Azithromycin modulates murine immune responses to pneumococcal conjugate vaccine and inhibits nasal clearance of bacteria

Journal of Infectious Diseases

Volumn 190, Issue 10, 2004, Pages 1762-1766

  Fernandez, Aracelis D ^a   Elmore, Monica K ^a,b   Metzger, Dennis W ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

^b BOSTON UNIVERSITY SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AZITHROMYCIN; CEFTRIAXONE; CIPROFLOXACIN; MACROLIDE; PNEUMOCOCCUS VACCINE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY RESPONSE; ARTICLE; CONTROLLED STUDY; FEMALE; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNITY; IMMUNOMODULATION; MOUSE; NONHUMAN; NOSE CAVITY; PRIORITY JOURNAL; STREPTOCOCCUS PNEUMONIA;

ANIMALS; ANTI-BACTERIAL AGENTS; ANTIBODIES, BACTERIAL; AZITHROMYCIN; COLONY COUNT, MICROBIAL; DISEASE MODELS, ANIMAL; FEMALE; IMMUNOLOGIC MEMORY; LYMPHOCYTE ACTIVATION; MENINGOCOCCAL VACCINES; MICE; MICE, INBRED BALB C; NASOPHARYNX; PNEUMOCOCCAL INFECTIONS; PNEUMOCOCCAL VACCINES; STREPTOCOCCUS PNEUMONIAE;

EID: 8444242083     PISSN: 00221899     EISSN: None     Source Type: Journal    
DOI: 10.1086/425038     Document Type: Article

References (15)

1. Purswani MU, Eckert SJ, Arora HK, Noel GJ. Effect of ciprofloxacin on lethal and sublethal challenge with endotoxin and on early cytokine responses in a murine in vivo model. J Antimicrob Chemother 2002;50: 51-8.
2. Hand WL, Hand DL, King-Thompson NL. Antibiotic inhibition of the respiratory burst response in human polymorphonuclear leukocytes. Antimicrob Agents Chemother 1990; 34:863-70.
3. Takeshita K, Yamagishi I, Harada M, Otomo S, Nakagawa T, Mizushima I. Immunological and anti-inflammatory effects of clarithromycin: inhibition of interleukin 1 production of murine peritoneal macrophages. Drugs Exp Clin Res 1989; 15:527-33.
4. Ianaro A, Ialenti A, Maffia P, et al. Anti-inflammatory activity of macrolide antibiotics. J Pharmacol Exp Ther 2000; 292:156-63.
5. Kurdowska A, Noble JM, Griffith DE. The effect of azithromycin and clarithromycin on ex vivo interleukin-8 (IL-8) release from whole blood and IL-8 production by human alveolar macrophages. J Antimicrob Chemother 2001; 47:867-70.
6. Culic O, Erakovic V, Cepelak I, et al. Azithromycin modulates neutrophil function and circulating inflammatory mediators in healthy human subjects. Eur J Pharmacol 2002; 450:277-89.
7. Morikawa K, Zhang J, Nonaka M, Morikawa S. Modulatory effect of macrolide antibiotics on the Th1- and Th2-type cytokine production, Int J Antimicrob Agents 2002; 19:53-9.
8. Koch CC, Esteban DJ, Chin AC, et al. Apoptosis, oxidative metabolism and interleukin-8 production in human neutrophils exposed to azithromycin: effects of Streptococcus pneumoniae. J Antimicrob Chemother 2000; 46:19-26.
9. Woo PC, Tsoi H, Wong L, Leung HC, Yuen K. Antibiotics modulate vaccine-induced humoral immune response. Clin Diagn Lab Immunol 1999; 6:832-7.
10. Van Vlem B, Vandholder R, De Paepe P, Vogelaers D, Ringoir S. Immunomodulating effects of antibiotics: literature review. Infection 1996; 24:275-91.
11. Labro MT. Anti-inflammatory activity of macrolides: a new therapeutic potential? J Antimicrob Chemother 1998; 41:37-46.
12. Wolter J, Seeney S, Bell S, Bowler S, Masel P, McCormack J. Effect of long term treatment with azithromycin on disease parameters in cystic fibrosis: a randomised trial. Thorax 2002; 57:212-6.
13. Saiman L, Marshall B, Mayer-Hamblett N, et al. Azithromycin in patients with cystic fibrosis chronically infected with Pseudomonas aeruginosa: a randomized controlled trial. JAMA 2003; 290:1749-56.
14. Wu H, Virolainen A, Mathews B, King J, Russell MW, Briles DE. Establishment of a Streptococcus pneumoniae nasopharyngeal colonization model in adult mice Microb Pathog 1997; 23:127-37.
15. Jayakumar K, Honnegowda, Krishnappa G, Sastry KN, Narayana K. Effect of ciprofloxacin on specific immune responses in rabbits. Indian J Exp Biol 2002; 40:111-4.