메뉴 건너뛰기




Volumn 48, Issue 5, 2008, Pages 756-764

Hepatic steatosis in HIV/HCV co-infected patients: Correlates, efficacy and outcomes of anti-HCV therapy: A paired liver biopsy study

Author keywords

Efficacy of therapy; HCV HIV; Steatosis

Indexed keywords

ALPHA2A INTERFERON; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; PEGINTERFERON ALPHA2A; RIBAVIRIN; TRIACYLGLYCEROL; VIRUS RNA;

EID: 41249092708     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2008.01.015     Document Type: Article
Times cited : (40)

References (42)
  • 1
    • 0034987263 scopus 로고    scopus 로고
    • Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity
    • Adinolfi L., Gambardella M., Andreana A., Tripodi M.F., Utili R., and Ruggiero G. Steatosis accelerates the progression of liver damage of chronic hepatitis C patients and correlates with specific HCV genotype and visceral obesity. Hepatology 33 (2001) 1358-1364
    • (2001) Hepatology , vol.33 , pp. 1358-1364
    • Adinolfi, L.1    Gambardella, M.2    Andreana, A.3    Tripodi, M.F.4    Utili, R.5    Ruggiero, G.6
  • 2
    • 1542377403 scopus 로고    scopus 로고
    • Hepatitis C: a metabolic liver disease
    • Weinman S.A., and Belalcazar L.M. Hepatitis C: a metabolic liver disease. Gastroenterology 126 (2004) 917-919
    • (2004) Gastroenterology , vol.126 , pp. 917-919
    • Weinman, S.A.1    Belalcazar, L.M.2
  • 3
    • 33646529840 scopus 로고    scopus 로고
    • Relationship between steatosis, inflammation, and fibrosis in chronic hepatitis C: a meta-analysis of individual patient data
    • Leandro G., Mangia A., Hui J., Fabris P., Rubbia-Brandt L., Colloredo G., et al. Relationship between steatosis, inflammation, and fibrosis in chronic hepatitis C: a meta-analysis of individual patient data. Gastroenterology 130 (2006) 1636-1642
    • (2006) Gastroenterology , vol.130 , pp. 1636-1642
    • Leandro, G.1    Mangia, A.2    Hui, J.3    Fabris, P.4    Rubbia-Brandt, L.5    Colloredo, G.6
  • 4
    • 0036830436 scopus 로고    scopus 로고
    • Hepatitis C virus genotype 3 is cytopathic to hepatocytes: Reversal of hepatic steatosis after sustained therapeutic response
    • Kumar D., Farrell G.C., Fung C., and George J. Hepatitis C virus genotype 3 is cytopathic to hepatocytes: Reversal of hepatic steatosis after sustained therapeutic response. Hepatology 36 (2002) 1266-1272
    • (2002) Hepatology , vol.36 , pp. 1266-1272
    • Kumar, D.1    Farrell, G.C.2    Fung, C.3    George, J.4
  • 5
    • 33646834131 scopus 로고    scopus 로고
    • Steatosis, insulin resistance and fibrosis progression in chronic hepatitis C
    • Castera L. Steatosis, insulin resistance and fibrosis progression in chronic hepatitis C. Minerva Gastroenterol Dietol 52 (2006) 125-134
    • (2006) Minerva Gastroenterol Dietol , vol.52 , pp. 125-134
    • Castera, L.1
  • 7
    • 33744532392 scopus 로고    scopus 로고
    • Association of cardiorespiratory fitness, body mass index, and waist circumference to nonalcoholic fatty liver disease
    • Church T., Kuk J., Ross R., Priest E.L., Biltoft E., and Blair S.N. Association of cardiorespiratory fitness, body mass index, and waist circumference to nonalcoholic fatty liver disease. Gastroenterology 130 (2006) 2023-2030
    • (2006) Gastroenterology , vol.130 , pp. 2023-2030
    • Church, T.1    Kuk, J.2    Ross, R.3    Priest, E.L.4    Biltoft, E.5    Blair, S.N.6
  • 9
    • 27444443876 scopus 로고    scopus 로고
    • Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement
    • Grundy S.M., Cleeman J.I., Daniels S.R., Donato K.A., Eckel R.H., Franklin B.A., et al. Diagnosis and management of the metabolic syndrome: an American Heart Association/National Heart, Lung, and Blood Institute Scientific Statement. Circulation 112 (2005) 2735-2752
    • (2005) Circulation , vol.112 , pp. 2735-2752
    • Grundy, S.M.1    Cleeman, J.I.2    Daniels, S.R.3    Donato, K.A.4    Eckel, R.H.5    Franklin, B.A.6
  • 10
    • 0038798716 scopus 로고    scopus 로고
    • Impact of human immunodeficiency virus (HIV) infection on the progression of liver fibrosis in hepatitis C virus infected patients
    • Mohsen A., Easterbrook P., Taylor C., Portmann B., Kulasegaram R., Murad S., et al. Impact of human immunodeficiency virus (HIV) infection on the progression of liver fibrosis in hepatitis C virus infected patients. Gut 52 (2003) 1035-1040
    • (2003) Gut , vol.52 , pp. 1035-1040
    • Mohsen, A.1    Easterbrook, P.2    Taylor, C.3    Portmann, B.4    Kulasegaram, R.5    Murad, S.6
  • 11
    • 30944433910 scopus 로고    scopus 로고
    • Correlation of insulin resistance with steatosis and fibrosis in hepatitis C and HIV co-infection: cross-sectional analysis of 101 patients
    • Agarwal K., Fiel M., Uriel A.J., Moorehead L., Kontorinis N., Thung S., et al. Correlation of insulin resistance with steatosis and fibrosis in hepatitis C and HIV co-infection: cross-sectional analysis of 101 patients. Hepatology 40 (2004) 587A
    • (2004) Hepatology , vol.40
    • Agarwal, K.1    Fiel, M.2    Uriel, A.J.3    Moorehead, L.4    Kontorinis, N.5    Thung, S.6
  • 12
    • 34249869301 scopus 로고    scopus 로고
    • Prevalence of and factors associated with hepatic steatosis in patients coinfected with hepatitis C virus and HIV: Agence Nationale pour la Recherche contre le SIDA et les hepatites virales CO3 Aquitaine Cohort
    • Neau D., Winnock M., Castera L., Bail B.L., Loko M.A., Geraut L., et al. Prevalence of and factors associated with hepatic steatosis in patients coinfected with hepatitis C virus and HIV: Agence Nationale pour la Recherche contre le SIDA et les hepatites virales CO3 Aquitaine Cohort. J Acquir Immune Defic Syndr 45 (2007) 168-173
    • (2007) J Acquir Immune Defic Syndr , vol.45 , pp. 168-173
    • Neau, D.1    Winnock, M.2    Castera, L.3    Bail, B.L.4    Loko, M.A.5    Geraut, L.6
  • 13
    • 27944452982 scopus 로고    scopus 로고
    • Histological findings and clinical characteristics associated with hepatic steatosis in patients coinfected with HIV and hepatitis C virus
    • Marks K.M., Petrovic L.M., Talal A.H., Murray M.P., Gulick R.M., and Glesby M.J. Histological findings and clinical characteristics associated with hepatic steatosis in patients coinfected with HIV and hepatitis C virus. J Infect Dis 192 (2005) 1943-1949
    • (2005) J Infect Dis , vol.192 , pp. 1943-1949
    • Marks, K.M.1    Petrovic, L.M.2    Talal, A.H.3    Murray, M.P.4    Gulick, R.M.5    Glesby, M.J.6
  • 14
    • 23044503946 scopus 로고    scopus 로고
    • Hepatic steatosis in HIV/hepatitis C coinfection: prevalence and significance compared with hepatitis C monoinfection
    • Monto A., Dove L.M., Bostrom A., Kakar S., Tien P.C., and Wright T.L. Hepatic steatosis in HIV/hepatitis C coinfection: prevalence and significance compared with hepatitis C monoinfection. Hepatology 42 (2005) 310-316
    • (2005) Hepatology , vol.42 , pp. 310-316
    • Monto, A.1    Dove, L.M.2    Bostrom, A.3    Kakar, S.4    Tien, P.C.5    Wright, T.L.6
  • 15
    • 33646127566 scopus 로고    scopus 로고
    • Impact of human immunodeficiency virus infection on the prevalence and severity of steatosis in patients with chronic hepatitis C virus infection
    • Gaslightwala I., and Bini E.J. Impact of human immunodeficiency virus infection on the prevalence and severity of steatosis in patients with chronic hepatitis C virus infection. J Hepatol 44 (2006) 1026-1032
    • (2006) J Hepatol , vol.44 , pp. 1026-1032
    • Gaslightwala, I.1    Bini, E.J.2
  • 16
    • 11844257549 scopus 로고    scopus 로고
    • Metabolic syndrome among HIV-infected patients: prevalence, characteristics, and related factors
    • Jerico C., Knobel H., Montero M., Ordoñez-Llanos J., Guelar A., Gimeno J.L., et al. Metabolic syndrome among HIV-infected patients: prevalence, characteristics, and related factors. Diabetes Care 28 (2005) 132-137
    • (2005) Diabetes Care , vol.28 , pp. 132-137
    • Jerico, C.1    Knobel, H.2    Montero, M.3    Ordoñez-Llanos, J.4    Guelar, A.5    Gimeno, J.L.6
  • 17
    • 0029154249 scopus 로고
    • Hepatomegaly and steatosis in HIV-infected patients receiving nucleoside analog antiretroviral therapy
    • Fortgang I.S., Belitsos P.C., Chaisson R.E., and Moore R.D. Hepatomegaly and steatosis in HIV-infected patients receiving nucleoside analog antiretroviral therapy. Am J Gastroenterol 90 (1995) 1433-1436
    • (1995) Am J Gastroenterol , vol.90 , pp. 1433-1436
    • Fortgang, I.S.1    Belitsos, P.C.2    Chaisson, R.E.3    Moore, R.D.4
  • 18
    • 0034254566 scopus 로고    scopus 로고
    • Lactic acidosis and hepatic steatosis associated with use of stavudine: report of four cases
    • Miller K.D., Cameron M., Wood L.V., Dalakas M.C., and Kovacs J.A. Lactic acidosis and hepatic steatosis associated with use of stavudine: report of four cases. Ann Intern Med 133 (2000) 192-196
    • (2000) Ann Intern Med , vol.133 , pp. 192-196
    • Miller, K.D.1    Cameron, M.2    Wood, L.V.3    Dalakas, M.C.4    Kovacs, J.A.5
  • 19
    • 0025872834 scopus 로고
    • Circulating interferon-alpha levels and hypertriglyceridemia in the acquired immunodeficiency syndrome
    • Grunfeld C., Kotler D.P., Shigenaga J.K., Doerrler W., Tierney A., Wang J., et al. Circulating interferon-alpha levels and hypertriglyceridemia in the acquired immunodeficiency syndrome. Am J Med 90 (1991) 154-162
    • (1991) Am J Med , vol.90 , pp. 154-162
    • Grunfeld, C.1    Kotler, D.P.2    Shigenaga, J.K.3    Doerrler, W.4    Tierney, A.5    Wang, J.6
  • 20
    • 0027164232 scopus 로고
    • Hypocholesterolemia is associated with immune dysfunction in early human immunodeficiency virus-1 infection
    • Shor-Posner G., Basit A., Lu Y., Cabrejos C., Chang J., Fletcher M., et al. Hypocholesterolemia is associated with immune dysfunction in early human immunodeficiency virus-1 infection. Am J Med 94 (1993) 515-519
    • (1993) Am J Med , vol.94 , pp. 515-519
    • Shor-Posner, G.1    Basit, A.2    Lu, Y.3    Cabrejos, C.4    Chang, J.5    Fletcher, M.6
  • 21
    • 33746584770 scopus 로고    scopus 로고
    • Important differences in components of the metabolic syndrome between HIV-patients with and without highly active antiretroviral therapy and healthy controls
    • Bergersen B.M., Schumacher A., Sandvik L., Bruun J.N., and Birkeland K. Important differences in components of the metabolic syndrome between HIV-patients with and without highly active antiretroviral therapy and healthy controls. Scand J Infect Dis 38 (2006) 682-689
    • (2006) Scand J Infect Dis , vol.38 , pp. 682-689
    • Bergersen, B.M.1    Schumacher, A.2    Sandvik, L.3    Bruun, J.N.4    Birkeland, K.5
  • 22
    • 33746059779 scopus 로고    scopus 로고
    • Hepatic steatosis is associated with fibrosis, nucleoside analogue use, and hepatitis C virus genotype 3 infection in HIV-seropositive patients
    • McGovern B., Ditelberg J., Taylor L., Gandhi R.T., Christopoulos K.A., Chapman S., et al. Hepatic steatosis is associated with fibrosis, nucleoside analogue use, and hepatitis C virus genotype 3 infection in HIV-seropositive patients. Clin Infect Dis 43 (2006) 365-372
    • (2006) Clin Infect Dis , vol.43 , pp. 365-372
    • McGovern, B.1    Ditelberg, J.2    Taylor, L.3    Gandhi, R.T.4    Christopoulos, K.A.5    Chapman, S.6
  • 23
    • 20144389653 scopus 로고    scopus 로고
    • Short statement of the first European Consensus Conference on the treatment of chronic hepatitis B and C in HIV co-infected patients
    • Alberti A., Clumeck N., Collins S., Gerlich W., Lundgren J., Palù G., et al. Short statement of the first European Consensus Conference on the treatment of chronic hepatitis B and C in HIV co-infected patients. J Hepatol 42 (2005) 615-624
    • (2005) J Hepatol , vol.42 , pp. 615-624
    • Alberti, A.1    Clumeck, N.2    Collins, S.3    Gerlich, W.4    Lundgren, J.5    Palù, G.6
  • 24
    • 27744531771 scopus 로고    scopus 로고
    • Management and treatment of hepatitis C virus infection in HIV-infected adults: recommendations from the Veterans Affairs Hepatitis C Resource Center Program and National Hepatitis C Program Office
    • Tien P.C. Management and treatment of hepatitis C virus infection in HIV-infected adults: recommendations from the Veterans Affairs Hepatitis C Resource Center Program and National Hepatitis C Program Office. Am J Gastroenterol 100 (2005) 2338-2354
    • (2005) Am J Gastroenterol , vol.100 , pp. 2338-2354
    • Tien, P.C.1
  • 26
    • 33750587348 scopus 로고    scopus 로고
    • Histological response to pegIFNα-2α (40KD) plus ribavirin in HIV-hepatitis C virus co-infection
    • Lissen E., Clumeck N., Sola R., Mendes-Correa M., Montaner J., Nelson M., et al. Histological response to pegIFNα-2α (40KD) plus ribavirin in HIV-hepatitis C virus co-infection. AIDS 20 (2006) 2175-2181
    • (2006) AIDS , vol.20 , pp. 2175-2181
    • Lissen, E.1    Clumeck, N.2    Sola, R.3    Mendes-Correa, M.4    Montaner, J.5    Nelson, M.6
  • 27
    • 33745797482 scopus 로고    scopus 로고
    • Impact of steatosis on long-term histological outcome in chronic hepatitis C after antiviral therapy
    • Hung C., Kuo F., Wang J., Lu S.N., Hu T.H., Chen C.H., et al. Impact of steatosis on long-term histological outcome in chronic hepatitis C after antiviral therapy. Antivir Ther 11 (2006) 483-489
    • (2006) Antivir Ther , vol.11 , pp. 483-489
    • Hung, C.1    Kuo, F.2    Wang, J.3    Lu, S.N.4    Hu, T.H.5    Chen, C.H.6
  • 28
    • 10744227418 scopus 로고    scopus 로고
    • The impact of steatosis on disease progression and early and sustained treatment response in chronic hepatitis C patients
    • Patton H., Patel K., Behling C., Bylund D., Blatt L.M., Vallée M., et al. The impact of steatosis on disease progression and early and sustained treatment response in chronic hepatitis C patients. J Hepatol 40 (2004) 484-490
    • (2004) J Hepatol , vol.40 , pp. 484-490
    • Patton, H.1    Patel, K.2    Behling, C.3    Bylund, D.4    Blatt, L.M.5    Vallée, M.6
  • 29
    • 0038122773 scopus 로고    scopus 로고
    • Effect of treatment with peginterferon or interferon alfa-2b and ribavirin on steatosis in patients infected with hepatitis C
    • Poynard T., Ratziu V., McHutchison J., Manns M., Goodman Z., Zeuzem S., et al. Effect of treatment with peginterferon or interferon alfa-2b and ribavirin on steatosis in patients infected with hepatitis C. Hepatology 38 (2003) 75-85
    • (2003) Hepatology , vol.38 , pp. 75-85
    • Poynard, T.1    Ratziu, V.2    McHutchison, J.3    Manns, M.4    Goodman, Z.5    Zeuzem, S.6
  • 31
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner D.E., Brunt E.M., Van Natta M., Behling C., Contos M.J., Cummings O.W., et al. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 41 (2005) 1313-1321
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3    Behling, C.4    Contos, M.J.5    Cummings, O.W.6
  • 32
    • 84872636119 scopus 로고
    • An approximate distribution of Estimates of Variance Components
    • Satterthwaite F.W. An approximate distribution of Estimates of Variance Components. Biometrics Bulletin 2 (1946) 110-114
    • (1946) Biometrics Bulletin , vol.2 , pp. 110-114
    • Satterthwaite, F.W.1
  • 34
    • 33645421568 scopus 로고    scopus 로고
    • Hepatic steatosis in HIV-HCV coinfected patients: analysis of risk factors
    • Bani-Sadr F., Carrat F., Bedossa P., Piroth L., Cacoub P., Perronne C., et al. Hepatic steatosis in HIV-HCV coinfected patients: analysis of risk factors. AIDS 20 (2006) 525-531
    • (2006) AIDS , vol.20 , pp. 525-531
    • Bani-Sadr, F.1    Carrat, F.2    Bedossa, P.3    Piroth, L.4    Cacoub, P.5    Perronne, C.6
  • 35
    • 33845670353 scopus 로고    scopus 로고
    • Fibrosis in genotype 3 chronic hepatitis C and nonalcoholic fatty liver disease: role of insulin resistance and hepatic steatosis
    • Bugianesi E., Marchesini G., Gentilcore E., Cua I.H., Vanni E., Rizzetto M., et al. Fibrosis in genotype 3 chronic hepatitis C and nonalcoholic fatty liver disease: role of insulin resistance and hepatic steatosis. Hepatology 44 (2006) 1648-1655
    • (2006) Hepatology , vol.44 , pp. 1648-1655
    • Bugianesi, E.1    Marchesini, G.2    Gentilcore, E.3    Cua, I.H.4    Vanni, E.5    Rizzetto, M.6
  • 36
    • 33745779893 scopus 로고    scopus 로고
    • Influence of hepatitis C genotypes on lipid levels in HIV-positive patients during highly active antiretroviral therapy
    • Lapadula G., Torti C., Paraninfo G., Castelnuovo F., Uccelli M.C., Costarelli S., et al. Influence of hepatitis C genotypes on lipid levels in HIV-positive patients during highly active antiretroviral therapy. Antivir Ther 11 (2006) 521-527
    • (2006) Antivir Ther , vol.11 , pp. 521-527
    • Lapadula, G.1    Torti, C.2    Paraninfo, G.3    Castelnuovo, F.4    Uccelli, M.C.5    Costarelli, S.6
  • 37
    • 0033985675 scopus 로고    scopus 로고
    • Lactic acidosis associated with stavudine administration: a report of five cases
    • Mokrzycki M., Harris C., May H., Laut J., and Palmisano J. Lactic acidosis associated with stavudine administration: a report of five cases. Clin Infect Dis 30 (2000) 198-200
    • (2000) Clin Infect Dis , vol.30 , pp. 198-200
    • Mokrzycki, M.1    Harris, C.2    May, H.3    Laut, J.4    Palmisano, J.5
  • 38
    • 33750943052 scopus 로고    scopus 로고
    • Incidence of metabolic syndrome in a cohort of HIV-infected adults and prevalence relative to the US population (National Health and Nutrition Examination Survey)
    • Jacobson D.L., Tang A.M., Spiegelman D., Thomas A.M., Skinner S.L., Gorbach S.L., et al. Incidence of metabolic syndrome in a cohort of HIV-infected adults and prevalence relative to the US population (National Health and Nutrition Examination Survey). J Acquir Immune Defic Syndr 43 (2006) 458-466
    • (2006) J Acquir Immune Defic Syndr , vol.43 , pp. 458-466
    • Jacobson, D.L.1    Tang, A.M.2    Spiegelman, D.3    Thomas, A.M.4    Skinner, S.L.5    Gorbach, S.L.6
  • 40
    • 41249102596 scopus 로고    scopus 로고
    • Tural C, Romero M, Solá R, Planas R, Viloria M, Gimenez M, et al. Insulin resistance in a prognostic factor of poor response to peg-interferon-alpha-2a + ribavirin in HCV + HIV patients. 13th Conferences on Retroviruses and Opportunistic Infections. Abstract 863.
    • Tural C, Romero M, Solá R, Planas R, Viloria M, Gimenez M, et al. Insulin resistance in a prognostic factor of poor response to peg-interferon-alpha-2a + ribavirin in HCV + HIV patients. 13th Conferences on Retroviruses and Opportunistic Infections. Abstract 863.


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.