Generation of conditional knockout alleles for PRL-3

Journal of Biomedical Research

Volumn 25, Issue 6, 2011, Pages 438-443

  Yan, Hong ^a,b   Kong, Dong ^b   Ge, Xiaomei ^b   Gao, Xiang ^b   Han, Xiao ^a  

^a NANJING MEDICAL UNIVERSITY   (China)

^b NANJING UNIVERSITY   (China)

Author keywords

Conditional knockout alleles; Cre recombinase; PRL 3; Tumor metastasis

Indexed keywords

CRE RECOMBINASE; PEPTIDE; PHOSPHATASE OF REGENERATING LIVER 3; PROTEIN TYROSINE PHOSPHATASE; UNCLASSIFIED DRUG;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BACTERIAL ARTIFICIAL CHROMOSOME; CONTROLLED STUDY; EXON; FRAMESHIFT MUTATION; GENE DELETION; GENE EXPRESSION; GENE TARGETING; GENE VECTOR; LOXP SITE; METASTASIS; MOUSE; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; WILD TYPE;

EID: 84455175423     PISSN: 16748301     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1674-8301(11)60058-4     Document Type: Article

References (22)

1. Ostman A, Hellberg C, Böhmer FD Protein-tyrosine phosphatases and cancer. Nat Rev Cancer 2006, 6:307-320.
2. Zeng Q, Hong W, Tan YH Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1. Biochem Biophys Res Commun 1998, 2:421-427.
3. Zeng Q, Si X, Horstmann H, Xu Y, Hong W, Pallen CJ Prenylation-dependent association of protein-tyrosine phosphatases PRL-1, -2, and -3 with the plasma mem-brane and the early endosome. J Biol Chem 2000, 275:21444-21452.
4. Saha S, Bardelli A, Buckhaults P, Velculescu VE, Rago C, St Croix B, et al. A phosphatase associated with metas-tasis of colorectal cancer. Science 2001, 294:1343-1346.
5. Peng L, Ning J, Meng L, Shou C The association of the expression level of protein tyrosine phosphatase PRL-3 protein with liver metastasis and prognosis of patients with colorectal cancer. J Cancer Res Clin Oncol 2004, 130:521-526.
6. Zhao GP, Zhou ZG, Lei WZ, Yu YY, Zheng XL, Gao HK Expression of phosphatase of regenerating liver-3 mRNA and its clinical implications in human colorectal carcinoma. Zhonghua Wei Chang Wai Ke Za Zhi 2005, 8:237-240.
7. Wu X, Zeng H, Zhang X, Zhao Y, Sha H, Ge X, et al. Phosphatase of regenerating liver-3 promotes motility and metastasis of mouse melanoma cells. Am J Pathol 2004, 164:2039-2054.
8. Fagerli UM, Holt RU, Holien T, Vaatsveen TK, Zhan F, Egeberg KW, et al. Overexpression and involvement in migration by the metastasis-associated phosphatase PRL-3 in human myeloma cells. Blood 2008, 111:806-815.
9. Yamashita S, Masuda Y, Matsumoto K, Okumura Y, Matsuzaki H, Kurizaki T, et al. Down-regulation of the human PRL-3 gene is associated with the metastasis of primary non-small cell lung cancer. Ann Thorac Car-diovasc Surg 2007, 13:236-239.
10. Wang Y, Li ZF, He J, Li YL, Zhu GB, Zhang LH, et al. Expression of the human phosphatases of regenerating liver (PRLs) in colonic adenocarcinoma and its correlation with lymph node metastasis. Int J Colorectal Dis 2007, 22:1179-1184.
11. Miskad UA, Semba S, Kato H, Matsukawa Y, Kodama Y, Mizuuchi E, et al. High PRL-3 expression in human gastric cancer is a marker of metastasis and grades of malignancies: an in situ hybridization study. Virchows Arch 2007, 450:303-310.
12. Li Z, Zhan W, Wang Z, Zhu B, He Y, Peng J, et al. In-hibition of PRL-3 gene expression in gastric cancer cell line SGC7901 via microRNA suppressed reduces peri-toneal metastasis. Biochem Biophys Res Commun 2006, 348:229-237.
13. Wang H, Quah SY, Dong JM, Manser E, Tang JP, Zeng Q PRL-3 down-regulates PTEN expression and signals through PI3K to promote epithelial-mesenchymal tran-sition. Cancer Res 2007, 67:2922-2926.
14. Stephens BJ, Han H, Gokhale V, Von Hoff DD PRL phosphatases as potential molecular targets in cancer. Molecular cancer therapeutics 2005, 4:1653-1661.
15. Bardelli A, Saha S, Sager JA, Romans KE, Xin B, Markowitz SD, et al. PRL-3 expression in metastatic cancers. Clin Cancer Res 2003, 9:5607-5615.
16. Miskad UA, Semba S, Kato H, Yokozaki H Expression of PRL-3 phosphatase in human gastric carcinomas: close correlation with invasion and metastasis. Pathobi-ology 2004, 71:176-184.
17. Liu P, Jenkins NA, Copeland NG A highly efficient recombineering-based method for generating conditional knockout mutations. Genome Res 2003, 13:476-484.
18. Lee EC, Yu D, Martinez de Velasco J, Tessarollo L, Swing DA, Court DL, et al. A highly efficient Es-cherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA. Genomics 2001, 73:56-65.
19. Zhang YL, Tan XH, Xiao MF, Li H, Mao YQ, Yang X, et al. Establishment of liver specific glucokinase gene knockout mice: a new animal model for screening anti-diabetic drugs. Acta Pharmacol Sin 2004, 25:1659-1665.
20. Peng L, Xing X, Li W, Qu L, Meng L, Lian S, et al. PRL-3 promotes the motility, invasion, and metastasis of LoVo colon cancer cells through PRL-3-integrin beta1-ERK1/2 and-MMP2 signaling. Mol Cancer 2009, 8:110.
21. Zeng Q, Dong JM, Guo K, Li J, Tan HX, Koh V, et al. PRL-3 and PRL-1 promote cell migration, invasion, and metastasis. Cancer Res 2003, 63:2716-2722.
22. Diamond RH, Cressman DE, Laz TM, Abrams CS, Taub R PRL-1, a unique nuclear protein tyrosine phosphatase, affects cell growth. Mol Cell Biol 1994, 14:3752-3762.