Use of highly compressible Ceolus™ microcrystalline cellulose for improved dosage form properties containing a hydrophilic solid dispersion

Drug Development and Industrial Pharmacy

Volumn 38, Issue 2, 2012, Pages 180-189

  Dinunzio, James C ^a,b   Schilling, Sandra U ^a,c   Coney, Andrew W ^a   Hughey, Justin R ^a   Kaneko, Nobuya ^d   McGinity, James W ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b HOFFMANN LA ROCHE INC   (United States)

^c Merck Serono GmbH   (Germany)

^d Asahi Kasei America Inc   (United States)

Author keywords

Compression; Dissolution; Melt extrusion; Solid dispersion; Supersaturation

Indexed keywords

CEOLUS; EXCIPIENT; INDOMETACIN; MAGNESIUM STEARATE; MICROCRYSTALLINE CELLULOSE; POVIDONE; SILICON DIOXIDE; UNCLASSIFIED DRUG;

ARTICLE; COMPRESSION; COMPRESSIVE STRENGTH; DISSOLUTION; DRUG BIOAVAILABILITY; DRUG FORMULATION; DRUG MIXTURE; HYDROPHILICITY; IN VITRO STUDY; NONHUMAN; PARTICLE SIZE; PHYSICAL CHEMISTRY; POROSITY; SOLID; TABLET; TABLET HARDNESS; THERMODYNAMICS;

ANALYSIS OF VARIANCE; BIOLOGICAL AVAILABILITY; CELLULOSE; DRUG COMPOUNDING; EXCIPIENTS; HOT TEMPERATURE; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; PARTICLE SIZE; SOLUBILITY;

EID: 84255182803     PISSN: 03639045     EISSN: 15205762     Source Type: Journal    
DOI: 10.3109/03639045.2011.595415     Document Type: Article

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