Automated detection and characterization of SPIO-labeled cells and capsules using magnetic field perturbations

Magnetic Resonance in Medicine

Volumn 67, Issue 1, 2012, Pages 278-289

  Mills, Parker H ^a   Hitchens, T Kevin ^a   Foley, Lesley M ^a   Link, Thomas ^b   Ye, Qing ^a   Weiss, Clifford R ^b   Thompson, Joe D ^c   Gilson, Wesley D ^d   Arepally, Aravind ^b   Melick, John A ^e   Kochanek, Patrick M ^e   Ho, Chien ^a   Bulte, Jeff W M ^b,c,d,e   Ahrens, Eric T ^a  

^a CARNEGIE MELLON UNIVERSITY   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c LOS ALAMOS NATIONAL LABORATORY   (United States)

^d SIEMENS CORPORATE RESEARCH   (United States)

^e UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

cell tracking; magnetic moment; magnetocapsules; MRI; SPIO; susceptibility

Indexed keywords

BIOMEDICAL SIGNAL PROCESSING; BRAIN; CYTOLOGY; IRON DEPOSITS; MACROPHAGES; MAGNETIC MOMENTS; MAGNETIC RESONANCE IMAGING; MAGNETIC SUSCEPTIBILITY; SIGNAL TO NOISE RATIO; SUPERPARAMAGNETISM; THERANOSTICS;

AUTOMATED DETECTION; CELL TRACKING; MAGNETIC FIELD PERTURBATIONS; MAGNETOCAPSULES; POSTPROCESSING METHODS; SPIO; SUPERPARAMAGNETIC IRON OXIDES; TRAUMATIC BRAIN INJURIES;

IRON OXIDES;

AGAROSE; IRON OXIDE; MICRON SIZED PARAMAGNETIC IRON OXIDE; SUPERPARAMAGNETIC IRON OXIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN; BRAIN SCINTISCANNING; CELLS; CONTROLLED STUDY; GRAFT REJECTION; HEART; LIVER; MACROPHAGE; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; RAT; SIGNAL NOISE RATIO; TRAUMATIC BRAIN INJURY;

EID: 84355162271     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.22998     Document Type: Article

References (40)

1. Mendonca-Dias MH, Gaggelli E, Lauterbur PC,. Paramagnetic contrast agents in nuclear magnetic resonance medical imaging. Semin Nucl Med 1983; 13: 364-376.
2. Muja N, Bulte JWM,. Magnetic resonance imaging of cells in experimental disease models. Prog Nucl Magn Reson Spectrosc 2009; 55: 61-77.
3. Williams JB, Ye Q, Hitchens TK, Kaufman CL, Ho C,. MRI detection of macrophages labeled using micrometer-sized iron oxide particles. J Magn Reson Imaging 2007; 25: 1210-1218. (Pubitemid 46870280)
4. Frank JA, Miller BR, Arbab AS, Zywicke HA, Jordan EK, Lewis BK, Bryant LH, Bulte JWM,. Clinically applicable labeling of mammalian and stem cells by combining superparamagnetic iron oxides and transfection agents. Radiology 2003; 228: 480-487. (Pubitemid 36910091)
5. Walczak P, Kedziorek DA, Gilad AA, Lin S, Bulte JW,. Instant MR labeling of stem cells using magnetoelectroporation. Magn Reson Med 2005; 54: 769-774. (Pubitemid 41457046)
6. Qiu B, Xie D, Walczak P, Li X, Ruiz-Cabello J, Minoshima S, Bulte JW, Yang X,. Magnetosonoporation: instant magnetic labeling of stem cells. Magn Reson Med 2010; 63: 1437-1441.
7. Bulte JW, Zhang S, van Gelderen P, Herynek V, Jordan EK, Duncan ID, Frank JA,. Neurotransplantation of magnetically labeled oligodendrocyte progenitors: magnetic resonance tracking of cell migration and myelination. Proc Natl Acad Sci USA 1999; 96: 15256-15261. (Pubitemid 30019799)
8. Pawelczyk E, Arbab AS, Pandit S, Hu E, Frank JA,. Expression of transferrin receptor and ferritin following ferumoxides-protamine sulfate labeling of cells: implications for cellular magnetic resonance imaging. NMR Biomed 2006; 19: 581-592.
9. Yang JX, Tang WL, Wang XX,. Superparamagnetic iron oxide nanoparticles may affect endothelial progenitor cell migration ability and adhesion capacity. Cytotherapy 2010; 12: 251-259.
10. Bulte JW,. In vivo MRI cell tracking: clinical studies. AJR Am J Roentgenol 2009; 193: 314-325.
11. Haacke EM, Xu YB, Cheng YCN, Reichenbach JR,. Susceptibility weighted imaging (SWI). Magn Reson Med 2004; 52: 612-618. (Pubitemid 39108975)
12. Cunningham CH, Arai T, Yang PC, McConnell MV, Pauly JM, Conolly SM,. Positive contrast magnetic resonance imaging of cells labeled with magnetic nanoparticles. Magn Reson Med 2005; 53: 999-1005. (Pubitemid 40627773)
13. Mani V, Briley-Saebo KC, Itskovich VV, Samber DD, Fayad ZA,. Gradient echo acquisition for superparamagnetic particles with positive contrast (GRASP): sequence characterization in membrane and glass superparamagnetic iron oxide phantoms at 1.5T and 3T. Magn Reson Med 2006; 55: 126-135. (Pubitemid 43062936)
14. Stuber M, Gilson WD, Schar M, Kedziorek DA, Hofmann LV, Shah S, Vonken EJ, Bulte JW, Kraitchman DL,. Positive contrast visualization of iron oxide-labeled stem cells using Inversion-Recovery with ON-resonant water suppression (IRON). Magn Reson Med 2007; 58: 1072-1077. (Pubitemid 350074377)
15. Seppenwoolde JH, Viergever MA, Bakker CJG,. Passive tracking exploiting local signal conservation: the white marker phenomenon. Magn Reson Med 2003; 50: 784-790. (Pubitemid 37187844)
16. Bakker CJ, Seppenwoolde JH, Vincken KL,. Dephased MRI. Magn Reson Med 2006; 55: 92-97. (Pubitemid 43062932)
17. Warren WS, Ahn S, Mescher M, Garwood M, Ugurbil K, Richter W, Rizi RR, Hopkins J, Leigh JS,. MR imaging contrast enhancement based on intermolecular zero quantum coherences. Science 1998; 281: 247-251. (Pubitemid 28334505)
18. Robson MD, Gatehouse PD, Bydder M, Bydder GM,. Magnetic resonance: an introduction to ultrashort TE (UTE) imaging. J Comput Assist Tomogr 2003; 27: 825-846. (Pubitemid 37420776)
19. Lai S, Reichenbach JR, Haacke EM,. Commutator filter: a novel technique for the identification of structures producing significant susceptibility inhomogeneities and its application to functional MRI. Magn Reson Med 1996; 36: 781-787. (Pubitemid 26376718)
20. Mills PH, Ahrens ET,. Enhanced positive-contrast visualization of paramagnetic contrast agents using phase images. Magn Reson Med 2009; 62: 1349-1355.
21. Bakker CJ, de Leeuw H, Vincken KL, Vonken EJ, Hendrikse J,. Phase gradient mapping as an aid in the analysis of object-induced and system-related phase perturbations in MRI. Phys Med Biol 2008; 53: 349-358.
22. McAuley G, Schrag M, Sipos P, Sun SW, Obenaus A, Neelavalli J, Haacke EM, Holshouser B, Madacsi R, Kirsch W,. Quantification of punctate iron sources using magnetic resonance phase. Magn Reson Med 2010; 63: 106-115.
23. Dixon WT, Blezek DJ, Lowery LA, Meyer DE, Kulkarni AM, Bales BC, Petko DL, Foo TK,. Estimating amounts of iron oxide from gradient echo images. Magn Reson Med 2009; 61: 1132-1136.
24. Bos C, Viergever MA, Bakker CJ,. On the artifact of a subvoxel susceptibility deviation in spoiled gradient-echo imaging. Magn Reson Med 2003; 50: 400-404. (Pubitemid 36950860)
25. Mowat P, Franconi F, Chapon C, Lemaire L, Dorat J, Hindre F, Benoit JP, Richomme P, Le Jeune JJ,. Evaluating SPIO-labelled cell MR efficiency by three-dimensional quantitative T2* MRI. NMR Biomed 2007; 20: 21-27. (Pubitemid 46335553)
26. Mills PH, Wu YJ, Ho C, Ahrens ET,. Sensitive and automated detection of iron-oxide-labeled cells using phase image cross-correlation analysis. Magn Reson Imaging 2008; 26: 618-628.
27. Barnett BP, Arepally A, Karmarkar PV, Qian D, Gilson WD, Walczak P, Howland V, Lawler L, Lauzon C, Stuber M, Kraitchman DL, Bulte JW,. Magnetic resonance-guided, real-time targeted delivery and imaging of magnetocapsules immunoprotecting pancreatic islet cells. Nat Med 2007; 13: 986-991. (Pubitemid 47222036)
28. Schenck JF,. The role of magnetic susceptibility in magnetic resonance imaging: MRI magnetic compatibility of the first and second kinds. Med Phys 1996; 23: 815-850. (Pubitemid 26192503)
29. Bakker CJ, de Roos R,. Concerning the preparation and use of substances with a magnetic susceptibility equal to the magnetic susceptibility of air. Magn Reson Med 2006; 56: 1107-1113. (Pubitemid 44691353)
30. Griffiths DJ,. Magnetic fields in matter. In:, Reeves A, editor. Introduction to electrodynamics. Upper Saddle River: Prentice Hall; 1999. pp 269-284.
31. Chavez S, Xiang QS, An L,. Understanding phase maps in MRI: a new cutline phase unwrapping method. IEEE Trans Med Imaging 2002; 21: 966-977. (Pubitemid 35476600)
32. Jenkinson M,. Fast, automated, N-dimensional phase-unwrapping algorithm. Magn Reson Med 2003; 49: 193-197. (Pubitemid 36042352)
33. Wu YL, Ye Q, Foley LM, Hitchens TK, Sato K, Williams JB, Ho C,. In situ labeling of immune cells with iron oxide particles: an approach to detect organ rejection by cellular MRI. Proc Natl Acad Sci USA 2006; 103: 1852-1857. (Pubitemid 43228782)
34. Foley LM, Hitchens TK, Ho C, Janesko-Feldman KL, Melick JA, Bayir H, Kochanek PM,. Magnetic resonance imaging assessment of macrophage accumulation in mouse brain after experimental traumatic brain injury. J Neurotrauma 2009; 26: 1509-1519.
35. Ye Q, Wu YL, Foley LM, Hitchens TK, Eytan DF, Shirwan H, Ho C,. Longitudinal tracking of recipient macrophages in a rat chronic cardiac allograft rejection model with noninvasive magnetic resonance imaging using micrometer-sized paramagnetic iron oxide particles. Circulation 2008; 118: 149-156.
36. Banks MA, Porter DW, Pailes WH, Schwegler-Berry D, Martin WG, Castranova V,. Taurine content of isolated rat alveolar type I cells. Comp Biochem Physiol B Biochem Mol Biol 1991; 100: 795-799.
37. Bomati-Miguel O, Morales MP, Tartaj P, Ruiz-Cabello J, Bonville P, Santos M, Zhao X, Veintemillas-Verdaguer S,. Fe-based nanoparticulate metallic alloys as contrast agents for magnetic resonance imaging. Biomaterials 2005; 26: 5695-5703. (Pubitemid 40616840)
38. Shen T, Weissleder R, Papisov M, Bogdanov A Jr, Brady TJ,. Monocrystalline iron oxide nanocompounds (MION): physicochemical properties. Magn Reson Med 1993; 29: 599-604. (Pubitemid 23138048)
39. Foster-Gareau P, Heyn C, Alejski A, Rutt BK,. Imaging single mammalian cells with a 1.5 T clinical MRI scanner. Magn Reson Med 2003; 49: 968-971. (Pubitemid 36523485)
40. Nieman BJ, Shyu JY, Rodriguez JJ, Garcia AD, Joyner AL, Turnbull DH,. In vivo MRI of neural cell migration dynamics in the mouse brain. Neuroimage 2010; 50: 456-464.