Bacterial load and degree of gastric mucosal inflammation in helicobacter pylori infection

Digestive Diseases

Volumn 29, Issue 6, 2011, Pages 592-599

  Varbanova, M ^a   Malfertheiner, P ^a  

^a OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

13C urease breath test; Bacterial load; Helicobacter pylori infection

Indexed keywords

ALUMINUM HYDROXIDE PLUS MAGNESIUM TRISILICATE; BISMUTH; BISMUTH SALICYLATE; OMEPRAZOLE; PIRENZEPINE; PLACEBO; SUCRALFATE; SULGLICOTIDE; TEPRENONE;

ADULT; BACTERIAL LOAD; BACTERIAL VIRULENCE; CHRONIC INFLAMMATION; DUODENUM ULCER; DYSPEPSIA; GASTRITIS; HELICOBACTER INFECTION; HUMAN; INFLAMMATION; MUCOSA INFLAMMATION; PRIORITY JOURNAL; REVIEW; UREA BREATH TEST;

BACTERIAL LOAD; BREATH TESTS; GASTRIC MUCOSA; HELICOBACTER INFECTIONS; HELICOBACTER PYLORI; HUMANS; INFLAMMATION;

EID: 84055217198     PISSN: 02572753     EISSN: 14219875     Source Type: Journal    
DOI: 10.1159/000333260     Document Type: Review

References (61)

1. McColl KE: Clinical practice. Helicobacter pylori infection. N Engl J Med 2010; 362: 1597-1604.
2. Graham DY, Yamaoka Y, Malaty HM: Contemplating the future without Helicobacter pylori and the dire consequences hypothesis. Helicobacter 2007; 12(suppl 2):64-68. (Pubitemid 350076226)
3. Khulusi S, Mendall MA, Patel P, Levy J, Badve S, Northfield TC: Helicobacter pylori infection density and gastric inflammation in duodenal ulcer and non-ulcer subjects. Gut 1995; 37: 319-324.
4. Atherton JC, Tham KT, Peek RM Jr, Cover TL, Blaser MJ: Density of Helicobacter pylori infection in vivo as assessed by quantitative culture and histology. J Infect Dis 1996; 174: 552-556. (Pubitemid 26299689)
5. Tummala S, Sheth SG, Goldsmith JD, Goldar- Najafi A, Murphy CK, Osburne MS, Mullin S, Buxton D, Wagner DA, Kelly CP: Quantifying gastric Helicobacter pylori infection: A comparison of quantitative culture, urease breath testing, and histology. Dig Dis Sci 2007; 52: 396-401. (Pubitemid 46202812)
6. Hackelsberger A, Günther T, Schultze V, Peitz U, Malfertheiner P: Role of aging in the expression of Helicobacter pylori gastritis in the antrum, corpus, and cardia. Scand J Gastroenterol 1999; 34: 138-143. (Pubitemid 29138862)
7. Yamaoka Y, Kodama T, Kita M, et al: Relation between clinical presentation, Helicobacter pylori density, interleukin 1b and 8 production, and cagA status. Gut 1999; 5: 804-811.
8. Dzierzanowska-Fangrat K, Crabtree JE, Rozynek E, Dura W, Celiñska-Cedro D, Wojda U, Dzierzanowska D: Helicobacter pylori cagA genotype and density of colonization in relation to gastric inflammation in children. Eur J Gastroenterol Hepatol 2002; 14: 1303-1307. (Pubitemid 36054917)
9. Soltermann A, Koetzer S, Eigenmann F, Komminoth P: Correlation of Helicobacter pylori virulence genotypes vacA and cagA with histological parameters of gastritis and patient's age. Mod Pathol 2007; 20: 878-883. (Pubitemid 47077272)
10. Uemura N, Oomoto Y, Mukai T, Okamoto S, Yamaguchi S, Mashiba H, Taniyama K, Sasaki N, Sumii K, Haruma K, Kajiyama G: Gastric corpus IL-8 concentration and neutrophil infiltration in duodenal ulcer patients. Aliment Pharmacol Ther 1997; 11: 793-800. (Pubitemid 27376370)
11. Dixon MF, Genta RM, Yardley JH, Correa P: Classification and grading of gastritis. The updated Sydney System. International Workshop on the Histopathology of Gastritis, Houston 1994. Am J Surg Pathol 1996; 20: 1161-1181.
12. el-Zimaity HM, Graham DY, al-Assi MT, Malaty H, Karttunen TJ, Graham DP, Huberman RM, Genta RM: Interobserver variation in the histopathological assessment of Helicobacter pylori gastritis. Hum Pathol 1996; 27: 35-41. (Pubitemid 26015579)
13. Chen XY, van der Hulst RW, Bruno MJ, van der Ende A, Xiao SD, Tytgat GN, Ten Kate FJ: Interobserver variation in the histopathological scoring of Helicobacter pylori related gastritis. J Clin Pathol 1999; 52: 612-615. (Pubitemid 29371907)
14. Davies GR, Banatvala N, Collins CE, Sheaff MT, Abdi Y, Clements L, Rampton DS: Relationship between infective load of Helicobacter pylori and reactive oxygen metabolite production in antral mucosa. Scand J Gastroenterol 1994; 29: 419-424. (Pubitemid 24144510)
15. Fiocca R, Villani L, Luinetti O, et al: Helicobacter colonization and histopathological profile of chronic gastritis in patients with or without dyspepsia, mucosal erosion and peptic ulcer: A morphological approach to the study of ulcerogenesis in man. Virchows Arch A Pathol Anat Histopathol 1992; 420: 489-498.
16. Yamamura F, Yoshikawa N, Akita Y, Mitamura K, Miyasaka N: Relationship between Helicobacter pylori infection and histologic features of gastritis in biopsy specimens in gastroduodenal diseases, including evaluation of diagnosis by polymerase chain reaction assay. J Gastroenterol 1999; 34: 461-466. (Pubitemid 29408171)
17. Stolte M, Stadelmann O, Bethke B, Burkard G: Relationships between the degree of Helicobacter pylori colonisation and the degree and activity of gastritis, surface epithelial degeneration and mucus secretion. Z Gastroenterol 1995; 33: 89-93.
18. Sepulveda A, Peterson LE, Shelton J, Gutierrez O, Graham DY: Histological patterns of gastritis in H. pylori -infected individuals with a family history of gastric cancer. Am J Gastroenterol 2002; 97: 1365-1370. (Pubitemid 34664778)
19. Alam K, Schubert TT, Bologna SD, Ma CK: Increased density of Helicobacter pylori on antral biopsy is associated with severity of acute and chronic inflammation and likelihood of duodenal ulceration. Am J Gastroenterol 1992; 87: 424-428.
20. Stolte M, Stadelmann O, Bethke B, Burkard G: Relationships between the degree of Helicobacter pylori colonisation and the degree of gastritis, surface epithelial degeneration and mucus secretion. Z Gastroenterol 1995; 33: 89-93.
21. Faigel DO, Furth EE, Childs M, Goin J, Metz DC: Histological predictors of active Helicobacter pylori infection. Dig Dis Sci 1996; 41: 937-943. (Pubitemid 26150353)
22. Nai GA, Parizi AC, Barbosa RL: Association between Helicobacter pylori concentration and the combining frequency of histopathological findings in gastric biopsies specimens. Arq Gastroenterol 2007; 44: 240-243. (Pubitemid 350223711)
23. Misra V, Misra S, Dwivedi M, Singh UP, Bhargava V, Gupta SC: A topographic study of Helicobacter pylori density, distribution and associated gastritis. J Gastroenterol Hepatol 2000; 15: 737-743. (Pubitemid 30615056)
24. Satoh K, Kimura K, Yoshida Y, Kasano T, Kihira K, Taniguchi Y: A topographical relationship between Helicobacter pylori and gastritis: Quantitative assessment of Helicobacter pylori in the gastric mucosa. Am J Gastroenterol 1991; 86: 285-291.
25. Al-Enezi SA, Alsurayei SA, Aly NY, Ismail AE, Ismail WA, Al-Brahim N, El-Dousari A: Endoscopic nodular gastritis in dyspeptic adults: Prevalence and association with Helicobacter pylori infection. Med Princ Pract 2010; 19: 40-45.
26. Bahú Mda G, da Silveira TR, Maguilnick I, Ulbrich-Kulczynski J: Endoscopic nodular gastritis: An endoscopic indicator of highgrade bacterial colonization and severe gastritis in children with Helicobacter pylori J Pediatr Gastroenterol Nutr 2003; 36: 217-222. (Pubitemid 39272972)
27. Andersen LP, Holck S, Janulaityte-Günther D, Kupcinskas L, Kiudelis G, Jonaitis L, Janciauskas D, Holck P, Bennedsen M, Permin H, Norn S, Wadström T: Gastric inflammatory markers and interleukins in patients with functional dyspepsia, with and without Helicobacter pylori infection. FEMS Immunol Med Microbiol 2005; 44: 233-238. (Pubitemid 41373382)
28. Holck S, Nrgaard A, Bennedsen M, Permin H, Norn S, Andersen LP: Gastric mucosal cytokine responses in Helicobacter pylori -infected patients with gastritis and peptic ulcers. Association with inflammatory parameters and bacteria load FEMS Immunol Med Microbiol 2003; 36: 175-180. (Pubitemid 36556036)
29. Fareed R, Abbas Z, Shah MA: Effect of Helicobacter pylori density on inflammatory activity in stomach. J Pak Med Assoc 2000; 50: 148-151.
30. Valentine J, Arthur R, Mobley H, Dick J: Detection of Helicobacter pylori by using the polymerase chain reaction. J Clin Microbiol 1991; 29: 689-695.
31. Kobayashi D, Eishi Y, Ohkusa T, Ishige, Suzuki T, Minami J, Yamada T, Takizawa T, Koike M: Gastric mucosal density of Helicobacter pylori estimated by real-time PCR compared with results of urea breath test and histological grading. J Med Microbiol 2002; 51: 305-311. (Pubitemid 34252651)
32. Molnar B, Szoke D, Ruzsovics A, Tulassay Z: Significantly elevated Helicobacter pylori density and different genotype distribution in erosions as compared with normal gastric biopsy specimen detected by quantitative real- time PCR. Eur J Gastroenterol Hepatol 2008; 20: 305-313. (Pubitemid 351374234)
33. Ladeira MS, Bueno RC, Dos Santos BF, Pinto CL, Prado RP, Silveira MG, Rodrigues MA, Bartchewsky W Jr, Pedrazzoli J Jr, Ribeiro ML, Salvadori DM: Relationship among oxidative DNA damage, gastric mucosal density and the relevance of cagA, vacA and iceA genotypes of Helicobacter pylori Dig Dis Sci 2008; 53: 248-255. (Pubitemid 350265677)
34. Zsikla V, Hailemariam S, Baumann M, Mund MT, Schaub N, Meier R, Cathomas G: Increased rate of Helicobacter pylori infection detected by PCR in biopsies with chronic gastritis. Am J Surg Pathol 2006; 30: 242-248. (Pubitemid 43740195)
35. Lu JJ, Perng CL, Shyu RY, Chen CH, Lou Q, Chong SK, Lee CH: Comparison of five PCR methods for detection of Helicobacter pylori DNA in gastric tissues. J Clin Microbiol 1999; 37: 772-774. (Pubitemid 29091302)
36. Cho YS, Chae HS, Jang SN, Kim JS, Son HS, Kim HK, Kim BW, Han SW, Choi KY, Lee HK, Chang ED: Comparison of the 13C-urea breath test and the endoscopic phenol red mucosal pH test in the quantification of Helicobacter pylori infection loading. Korean J Intern Med 2008; 23: 134-139.
37. Zagari RM, Pozzato P, Martuzzi C, Fuccio L, Martinelli G, Roda E, Bazzoli F: 13C-urea breath test to assess Helicobacter pylori bacterial load. Helicobacter 2005; 10: 615-619. (Pubitemid 41668347)
38. Chang YW, Min SK, Kim KJ, Han YS, Lee JH, Dong SH, Kim HJ, Kim BH, Lee JI, Chang R: Delta (13)C-urea breath test value is a useful indicator for Helicobacter pylori eradication in patients with functional dyspepsia. J Gastroenterol Hepatol 2003; 18: 726-731. (Pubitemid 36791713)
39. Chang MC, Chang YT, Sun CT, Wu MS, Wang HP, Lin JT: Quantitative correlation of Helicobacter pylori stool antigen (HpSA) test with 13C-urea breath test (13C-UBT) by the updated Sydney grading system of gastritis. Hepatogastroenterology 2002; 49: 576-579.
40. Chen X, Haruma K, Kamada T, Mihara M, Komoto K, Yoshihara M, Sumii K, Kajiyama G: Factors that affect results of the 13C urea breath test in Japanese patients. Helicobacter 2000; 5: 98-103. (Pubitemid 34948015)
41. Sheu BS, Lee SC, Yang HB, Lin XZ: Quantitative result of 13C urea breath test at 15 minutes may correlate with the bacterial density of H. pylori in the stomach. Hepatogastroenterology 1999; 46: 2057-2062.
42. Perri F, Clemente R, Pastore M, Quitadamo M, Festa V, Bisceglia M, Li Bergoli M, Lauriola G, Leandro G, Ghoos Y, Rutgeerts P, Andriulli A: The 13C-urea breath test as a predictor of intragastric bacterial load and severity of Helicobacter pylori gastritis. Scand J Clin Lab Invest 1998; 58: 19-27. (Pubitemid 28076229)
43. Ellenrieder V, Glasbrenner B, Stoffels C, Weiler S, Bode G, Möller P, Adler G: Qualitative and semi-quantitative value of a modified 13C-urea breath test for identification of Helicobacter pylori infection. Eur J Gastroenterol Hepatol 1997; 9: 1085-1089. (Pubitemid 27488873)
44. Machado RS, Kawakami E, Da Silva Patrício FR, Reber M: Urease activity does not reflect the degree of colonization by Helicobacter pylori in children. Pediatr Int 2006; 48: 398-402. (Pubitemid 44127891)
45. Logan RP, Polson RJ, Misiewicz JJ, Rao G, Karim NQ, Newell D, Johnson P, Wadsworth J, Walker MM, Baron JH: Simplified single sample 13Carbon urea breath test for Helicobacter pylori : Comparison with histology, culture, and ELISA serology. Gut 1991; 32: 1461-1464.
46. Auroux J, Lamarque D, Tankovic J, Benamouzig R, Mahé S, Chaumette MT, Delchier JC: Comparison of quantifying Helicobacter pylori gastric infection by culture, histology and C13 urea breath test. Gastroenterol Clin Biol 1998; 22: 407-412. (Pubitemid 28259464)
47. Epple HJ, Kirstein FW, Bojarski C, Frege J, Fromm M, Riecken EO, Schulzke JD: 13Curea breath test in Helicobacter pylori diagnosis and eradication. Correlation to histology, origin of 'false' results, and influence of food intake. Scand J Gastroenterol 1997; 32: 308-314. (Pubitemid 27156166)
48. Tokunaga Y, Hata K, Ryo J, Kitaoka A, Tokuka A, Ohsumi K: Density of Helicobacter pylori infection in patients with peptic ulcer perforation. J Am Coll Surg 1998; 186: 659-663. (Pubitemid 28262235)
49. Asante M, Ahmed H, Patel P, Davis T, Finlayson C, Mendall M, Northfield T: Gastric mucosal hydrophobicity in duodenal ulceration: Role of Helicobacter pylori infection density and mucus lipids. Gastroenterology 1997; 113: 449-454. (Pubitemid 27351770)
50. Bor-Shyang S, Chih-Hsein C, Hsiao-Bai Y, Shu-Chu S, Xi-Zhang L: Heavy bacterial loads of H. pylori may precipitate duodenal ulcer bleeding but not bleeding severity. Hepatogastroenterology 1998; 45: 2165-2170. (Pubitemid 29055798)
51. Lynch DA, Mapstone NP, Clarke AM, Jackson P, Moayyedi P, Dixon MF, Quirke P, Axon AT: Correlation between epithelial cell proliferation and histological grading in gastric mucosa. J Clin Pathol 1999; 52: 367-371. (Pubitemid 29200030)
52. Jang TJ, Kim JR: Proliferation and apoptosis in gastric antral epithelial cells of patients infected with Helicobacter pylori J Gastroenterol 2000; 35: 265-271. (Pubitemid 30229739)
53. Malfertheiner P, Megraud F, O'Morain C, Bazzoli F, El-Omar E, Graham D, Hunt R, Rokkas T, Vakil N, Kuipers EJ: Current concepts in the management of Helicobacter pylori infection: The Maastricht III Consensus Report. Gut 2007; 56: 772-781. (Pubitemid 46854190)
54. Wagner S, Varrentrapp M, Haruma K, Lange P, Müller MJ, Schorn T, Soudah B, Bär W, Gebel M: The role of omeprazole (40 mg) in the treatment of gastric Helicobacter pylori infection. Z Gastroenterol 1991; 29: 595-598.
55. Miyake K, Tsukui T, Shinji Y, Shinoki K, Hiratsuka T, Nishigaki H, Futagami S, Wada K, Gudis K, Iwakiri K, Yamada N, Sakamoto C: Teprenone, but not H2-receptor blocker or sucralfate, suppresses corpus Helicobacter pylori colonization and gastritis in humans: Teprenone inhibition of H. pylori -induced interleukin- 8 in MKN28 gastric epithelial cell lines. Helicobacter 2004; 9: 130-137. (Pubitemid 38506595)
56. Goh KL, Parasakthi N, Peh SC, Wong NW, Lo YL, Puthucheary SD: Helicobacter pylori infection and non-ulcer dyspepsia: The effect of treatment with colloidal bismuth subcitrate. Scand J Gastroenterol 1991; 26: 1123-1131.
57. Berstad A, Alexander B, Weberg R, Serck- Hanssen A, Holland S, Hirschowitz BI: Antacids reduce Campylobacter pylori colonization without healing the gastritis in patients with nonulcer dyspepsia and erosive prepyloric changes. Gastroenterology 1988; 95: 619-624.
58. Barbara L, Biasco G, Capurso L, Dobrilla G, Lalli A, Paganelli GM, Pallone F, Torsoli A: Effects of sucralfate and sulglycotide treatment on active gastritis and Helicobacter pylori colonization of the gastric mucosa in non-ulcer dyspepsia patients. Am J Gastroenterol 1990; 85: 1109-1113. (Pubitemid 20348395)
59. Banerjee S, El-Omar E, Mowat A, Ardill JE, Park RH, Watson W, Beattie AD, McColl KE: Sucralfate suppresses Helicobacter pylori infection and reduces gastric acid secretion by 50% in patients with duodenal ulcer. Gastroenterology 1996; 110: 717-724. (Pubitemid 26071838)
60. Graham DY, Fischbach L: Helicobacter pylori treatment in the era of increasing antibiotic resistance. Gut 2010; 59: 1143-1153.
61. Tomb JF, White O, Kerlavage AR, Clayton RA, et al: The complete genome sequence of the gastric pathogen Helicobacter pylori Nature 1997; 388: 539-547. (Pubitemid 27339996)