 89: 54-60, 2003.
71. Zwanenburg JJ, Götte MJ, Kuijer JP, Heethaar RM, van Rossum AC, Marcus JT. Timing of cardiac contraction in humans mapped by high-temporal-resolution MRI tagging: early onset and late peak of shortening in lateral wall. Am J Physiol Heart Circ Physiol 286: H1872-H1880, 2004.