Studies on the preparation, characterization and solubility of nimodipine inclusion complexes with β-cyclodextrin

International Journal of Pharma and Bio Sciences

Volumn 1, Issue 2, 2010, Pages

  Majahar, S K ^a   Rao Kusumanchi, R M ^a   Gayatri, B N ^a  

^a Hetero Drugs Limited   (India)

Author keywords

cyclodextrin; Complexation; DSC; Nimodipine; Phase solubility; XRD

Indexed keywords

BETA CYCLODEXTRIN; NIMODIPINE;

ARTICLE; COMPLEX FORMATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG FORMULATION; DRUG SOLUBILITY; DRUG STABILITY; IN VITRO STUDY; X RAY DIFFRACTION;

EID: 84455207877     PISSN: None     EISSN: 09756299     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. th Edn, 3986, (2005).
2. George Z. Papageorgiou, Dimitrios Bikiaris, Evagelos Karavas, Stavros Politis, Aristides Docoslis,, Yong Park Anagnostis Stergiou and Emmanouel Georgarakis, Effect of physical state and particle size distribution on dissolution enhancement of nimodipine/PEG solid dispersions prepared by melt mixing and solvent evaporation. AAPS Pharm Sci Tech, 7 (4): article 71: E623-31, (2006).
3. H. Meyer, F. Bosset, W. Vater and K. Stoepel. Pharmaceutical compositions containing unsymmetrical esters of 1, 4-dihydropyridine 3,5-dicarboxylic acid, U.S. Patent US3932645, 1976.
4. Leuner C and Dressman J, Improving drug solubility for oral delivery using solid dispersions. Eur J Pharm Biopharm, 50: 47-60, (2000).
5. Rao BP, Suresh S and Narendra C, Recent advances in cyclodextrin complexes: Mechanistic analysis as permeation enhancer.Iindian J Pharm Edu Res, 41(2): 102-113, (2007).
6. Chowdary KPR, Cyclodextrins as Drug carriers. The Indian Pharmacist, 11-14, (2003).
7. Loftsson T and Brewester M, Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization. J Pharm Sci, 85(10): 1017-1025, (1996).
8. Szejtli J, Cyclodextrin Technology. Dordrecht, The Netherlands: Kluwer Academic Publishers: 81-83, (1988).
9. Uekama K, Hirayama F and Irie T, Cyclodextrin Drug Carrier Systems. Chem Rev, 98(5): 2045-2076, (1998).
10. Stella VJ and Rajiwski RA, Cyclodextrins: Their future in drug formulation and delivery. Pharm Res, 14: 556-7, (1997).
11. Higuchi T and Connors KA, Phase-solubility techniques. Adva Anal Chem Instr, 4: 217-212, (1965).
12. Khan KA, The concept of dissolution efficiency. J Pharm Pharmacol, 27: 48-49, (1975).