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Volumn 25, Issue 1, 2012, Pages 10-16

From nonalcoholic fatty liver to nonalcoholic steatohepatitis and cirrhosis in HIV-infected patients: Diagnosis and management

Author keywords

Fibrosis; HIV; HIV HCV coinfection; NAFLD; NASH

Indexed keywords

2,4 THIAZOLIDINEDIONE DERIVATIVE; ALCOHOL; ALPHA TOCOPHEROL; ANTIRETROVIRUS AGENT; BIOLOGICAL MARKER; DIDANOSINE; GLITAZONE DERIVATIVE; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; INSULIN SENSITIZING AGENT; LIVER PROTECTIVE AGENT; METFORMIN; PIOGLITAZONE; RITONAVIR; RNA DIRECTED DNA POLYMERASE INHIBITOR; ROSIGLITAZONE; STAVUDINE; URSODEOXYCHOLIC ACID; ZIDOVUDINE;

EID: 84055192760     PISSN: 09517375     EISSN: 14736527     Source Type: Journal    
DOI: 10.1097/QCO.0b013e32834ef599     Document Type: Review
Times cited : (70)

References (51)
  • 1
    • 85062055676 scopus 로고    scopus 로고
    • Liver-related deaths in persons infected with the human immunodeficiency virus: The D: A: D study
    • Weber R, Sabin CA, Friis-Moller N, et al. Liver-related deaths in persons infected with the human immunodeficiency virus: the D:A:D study. Arch Intern Med 2006; 166:1632-1641.
    • (2006) Arch Intern Med , vol.166 , pp. 1632-1641
    • Weber, R.1    Sabin, C.A.2    Friis-Moller, N.3
  • 2
    • 50949097982 scopus 로고    scopus 로고
    • Changes in causes of death among adults infected by HIV between 2000 and 2005: The 'Mortalité 2000 and 2005' surveys (ANRS EN19 and Mortavic)
    • Lewden C, May T, Rosenthal E, et al. Changes in causes of death among adults infected by HIV between 2000 and 2005: The 'Mortalité 2000 and 2005' surveys (ANRS EN19 and Mortavic). J Acquir Immune Defic Syndr 2008; 48:590-598.
    • (2008) J Acquir Immune Defic Syndr , vol.48 , pp. 590-598
    • Lewden, C.1    May, T.2    Rosenthal, E.3
  • 3
    • 77951819361 scopus 로고    scopus 로고
    • Causes of death in HIV-1-infected patients treated with antiretroviral therapy, 1996-2006: Collaborative analysis of 13 HIV cohort studies
    • Causes of death in HIV-1-infected patients treated with antiretroviral therapy, 1996-2006: collaborative analysis of 13 HIV cohort studies. Clin Infect Dis 2010; 50:1387-1396.
    • (2010) Clin Infect Dis , vol.50 , pp. 1387-1396
  • 4
    • 78650486196 scopus 로고    scopus 로고
    • Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: A prospective study
    • Williams CD, Stengel J, Asike MI, et al. Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study. Gastroenterology 2011; 140:124-131.
    • (2011) Gastroenterology , vol.140 , pp. 124-131
    • Williams, C.D.1    Stengel, J.2    Asike, M.I.3
  • 5
    • 77952529040 scopus 로고    scopus 로고
    • A position statement on NAFLD/ NASH based on the EASL 2009 special conference
    • Ratziu V, Bellentani S, Cortez-Pinto H, et al. A position statement on NAFLD/ NASH based on the EASL 2009 special conference. J Hepatol 2010; 53:372-384.
    • (2010) J Hepatol , vol.53 , pp. 372-384
    • Ratziu, V.1    Bellentani, S.2    Cortez-Pinto, H.3
  • 6
    • 33646346335 scopus 로고    scopus 로고
    • The evolution of severe steatosis after bariatric surgery is related to insulin resistance
    • Mathurin P, Gonzalez F, Kerdraon O, et al. The evolution of severe steatosis after bariatric surgery is related to insulin resistance. Gastroenterology 2006; 130:1617-1624.
    • (2006) Gastroenterology , vol.130 , pp. 1617-1624
    • Mathurin, P.1    Gonzalez, F.2    Kerdraon, O.3
  • 7
    • 0035068318 scopus 로고    scopus 로고
    • Hepatitis C virus induced hypobetalipoproteinemia: A possible mechanism for steatosis in chronic hepatitis C
    • Serfaty L, Andreani T, Giral P, et al. Hepatitis C virus induced hypobetalipoproteinemia: a possible mechanism for steatosis in chronic hepatitis C. J Hepatol 2001; 34:428-434.
    • (2001) J Hepatol , vol.34 , pp. 428-434
    • Serfaty, L.1    Andreani, T.2    Giral, P.3
  • 8
    • 56749096610 scopus 로고    scopus 로고
    • Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease
    • Romeo S, Kozlitina J, Xing C, et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nature Genet 2008; 40:1461-1465.
    • (2008) Nature Genet , vol.40 , pp. 1461-1465
    • Romeo, S.1    Kozlitina, J.2    Xing, C.3
  • 9
    • 46349092154 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease in HIV-infected patients referred to a metabolic clinic: Prevalence, characteristics, and predictors
    • Guaraldi G, Squillace N, Stentarelli C, et al. Nonalcoholic fatty liver disease in HIV-infected patients referred to a metabolic clinic: prevalence, characteristics, and predictors. Clin Infect Dis 2008; 47:250-257.
    • (2008) Clin Infect Dis , vol.47 , pp. 250-257
    • Guaraldi, G.1    Squillace, N.2    Stentarelli, C.3
  • 11
    • 56749168891 scopus 로고    scopus 로고
    • Hepatic histopathology and clinical characteristics associated with antiretroviral therapy in HIV patients without viral hepatitis
    • Akhtar MA, Mathieson K, Arey B, et al. Hepatic histopathology and clinical characteristics associated with antiretroviral therapy in HIV patients without viral hepatitis. Eur J Gastroenterol Hepatol 2008; 20:1194-1204.
    • (2008) Eur J Gastroenterol Hepatol , vol.20 , pp. 1194-1204
    • Akhtar, M.A.1    Mathieson, K.2    Arey, B.3
  • 12
    • 77953971188 scopus 로고    scopus 로고
    • Disease progression of nonalcoholic fatty liver disease: A prospective study with paired liver biopsies at 3 years
    • Wong VW, Wong GL, Choi PC, et al. Disease progression of nonalcoholic fatty liver disease: a prospective study with paired liver biopsies at 3 years. Gut 2010; 59:969-974.
    • (2010) Gut , vol.59 , pp. 969-974
    • Wong, V.W.1    Wong, G.L.2    Choi, P.C.3
  • 13
    • 33750606061 scopus 로고    scopus 로고
    • Long-term follow-up of patients with NAFLD and elevated liver enzymes
    • Ekstedt M, Franzen LE, Mathiesen UL, et al. Long-term follow-up of patients with NAFLD and elevated liver enzymes. Hepatology 2006; 44:865-873.
    • (2006) Hepatology , vol.44 , pp. 865-873
    • Ekstedt, M.1    Franzen, L.E.2    Mathiesen, U.L.3
  • 14
    • 34447325127 scopus 로고    scopus 로고
    • HIV-positive patients with nonalcoholic fatty liver disease have a lower body mass index and are more physically active than HIV-negative patients
    • Mohammed SS, Aghdassi E, Salit IE, et al. HIV-positive patients with nonalcoholic fatty liver disease have a lower body mass index and are more physically active than HIV-negative patients. J Acquir Immune Defic Syndr 2007; 45:432-438.
    • (2007) J Acquir Immune Defic Syndr , vol.45 , pp. 432-438
    • Mohammed, S.S.1    Aghdassi, E.2    Salit, I.E.3
  • 15
    • 33645027391 scopus 로고    scopus 로고
    • Altered hepatic expression of SREBP-1 and PPARgamma is associated with liver injury in insulin-resistant lipodystrophic HIV-infected patients
    • Lemoine M, Barbu V, Girard PM, et al. Altered hepatic expression of SREBP-1 and PPARgamma is associated with liver injury in insulin-resistant lipodystrophic HIV-infected patients. AIDS 2006; 20:387-395.
    • (2006) AIDS , vol.20 , pp. 387-395
    • Lemoine, M.1    Barbu, V.2    Girard, P.M.3
  • 16
    • 61949414868 scopus 로고    scopus 로고
    • Liver damage underlying unexplained transaminase elevation in human immunodeficiency virus-1 mono-infected patients on antiretroviral therapy
    • Ingiliz P, Valantin MA, Duvivier C, et al. Liver damage underlying unexplained transaminase elevation in human immunodeficiency virus-1 mono-infected patients on antiretroviral therapy. Hepatology 2009; 49:436-442.
    • (2009) Hepatology , vol.49 , pp. 436-442
    • Ingiliz, P.1    Valantin, M.A.2    Duvivier, C.3
  • 18
    • 78650278763 scopus 로고    scopus 로고
    • Risk factors for advanced liver fibrosis in HIV-infected individuals: Role of antiretroviral drugs and insulin resistance
    • Blanco F, Barreiro P, Ryan P, et al. Risk factors for advanced liver fibrosis in HIV-infected individuals: role of antiretroviral drugs and insulin resistance. J Viral Hepat 2011; 11-16.
    • (2011) J Viral Hepat , pp. 11-16
    • Blanco, F.1    Barreiro, P.2    Ryan, P.3
  • 19
    • 79951843023 scopus 로고    scopus 로고
    • HIV mono-infection is associated with FIB-4 - A noninvasive index of liver fibrosis - In women
    • Blackard JT, Welge JA, Taylor LE, et al. HIV mono-infection is associated with FIB-4 - a noninvasive index of liver fibrosis - in women. Clin Infect Dis 2011; 52:674-680.
    • (2011) Clin Infect Dis , vol.52 , pp. 674-680
    • Blackard, J.T.1    Welge, J.A.2    Taylor, L.E.3
  • 20
    • 79953865880 scopus 로고    scopus 로고
    • Evaluation of liver fibrosis: Concordance analysis between noninvasive scores (APRI and FIB-4) evolution and predictors in a cohort of HIV-infected patients without hepatitis C and B infection
    • Mendeni M, Foca E, Gotti D, et al. Evaluation of liver fibrosis: concordance analysis between noninvasive scores (APRI and FIB-4) evolution and predictors in a cohort of HIV-infected patients without hepatitis C and B infection. Clin Infect Dis 2011; 52:1164-1173.
    • (2011) Clin Infect Dis , vol.52 , pp. 1164-1173
    • Mendeni, M.1    Foca, E.2    Gotti, D.3
  • 21
    • 77952085462 scopus 로고    scopus 로고
    • Prevalence and risk factors for significant liver fibrosis among HIV-monoinfected patients
    • DallaPiazza M, Amorosa VK, Localio R, et al. Prevalence and risk factors for significant liver fibrosis among HIV-monoinfected patients. BMC Infect Dis 2010; 10:116.
    • (2010) BMC Infect Dis , vol.10 , pp. 116
    • Dallapiazza, M.1    Amorosa, V.K.2    Localio, R.3
  • 22
    • 77956314910 scopus 로고    scopus 로고
    • Increasing rates of obesity among HIV-infected persons during the HIV epidemic
    • Crum-Cianflone N, Roediger MP, Eberly L, et al. Increasing rates of obesity among HIV-infected persons during the HIV epidemic. PloS One 2010; 5:e10106.
    • (2010) PloS One , vol.5
    • Crum-Cianflone, N.1    Roediger, M.P.2    Eberly, L.3
  • 23
    • 65649102237 scopus 로고    scopus 로고
    • Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection
    • Jiang W, Ledermann MM, Hunt P, et al. Plasma levels of bacterial DNA correlate with immune activation and the magnitude of immune restoration in persons with antiretroviral-treated HIV infection. J Infect Dis 2009; 199:1177-1185.
    • (2009) J Infect Dis , vol.199 , pp. 1177-1185
    • Jiang, W.1    Ledermann, M.M.2    Hunt, P.3
  • 24
    • 77956624153 scopus 로고    scopus 로고
    • Clinical syndromes and consequences of antiretroviral-related hepatotoxicity
    • Nunez M. Clinical syndromes and consequences of antiretroviral-related hepatotoxicity. Hepatology 2010; 52:1143-1155.
    • (2010) Hepatology , vol.52 , pp. 1143-1155
    • Nunez, M.1
  • 25
    • 77952420363 scopus 로고    scopus 로고
    • HIV-associated lipodystrophy: From fat injury to premature aging
    • Caron-Debarle M, Lagathu C, Boccara F, et al. HIV-associated lipodystrophy: from fat injury to premature aging. Trends Molec Med 2010; 16:218-229.
    • (2010) Trends Molec Med , vol.16 , pp. 218-229
    • Caron-Debarle, M.1    Lagathu, C.2    Boccara, F.3
  • 26
    • 80051578427 scopus 로고    scopus 로고
    • Fatty liver disease is associated with underlying cardiovascular disease in HIV-infected persons
    • Crum-Cianflone N, Krause D, Wessman D, et al. Fatty liver disease is associated with underlying cardiovascular disease in HIV-infected persons. HIV Med 2011; 12:463-471.
    • (2011) HIV Med , vol.12 , pp. 463-471
    • Crum-Cianflone, N.1    Krause, D.2    Wessman, D.3
  • 27
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner DE, Brunt EM, Van Natta M, et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41:1313-1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3
  • 28
    • 20444443042 scopus 로고    scopus 로고
    • Sampling variability of liver biopsy in nonalcoholic fatty liver disease
    • Ratziu V, Charlotte F, Heurtier A, et al. Sampling variability of liver biopsy in nonalcoholic fatty liver disease. Gastroenterology 2005; 128:1898-1906.
    • (2005) Gastroenterology , vol.128 , pp. 1898-1906
    • Ratziu, V.1    Charlotte, F.2    Heurtier, A.3
  • 29
    • 51349083814 scopus 로고    scopus 로고
    • Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: A role for insulin resistance and diabetes
    • Fracanzani AL, Valenti L, Bugianesi E, et al. Risk of severe liver disease in nonalcoholic fatty liver disease with normal aminotransferase levels: a role for insulin resistance and diabetes. Hepatology 2008; 48:792-798.
    • (2008) Hepatology , vol.48 , pp. 792-798
    • Fracanzani, A.L.1    Valenti, L.2    Bugianesi, E.3
  • 30
    • 33846015006 scopus 로고    scopus 로고
    • Screening for liver disease using noninvasive biomarkers (FibroTest, SteatoTest and NashTest) in patients with hyperlipidaemia
    • Ratziu V, Giral P, Munteanu M, et al. Screening for liver disease using noninvasive biomarkers (FibroTest, SteatoTest and NashTest) in patients with hyperlipidaemia. Aliment Pharmacol Therapeut 2007; 25:207-218.
    • (2007) Aliment Pharmacol Therapeut , vol.25 , pp. 207-218
    • Ratziu, V.1    Giral, P.2    Munteanu, M.3
  • 31
    • 70350046669 scopus 로고    scopus 로고
    • Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: A multicenter validation study
    • Feldstein AE, Wieckowska A, Lopez AR, et al. Cytokeratin-18 fragment levels as noninvasive biomarkers for nonalcoholic steatohepatitis: a multicenter validation study. Hepatology 2009; 50:1072-1078.
    • (2009) Hepatology , vol.50 , pp. 1072-1078
    • Feldstein, A.E.1    Wieckowska, A.2    Lopez, A.R.3
  • 32
    • 70449730945 scopus 로고    scopus 로고
    • Serum adipokine levels predictive of liver injury in nonalcoholic fatty liver disease
    • Lemoine M, Ratziu V, Kim M, et al. Serum adipokine levels predictive of liver injury in nonalcoholic fatty liver disease. Liver Int 2009; 29:1431-1438.
    • (2009) Liver Int , vol.29 , pp. 1431-1438
    • Lemoine, M.1    Ratziu, V.2    Kim, M.3
  • 33
    • 79956292596 scopus 로고    scopus 로고
    • Early detection of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease by using MR elastography
    • Chen J, Talwalkar JA, Yin M, et al. Early detection of nonalcoholic steatohepatitis in patients with nonalcoholic fatty liver disease by using MR elastography. Radiology 2011; 259:749-756.
    • (2011) Radiology , vol.259 , pp. 749-756
    • Chen, J.1    Talwalkar, J.A.2    Yin, M.3
  • 34
    • 75449091784 scopus 로고    scopus 로고
    • Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease
    • Wong VW, Vergniol J, Wong GL, et al. Diagnosis of fibrosis and cirrhosis using liver stiffness measurement in nonalcoholic fatty liver disease. Hepatology 2010; 51:454-462.
    • (2010) Hepatology , vol.51 , pp. 454-462
    • Wong, V.W.1    Vergniol, J.2    Wong, G.L.3
  • 35
    • 77956115313 scopus 로고    scopus 로고
    • Abnormalities of lipid metabolism in hepatitis C virus infection
    • Negro F. Abnormalities of lipid metabolism in hepatitis C virus infection. Gut 2010; 59:1279-1287.
    • (2010) Gut , vol.59 , pp. 1279-1287
    • Negro, F.1
  • 36
    • 33646127566 scopus 로고    scopus 로고
    • Impact of human immunodeficiency virus infection on the prevalence and severity of steatosis in patients with chronic hepatitis C virus infection
    • Gaslightwala I, Bini EJ. Impact of human immunodeficiency virus infection on the prevalence and severity of steatosis in patients with chronic hepatitis C virus infection. J Hepatol 2006; 44:1026-1032.
    • (2006) J Hepatol , vol.44 , pp. 1026-1032
    • Gaslightwala, I.1    Bini, E.J.2
  • 37
    • 36549085652 scopus 로고    scopus 로고
    • Hepatic steatosis in HIV-HCV coinfected patients in France: Comparison with HCV monoinfected patients matched for body mass index and HCV genotype
    • Castera L, Loko MA, Le Bail B, et al. Hepatic steatosis in HIV-HCV coinfected patients in France: comparison with HCV monoinfected patients matched for body mass index and HCV genotype. Aliment Pharmacol Therapeut 2007; 26 (11-12):1489-1498.
    • (2007) Aliment Pharmacol Therapeut , vol.26 , Issue.11-12 , pp. 1489-1498
    • Castera, L.1    Loko, M.A.2    Le Bail, B.3
  • 38
    • 77954220008 scopus 로고    scopus 로고
    • Hepatic steatosis in patients coinfected with human immunodeficiency virus/hepatitis C virus: A metaanalysis of the risk factors
    • Machado MV, Oliveira AG, Cortez-Pinto H. Hepatic steatosis in patients coinfected with human immunodeficiency virus/hepatitis C virus: a metaanalysis of the risk factors. Hepatology 2010; 52:71-78.
    • (2010) Hepatology , vol.52 , pp. 71-78
    • MacHado, M.V.1    Oliveira, A.G.2    Cortez-Pinto, H.3
  • 39
    • 33645421568 scopus 로고    scopus 로고
    • Hepatic steatosis in HIV-HCV coinfected patients: Analysis of risk factors
    • Bani-Sadr F, Carrat F, Bedossa P, et al. Hepatic steatosis in HIV-HCV coinfected patients: analysis of risk factors. AIDS 2006; 20:525-531.
    • (2006) AIDS , vol.20 , pp. 525-531
    • Bani-Sadr, F.1    Carrat, F.2    Bedossa, P.3
  • 40
    • 41249092708 scopus 로고    scopus 로고
    • Hepatic steatosis in HIV/ HCV co-infected patients: Correlates, efficacy and outcomes of anti-HCV therapy: A paired liver biopsy study
    • Rodriguez-Torres M, Govindarajan S, Sola R, et al. Hepatic steatosis in HIV/ HCV co-infected patients: correlates, efficacy and outcomes of anti-HCV therapy: a paired liver biopsy study. J Hepatol 2008; 48:756-764.
    • (2008) J Hepatol , vol.48 , pp. 756-764
    • Rodriguez-Torres, M.1    Govindarajan, S.2    Sola, R.3
  • 41
    • 79959577367 scopus 로고    scopus 로고
    • Impact of HAART exposure and associated lipodystrophy on advanced liver fibrosis in HIV/HCV-coinfected patients
    • Loko MA, Bani-Sadr F, Winnock M, et al. Impact of HAART exposure and associated lipodystrophy on advanced liver fibrosis in HIV/HCV-coinfected patients. J Viral Hepatitis 2011; 18:e307-e314.
    • (2011) J Viral Hepatitis , vol.18
    • Loko, M.A.1    Bani-Sadr, F.2    Winnock, M.3
  • 42
    • 73449116035 scopus 로고    scopus 로고
    • Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis
    • Promrat K, Kleiner DE, Niemeier HM, et al. Randomized controlled trial testing the effects of weight loss on nonalcoholic steatohepatitis. Hepatology 2010; 51:121-129.
    • (2010) Hepatology , vol.51 , pp. 121-129
    • Promrat, K.1    Kleiner, D.E.2    Niemeier, H.M.3
  • 43
    • 43049170503 scopus 로고    scopus 로고
    • Fructose consumption as a risk factor for nonalcoholic fatty liver disease
    • Ouyang X, Cirillo P, Sautin Y, et al. Fructose consumption as a risk factor for nonalcoholic fatty liver disease. J Hepatol 2008; 48:993-999.
    • (2008) J Hepatol , vol.48 , pp. 993-999
    • Ouyang, X.1    Cirillo, P.2    Sautin, Y.3
  • 44
    • 77954239704 scopus 로고    scopus 로고
    • A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease
    • Musso G, Gambino R, Cassader M, Pagano G. A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease. Hepatology 2010; 52:79-104.
    • (2010) Hepatology , vol.52 , pp. 79-104
    • Musso, G.1    Gambino, R.2    Cassader, M.3    Pagano, G.4
  • 45
    • 79961216168 scopus 로고    scopus 로고
    • Impact of metformin on the prognosis of cirrhosis induced by viral hepatitis C in diabetic patients
    • Nkontchou G, Cosson E, Aout M, et al. Impact of metformin on the prognosis of cirrhosis induced by viral hepatitis C in diabetic patients. J Clin Endocrinol Metab 2011; 96:2601-2608.
    • (2011) J Clin Endocrinol Metab , vol.96 , pp. 2601-2608
    • Nkontchou, G.1    Cosson, E.2    Aout, M.3
  • 46
    • 46349088361 scopus 로고    scopus 로고
    • Rosiglitazone for nonalcoholic steatohepatitis: One-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial
    • Ratziu V, Giral P, Jacqueminet S, et al. Rosiglitazone for nonalcoholic steatohepatitis: one-year results of the randomized placebo-controlled Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) Trial. Gastroenterology 2008; 135:100-110.
    • (2008) Gastroenterology , vol.135 , pp. 100-110
    • Ratziu, V.1    Giral, P.2    Jacqueminet, S.3
  • 47
    • 75449116707 scopus 로고    scopus 로고
    • Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: Results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial
    • Ratziu V, Charlotte F, Bernhardt C, et al. Long-term efficacy of rosiglitazone in nonalcoholic steatohepatitis: results of the fatty liver improvement by rosiglitazone therapy (FLIRT 2) extension trial. Hepatology 2010; 51:445-453.
    • (2010) Hepatology , vol.51 , pp. 445-453
    • Ratziu, V.1    Charlotte, F.2    Bernhardt, C.3
  • 48
    • 77951874018 scopus 로고    scopus 로고
    • Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis
    • Sanyal AJ, Chalasani N, Kowdley KV, et al. Pioglitazone, vitamin E, or placebo for nonalcoholic steatohepatitis. N Engl J Med 2010; 362:1675-1685.
    • (2010) N Engl J Med , vol.362 , pp. 1675-1685
    • Sanyal, A.J.1    Chalasani, N.2    Kowdley, K.V.3
  • 49
    • 84055160795 scopus 로고    scopus 로고
    • Multicentric, double-blind, randomised-controlled trial (RCT) of high dose ursodeoxycholic acid in patients with NASH
    • Ratziu V. Multicentric, double-blind, randomised-controlled trial (RCT) of high dose ursodeoxycholic acid in patients with NASH. Hepatology 2009; 50 (Suppl.1):49.
    • (2009) Hepatology , vol.50 , Issue.SUPPL.1 , pp. 49
    • Ratziu, V.1
  • 50
    • 33845336554 scopus 로고    scopus 로고
    • Randomized placebo-controlled trial of ursodeoxycholic acid with vitamin e in nonalcoholic steatohepatitis
    • Dufour JF, Oneta CM, Gonvers JJ, et al. Randomized placebo-controlled trial of ursodeoxycholic acid with vitamin E in nonalcoholic steatohepatitis. Clin Gastroenterol Hepatol 2006; 4:1537-1543.
    • (2006) Clin Gastroenterol Hepatol , vol.4 , pp. 1537-1543
    • Dufour, J.F.1    Oneta, C.M.2    Gonvers, J.J.3
  • 51
    • 79953285141 scopus 로고    scopus 로고
    • Increasing burden of liver disease in patients with HIV infection
    • Joshi D, O'Grady J, Dieterich D, et al. Increasing burden of liver disease in patients with HIV infection. Lancet 2011; 377:1198-1209.
    • (2011) Lancet , vol.377 , pp. 1198-1209
    • Joshi, D.1    O'Grady, J.2    Dieterich, D.3


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