Measurement of precursor enrichment for calculating intramuscular triglyceride fractional synthetic rate

Journal of Lipid Research

Volumn 53, Issue 1, 2012, Pages 119-125

  Zhang, Xiao Jun ^a,b   Rodriguez, Noe A ^a,b   Wang, Lijian ^b   Tuvdendorj, Demidmaa ^b   Wu, Zhanpin ^a,b   Tan, Alai ^b   Herndon, David N ^b   Wolfe, Robert R ^c  

^a SHRINERS HOSPITALS FOR CHILDREN   (United States)

^b University of Texas Medical Branch School of Medicine   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

Author keywords

Fatty acyl carnitine; Fatty acyl coenzyme A; Mass spectrometry; Rabbits; Stable isotopes

Indexed keywords

FATTY ACID; PALMITIC ACID; PALMITOYL COENZYME A; PALMITOYLCARNITINE; TRIACYLGLYCEROL;

ADDUCTOR MUSCLE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME BLOOD LEVEL; FREEZE THAWING; IN VIVO STUDY; LEG MUSCLE; LIPID DEGRADATION; MALE; MUSCLE TISSUE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROCESSING; RABBIT;

ANIMALS; FATTY ACIDS; INJECTIONS, INTRAMUSCULAR; MALE; MUSCLE, SKELETAL; PALMITATES; PALMITOYL COENZYME A; PALMITOYLCARNITINE; RABBITS; TRIGLYCERIDES;

EID: 84455172908     PISSN: 00222275     EISSN: 15397262     Source Type: Journal    
DOI: 10.1194/jlr.M019901     Document Type: Article

References (24)

1. Wolfe, R. R. 2006. The underappreciated role of muscle in health and disease. Am. J. Clin. Nutr. 84: 475-482. (Pubitemid 44713395)
2. Moro, C., S. Bajpeyi, and S. R. Smith. 2008. Determinations of intramyocellular triglyceride turnover: implications for insulin sensitivity. Am. J. Physiol. Endocrinol. Metab. 294: E203-E213. (Pubitemid 351231448)
3. Hegarty, B. D., S. M. Furler, J. Ye, G. J. Cooney, and E. W. Kraegen. 2003. The role of intramuscular lipid in insulin resistance. Acta Physiol. Scand. 178: 373-383. (Pubitemid 36960428)
4. Schrauwen, P. 2007. High-fat diet, muscular lipotoxicity and insulin resistance. Proc. Nutr. Soc. 66: 33-41. (Pubitemid 46748242)
5. Kelley, D. E., B. H. Goodpaster, and L. Storlien. 2002. Muscle triglyceride and insulin resistance. Annu. Rev. Nutr. 22: 325-346. (Pubitemid 35221465)
6. Krssak, M., F. K. Petersen, A. Dresner, L. DiPietro, S. M. Vogel, D. L. Rothman, M. Roden, and G. L. Shulman. 1999. Intramyocellular lipid concentrations are corrected with insulin sensitivity in humans: a 1H NMR spectroscopy study. Diabetologia. 42: 113-116. (Pubitemid 29039748)
7. Goodpaster, B. H., J. He, S. Watkins, and D. E. Kelley. 2001. Skeletal muscle lipid content and insulin resistance: evidence for paradox in endurance-trained athletes. J. Clin. Endocrinol. Metab. 86: 5755-5761. (Pubitemid 33152620)
8. Schenk, S., and J. F. Horowitz. 2007. Acute exercise increases triglyceride synthesis in skeletal muscle and prevents fatty acid induced insulin resistance. J. Clin. Invest. 117: 1690-1698. (Pubitemid 46871353)
9. Bergman, B. C., L. Perreault, D. M. Hunderdosse, M. C. Koehler, A. M. Samek, and R. H. Eckel. 2010. Increased intramuscular lipid synthesis and low saturation relate to insulin sensitivity in endurance-trained athletes. J. Appl. Physiol. 108: 1134-1141.
10. Bergman, B. C., L. Perreault, D. M. Hunerdosse, M. C. Koehler, A. M. Samek, and R. H. Ecket. 2009. Intramuscular lipid metabolism in the insulin resistance of smoking. Diabetes. 58: 2220-2227.
11. Perreault, L., B. C. Bergman, D. M. Hunerdosse, and R. H. Eckel. 2010. Altered intramuscular lipid metabolism relates to diminished insulin action in men, but not women, in progression to diabetes. Obesity (Silver Spring). 18: 2093-2100.
12. Guo, Z., and M. D. Jensen. 1998. Intramuscular fatty acid metabolism evaluated with stable isotopic tracers. J. Appl. Physiol. 84: 1674-1679. (Pubitemid 28225907)
13. Sacchetti, M., B. Saltin, D. B. Olsen, and G. van Hall. 2004. High triacylglycerol turnover rate in human skeletal muscle. J. Physiol. 561: 883-891. (Pubitemid 40074942)
14. Zhang, X-J., D. L. Chinkes, Z. Wu, D. N. Herndon, and R. R. Wolfe. 2009. The synthetic rate of muscle triglyceride but not phospholipids is increased in obese rabbits in comparison with lean rabbits. Metabolism. 58: 1649-1656.
15. 13C tracer enrichment of long-chain fatty acylcoenzyme A in muscle by liquid chromatography/mass spectrometry. Anal. Biochem. 349: 87-95.
16. Sun, D., M. G. Cree, X-J. Zhang, E. Boersheim, and R. R. Wolfe. 2006. Measurement of stable isotopic enrichment and concentration of long-chain fatty acyl-carnitines in tissue by HPLC-MS. J. Lipid Res. 47: 431-439. (Pubitemid 43276929)
17. Zhang, X-J., D. L. Chinkes, A. Aarsland, D. N. Herndon, and R. R. Wolfe. 2008. Lipid metabolism in diet-induced obese rabbits is similar to that of obese humans. J. Nutr. 138: 515-518. (Pubitemid 351355250)
18. nd edition. John Wiley & Sons, Hoboken, New Jersey.
19. Harris, I. R., A. M. Farrell, R. A. Memon, C. Grunfeld, P. M. Elias, and K. R. Feingold. 1998. Expression and regulation of mRNA for putative fatty acid transport related proteins and fatty acyl CoA synthase in murine epidermis and cultured human keratinocytes. J. Invest. Dermatol. 111: 722-726. (Pubitemid 28509308)
20. Pei, Z., P. Sun, P. Huang, B. Lal, J. Laterra, and P. A. Watkins. 2009. Acyl-CoA synthetase VL3 knockdown inhibits human Glioma cell proliferation and tumorigenicity. Cancer Res. 69: 9175-9182.
21. Chien, D., D. Dean, A. K. Saha, J. P. Flatt, and N. B. Ruderman. 2000. Malonyl-CoA content and fatty acid oxidation in rat muscle and liver in vivo. Am. J. Physiol. 279: E259-E265.
22. Ferreira, L. D., L. K. Pulawa, D. R. Jensen, and R. H. Eckel. 2001. Overexpressing human lipoprotein lipase in mouse skeletal muscle is associated with insulin resistance. Diabetes. 50: 1064-1068. (Pubitemid 32377287)
23. Ohira, M., Y. Miyashita, T. Murano, F. Watanabe, and K. Shirai. 2009. Metformin promotes induction of lipoprotein lipase in skeletal muscle through activation of adenosine monophosphate-activated protein kinase. Metabolism. 58: 1408-1414.
24. Guo, Z., and M. D. Jensen. 2002. Determination of skeletal muscle triglyceride synthesis using a single muscle biopsy. Metabolism. 51: 1198-1205.