Establishment of liver specific glucokinase gene knockout mice: A new animal model for screening anti-diabetic drugs

Acta Pharmacologica Sinica

Volumn 25, Issue 12, 2004, Pages 1659-1665

  Zhang, Ya Li ^a   Tan, Xiao Hong ^b   Xiao, Mei Fang ^a   Li, Hui ^a   Mao, Yi Qing ^a   Yang, Xiao ^b   Tan, Huan Ran ^a  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b BEIJING INSTITUTE OF MICROBIOLOGY AND EPIDEMIOLOGY   (China)

Author keywords

Animal disease model; Glucokinase; Knockout mice; Non insulin dependent diabetes mellitus; Type 2 diabetes mellitus

Indexed keywords

ALANINE AMINOTRANSFERASE; ANTIDIABETIC AGENT; ASPARTATE AMINOTRANSFERASE; CHOLESTEROL; GANCICLOVIR; GENOMIC DNA; GLUCOKINASE; GLUCOSE; TRIACYLGLYCEROL;

ALLELE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL SPECIFICITY; CHIMERA; CLONE; CONTROLLED STUDY; DIABETES MELLITUS; DNA VECTOR; DRUG SCREENING; ELECTROPORATION; ENZYME ACTIVITY; EXON; EXPERIMENTAL MODEL; FEMALE; GENE INSERTION; GENE SEQUENCE; GENE TARGETING; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; HISTOPATHOLOGY; HOMOLOGOUS RECOMBINATION; IMPAIRED GLUCOSE TOLERANCE; KNOCKOUT GENE; KNOCKOUT MOUSE; LIVER; LIVER CELL; MALE; MICROINJECTION; MOUSE; NONHUMAN; POLYMERASE CHAIN REACTION; SOUTHERN BLOTTING; TECHNIQUE; TISSUE SPECIFICITY;

ANIMALS; BLOOD GLUCOSE; DIABETES MELLITUS, TYPE 2; DISEASE MODELS, ANIMAL; GLUCOKINASE; HOMEOSTASIS; LIVER; MICE; MICE, KNOCKOUT;

EID: 10344261431     PISSN: 16714083     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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