Stage-III NSCLC: Multimodality therapy for inoperable tumours

Lung Cancer

Volumn 45, Issue SUPPL. 2, 2004, Pages

  Fietkau, Rainer ^a  

^a UNIVERSITY OF ROSTOCK   (Germany)

Author keywords

Chemotherapy; Concurrent radiochemotherapy; Lung cancer; noperability; NSCLC; Radiochemotherapy; Radiotherapy; Sequential radiochemotherapy

Indexed keywords

ANTINEOPLASTIC AGENT; CISPLATIN; ETOPOSIDE; GEMCITABINE; NAVELBINE; PACLITAXEL; TAXANE DERIVATIVE; VINCA ALKALOID;

BLOOD TOXICITY; CANCER COMBINATION CHEMOTHERAPY; CANCER GRADING; CANCER RADIOTHERAPY; CANCER RECURRENCE; CANCER RISK; CANCER STAGING; CANCER SURVIVAL; COMPARATIVE STUDY; CONFERENCE PAPER; ESOPHAGITIS; GRANULOCYTOPENIA; HUMAN; LEUKOPENIA; LIFE EXPECTANCY; LUNG NON SMALL CELL CANCER; LUNG TOXICITY; PRIORITY JOURNAL; RADIATION DOSE FRACTIONATION; RADIATION INJURY; SURVIVAL RATE; SURVIVAL TIME; THROMBOCYTOPENIA; WORLD HEALTH ORGANIZATION;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CARCINOMA, NON-SMALL-CELL LUNG; COMBINED MODALITY THERAPY; HUMANS; LUNG NEOPLASMS; NEOPLASM STAGING; SURVIVAL RATE;

EID: 8444241615     PISSN: 01695002     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.lungcan.2004.07.983     Document Type: Conference Paper

References (59)

1. Kubota K., Furuse K., and Kawahara M. Role of radiotherapy in combined treatment of locally advanced non-small-cell lung cancer J Clin Oncol 8 1994 1547 1552
2. Sculier J.P., Paesmans M., and Lafitte J.J. A randomized phase III trial comparing consolidation treatment with further chemotherapy to chest irradiation in patients with initially unresectable locoregional non-small-cell lung cancer responding to induction chemotherapy. European Lung Cancer Working Party Ann Oncol 10 1999 295 303
3. Fietkau R. Concomitant radiochemotherapy of advanced non-small-cell lung cancer Lung Cancer 33 2001 S65 S76
4. Dillman R.O., Herndon J., and Eaton W.L. Improved survival in stage III non-small-cell lung cancer: seven year follow up of Cancer and Leukaemia Group B 8433 trial J Natl Cancer Inst 88 1996 1210 1215
5. Le Chevalier T., Arriagada R., and Quiox E. Radiotherapy alone versus combined chemotherapy and radiotherapy in nonresectable non-small-cell lung cancer: first analysis of a randomised trial in 353 patients J Natl Cancer Inst 83 1991 417 423
6. Sause W., Kolesar P., and Taylor S. IV Final results of a phase III trial in regionally advanced unresectable non-small-cell lung cancer: Radiation Therapy Oncology Group, Eastern Cooperative Oncology Group and Southwest Oncology Group Chest 117 2000 358 364
7. Jeremic B., Shibamoto Y., and Acimovic L. Hyperfractionated radiation therapy with or without concurrent Low-dose daily carboplatin/etoposide for stage III non-small-cell lung cancer: a randomized study J Clin Oncol 14 1996 1065 1070
8. Schaake-Koning C., van den Bogaert W., and Dalesio O. Effects of concomitant cisplatin and radiotherapy on inoperable non-small-cell lung cancer N Eng J Med 20 1992 524 530
9. NSCLC Collaborative Group 1995 Chemotherapy in nonsmall cell lung cancer: a meta-analysis using updated data on individual patients from 52 randomized clinical trials Br Med J 311 1995 899 909
10. Pritchard R.S., and Anthony S.P. Chemotherapy plus radiotherapy compared with radiotherapy alone in the treatment of locally advanced, unresectable, non-small cell lung cancer: a meta-analysis Ann Intern Med 125 1996 723 729
11. Marino P., Preatoni A., and Cantoni A. Randomized trials of radiotherapy alone vs combined chemotherapy and radiotherapy in stages IIIa and IIIb non-small cell lung cancer: a meta-analysis J Clin Oncol 15 1997 2996 3018
12. Furuse K., Fukuoka M., and Kawahara M. Phase III study of concorrent versus sequential thoracic radiotherapy in combination with Mitomycin, Vindesine and Cisplatin in unresectable stage III non-small-cell lung cancer J Clin Oncol 17 9 1999 2692 2699
13. Curran W.J., Scott C.B., and Langer C. Phase III comparison of sequential versus concurrent chemo-radiation for patients with unresected stage III non-small-cell lung cancer: initial report of Radiation Oncology Group (RTOG) 9410 Proc Am Soc Clin Oncol 2000 1891
14. Curran W.J., Scott C.B., and Langer C.J. Long-term benefit is observed in a phase III comparison of sequential vs concurrent chemo-radiation for patients with unresected stage III NSCLC: RTOG 9410 Proc Am Soc Clin Oncol 2003 2499
15. Pierre F., Maurice P., and Gilles R. A randomized phase III trial of sequential chemoradiotherapy in locally advanced non-small cell lung cancer Proc Am Soc Clin Oncol 20 2001 312a
16. Zatloukal P., Petruzelka L., and Zemanova M. Concurrent versus sequential radiochemotherapy with vinorelbine plus cisplatin (V-P) in locally advanced non-small cell lung cancer. A randomized phase II study Proc Am Soc Clin Oncol 2000 1976
17. Zemanova M., Petruzelka L., and Havel L. Concurrent versus sequential radiochemotherapy with vinorelbine plus cisplatin in locally advanced non-small cell lung cancer. A randomized phase II study Proc Am Soc Clin Oncol 2002 1159
18. Jett J.R., Scott W.J., and Rivera M.P. Guidelines on treatment of stage IIIB non-small cell lung cancer Chest 123 2003 221S 225S
19. Cox J.D., Le Chevalier T., and Arriagada R. Management of unresectable non-small cell carcinoma of the lung (NSCLC) Lung Cancer 42 2003 15 16
20. Belani C.P., Wang W., and Johnson D.H. Induction chemotherapy followed by standard thoracic radiotherapy (Std. TRT) vs. hyperfractionated accelerated radiotherapy (HART) for patients with unresectable stage III A&B non-small cell lung cancer (NSCLC): Phase III study of the Eastern Cooperative Oncology Group (ECOG 2597) Proc Am Soc Clin Oncol 2003 2500
21. Curran W.J. Jr, Scott C.B., and Bonomi P. Initial report of locally advanced multimodality protocol (LAMP): ACR 427: A randomized 3-arm phase II study of paclitaxel (T), carboplatin (C), and thoracic radiation (TRT) for patients with stage III non-small cell lung cancer (NSCLC) Proc Am Soc Clin Oncol 2001 1244
22. Choy H., Curran W.J. Jr, and Scott C.B. Preliminary report of locally advanced multimodality protocol (LAMP): ACR 427: a randomized phase II study of three chemo radiation regimens with paclitaxel, carboplatin, and thoracic radiation (TRT) for patients with locally advanced non small cell lung cancer (LA-NSCLC) Proc Am Soc Clin Oncol 2002 1160
23. Huber R.M., Schmidt M., and Flentje M. Induction chemotherapy and following simultaneous radio/chemotherapy versus induction chemotherapy and radiotherapy alone in inoperable NSCLC (Stage IIIA/IIIB) Proc Am Soc Clin Oncol 2003 2501
24. Clamon G., Herndon J., and Cooper R. Radiosensitization with carboplatin for patients with unresectable stage III non-small-cell lung cancer: a phase III trial of the Cancer and Leukemia Group B and the Eastern Cooperative Oncology Group J Clin Oncol 17 1 1999 4 11
25. Depierre A., Quoix E., and Mercier M. Maintenance chemotherapy in advanced non-small cell lung cancer (NSCLC): a randomized study of vinorelbine (V) versus observation (OB) in patients (Pts) responding to induction therapy (French Cooperative Oncology Group) Proc Am Soc Clin Oncol 2001 1231
26. Choi E.K., Lee S.W., and Kim S. A randomised phase III study of paclitaxel, cisplatin and concurrent high-dose radiation therapy with or without maintenance chemotherapy for unresectable non-small-cell lung cancer: Preliminary results Proc Am Soc Clin Oncol 2003 2812
27. Choy H., Kim D.W., and Akerley W.L. Combined modality therapy using concurrent radiation therapy with paclitaxel based chemotherapeutic regimen in unresectable locally advanced nonsmall cell lung cancer; long term follow up on three sequential multi-institutional prospective phase II studies Proc Am Soc Clin Oncol 2003 2564
28. Gandara D.R., Lovato L.C., and Albain K.S. Prolonged survival in pathologic stage IIIB non-small cell lung cancer (NSCLC) with concurrent chemoradiotherapy followed by consolidation docetaxel: a phase II study (59504) of the Southwest Oncology Group (SWOG) Proc Am Soc Clin Oncol 2000 1916
29. Gandara D.R., Chansky K., and Albain K.S. Consolidation docetaxel after concurrent chemoradiotherapy in stage IIIB non-small-cell lung cancer: phase II Southwest Oncology Group study 59504 J Clin Oncol 21 10 2003 2004 2010
30. Fietkau R., and Sauer R. Die frühzeitige Radiochemotherapie im Rahmen der Radiochemotherapie des kleinzelligen Bronchialkarzinoms ist im Stadium "Limited Disease" der späteren Bestrahlung überlegen Strahlenther Onkol 178 2002 585 588
31. Murray N., Coy P., and Patr J.L. Importance of timing for thoracic irradiation in the combined modality treatment of limited-stage small-cell lung cancer J Clin Oncol 11 1993 336 344
32. Davies A.M., Lau D.H., and Crowley J. Concurrent carboplatin/etoposide and radiation followed by paclitaxel consolidation for poor risk stage III non-small cell lung cancer: a Southwest Oncology Group (SWOG) study Proc Am Soc Clin Oncol 53 2002 1191
33. Eberhardt W., Wilke H., and Stamatis M. Preoperative chemotherapy followed by concurrent chemoradiotherapy based on hyperfractionated accelerated radiotherapy and definitive surgery in locally advanced non-small-cell lung cancer: mature results of a phase II trial J Clin Oncol 16 1998 622 634
34. Albain K.S., Scott C.B., and Rusch V.R. Phase III comparison of concurrent chemotherapy plus radiotherapy (CT/RT) and CT/RT followed by surgical resection for stage IIIA (pN2) non-small cell lung cancer (NSCLC): Initial results from intergroup trial 0139 (RTOG 93-09) Proc Am Soc Clin Oncol 2003 2497
35. Morere J.F., Diana C., and Pailler M. Concurrent chemoradiotherapy in locally advanced non-small cell lung cancer (NSCLC): A multicenter randomized phase II study Proc Am Soc Clin Oncol 2003 2813
36. Vokes E., Szeto L., and Mauer A. A phase I trial of pemetrexed + chest radiotherapy in patients with advanced or metastatic non-small-cell lung cancer or esophageal cancer Lung Cancer 2003 41
37. Vokes E.E., Herndon J.E., and Crawford J. Randomized phase II study of cisplatin with gemcitabine or paclitaxel or vinorelbine as induction chemotherapy followed by concomitant chemoradiotherapy for stage IIIB non-small-cell lung cancer: Cancer and Leukaemia Group B Study 9431 J Clin Oncol 20 2002 4191 4198
38. Brunner T.B., Gupta A.K., and Shi Y. Farnesyltransferase inhibitors as radiation sensitizers Int J Radiat Biol 79 7 2003 569 576
39. Choy H., and Milas L. Enhancing radiotherapy with cyclooxygenase-2 enzyme inhibitors: a rational advance? J Natl Cancer Inst 95 19 2003 1440 1452
40. Liao Z., Milas L., and Komaki R. Combination of a COX-2 inhibitor with radiotherapy or radiochemotherapy in the treatment of thoracic cancer Am J Clin Oncol 26 4 2003 S85 S91
41. Davis T.W., Hunter N., and Trifan O.C. COX-2 inhibitors as radiosensitizing agents for cancer therapy Am J Clin Oncol 26 4 2003 S58 S61
42. Adams J. Development of the proteasome inhibitor PS-341 Oncologist 7 2002 9 16
43. Russo S.M., Tepper J.E., and Baldwin A.S. Jr Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-NB Int J Radiat OncoL Biol Phys 50 2001 183 193
44. Huang S.M., Li J., and Armstrong E.A. Modulation of radiation response and tumor-induced angiogenesis after epidermal growth factor receptor inhibitation by ZD1839 (Iressa) Cancer Res 62 15 2002 4300 4306
45. Raben D., Bianco C., and Helfrich B. Interference with EGFR signaling: paradigm for improving radiation response in cancer treatment Expert Rev Anticancer Ther 2 4 2002 461 471
46. Liang K., Ang K.K., and Milas L. The epidermal growth factor receptor mediates radioresistance Int J Radiat Oncol BioL Phys 57 1 2003 246 254
47. Grana T.M., Sartor C.I., and Cox A.D. Epidermal growth factor receptor autocrine signaling in RIE-1 cells transformed by the ras oncogene enhances radiation resistance Cancer 63 2003 7807 7814
48. Lee C.G., Heijn M., and di Tomaso E. Anti-vascular endothelial growth factor treatment augments tumour radiation response under normoxic or hypoxic conditions Cancer Res 60 2000 5565 5570
49. Hahn S.M., Bernhard E., and Regine W. A phase I trial of the farnesyltransferase inhibitor L-778,123 and radiotherapy for locally advanced lung and head and neck cancer Clinical Cancer Research 8 2002 1065 1072
50. Vokes E.E., and Choy H. Targeted therapies for stage III non-small cell lung cancer: integration in the combined modality setting Lung Cancer 41 2003 S115 S121
51. Lu C., Komaki R., and Herbst R.S. A phase III study of AE-941 with induction chemotherapy (IC) and concomitant chemoradiotherapy (CRT) for stage III non-small cell lung cancer (NSCLC) (NCI T99-0046, RTOG 02-70, MDA 99-303): An interim overall toxicity report Proc Am Soc Clin Oncol 2003 2665
52. Rosenow E.C. Lung cancer: update on screening, diagnosis and prognosis Consultant 35 1995 1355 1371
53. Semrau S., Bier A., and Thierbach U. Concurrent radiochemotherapy with vinorelbine plus cisplatin or carboplatin in patients with locally advanced non-small-cell lung cancer and an increased risk of treatment complications Strahlenther Oncol 12 2003 823 830
54. Lau D.H., Ryu J.K., and Gandara D.R. Concurrent carboplatin, etoposide and thoracic radiation for poor-risk stage III non-small-cell lung carcinoma: a pilot study Int J Radiat Oncol Biol Phys 38 1997 157 161
55. Hainsworth J.D., and Vokes E.E. Docetaxel (Taxotere) in combination with radiation therapy and the potential of weekly administration in elderly and/or poor performance status patients with advanced non-small cell lung cancer Semin Oncol 281 Suppl 2 2001 22 27
56. Jeremic B., Shibamoto Y., and Milicic B. A phase II study of concurrent accelerated hyperfractionated radiotherapy and carboplatin/oral etoposide for elderly patients with stage III non-small cell lung cancer Int J Radiat Oncol Biol Phys 44 1999 343 348
57. Movsas B., Scott C., and Sause W. The benefit of treatment intensification is age and histology-dependent in patients with locally advanced non-small-cell lung cancer: a quality adjusted survival analysis of Radiation Therapy Oncology Group chemoradiation studies Int J Radiat Oncol Biol Phys 45 1999 1143 1149
58. Komaki R., Scott C., and Ettinger D. Randomized study of chemotherapy/radiation therapy combinations for favorable patients with locally advanced inoperable non-small cell lung cancer: Radiation Therapy Oncology Group (RTOG) 92-04 Int J Radiat Oncol Biol Phys 38 1997 149 155
59. Sause W.T., Scott C., and Taylor S. Phase II trial of combination chemotherapy and irradiation in non-small-cell lung cancer, Radiation Therapy Oncology Group 88-04 Am J Clin Oncol 15 1992 163 167