Induction of mouse c-src in RAW264 cells is dependent on AP-1 and NF-κB and important for progression to multinucleated cell formation

Biochemical and Biophysical Research Communications

Volumn 325, Issue 3, 2004, Pages 758-768

  Kumagai, Naoko ^a   Ohno, Keita ^a   Tameshige, Ryusuke ^a   Hoshijima, Mitsuhiro ^a   Yogo, Keiichiro ^a   Ishida, Norihiro ^a   Takeya, Tatsuo ^a  

^a NARA INSTITUTE OF SCIENCE AND TECHNOLOGY   (Japan)

Author keywords

AP 1; Bone resorption; c src; Multinucleated cells; NF B; Osteoclastogenesis; RAW264 cells

Indexed keywords

IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN C FOS; STRESS ACTIVATED PROTEIN KINASE; TRANSCRIPTION FACTOR AP 1;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL LINE; CONTROLLED STUDY; DNA FLANKING REGION; GENE EXPRESSION; GENE FUNCTION; GENE INDUCTION; GENOMICS; MOUSE; MULTINUCLEAR CELL; MUTATIONAL ANALYSIS; NONHUMAN; ONCOGENE SRC; PRIORITY JOURNAL; REGULATORY MECHANISM; TRANSCRIPTION INITIATION SITE;

ANIMALS; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; GENE EXPRESSION REGULATION; GIANT CELLS; MACROPHAGES; MEMBRANE GLYCOPROTEINS; MICE; NF-KAPPA B; PROTO-ONCOGENE PROTEINS PP60(C-SRC); RANK LIGAND; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR-KAPPA B; TRANSCRIPTION FACTOR AP-1;

EID: 8444227384     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.10.094     Document Type: Article

References (50)

1. S.M. Thomas, and J.S. Brugge Cellular functions regulated by src family kinases Annu. Rev. Cell. Dev. Biol. 13 1997 513 609
2. P. Soriano, C. Montgomery, R. Geske, and A. Bradley Targeted disruption of the c-src proto-oncogene leads to osteopetrosis in mice Cell 64 1991 693 702
3. G.D. Roodman Advances in bone biology: the osteoclast Endocr. Rev. 17 1996 308 332
4. S.L. Teitelbaum Bone resorption by osteoclasts Science 289 2000 1504 1508
5. T.J. Chambers Regulation of the differentiation and function of osteoclasts J. Pathol. 192 2000 4 13
6. T. Suda, N. Takahashi, N. Udagawa, E. Jimi, M. Gillespie, and T.J. Martin Modulation of osteoclast differentiation and function by the new members of the tumor necrosis factor receptor and ligand families Endocr. Rev. 20 1999 345 357
7. H. Hsu, D.L. Lacey, C.R. Dunstan, I. Solovyev, A. Colombero, E. Timms, H.L. Tan, G. Elliott, M.J. Kelley, and I. Sarosi Tumor necrosis factor receptor family member RANK mediates osteoclast differentiation and activation induced by osteoprotegerin ligand Proc. Natl. Acad. Sci. USA 96 1999 3540 3545
8. E. Meiyanto, M. Hoshijima, T. Ogawa, N. Ishida, and T. Takeya Osteoclast differentiation factor modulates cell cycle machinery and causes a delay in S phase progression in RAW264 cells Biochem. Biophys. Res. Commun. 282 2001 278 283
9. C. Shui, B.L. Riggs, and S. Khosla The immunosuppressant rapamycin, alone or with transforming growth factor-β, enhances osteoclast differentiation of RAW264.7 monocyte-macrophage cells in the presence of RANK-ligand Calcified Tissue Intl. 71 2002 437 446
10. B.R. Troen Molecular mechanisms underlying osteoclast formation and activation Exp. Gerontol. 38 2003 605 614
11. S. Tanaka, I. Nakamura, J.-I. Inoue, H. Oda, and K. Nakamura Signal transduction pathways regulating osteoclast differentiation and function J. Bone Miner. Metab. 21 2003 123 133
12. N. Kobayashi, Y. Kadono, A. Naito, K. Matsumoto, T. Yamamoto, S. Tanaka, and J. Inoue Segregation of TRAF6-mediated signaling pathways clarifies its role in osteoclastogenesis EMBO J. 20 2001 1271 1280
13. c-src expression for osteoclasts to form ruffled borders and resorb bone in mice J. Clin. Invest. 90 1992 1622 1627
14. B.F. Boyce, and H.E. Varmus Rescue of osteoclast function by transgenic expression of kinase-deficient Src in src-/- mutant mice Genes Dev. 11 1997 2835 2844
15. 3 integrin-mediated signaling, cell adhesion, and osteoclast motility J. Cell Biol. 152 2001 181 195
16. N. Ishida, K. Hayashi, M. Hoshijima, T. Ogawa, S. Koga, Y. Miyatake, M. Kumegawa, T. Kimura, and T. Takeya Large scale gene expression analysis of osteoclastogenesis in vitro and elucidation of NFAT2 as a key regulator J. Biol. Chem. 277 2002 41147 41156
17. N. Sakai, T. Ogawa, S. Koga, H. Samori, N. Ishida, K. Yogo, and T. Takeya A novel assessment system for bisphosphonate using mouse RAW264 cells and biomimetic hydroxyapatite-coated plates Preclinica 2 2004 57 66
18. N. Takahashi, N. Udagawa, S. Tanaka, and T. Suda Generating murine osteoclasts form bone marrow M.H. Helfrich S.H. Ralston Bone Research Protocols 2003 Human Press New Jersey 129 144
19. H. Yoshida, S. Hayashi, T. Kunisada, M. Ogawa, S. Nishikawa, H. Okamura, T. Sudo, L.D. Shultz, and S. Nishikawa The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene Nature 345 1990 442 445
20. c-src contains a six-amino acid insertion relative to its non-neuronal counterpart Science 237 1987 411 415
21. + T cells J. Immunol. 166 2001 6530 6536
22. H. Schjerven, P. Brandtzaeg, and F.E. Johansen A novel NF-κB/Rel site in intron 1 cooperates with proximal promoter elements to mediate TNF-α-induced transcription of human polymeric Ig receptor J. Immunol. 167 2001 6412 6420
23. J.D. Dignam, R.M. Lebovitz, and R.G. Roeder Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei Nucleic Acids Res. 11 1983 1475 1489
24. D. Morse, S.E. Pischke, Z. Zhou, R.J. Davis, R.A. Flavell, T. Loop, S.L. Otterbein, L.E. Otterbein, and A.M. Choi Suppression of inflammatory cytokine production by carbon monoxide involves the JNK J. Biol. Chem. 278 2003 36993 36998
25. X. Liu, and M.A. Gorovsky Mapping the 5′ and 3′ ends of Tetrahymena thermophila mRNAs using RNA ligase mediated amplification of cDNA ends (RLM-RACE) Nucleic Acids Res. 21 1993 4954 4960
26. T. Takeya, and H. Hanafusa Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus Cell 32 1983 881 890
27. c-src Mol. Cell. Biol. 5 1985 1122 1129
28. K. Bonham, and D.J. Fujita Organization and analysis of the promoter region and 5′ non-coding exons of the human c-src proto-oncogene Oncogene 8 1993 1973 1981
29. S. Ritchie, F.M. Boyd, J. Wong, and K. Bonham Transcription of the human c-Src promoter is dependent on Sp1, a novel pyrimidine binding factor Spy, and can be inhibited by Triplex-forming oligonucleotides J. Biol. Chem. 275 2000 847 854
30. K.M. Warpeha, W. Xu, L. Liu, I.G. Charles, C.C. Patterson, F. Ah-Fat, S. Harding, P.M. Hart, U. Chakravarthy, and A.E. Hughes Genotyping and functional analysis of a polymorphic (CCTTT)n repeat of NOS2A in diabetic retinopathy FASEB J. 13 1999 1825 1832
31. K. Furukawa, M. Horie, K. Okutomi, S. Sugano, and K. Furukawa Isolation and functional analysis of the melanoma specific promoter region of human GD3 synthase gene Biochim. Biophys. Acta 1627 2003 71 78
32. K. Bonham, S.A. Ritchie, S.M. Dehm, K. Snyder, and F.M. Boyd An alternative human SRC promoter and its regulation by hepatic nuclear factor-1α J. Biol. Chem. 275 2000 37604 37611
33. E.F. Wagner, and K. Matsuo Signaling in osteoclasts and the role of Fos/AP-1 proteins Ann. Rheum. Dis. 62 2003 ii83 ii85
34. J.P. David, K. Sabapathy, O. Hoffmann, M.H. Idarraga, and E.F. Wagner JNK1 modulates osteoclastogenesis through both c-Jun phosphorylation-dependent and -independent mechanisms J. Cell Sci. 115 2000 4317 4325
35. A. Hess, N. Wijayanti, A.P. Neuschäfer-Ruber, N. Katz, T. Kietzmann, and S. Immenschuh Phorbol ester-dependent activation of peroxiredoxin I gene expression via a protein kinase C, Ras, p38 mitogen-activated protein kinase signaling pathway J. Biol. Chem. 278 2003 45419 45434
36. H. Takayanagi, S. Kim, K. Matsuo, H. Suzuki, T. Suzuki, K. Sato, T. Yokochi, H. Oda, K. Nakamura, N. Ida, E.F. Wagner, and T. Taniguchi RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-β Nature 416 2002 744 749
37. M. Sudol, C. Kieswetter, Y.H. Zhao, T. Dorai, L.H. Wang, and H. Hanafusa Nucleotide sequence of a cDNA for the chick yes proto-oncogene: comparison with the viral yes gene Nucleic Acids Res. 16 1988 9876
38. c-src in association with intracellular membranes J. Cell Biol. 119 1992 1003 1013
39. Cytokine Res. 19 1999 429 438
40. G. Franzoso, L. Carlson, L. Xing, L. Polijak, E.W. Shores, K.D. Brown, A. Leonardi, T. Tran, B.F. Boyce, and U. Siebenlist Requirement for NF-κB in osteoclast and B-cell development Genes Dev. 11 1997 3482 3496
41. V. Isotova, J. Caamano, J. Loy, Y. Yang, A. Lewin, and R. Bravo Osteopetrosis in mice lacking NF-κB1 and NF-κB2 Nat. Med. 3 1997 1285 1289
42. Z.Q. Wang, C. Ovitt, A.E. Grigoriadis, U. Mohle-Steinlein, U. Ruther, and E.F. Wagner Bone and haematopoietic defects in mice lacking c-fos Nature 360 1992 741 745
43. A.E. Grigoriadis, Z.Q. Wang, M.G. Cecchini, W. Hofstetter, R. Felix, H.A. Fleisch, and E.F. Wagner c-Fos: a key regulator of osteoclast-macrophage lineage determination and bone remodeling Science 266 1994 443 448
44. κB kinase 2 and MKK7 in osteoclastogenesis induced by receptor activator of nuclear factor κB ligand J. Bone Miner. Res. 17 2002 612 621
45. I.M. Adcock Transcription factors as activators of gene transcription: AP-1 and NF-kappa B Monaldi. Arch. Chest. Dis. 52 1997 178 186
46. T.C. Hsu, M.R. Young, J. Cmarik, and N.H. Colburn Activator protein 1 (AP-1)- and nuclear factor κB (NF-κB)-dependent transcriptional events in carcinogenesis Free Radic. Biol. Med. 28 2000 1338 1348
47. B. Stein, A.S. Baldwin Jr., D.W. Ballard, W.C. Greene, P. Angel, and P. Herrlich Cross-coupling of the NF-κB p65 and Fos/Jun transcription factors produces potentiated biological function EMBO J. 12 1993 3879 3891
48. K.A. Roebuck Regulation of interleukin-8 gene expression J. Interferon Cytokine Res. 19 1999 429 438
49. N.K. Shevde, A.C. Bendixen, K.M. Dienger, and J.W. Pike Estrogen suppress RANK ligand-induced osteoclast differentiation via a stromal cell independent mechanism involving c-Jun repression Proc. Natl. Acad. Sci. USA 97 2000 7829 7834
50. S. Srivastava, G. Toraldo, M.N. Weitzmann, S. Cenci, F.P. Ross, and R. Pacifici Estrogen decreases osteoclast formation by down-regulating receptor activator of NF-B ligand (RANKL)-induced JNK activation J. Biol. Chem. 276 2001 8836 8840