Albumin modification and fragmentation in renal disease

Clinica Chimica Acta

Volumn 413, Issue 3-4, 2012, Pages 391-395

  Donadio, Carlo ^a   Tognotti, Danika ^a   Donadio, Elena ^a  

^a UNIVERSITY OF PISA   (Italy)

Author keywords

End stage renal disease; Human serum albumin; Low molecular weight proteins; Plasma proteomics; Uremic syndrome

Indexed keywords

ADRENOMEDULLIN; ALBUMIN; AMYLOID PROTEIN; BETA 2 MICROGLOBULIN; CHROMOGRANIN A; HEMOGLOBIN; IMMUNOGLOBULIN KAPPA CHAIN; IMMUNOGLOBULIN LAMBDA CHAIN; LEPTIN; LYSOZYME; MYOGLOBIN; PARATHYROID HORMONE;

CHRONIC KIDNEY FAILURE; DIABETES MELLITUS; HEMODIALYSIS; HUMAN; KIDNEY DISEASE; KIDNEY FAILURE; MOLECULAR WEIGHT; NEPHROSIS; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN MODIFICATION; PROTEIN PROCESSING; PROTEOMICS; REVIEW; UREMIA;

HUMANS; KIDNEY; KIDNEY DISEASES; MOLECULAR WEIGHT; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEOLYSIS; SERUM ALBUMIN;

EID: 84355161382     PISSN: 00098981     EISSN: 18733492     Source Type: Journal    
DOI: 10.1016/j.cca.2011.11.009     Document Type: Review

References (43)

1. Maack T., Hyung Park C., Camargo M.J.F. Renal filtration, transport, and metabolism of proteins. Kidney Physiol Pathophysiol 1985, 1773-1803.
2. Bianchi C., Donadio C., Tramonti G., et al. Renal handing of cationic and anionic small proteins: experiments in intact rats. Control Nephrol 1988, 68:37-44.
3. Nielsen R., Christensen E.I. Proteinuria and events beyond the slit. Pediatr Nephrol 2010, 25:813-822.
4. Johanson B.G., Ravnskov U. The serum level and urinary excretion of a2-globulin, ß2-microglobulin and lysozyme in renal disease. Scand J Urol Nephrol 1972, 6:249-256.
5. Itoh Y., Enomoto H., Takagi K., Kawai T. Clinical usefulness of serum a1-microglobulin as a sensitive indicator for renal insufficiency. Nephron 1983, 33:69-70.
6. Grubb A., Simonsen O., Sturfelt G., Truedsson L., Thysell H. Serum concentration of cystatin C, Factor D, and ß2-microglobulin as a measure of glomerular filtration rate. Acta Med Scand 1985, 218:499-503.
7. Schardijn G.H.C., Statius van Eps L.W. ß2-microglobulin: its significance in the evaluation of renal function. Kidney Int 1987, 32:635-641.
8. Priem F., Althaus H., Birnbaum M., Sinha P., Conradt H.S., Jung K. ß-trace protein in serum: a new marker of glomerular filtration rate in the creatinine-blind range. Clin Chem 1999, 45:567-568.
9. Tramonti G., Ferdeghini M., Annichiarico C., et al. Relationship between renal function and blood level of chromogranin, A. Ren Fail 2001, 23:449-457.
10. Donadio C., Lucchesi A., Ardini M., Donadio E., Giordani R. Serum levels of beta-trace protein and glomerular filtration rate - preliminary results. J Pharm Biomed Anal 2003, 32:1099-1104.
11. Clark W.R., Gao D. Low-molecular weight proteins in end-stage renal disease: potential toxicity and dialytic removal mechanisms. J Am Soc Nephrol 2002, 13:S41-S47.
12. Russo L.M., Bakris G.L., Comper W.D. Renal Handling of Albumin: A critical review of basic concepts and perspective. Am J Kidney Dis 2002, 39:899-919.
13. Comper W.D., Osicka T.M., Jerums G. High prevalence of immunounreactive intact albumin in the urine of diabetic patients. Am J Kidney Dis 2003, 41:336-342.
14. Osicka T.M., Comper W.D. Characterization of immunochemically nonreactive urinary albumin. Clin Chem 2004, 50:2286-2291.
15. Comper W.D., Lucinda M., Hilliard L.M., Nikolic-Paterson D.J., Russo L.M. Disease-dependent mechanisms of albuminuria. Am J Physiol Renal Physiol 2008, 295:F1589-F1600.
16. Gudehithlu K.P., Pegoraro A.A., Dunea G., Arruda J.A.L., Singh A.K. Degradation of albumin by the renal proximal tubule cells and the subsequent fate of its fragments. Kidney Int 2004, 65:2113-2122.
17. Tanner G.A. Glomerular sieving coefficient of serum albumin in the rat: a two-photon microscopy study. Am J Physiol Renal Physiol 2009, 296:F1258-F1265.
18. Peti-Peterdi J. Independent two-photon measurements of albumin GSC give low values. Am J Physiol Renal Physiol 2009, 296:F1255-F1257.
19. Peti-Peterdi J., Sipos A. A high-powered view of the filtration barrier. J Am Soc Nephrol 2010, 21:1825-1841.
20. Vanholder R., De Smet R. Pathophysiologic effects of uremic retention solutes. J Am Soc Nephrol 1999, 10:1181-1823.
21. Aoike I. Clinical significance of protein adsorbable membranes. Long-term clinical effects and analysis using a proteomic technique. Nephrol Dial Transplant 2007, 22(Suppl. 5):v13-v19.
22. Candiano G., Musante L., Bruschi M., et al. Repetitive fragmentation products of albumin and alpha 1- antitrypsin in glomerular diseases associated with nephrotic syndrome. J Am Soc Nephrol 2006, 17:3139-3148.
23. Magistroni R., Ligabue G., Lupo V., et al. Proteomic analysis of urine from proteinuric patients shows a proteolytic activity directed against albumin. Nephrol Dial Transplant 2009, 24:1672-1681.
24. Hellin J.L., Bech-Serra J.J., Moctezuma E.L., et al. Very low-molecular-mass fragments of albumin in the plasma of patients with focal segmental glomerulosclerosis. Am J Kidney Dis 2009, 54:871-880.
25. Donadio E., Piccolomini F., Dimuccio V., et al. Serum albumin fragmentation in end-stage renal disease patients - A pilot study. Clin Chem Lab Med 2009, 47:1373-1379.
26. Odani H., Shinzato T., Matsumoto Y., Usami J., Maeda K. Increase in three alpha, beta-dicarbonyl compound levels in human uremic plasma: specific in vivo determination of intermediates in advanced Maillard reaction. Biochem Biophys Res Commun 1999, 256:89-93.
27. De Vecchi A.F., Bamonti F., Novembrino C., et al. Free and total plasma malondialdehyde in chronic renal insufficiency and in dialysis patients. Nephrol Dial Transplant 2009, 24:2524-2529.
28. Agarwal R. On the nature of proteinuria with acute renal injury in patients with chronic kidney disease. Am J Physiol Renal Physiol 2005, 288:F265-F271.
29. Terawaki H., Yoshimura K., Hasegawa T., et al. Oxidative stress is enhanced in correlation with renal dysfunction: examination with the redox state of albumin. Kidney Int 2004, 66:1988-1993.
30. Mitrogianni Z., Barbouti A., Galaris D., Siamopoulos K.C. Oxidative modification of albumin in predialysis, hemodialysis, and peritoneal dialysis patients. Nephron Clin Pract 2009, 113:c234-c240.
31. Pavone B., Sirolli V., Giardinelli A., et al. Plasma protein carbonylation in chronic uremia. J Nephrol 2011, 24:453-464.
32. Prakash M., Upadhya S., Prabhu R. Protein thiol oxidation and lipid peroxidation in patients with uraemia. Scand J Clin Lab Invest 2004, 64:599-604.
33. Himmelfarb J., McMonagle E. Albumin is the major plasma protein target of oxidant stress in uremia. Kidney Int 2001, 60:358-363.
34. Ward R.A., McLeish K.R. Oxidant stress in hemodialysis patients: what are the determining factors?. Artif Organs 2003, 27:230-236.
35. Lim P.-S., Cheng Y.-M., Yang S.-M. Impairments of the biological properties of serum albumin in patient on hemodialysis. Nephrology 2007, 12:18-24.
36. Spittle M.A., Hoenich N.A., Handelman G.J., Adhikarla R., Homel P., Levin N.W. Oxidative stress and inflammation in hemodialysis patients. Am J Kidney Dis 2001, 38:1408-1413.
37. Thongboonkerd V., Malasit P. Renal and urinary proteomics: Current applications and Challenges. Proteomics 2005, 5:1033-1042.
38. Janech M.G., Raymond J.R., Arthur J.M. Proteomics in renal research. Am J Physiol Renal Physiol 2007, 292:F501-F512.
39. Weissinger E.M., Kaiser T., Meert N., et al. Proteomics: a novel tool to unravel the patho-physiology of uraemia. Nephrol Dial Transplant 2004, 19:3068-3077.
40. Molina H., Bunkenborg J., Reddy G.H., Muthusamy B., Scheel P.J., Pandey A. A proteomic analysis of human hemodialysis fluid. Mol Cell Proteomics 2005, 4:637-650.
41. De Roos B., Duthie S.J., Polley A.C., et al. Proteomic methodological recommendations for studies involving human plasma, platelets, and peripheral blood mononuclear cells. J Proteome Res 2008, 7:2280-2290.
42. Gygi S.P., Corthals G.L., Zhang Y., Rochon Y., Aebersold R. Evaluation of two-dimensional gel electrophoresis-based proteome analysis technology. Proc Natl Acad Sci U S A 2000, 97:9390-9395.
43. Tirumalai R.S., Chan K.C., Prieto D.A., Issaq H.J., Conrads T.P., Veenstra T.D. Characterization of the low molecular weight human serum proteome. Mol Cell Proteomics 2003, 2:1096-1103.