New approaches to clarify antinociceptive and anti-inflammatory effects of the ethanol extract from Vernonia condensata leaves

International Journal of Molecular Sciences

Volumn 12, Issue 12, 2011, Pages 8993-9008

  da Silva, Jucélia Barbosa ^a   Temponi, Vanessa dos Santos ^a   Fernandes, Felipe Valente ^a   Alves, Geórgia de Assis Dias ^a   de Matos, Dalyara Mendoņa ^a   Gasparetto, Carolina Miranda ^a   Ribeiro, Antônia ^a   de Pinho, José de Jesus R G ^a   Alves, Maria Silvana ^a   de Sousa, Orlando Vieira ^a  

^a FEDERAL UNIVERSITY OF JUIZ DE FORA   (Brazil)

Author keywords

Anti inflammatory activity; Antinociceptive activity; Sedative effect; Vernonia condensata

Indexed keywords

ANTIINFLAMMATORY AGENT; ANTINOCICEPTIVE AGENT; INDOMETACIN; MORPHINE; NALOXONE; PLANT EXTRACT; UNCLASSIFIED DRUG; VERNONIA CONDENSATA EXTRACT; ALCOHOL; ANALGESIC AGENT;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIINFLAMMATORY ACTIVITY; ANTINOCICEPTION; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MECHANISM; HOT PLATE TEST; LATENT PERIOD; LICKING; MALE; MOUSE; NOCICEPTION; NONHUMAN; PAW EDEMA; PHYTOCHEMISTRY; PLANT LEAF; PLEURISY; RAT; SLEEP TIME; TOXICITY TESTING; VERNONIA; VERNONIA CONDENSATA; WRITHING TEST; ANIMAL; CHEMISTRY; DRUG EFFECTS; SLEEP; VERONICA; WISTAR RAT;

ANALGESICS; ANIMALS; ANTI-INFLAMMATORY AGENTS; ETHANOL; MALE; MICE; NOCICEPTION; PLANT EXTRACTS; PLANT LEAVES; RATS; RATS, WISTAR; SLEEP; VERONICA;

EID: 84055221763     PISSN: None     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms12128993     Document Type: Article

References (52)

1. White, F.A.; Bhangoo, S.K.; Miller, R.J. Chemokines: Integrators of pain and inflammation. Nat. Rev. Drug Discov. 2005, 4, 834-844.
2. Cunha, T.M.; Verri, W.A., Jr.; Schivo, I.R.; Napimoga, M.H.; Parada, C.A.; Poole, S.; Teixeira, M.M.; Ferreira, S.H.; Cunha, F.Q. Crucial role of neutrophils in the development of mechanical inflammatory hypernociception. J. Leukoc. Biol. 2008, 83, 824-832.
3. Kaye, A.D.; Baluch, A.; Scott, J. Pain management in the elderly population: A review. Ochsner J. 2010, 10, 179-187.
4. Macfarlane, T.V.; Glenny, A.-M.; Worthington, H.V. Systematic review of population-based epidemiological studies of oro-facial pain. J. Dentist. 2001, 29, 451-467.
5. Bovill, J.G. Mechanisms of actions of opioids and non-steroidal anti-inflammatory drugs. Eur. J. Anaesthesiol. 1997, 15, 9S-15S.
6. Sousa, O.V.; Del-Vechio-Vieira, G.; Pinho, J.J.R.G.; Yamamoto, C.H.; Alves, M.S. Antinociceptive and anti-inflammatory activities of the ethanol extract of Annona muricata L. leaves in animal models. Int. J. Mol. Sci. 2010, 11, 2067-2078.
7. Fagundes, L.L.; Del-Vechio-Vieira, G.; Pinho, J.J.R.G.; Yamamoto, C.H.; Alves, M.S.; Stringheta, P.C.; Sousa, O.V. Pharmacological proprieties of the ethanol extract of Muehlenbeckia platyclada (F. Muell.) Meisn. leaves. Int. J. Mol. Sci. 2010, 11, 3942-3953.
8. Vázquez, A.I.F.; Sánchez, C.M.D.; Delgado, N.G.; Alfonso, A.M.S.; Ortega, Y.S.; Sánchez, H.C. Anti-inflammatory and analgesic activities of red seaweed Dichotomaria obtusata. Braz. J. Pharm. Sci. 2011, 47, 111-118.
9. King, B.L.; Jones, S.B. Chemosystematics of Vernonia series flexuosae (Vernonieae: Compositae). Bull. Torrey Bot. Club 1982, 109, 279-286.
10. Lorenzi, H.; Matos, F.J.A. Plantas Medicinais no Brasil: Nativas e Exóticas, 2nd ed.; Instituto Plantarum: Nova Odessa, Brazil, 2008; pp. 165-166.
11. Alves, V.F.G.; Neves, L.J. Anatomia foliar de Vernonia polyanthes Less (Asteraceae). Rev. Univ. Rural Sér. Ciên. da Vida 2003, 22, 1-8.
12. Achola, K.J.; Mwangi, J.W.; Munenge, R.W.; Mwaura, A.M. Pharmacological activities of Vernonia glabra. Pharm. Biol. 1996, 34, 141-144.
13. Pérez-Amador, M.C.; Ocotero, V.M.; Benitez, S.P.; Jiménez, F.G. Vernonia patens Kunth, an Asteraceae species with phototoxic and pharmacological activity. Phyton 2008, 77, 275-282.
14. Nergard, C.S.; Diallo, D.; Michaelsen, T.E.; Malterud, K.E.; Kiyohara, H.; Matsumoto, T.; Yamada, H.; Paulsen, B.S. Isolation, partial characterisation and immunomodulating activities of polysaccharides from Vernonia kotschyana Sch. Bip. ex Walp. J. Ethnopharmacol. 2004, 91, 141-152.
15. Laekeman, G.M.; Mertens, J.; Totté, J.; Bult, H.; Vlietinck, A.J.; Herman, A.G. Isolation and pharmacological characterization of vernolepin. J. Nat. Prod. 1983, 46, 161-169.
16. Ojiako, O.A.; Nwanjo, H.U. Is Vernonia amygdalina hepatotoxic or hepatoprotective? Response from biochemical and toxicity studies in rats. Afr. J. Biotechnol. 2006, 5, 1648-1651.
17. Carvalho, M.G.; Costa, P.M.; Abreu, H.S. Flavanones from Vernonia diffusa. J. Braz. Chem. Soc. 1999, 10, 163-166.
18. Frutuoso, V.S.; Gurjão, M.R.R.; Cordeiro, R.S.B.; Martins, M.A. Analgesic and anti-ulcerogenic effects of a polar extract from leaves of Vernonia condensata. Planta Med. 1994, 60, 21-25.
19. Monteiro, M.H.; Gomes-Carneiro, M.R.; Felzenszwalb, I.; Chahoud, I.; Paumgartten, F.J. Toxicological evaluation of a tea from leaves of Vernonia condensata. J. Ethnopharmacol. 2001, 74, 149-157.
20. Valverde, A.L.; Cardoso, G.L.C.; Pereira, N.A.; Silva, A.J.R.; Kuster, R.M. Analgesic and antiinflammatory activities of vernonioside B2 from Vernonia condensata. Phytother. Res. 2001, 15, 263-264.
21. Risso, W.E.; Scarminio, I.S.; Moreira, E.G. Antinociceptive and acute toxicity evaluation of Vernonia condensata Baker leaves extracted with different solvents and their mixtures. Indian J. Exp. Biol. 2010, 48, 811-816.
22. Matta, C.B.B.; Souza, É.T.; Queiroz, A.C.; Lira, D.P.; Araújo, M.V.; Cavalcante-Silva, L.H.A.; Miranda, G.E.C.; Araújo-Júnior, J.X.; Barbosa-Filho, J.M.; Santos, B.V.O.; et al. Antinociceptive and anti-inflammatory activity from algae of the Genus Caulerpa. Mar. Drugs 2011, 9, 307-318.
23. Yuan, G.; Wahlgvist, M.L.; He, G.; Yang, M.; Li, D. Natural products and anti-inflammatory activity. Asia Pac. J. Clin. Nutr. 2006, 15, 143-152.
24. Salminen, A.; Lehtonen, M.; Suuronena, T.; Kaarnirantad, K.; Huuskonen, J. Terpenoids: Natural inhibitors of NF-B signaling with anti-inflammatory and anticancer potential. Cell. Mol. Life Sci. 2008, 65, 2979-2999.
25. García-Lafuente, A.; Guillamón, E.; Villares, A.; Rostagno, M.A.; Martínez, J.A. Flavonoids as anti-inflammatory agents: Implications in cancer and cardiovascular disease. Inflamm. Res. 2009, 58, 537-552.
26. Collier, H.D.J.; Dinnin, L.C.; Johnson, C.A.; Schneider, C. The abdominal response and its suppression by analgesic drugs in the mouse. Brit. J. Pharm. 1968, 32, 295-310.
27. Nemirovsky, A.; Chen, L.; Zelma, V.; Jurna, I. The antinociceptive effect of the combination of spinal morphine with systemic morphine or buprenorphine. Anesth. Analg. 2001, 93, 197-203.
28. Dubuisson, D.; Dennis, S.G. The formalin test: A quantitative study of the analgesic affects of morphine, meperidine, and brain stem stimulation in rats and cats. Pain 1977, 21, 161-174.
29. Hunskaar, S.; Fasmer, O.B.; Hole, K. Formalin test in mice, a useful technique for evaluating mild analgesics. J. Neurosci. Meth. 1985, 14, 69-79.
30. Campo-Soria, C.; Chang, Y.; Weiss, D.S. Mechanism of action of benzodiazepines on GABAA receptors. Br. J. Pharmacol. 2006, 148, 984-990.
31. Ho, I.K.; Harris, R.A. Mechanism of action of barbiturates. Ann. Rev. Pharmacol. Toxicol. 1981, 21, 83-111.
32. Hinton, J.M.; Marley, E. The effects of meprobamate and pentobarbitone sodium on sleep and motility during sleep: A controlled trial with psychiatric patients. J. Neurol. Neurosurg. Psychiatry 1959, 22, 137-140.
33. Rakotonirina, V.S.; Bum, E.N.; Rakotonirina, A.; Bopelet, M. Sedative properties of the decoction of the rhizome of Cyperus articulatus. Fitoterapia 2001, 72, 22-29.
34. Rocha, F.F.; Lapa, A.J.; DeLima, T.C. Evaluation of the anxiolytic-like effects of Cecropia glazioui Sneth in mice. Pharmacol. Biochem. Behav. 2002, 71, 183-190.
35. Di Rosa, M.; Giroud, P.P.; Willoughby, D.A. Studies on the mediators of the acute inflammatory response induced in rats in different sites by carrageenan and turpentine. J. Pathol. 1971, 104, 15-29.
36. Seibert, K.; Zhang, Y.; Leahy, K.; Hauser, S.; Masferrer, J.; Perkins, W.; Lee, L.; Isakson, P. Pharmacological and biochemical demonstration of the role of cyclooxygenase 2 in inflammation and pain. Proc. Natl. Acad. Sci. USA 1994, 54, 7-10.
37. Nantel, F.; Denis, D.; Gordon, R.; Northey, A.; Cirino, M.; Metters, K.M.; Chan, C.C. Distribution and regulation of cyclooxygenase-2 in carrageenan-induced inflammation. Br. J. Pharmacol. 1999, 128, 853-859.
38. Stochla, K.; Maslinski, S. Carrageenan-induced oedema in the rat paw-histamine participation. Agents Actions 1982, 12, 201-202.
39. Hwang, S.B.; Lam, M.H.; Li, C.L.; Shen, T.Y. Release of platelet activation factor and its involvement in the first phase of carrageenin-induced rat foot edema. Eur. J. Pharmacol. 1986, 120, 33-41.
40. De Campos, R.O.; Alves, R.V.; Kyle, D.J.; Chakravarty, S.; Mavunkel, B.J.; Calixto, J.B. Antioedematogenic and antinociceptive actions of NPC 18521, a novel bradykinin B2 receptor antagonist. Eur. J. Pharmacol. 1996, 316, 277-286.
41. Gilligan, J.P.; Lovato, S.J.; Erion, M.D.; Jeng, A.Y. Modulation of carrageenan-induced hind paw edema by substance P. Inflammation 1994, 18, 285-292.
42. Vinegar, R.; Truax, J.F.; Selph, J.L. Some quantitative temporal characteristics of carrageenin-induced pleurisy in the rat. Proc. Soc. Exp. Biol. Med. 1973, 143, 711-714.
43. Ammendola, G.; Di Rosa, G.M.; Sorrentino, L. Leucocyte migration and lysosomal enzymes release in rat carrageenin pleurisy. Agents Actions 1975, 5, 250-255.
44. Compasso, F.; Dunn, C.J.; Yamamoto, S.; Willougbby, D.A.; Giroud, J.P. Further studies on carrageenan-induced pleurisy in rats. J. Pathol. 1975, 116, 117-124.
45. Miyasaka, K.; Mikami, T. Comparison of the anti-inflammatory effects of dexamethasone, indomethacin and BW755C on carrageenin-induced pleurisy in rats. Eur. J. Pharmacol. 1982, 77, 229-236.
46. Matos, F.J.A. Introdução à Fitoquímica Experimental, 2nd ed.; Edições UFC: Fortaleza, Brazil, 1997; pp. 41-75.
47. Dietrich, L. A new approach to practical acute toxicity testing. Arch. Toxicol. 1983, 54, 275-287.
48. Litchfield, J.T.; Wilcoxon, F. A simplified method of evaluating dose-effect experiments. J. Pharmacol. Exp. Therap. 1949, 96, 99-113.
49. Hunskaar, S.; Hole, K. The formalin test in mice: Dissociation between inflammatory and non-inflammatory pain. Pain 1987, 30, 103-114.
50. Eddy, N.B.; Leimbach, D. Synthetic analgesics. II. Dithienylbutenyl and dithienylbutilamines. J. Pharmacol. Exp. Ther. 1953, 107, 385-393.
51. Fujimori, H. Potentiation of barbital hypnosis as an evaluation method for central nervous system depressants. Psychopharmacologia 1965, 7, 374-378.
52. Winter, C.A.; Risley, E.A.; Nuss, G.W. Carrageenin-induced edema in hind paw of the rat as an assay for anti-inflammatory drugs. Proc. Soc. Exp. Biol. Med. 1962, 111, 544-547.