Basic calcium phosphate crystals induce NLRP3 inflammasome activation: The in vitro and in vivo face to face

Proceedings of the National Academy of Sciences of the United States of America

Volumn 108, Issue 50, 2011, Pages

  Ea, Hang Korng ^a,b   So, Alexander ^c   Lioté, Frédéric ^a,b   Busso, Nathalie ^c  

^a UNIVERSITÉ PARIS DESCARTES   (France)

^b HÔPITAL LARIBOISIÈRE   (France)

^c LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM PHOSPHATE; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; TUMOR NECROSIS FACTOR ALPHA;

ARTHRITIS; LETTER; MACROPHAGE; NONHUMAN; PERITONITIS; PRIORITY JOURNAL;

ANIMALS; BIOCOMPATIBLE MATERIALS; CARRIER PROTEINS; DURAPATITE; INFLAMMASOMES; OSTEOARTHRITIS;

EID: 84055216927     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1114968108     Document Type: Letter

References (5)

1. Jin C, et al. (2011) NLRP3 inflammasome plays a critical role in the pathogenesis of-hydroxyapatite- associated arthropathy. Proc Natl Acad Sci USA 108:14867-14872.
2. Nadra I, et al. (2005) Proinflammatory activation of macrophages by basic calcium phosphate crystals via protein kinase C and MAP kinase pathways: A vicious cycle of inflammation and arterial calcification? Circ Res 96:1248-1256. (Pubitemid 40962102)
3. Chen CJ, et al. (2006) MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. J Clin Invest 116:2262-2271.
4. Joosten LA, Ea HK, Netea MG, Busso N (2011) Interleukin-1β activation during acute joint inflammation: A limited role for the NLRP3 inflammasome in vivo. Joint Bone Spine 78:107-110.
5. Kapoor M, Martel-Pelletier J, Lajeunesse D, Pelletier JP, Fahmi H (2011) Role of proinflammatory cytokines in the pathophysiology of osteoarthritis. Nat Rev Rheumatol 7:33-42.