Granulysin-Expressing CD4 + T cells as candidate immune marker for tuberculosis during childhood and adolescence

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Mueller, Henrik ^a   Faé, Kellen C ^a   Magdorf, Klaus ^b   Ganoza, Christian A ^a   Wahn, Ulrich ^b   Guhlich, Ute ^a   Feiterna Sperling, Cornelia ^b   Kaufmann, Stefan H E ^a  

^a MAX PLANCK INSTITUTE FOR INFECTION BIOLOGY   (Germany)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR3; GAMMA INTERFERON; GRANULYSIN; TUBERCULOSTATIC AGENT; BIOLOGICAL MARKER; GNLY PROTEIN, HUMAN; T LYMPHOCYTE ANTIGEN;

ADOLESCENT; ANTIGEN SPECIFICITY; ARTICLE; ATYPICAL MYCOBACTERIOSIS; CD4+ T LYMPHOCYTE; CELL ACTIVATION; CHILD; CONTROLLED STUDY; DISEASE MARKER; FEMALE; HUMAN; LATENT TUBERCULOSIS; LYMPHOCYTE PROLIFERATION; MAJOR CLINICAL STUDY; MALE; MEMORY T LYMPHOCYTE; MYCOBACTERIUM TUBERCULOSIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PHENOTYPE; PROTEIN EXPRESSION; PROTEIN FUNCTION; SCHOOL CHILD; IMMUNOLOGICAL MEMORY; IMMUNOLOGY; INFANT; METABOLISM; PRESCHOOL CHILD; TUBERCULOSIS;

ADOLESCENT; ANTIGENS, DIFFERENTIATION, T-LYMPHOCYTE; BIOLOGICAL MARKERS; CD4-POSITIVE T-LYMPHOCYTES; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; IMMUNOLOGIC MEMORY; INFANT; MALE; TUBERCULOSIS;

EID: 84455192424     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0029367     Document Type: Article

References (56)

1. Dolin PJ, Raviglione MC, Kochi A, (1994) Global tuberculosis incidence and mortality during 1990-2000. Bull World Health Organ 72: 213-220.
2. Nelson LJ, Wells CD, (2004) Global epidemiology of childhood tuberculosis. Int J Tuberc Lung Dis 8: 636-647.
3. Walls T, Shingadia D, (2004) Global epidemiology of paediatric tuberculosis. J Infect 48: 13-22.
4. Marais BJ, Gie RP, Schaaf HS, Hesseling AC, Obihara CC, et al. (2004) The natural history of childhood intra-thoracic tuberculosis: a critical review of literature from the pre-chemotherapy era. Int J Tuberc Lung Dis 8: 392-402.
5. Beyers N, Gie RP, Schaaf HS, Van Zyl S, Talent JM, et al. (1997) A prospective evaluation of children under the age of 5 years living in the same household as adults with recently diagnosed pulmonary tuberculosis. Int J Tuberc Lung Dis 1: 38-43.
6. Jacobs RF, Starke JR, (1993) Tuberculosis in children. Med Clin North Am 77: 1335-1351.
7. Starke JR, (2003) Pediatric tuberculosis: time for a new approach. Tuberculosis (Edinb) 83: 208-212.
8. Dinnes J, Deeks J, Kunst H, Gibson A, Cummins E, et al. (2007) A systematic review of rapid diagnostic tests for the detection of tuberculosis infection. Health Technol Assess 11: 1-196.
9. Pai M, Riley LW, Colford JM Jr, (2004) Interferon-gamma assays in the immunodiagnosis of tuberculosis: a systematic review. Lancet Infect Dis 4: 761-776.
10. Detjen AK, Loebenberg L, Grewal HM, Stanley K, Gutschmidt A, et al. (2009) Short-term reproducibility of a commercial interferon gamma release assay. Clin Vaccine Immunol 16: 1170-1175.
11. Rigouts L, (2009) Clinical practice: diagnosis of childhood tuberculosis. Eur J Pediatr 168: 1285-1290.
12. Muller I, Cobbold SP, Waldmann H, Kaufmann SH, (1987) Impaired resistance to Mycobacterium tuberculosis infection after selective in vivo depletion of L3T4+ and Lyt-2+ T cells. Infect Immun 55: 2037-2041.
13. Orme IM, Collins FM, (1983) Protection against Mycobacterium tuberculosis infection by adoptive immunotherapy. Requirement for T cell-deficient recipients. J Exp Med 158: 74-83.
14. Caruso AM, Serbina N, Klein E, Triebold K, Bloom BR, et al. (1999) Mice deficient in CD4 T cells have only transiently diminished levels of IFN-gamma, yet succumb to tuberculosis. J Immunol 162: 5407-5416.
15. Boom WH, Wallis RS, Chervenak KA, (1991) Human Mycobacterium tuberculosis-reactive CD4+ T-cell clones: heterogeneity in antigen recognition, cytokine production, and cytotoxicity for mononuclear phagocytes. Infect Immun 59: 2737-2743.
16. Hansen PW, Petersen CM, Povlsen JV, Kristensen T, (1987) Cytotoxic human HLA class II restricted purified protein derivative-reactive T-lymphocyte clones. IV. Analysis of HLA restriction pattern and mycobacterial antigen specificity. Scand J Immunol 25: 295-303.
17. Kumararatne DS, Pithie AS, Drysdale P, Gaston JS, Kiessling R, et al. (1990) Specific lysis of mycobacterial antigen-bearing macrophages by class II MHC-restricted polyclonal T cell lines in healthy donors or patients with tuberculosis. Clin Exp Immunol 80: 314-323.
18. Kaufmann SH, (1999) Cell-mediated immunity: dealing a direct blow to pathogens. Curr Biol 9: R97-99.
19. Ottenhoff TH, Ab BK, Van Embden JD, Thole JE, Kiessling R, (1988) The recombinant 65-kD heat shock protein of Mycobacterium bovis Bacillus Calmette-Guerin/M. tuberculosis is a target molecule for CD4+ cytotoxic T lymphocytes that lyse human monocytes. J Exp Med 168: 1947-1952.
20. Djoba Siawaya JF, Ruhwald M, Eugen-Olsen J, Walzl G, (2007) Correlates for disease progression and prognosis during concurrent HIV/TB infection. Int J Infect Dis 11: 289-299.
21. Canaday DH, Wilkinson RJ, Li Q, Harding CV, Silver RF, et al. (2001) CD4(+) and CD8(+) T cells kill intracellular Mycobacterium tuberculosis by a perforin and Fas/Fas ligand-independent mechanism. J Immunol 167: 2734-2742.
22. Stenger S, Hanson DA, Teitelbaum R, Dewan P, Niazi KR, et al. (1998) An antimicrobial activity of cytolytic T cells mediated by granulysin. Science 282: 121-125.
23. Ernst WA, Thoma-Uszynski S, Teitelbaum R, Ko C, Hanson DA, et al. (2000) Granulysin, a T cell product, kills bacteria by altering membrane permeability. J Immunol 165: 7102-7108.
24. Kaspar AA, Okada S, Kumar J, Poulain FR, Drouvalakis KA, et al. (2001) A distinct pathway of cell-mediated apoptosis initiated by granulysin. J Immunol 167: 350-356.
25. Latinovic-Golic S, Walch M, Sundstrom H, Dumrese C, Groscurth P, et al. (2007) Expression, processing and transcriptional regulation of granulysin in short-term activated human lymphocytes. BMC Immunol 8: 9.
26. Huang LP, Lyu SC, Clayberger C, Krensky AM, (2007) Granulysin-mediated tumor rejection in transgenic mice. J Immunol 178: 77-84.
27. Donald PR, Schaaf HS, (2007) Old and new drugs for the treatment of tuberculosis in children. Paediatr Respir Rev 8: 134-141.
28. WHO (2006) Guidance for National Tuberculosis Programmes on the management of tuberculosis in children. Chapter 1: introduction and diagnosis of tuberculosis in children. Int J Tuberc Lung Dis 10: 1091-1097.
29. WHO (2006) Guidance for national tuberculosis programmes on the management of tuberculosis in children. Chapter 2: anti-tuberculosis treatment in children. Int J Tuberc Lung Dis 10: 1205-1211.
30. Comstock GW, (1999) How much isoniazid is needed for prevention of tuberculosis among immunocompetent adults? Int J Tuberc Lung Dis 3: 847-850.
31. Schuck SD, Mueller H, Kunitz F, Neher A, Hoffmann H, et al. (2009) Identification of T-cell antigens specific for latent mycobacterium tuberculosis infection. PLoS One 4: e5590.
32. Franken KL, Hiemstra HS, van Meijgaarden KE, Subronto Y, den Hartigh J, et al. (2000) Purification of his-tagged proteins by immobilized chelate affinity chromatography: the benefits from the use of organic solvent. Protein Expr Purif 18: 95-99.
33. Rivino L, Messi M, Jarrossay D, Lanzavecchia A, Sallusto F, et al. (2004) Chemokine receptor expression identifies Pre-T helper (Th)1, Pre-Th2, and nonpolarized cells among human CD4+ central memory T cells. J Exp Med 200: 725-735.
34. Qin S, Rottman JB, Myers P, Kassam N, Weinblatt M, et al. (1998) The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions. J Clin Invest 101: 746-754.
35. Meier S, Stark R, Frentsch M, Thiel A, (2008) The influence of different stimulation conditions on the assessment of antigen-induced CD154 expression on CD4+ T cells. Cytometry A 73: 1035-1042.
36. Noel PJ, Boise LH, Thompson CB, (1996) Regulation of T cell activation by CD28 and CTLA4. Adv Exp Med Biol 406: 209-217.
37. Kamoun M, Zerva L, Sloan S, Zmijewski C, Monos D, et al. (1992) Induction of HLA class II molecules on human T cells: relationship to immunoregulation and the pathogenesis of AIDS. DNA Cell Biol 11: 265-268.
38. Russell JH, Ley TJ, (2002) Lymphocyte-mediated cytotoxicity. Annu Rev Immunol 20: 323-370.
39. Lieberman J, (2003) The ABCs of granule-mediated cytotoxicity: new weapons in the arsenal. Nat Rev Immunol 3: 361-370.
40. Lewinsohn DM, Bement TT, Xu J, Lynch DH, Grabstein KH, et al. (1998) Human purified protein derivative-specific CD4+ T cells use both CD95-dependent and CD95-independent cytolytic mechanisms. J Immunol 160: 2374-2379.
41. Klucar P, Barnes PF, Kong Y, Samten B, Tvinnereim A, et al. (2008) Characterization of effector functions of human peptide-specific CD4+ T-cell clones for an intracellular pathogen. Hum Immunol 69: 475-483.
42. Stenger S, (2001) Cytolytic T cells in the immune response to mycobacterium tuberculosis. Scand J Infect Dis 33: 483-487.
43. Nemeth J, Winkler HM, Karlhofer F, Selenko-Gebauer N, Graninger W, et al. (2010) T cells co-producing Mycobacterium tuberculosis-specific type 1 cytokines for the diagnosis of latent tuberculosis. Eur Cytokine Netw 21: 34-39.
44. Cosmi L, Maggi L, Santarlasci V, Liotta F, Frosali F, et al. (2007) Detection by flow cytometry of ESAT-6- and PPD-specific circulating CD4+ T lymphocytes as a diagnostic tool for tuberculosis. Int Arch Allergy Immunol 143: 1-9.
45. Hughes AJ, Hutchinson P, Gooding T, Freezer NJ, Holdsworth SR, et al. (2005) Diagnosis of Mycobacterium tuberculosis infection using ESAT-6 and intracellular cytokine cytometry. Clin Exp Immunol 142: 132-139.
46. Wood R, Liang H, Wu H, Middelkoop K, Oni T, et al. (2010) Changing prevalence of tuberculosis infection with increasing age in high-burden townships in South Africa. Int J Tuberc Lung Dis 14: 406-412.
47. Bastian M, Braun T, Bruns H, Rollinghoff M, Stenger S, (2008) Mycobacterial lipopeptides elicit CD4+ CTLs in Mycobacterium tuberculosis-infected humans. J Immunol 180: 3436-3446.
48. Di Liberto D, Buccheri S, Caccamo N, Meraviglia S, Romano A, et al. (2007) Decreased serum granulysin levels in childhood tuberculosis which reverse after therapy. Tuberculosis (Edinb) 87: 322-328.
49. Semple PL, Watkins M, Davids V, Krensky AM, Hanekom WA, et al. (2011) Induction of granulysin and perforin cytolytic mediator expression in 10-week-old infants vaccinated with BCG at birth. Clin Dev Immunol 2011: 438463.
50. Yang C, He YL, Zhang L, Xu L, Yi Z, et al. (2009) GLS/IL-12-modified Mycobacterium smegmatis as a novel anti-tuberculosis immunotherapeutic vaccine. Int J Tuberc Lung Dis 13: 1360-1366.
51. Mutis T, Cornelisse YE, Ottenhoff TH, (1993) Mycobacteria induce CD4+ T cells that are cytotoxic and display Th1-like cytokine secretion profile: heterogeneity in cytotoxic activity and cytokine secretion levels. Eur J Immunol 23: 2189-2195.
52. Merlo A, Saverino D, Tenca C, Grossi CE, Bruno S, et al. (2001) CD85/LIR-1/ILT2 and CD152 (cytotoxic T lymphocyte antigen 4) inhibitory molecules down-regulate the cytolytic activity of human CD4+ T-cell clones specific for Mycobacterium tuberculosis. Infect Immun 69: 6022-6029.
53. Berke G, (1995) The CTL's kiss of death. Cell 81: 9-12.
54. Williams NS, Engelhard VH, (1996) Identification of a population of CD4+ CTL that utilizes a perforin- rather than a Fas ligand-dependent cytotoxic mechanism. J Immunol 156: 153-159.
55. Yasukawa M, Ohminami H, Arai J, Kasahara Y, Ishida Y, et al. (2000) Granule exocytosis, and not the fas/fas ligand system, is the main pathway of cytotoxicity mediated by alloantigen-specific CD4(+) as well as CD8(+) cytotoxic T lymphocytes in humans. Blood 95: 2352-2355.
56. Norris PJ, Sumaroka M, Brander C, Moffett HF, Boswell SL, et al. (2001) Multiple effector functions mediated by human immunodeficiency virus-specific CD4(+) T-cell clones. J Virol 75: 9771-9779.