The conformational behavior of novel glycosidase inhibitors with substituted azepan structures: An NMR and modeling study

European Journal of Organic Chemistry

Volumn , Issue 20, 2004, Pages 4119-4129

  Martínez Mayorga, Karina ^a   Medina Franco, José L ^a   Mari, Silvia ^a   Javier Canada F ^a   Rodríguez García, Eliazar ^c   Vogel, Pierre ^c   Li, Hongqing ^b   Blériot, Yves ^b   Sinaÿ, Pierre ^b   Jiménez Barbero, Jesús ^a  

^a CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

^b ECOLE NORMALE SUPÉRIEURE   (France)

^c EPFL   (Switzerland)

Author keywords

Conformational analysis; Glycomimetics; Glycosidase inhibitors; Molecular modeling; Nuclear magnetic resonance; Polyhydroxyazepanes

Indexed keywords

2 (HYDROXYMETHYL)AZEPAN 3,4,5,6 TETROL DERIVATIVE; ALPHA GALACTOSIDASE; BETA GLUCOSIDASE; GLUCAN 1,4 ALPHA GLUCOSIDASE; GLYCOSIDASE INHIBITOR; UNCLASSIFIED DRUG;

ALMOND; ARTICLE; BINDING SITE; CONFORMATION; CRYSTAL STRUCTURE; ISOMER; MOLECULAR DYNAMICS; MOLECULAR MECHANICS; MOLECULAR MODEL; MONTE CARLO METHOD; NUCLEAR OVERHAUSER EFFECT; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOCHEMISTRY;

EID: 8444249714     PISSN: 1434193X     EISSN: None     Source Type: Journal    
DOI: 10.1002/ejoc.200400320     Document Type: Article

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