Effect of oscillating fluid flow stimulation on osteocyte mRNA expression

Journal of Biomechanics

Volumn 45, Issue 2, 2012, Pages 247-251

  Li, Jason ^a,b   Rose, Emily ^b   Frances, Daniel ^a   Sun, Yu ^a,b   You, Lidan ^a,b  

^a UNIVERSITY OF TORONTO   (Canada)

^b UNIVERSITY OF TORONTO   (Canada)

Author keywords

Bone remodeling; Fluid flow; Mechanotransduction; Osteocyte

Indexed keywords

BONE FORMATION; BONE MICROSTRUCTURE; BONE REMODELING; BONE TISSUE; DYNAMIC FLUIDS; FLOW DURATION; IN-VITRO; INTERSTITIAL FLUID FLOW; LOADING DURATION; MECHANOTRANSDUCTION; MRNA EXPRESSION; MRNA LEVEL; OSCILLATING FLUIDS; OSCILLATING FREQUENCIES; OSTEOCYTES; SHEAR STRESS AMPLITUDE; STRUCTURAL ADAPTATION;

BONE; FLUIDS; OSCILLATING FLOW; SHEAR FLOW; SHEAR STRESS; STRESS ANALYSIS; TISSUE;

FLOW OF FLUIDS;

CYCLOOXYGENASE 2; MESSENGER RNA; OSTEOCLAST DIFFERENTIATION FACTOR; OSTEOPROTEGERIN;

AMPLITUDE MODULATION; ANALYTICAL PARAMETERS; ANIMAL CELL; ARTICLE; CELL ACTIVITY; CELL STIMULATION; CELL STRESS; CONTROLLED STUDY; FLUID FLOW; GENE EXPRESSION; IN VITRO STUDY; NONHUMAN; OSCILLATING FLUID FLOW; OSTEOCYTE; PRIORITY JOURNAL; RAT; SHEAR STRESS;

ANIMALS; BONE MATRIX; CELL LINE; CYCLOOXYGENASE 2; GENE EXPRESSION REGULATION; HYDRODYNAMICS; MECHANOTRANSDUCTION, CELLULAR; MICE; OSTEOCYTES; OSTEOPROTEGERIN; RANK LIGAND; RNA, MESSENGER; STRESS, PHYSIOLOGICAL;

EID: 84455205545     PISSN: 00219290     EISSN: 18732380     Source Type: Journal    
DOI: 10.1016/j.jbiomech.2011.10.037     Document Type: Article

References (30)

1. Ajubi N.E., Klein-Nulend J., Alblas M.J., Burger E.H., Nijweide P.J. Signal transduction pathways involved in fluid flow-induced PGE2 production by cultured osteocytes. American Journal of Physiology 1999, 276:E171-178.
2. Bacabac R.G., Smit T.H., Mullender M.G., Dijcks S.J., Van Loon J.J., Klein-Nulend J. Nitric oxide production by bone cells is fluid shear stress rate dependent. Biochemical and Biophysical Research Communications 2004, 315:823-829.
3. Cheung W.Y., Liu C., Tonelli-Zasarsky R.M.L., You L.D., Simmons C.A. Osteocyte apoptosis is mechanically regulated and induces angiogenesis in vitro. Journal of Orthopaedic Research 2011, 29:523-530.
4. Cowin S.C., Weinbaum S., Zeng Y. A case for bone canaliculi as the anatomical site of strain generated potentials. Journal of Biomechanics 1995, 28:1281-1297.
5. Donahue S.W., Jacobs C.R., Donahue H.J. Flow-induced calcium oscillations in rat osteoblasts are age, loading frequency, and shear stress dependent. American Journal of Physiology-Cell Physiology 2001, 281:C1635-1641.
6. Fritton S.P., Weinbaum S. Fluid and solute transport in bone: flow-induced mechanotransduction. Annual Review of Fluid Mechanics 2009, 41:347-374.
7. Han Y., Cowin S.C., Schaffler M.B., Weinbaum S. Mechanotransduction and strain amplification in osteocyte cell processes. Proceedings of the National Academy of Sciences of the United States of America 2004, 101:16689-16694.
8. Hofbauer L.C., Gori F., Riggs B.L., Lacey D.L., Dunstan C.R., Spelsberg T.C., Khosla S. Stimulation of osteoprotegerin ligand and inhibition of osteoprotegerin production by glucocorticoids in human osteoblastic lineage cells: potential paracrine mechanisms of glucocorticoid-induced osteoporosis. Endocrinology 1999, 140:4382-4389.
9. Huo B., Lu X.L., Costa K.D., Xu Q., Guo X.E. An ATP-dependent mechanism mediates intercellular calcium signaling in bone cell network under single cell nanoindentation. Cell Calcium 2010, 47:234-241.
10. Jacobs C.R., Yellowley C.E., Davis B.R., Zhou Z., Cimbala J.M., Donahue H.J. Differential effect of steady versus oscillating flow on bone cells. Journal of Biomechanics 1998, 31:969-976.
11. Kamel M.A., Picconi J.L., Lara-Castillo N., Johnson M.L. Activation of Β-catenin signaling in MLO-Y4 osteocytic cells versus 2T3 osteoblastic cells by fluid flow shear stress and PGE2: implications for the study of mechanosensation in bone. Bone 2010, 47:872-881.
12. Kim C.H., You L., Yellowley C.E., Jacobs C.R. Oscillatory fluid flow-induced shear stress decreases osteoclastogenesis through RANKL and OPG signaling. Bone 2006, 39:1043-1047.
13. Kitase Y., Barragan L., Qing H., Kondoh S., Jiang J.X., Johnson M.L., Bonewald L.F. Mechanical induction of PGE2 in osteocytes blocks glucocorticoid-induced apoptosis through both the Β-catenin and PKA pathways. Journal of Bone and Mineral Research 2010, 25:2657-2668.
14. Klein-Nulend J., van der Plas A., Semeins C.M., Ajubi N.E., Frangos J.A., Nijweide P.J., Burger E.H. Sensitivity of osteocytes to biomechanical stress in vitro. The Journal of the Federation of American Societies for Experimental Biology 1995, 9:441-445.
15. Kwon R.Y., Frangos J.A. Quantification of lacunar-canalicular interstitial fluid flow through computational modeling of fluorescence recovery after photobleaching. Cellular and Molecular Bioengineering 2010, 3:296-306.
16. Kwon R.Y., Jacobs C.R. Time-dependent deformations in bone cells exposed to fluid flow in vitro: investigating the role of cellular deformation in fluid flow-induced signaling. Journal of Biomechanics 2007, 40:3162-3168.
17. Liu X., Zhang X., Lee I. A quantitative study on morphological responses of osteoblastic cells to fluid shear stress. Acta Biochimica et Biophysica Sinica 2010, 42:195-201.
18. Malone A.M., Batra N.N., Shivaram G., Kwon R.Y., You L., Kim C.H., Rodriguez J., Jair K., Jacobs C.R. The role of actin cytoskeleton in oscillatory fluid flow-induced signaling in MC3T3-E1 osteoblasts. American Journal of Physiology-Cell Physiology 2007, 292:C1830-1836.
19. Mullender M.G., Dijcks S.J., Bacabac R.G., Semeins C.M., Van Loon J.J., Klein-Nulend J. Release of nitric oxide, but not prostaglandin E2, by bone cells depends on fluid flow frequency. Journal of Orthopaedic Research 2006, 24:1170-1177.
20. Nagai M., Sato N. Reciprocal gene expression of osteoclastogenesis inhibitory factor and osteoclast differentiation factor regulates osteoclast formation. Biochemical and Biophysical Research Communications 1999, 257:719-723.
21. Ponik S.M., Triplett J.W., Pavalko F.M. Osteoblasts and osteocytes respond differently to oscillatory and unidirectional fluid flow profiles. Journal of Cellular Biochemistry 2007, 100:794-807.
22. Price C., Zhou X., Li W., Wang L. Real-time measurement of solute transport within the lacunar-canalicular system of mechanically loaded bone: direct evidence for load-induced fluid flow. Journal of Bone and Mineral Research 2011, 26:277-285.
23. Rath A.L., Bonewald L.F., Ling J., Jiang J.X., Van Dyke M.E., Nicolella D.P. Correlation of cell strain in single osteocytes with intracellular calcium, but not intracellular nitric oxide, in response to fluid flow. Journal of Biomechanics 2010, 43:1560-1564.
24. Reich K.M., Gay C.V., Frangos J.A. Fluid shear stress as a mediator of osteoblast cyclic adenosine monophosphate production. Journal of Cellular Physiology 1990, 143:100-104.
25. Tan S.D., de Vries T.J., Kuijpers-Jagtman A.M., Semeins C.M., Everts V., Klein-Nulend J. Osteocytes subjected to fluid flow inhibit osteoclast formation and bone resorption. Bone 2007, 41:745-751.
26. Wang L., Ciani C., Doty S.B., Fritton S.P. Delineating bone's interstitial fluid pathway in vivo. Bone 2004, 34:499-509.
27. Weinbaum S., Cowin S.C., Zeng Y. A model for the excitation of osteocytes by mechanical loading-induced bone fluid shear stresses. Journal of Biomechanics 1994, 27:339-360.
28. Williams J.L., Iannotti J.P., Ham A., Bleuit J., Chen J.H. Effects of fluid shear stress on bone cells. Biorheology 1994, 31:163-170.
29. You L., Cowin S.C., Schaffler M.B., Weinbaum S. A model for strain amplification in the actin cytoskeleton of osteocytes due to fluid drag on pericellular matrix. Journal of Biomechanics 2001, 34:1375-1386.
30. You L., Temiyasathit S., Lee P., Kim C.H., Tummala P., Yao W., Kingery W., Malone A.M., Kwon R.Y., Jacobs C.R. Osteocytes as mechanosensors in the inhibition of bone resorption due to mechanical loading. Bone 2008, 42:172-179.