A novel approach to prevent endothelial hyperpermeability: The Crataegus extract WS® 1442 targets the cAMP/Rap1 pathway

Journal of Molecular and Cellular Cardiology

Volumn 52, Issue 1, 2012, Pages 196-205

  Bubik, Martin F ^a   Willer, Elisabeth A ^a   Bihari, Peter ^b   Jürgenliemk, Guido ^c   Ammer, Hermann ^a   Krombach, Fritz ^b   Zahler, Stefan ^a   Vollmar, Angelika M ^a   Fürst, Robert ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^c UNIVERSITY OF REGENSBURG   (Germany)

Author keywords

Crataegus extract; Endothelium; Hyperpermeability; Signaling pathways

Indexed keywords

CALCIUM; CORTACTIN; CRATAEGUS EXTRACT; CYCLIC AMP; F ACTIN; MYOSIN LIGHT CHAIN; PROTEIN KINASE C; RAP1 PROTEIN; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMALL INTERFERING RNA; VASCULAR ENDOTHELIAL CADHERIN;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CALCIUM CELL LEVEL; CELL JUNCTION; CONTROLLED STUDY; CREMASTER MUSCLE; CYTOSKELETON; DRUG ACTIVITY; DRUG TARGETING; ENDOTHELIAL HYPERPERMEABILITY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXTRAVASATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PERMEABILITY; PRIORITY JOURNAL;

ADHERENS JUNCTIONS; ANIMALS; CALCIUM; CAPILLARY PERMEABILITY; CELLS, CULTURED; CORTACTIN; CRATAEGUS; CYCLIC AMP; CYCLIC AMP-DEPENDENT PROTEIN KINASES; ENDOTHELIAL CELLS; ENZYME ACTIVATION; FLAVONOIDS; GUANINE NUCLEOTIDE EXCHANGE FACTORS; HUMANS; MALE; MICE; MICE, INBRED C57BL; PLANT EXTRACTS; PROTEIN KINASE C; RAP1 GTP-BINDING PROTEINS; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; STRESS FIBERS; THROMBIN;

CRATAEGUS;

EID: 84155195006     PISSN: 00222828     EISSN: 10958584     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2011.10.020     Document Type: Article

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