Quantification of punctate iron sources using magnetic resonance phase

Magnetic Resonance in Medicine

Volumn 63, Issue 1, 2010, Pages 106-115

  McAuley, Grant ^a   Schrag, Matthew ^a   Sipos, Pál ^b   Sun, Shu Wei ^c   Obenaus, Andre ^c,d   Neelavalli, Jaladhar ^e,f   Haacke, E Mark ^d,e,g   Holshouser, Barbara ^d   Madácsi, Ramóna ^b   Kirsch, Wolff ^a  

^a LOMA LINDA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF SZEGED   (Hungary)

^c LOMA LINDA UNIVERSITY   (United States)

^d LOMA LINDA UNIVERSITY MEDICAL CENTER   (United States)

^e Magnetic Resonance Institute for Biomedical Research   (United States)

^f UNIVERSITY OF OXFORD   (United Kingdom)

^g WAYNE STATE UNIVERSITY   (United States)

Author keywords

Blooming effect; Brain microbleeds; Iron quantification; Phase images; Susceptibility weighted imaging

Indexed keywords

BRAIN; IRON; MAGNETIC RESONANCE; NEURODEGENERATIVE DISEASES;

BLOOMING EFFECTS; CONVENTIONAL APPROACH; DIPOLE FIELDS; FERRIC OXYHYDROXIDE; GEOMETRIC FEATURE; MAGNETIC DIPOLE; PHASE IMAGE; SUSCEPTIBILITY WEIGHTED IMAGING;

IRON RESEARCH;

CHITOSAN; FERRIC HYDROXIDE; HEMOSIDERIN; IRON;

ARTICLE; BRAIN REGION; COMPOSITE MATERIAL; DIPOLE; GEOMETRY; IMAGE PROCESSING; MAGNETIC FIELD; NUCLEAR MAGNETIC RESONANCE IMAGING; PHANTOM; PREDICTION; RADIUS; VALIDATION PROCESS;

EID: 73349133279     PISSN: 07403194     EISSN: 15222594     Source Type: Journal    
DOI: 10.1002/mrm.22185     Document Type: Article

References (48)

1. Greenberg SM, Vernooij MW, Cordonnier C, Viswanathan A, Al-Shahi Salman R, Warach S, Launer LJ, Van Buchem MA, Breteler MMB. Cerebral microbleeds: a guide to detection and interpretation. Lancet Neurol 2009;8:165-174.
2. Cordonnier C, Salman RA-S, Wardlaw J. Spontaneous brain microbleeds: systematic review, subgroup analyses and standards for study design and reporting. Brain 2007;130(pt 8):1988-2003.
3. Nighoghossian N, Hermier M, Adeleine P, Blanc-Lasserre K, Derex L, Honnorat J, Philippeau F, Dugor JF, Froment JC, Trouillas P. Old microbleeds are a potential risk factor for cerebral bleeding after ischemic stroke: a gradient-echo T2*-weighted brain MRI study. Stroke 2002;33:735-742.
4. Tong KA, Ashwal S, Holshouser BA, Shutter LA, Herigault G, Haacke EM, Kido DK. Hemorrhagic shearing lesions in children and adolescents with posttraumatic diffuse axonal injury: improved detection and initial results. Radiology 2003;227:332-339.
5. Tong KA, Ashwal S, Holshouser BA, Nickerson JP, Wall CJ, Shutter LA, Osterdock RJ, Haacke EM, Kido D. Diffuse axonal injury in children: clinical correlation with hemorrhagic lesions. Ann Neurol 2004;56:36-50.
6. Scheid R, Preul C, Gruber O, Wiggins C, von Cramon DY. Diffuse axonal injury associated with chronic traumatic brain injury: evidence from T2*-weighted gradient-echo imaging at 3 T. AJNR Am J Neuroradiol 2003;24:1049-1056.
7. Yakushiji Y, Nishiyama M, Yakushiji S, Hirotsu T, Uchino A, Nakajima J, Eriguchi M, Nanri Y, Hara M, Horikawa E, Kuroda Y. Brain microbleeds and global cognitive function in adults without neurological disorder. Stroke 2008;39:3323-3328.
8. Bizzi A, Brooks RA, Brunetti A, Hill JM, Alger JR, Miletich RS, Francavilla TL, Di Chiro G. Role of iron and ferritin in MR imaging of the brain: a study in primates at different field strengths. Radiology 1990;177:59-65.
9. Atlas SW, Mark AS, Grossman RI, Gomori JM. Intracranial hemorrhage: gradient-echo MR imaging at 1.5 T. Comparison with spinecho imaging and clinical applications. Radiology 1988;168:803-807.
10. Viswanathan A, Chabriat H. Cerebral microhemorrhage. Stroke 2006; 37:550-555.
11. Vymazal J, Klempír J, Jech R, Zidovská J, Syka M, Růzicka E, Roth J. MR relaxometry in Huntington's disease: correlation between imaging, genetic and clinical parameters. J Neurol Sci 2007;263:20-25.
12. Gaasch JA, Lockman PR, Geldenhuys WJ, Allen DD, Van der Schyf CJ. Brain iron toxicity: differential responses of astrocytes, neurons, and endothelial cells. Neurochem Res 2007;32:1196-1208.
13. Bush AI. The metallobiology of Alzheimer's disease. Trends Neurosci 2003;26:207-214.
14. Andersen JK. Iron dysregulation and Parkinson's disease. J Alzheimers Dis 2004;6(6 suppl):S47-52.
15. Neema M, Arora A, Healy BC, Guss ZD, Brass SD, Duan Y, Buckle GJ, Glanz BI, Stazzone L, Khoury SJ, Weiner HL, Guttmann CRG, Bakshi R. Deep gray matter involvement on brain MRI scans is associated with clinical progression in multiple sclerosis. J Neuroimaging 2009;19:3-8.
16. Schenck JF, Zimmerman EA. High-field magnetic resonance imaging of brain iron: birth of a biomarker?NMR Biomed 2004;17:433-445.
17. Haacke EM, Cheng NYC, House MJ, Liu Q, Neelavalli J, Ogg RJ, Khan A, Ayaz M, Kirsch W, Obenaus A. Imaging iron stores in the brain using magnetic resonance imaging. Magn Reson Imaging 2005; 23:1-25.
18. Reichenbach JR, Venkatesan R, Schillinger DJ, Kido DK, Haacke EM. Small vessels in the human brain: MR venography with deoxyhemoglobin as an intrinsic contrast agent. Radiology 1997;204:272-277.
19. Haacke EM, Xu Y, Cheng Y-CN, Reichenbach R Jr. Susceptibility weighted imaging (SWI). Magn Reson Med 2004;52:612-618.
20. Akter M, Hirai T, Hiai Y, Kitajima M, Komi M, Murakami R, Fukuoka H, Sasao A, Toya R, Haacke EM, Takahashi M, Hirano T, Kai Y, Morioka M, Hamasaki K, Kuratsu J-I, Yamashita Y. Detection of hemorrhagic hypointense foci in the brain on susceptibility-weighted imaging clinical and phantom studies. Acad Radiol 2007; 14:1011-1019.
21. Haacke EM, Ayaz M, Khan A, Manova ES, Krishnamurthy B, Gollapalli L, Ciulla C, Kim I, Petersen F, Kirsch W. Establishing a baseline phase behavior in magnetic resonance imaging to determine normal vs. abnormal iron content in the brain. J Magn Reson Imaging 2007; 26:256-264.
22. Duyn JH, Gelderen PV, Li T-Q, Zwart JAD, Koretsky AP, Fukunaga M. High-field MRI of brain cortical substructure based on signal phase. Proc Natl Acad Sci U|S|A 2007;104:11796-11801.
23. Ogg RJ, Langston JW, Haacke EM, Steen RG, Taylor JS. The correlation between phase shifts in gradient-echo MR images and regional brain iron concentration. Magn Reson Imaging 1999;17: 1141-1148.
24. Pintaske J, Müller-Bierl B, Schick F. Geometry and extension of signal voids in MR images induced by aggregations of magnetically labelled cells. Phys Med Biol 2006;51:4707-4718.
25. Bos C, Viergever MA, Bakker CJG. On the artifact of a subvoxel susceptibility deviation in spoiled gradient-echo imaging. Magn Reson Med 2003;50:400-404.
26. Dixon WT, Blezek DJ, Lowery LA, Meyer DE, Kulkarni AM, Bales BC, Petko DL, Foo TK. Estimating amounts of iron oxide from gradient echo images. Magn Reson Med 2009;61:1132-1136.
27. Robson P, Hall L. Identifying particles in industrial systems using MRI susceptibility artefacts. AICHE J 2005;51:1633-1640.
28. Sipos P, Berkesi O, Tombácz E, Pierre TGS, Webb J. Formation of spherical iron(III) oxyhydroxide nanoparticles sterically stabilized by chitosan in aqueous solutions. J Inorg Biochem 2003;95:55-63.
29. Haacke EM, Brown RW, Thompson MR, Venkatesan R. Magnetic resonance imaging: physical principles and sequence design. New York: Wiley-Liss; 1999. 914 p.
30. Wang Y, Yu Y, Li D, Bae KT, Brown JJ, Lin W, Haacke EM. Artery and vein separation using susceptibility-dependent phase in contrast-enhanced MRA. J Magn Reson Imaging 2000;12:661-670.
31. Helmer O, Emerson C. The iron content of whole blood in normal individuals. J Biol Chem 1934;104:157-161.
32. Kim JK, Kucharczyk W, Henkelman RM. Cavernous hemangiomas: dipolar susceptibility artifacts at MR imaging. Radiology 1993;187: 735-741.
33. Bartzokis G, Aravagiri M, Oldendorf WH, Mintz J, Marder SR. Field dependent transverse relaxation rate increase may be a specific measure of tissue iron stores. Magn Reson Med 1993;29:459-464.
34. House MJ, Pierre TGS, Kowdley KV, Montine T, Connor J, Beard J, Berger J, Siddaiah N, Shankland E, Jin L-W. Correlation of proton transverse relaxation rates (R2) with iron concentrations in postmortem brain tissue from Alzheimer's disease patients. Magn Reson Med 2007;57:172-180.
35. Gilissen EP, Jacobs RE, Allman JM. Magnetic resonance microscopy of iron in the basal forebrain cholinergic structures of the aged mouse lemur. J Neurol Sci 1999;168:21-27.
36. Jara H, Sakai O, Mankal P, Irving RP, Norbash AM. Multispectral quantitative magnetic resonance imaging of brain iron stores: a theoretical perspective. Top Magn Reson Imaging 2006;17:19-30.
37. Ordidge RJ, Gorell JM, Deniau JC, Knight RA, Helpern JA. Assessment of relative brain iron concentrations using T2-weighted and T2*-weighted MRI at 3 tesla. Magn Reson Med 1994;32:335-341.
38. Gelman N, Gorell JM, Barker PB, Savage RM, Spickler EM, Windham JP, Knight RA. MR Imaging of human brain at 3.0 T: preliminary report on transverse relaxation rates and relation to estimated iron content. Radiology 1999;210:759-767.
39. MacKay A, Null N, Vavasour I, Bjarnason T, Kolind S, Mädler B. Insights into brain microstructure from the T2 distribution. Magn Reson Imaging 2006;24:515-525.
40. Gossuin Y, Gillis P, Muller RN, Hocq A. Relaxation by clustered ferritin: a model for ferritin-induced relaxation in vivo. NMR Biomed 2007;20:749-756.
41. Jensen JH, Szulc K, Hu C, Ramani A, Lu H, Xuan L, Falangola MF, Chandra R, Knopp EA, Schenck J, Zimmerman EA, Helpern JA. Magnetic field correlation as a measure of iron-generated magnetic field inhomogeneities in the brain. Magn Reson Med 2009;61:481-485.
42. Wang ZJ, Lian L, Chen Q, Zhao H, Asakura T, Cohen AR. 1/T2 And magnetic susceptibility measurements in a gerbil cardiac iron overload model. Radiology 2005;234:749-755.
43. Cheng Y-CN, Hsieh C-Y, Neelavalli J, Liu Q, Dawood MS, Haacke EM. A complex sum method of quantifying susceptibilities in cylindrical objects: the first step toward quantitative diagnosis of small objects in MRI. Magn Reson Imaging 2007;25:1171-1180.
44. Pintaske J, Müller-Bierl B, Schick F. Effect of spatial distribution of magnetic dipoles on Lamor frequency distribution and MR signal decay-a numerical approach under static dephasing conditions. MAGMA 2006;19:46-53.
45. Mills PH, Wu Y-JL, Ho C, Ahrens ET. Sensitive and automated detection of iron-oxide-labeled cells using phase image cross-correlation analysis. Magn Reson Imaging 2008;26:618-628.
46. Smirnov P, Gazeau F, Beloeil JC, Doan BT, Wilhelm C, Gillet B. Single-cell detection by gradient echo 9.4 T MRI: a parametric study. Contrast Media Mol Imaging 2006;1:165-174.
47. Yamada N, Imakita S, Sakuma T, Takamiya M. Intracranial calcification on gradient-echo phase image: depiction of diamagnetic susceptibility. Radiology 1996;198:171-178.
48. Neelavalli J, Cheng Y-CN, Jiang J, Haacke EM. Removing background phase variations in susceptibility-weighted imaging using a fast, forward-field calculation. J Magn Reson Imaging 2009;29:937-948.