-
1
-
-
18244365849
-
Protein drug stability: A formulation challenge
-
DOI 10.1038/nrd1695
-
S. Frokjaer, and D.E. Otzen Protein drug stability: a formulation challenge Nat. Rev. Drug Discovery 4 2005 298 306 (Pubitemid 41130943)
-
(2005)
Nature Reviews Drug Discovery
, vol.4
, Issue.4
, pp. 298-306
-
-
Frokjaer, S.1
Otzen, D.E.2
-
2
-
-
77957278109
-
Enhancement of sustained and controlled protein release using polyelectrolyte complex-loaded injectable and thermosensitive hydrogel
-
M.R. Park, C. Chun, C.S. Cho, and S.C. Song Enhancement of sustained and controlled protein release using polyelectrolyte complex-loaded injectable and thermosensitive hydrogel Eur. J. Pharm. Biopharm. 76 2010 179 188
-
(2010)
Eur. J. Pharm. Biopharm.
, vol.76
, pp. 179-188
-
-
Park, M.R.1
Chun, C.2
Cho, C.S.3
Song, S.C.4
-
3
-
-
1842850706
-
Biodegradable PLGA microparticles for sustained release of a new GnRH antagonist: Part II. In vivo performance
-
DOI 10.1016/j.ejpb.2004.01.005, PII S0939641104000293
-
G. Schwach, N. Oudry, J.P. Giliberto, P. Broqua, M. Luck, H. Lindner, and R. Gurny Biodegradable PLGA microparticles for sustained release of a new GnRH antagonist: Part II. In vivo performance Eur. J. Pharm. Biopharm. 57 2004 441 446 (Pubitemid 38490560)
-
(2004)
European Journal of Pharmaceutics and Biopharmaceutics
, vol.57
, Issue.3
, pp. 441-446
-
-
Schwach, G.1
Oudry, N.2
Giliberto, J.-P.3
Broqua, P.4
Luck, M.5
Lindner, H.6
Gurny, R.7
-
4
-
-
39649106936
-
Controlled release of growth hormone from thermosensitive triblock copolymer systems: In vitro and in vivo evaluation
-
DOI 10.1016/j.ijpharm.2007.10.016, PII S037851730700840X
-
S. Chen, and J. Singh Controlled release of growth hormone from thermosensitive triblock copolymer systems: in vitro and in vivo evaluation Int. J. Pharm. 352 2008 58 65 (Pubitemid 351284586)
-
(2008)
International Journal of Pharmaceutics
, vol.352
, Issue.1-2
, pp. 58-65
-
-
Chen, S.1
Singh, J.2
-
5
-
-
0030826964
-
Controlled release of human growth hormone in rats following parenteral administration of poloxamer gels
-
DOI 10.1016/S0168-3659(97)01648-9, PII S0168365997016489
-
M. Katakam, W.R. Ravis, and A.K. Banga Controlled release of human growth hormone in rats following parenteral administration of poloxamer gels J. Controlled Release 49 1997 21 26 (Pubitemid 27417897)
-
(1997)
Journal of Controlled Release
, vol.49
, Issue.1
, pp. 21-26
-
-
Katakam, M.1
Ravis, W.R.2
Banga, A.K.3
-
6
-
-
0030033719
-
Mechanisms of polymer degradation and erosion
-
DOI 10.1016/0142-9612(96)85755-3
-
A. Göpferich Mechanisms of polymer degradation and erosion Biomaterials 17 1996 103 114 (Pubitemid 26031366)
-
(1996)
Biomaterials
, vol.17
, Issue.2
, pp. 103-114
-
-
Gopferich, A.1
-
7
-
-
33746315442
-
Synthesis and hydrolysis behaviour of poly(ester anhydrides) from polylactone precursors containing alkenyl moieties
-
DOI 10.1002/mabi.200600060
-
H. Korhonen, R. Hakala, A. Helminen, and J. Seppälä Synthesis and hydrolysis behaviour of poly(ester anhydrides) from polylactone precursors containing alkenyl moieties Macromol. Biosci. 6 2006 496 505 (Pubitemid 44105946)
-
(2006)
Macromolecular Bioscience
, vol.6
, Issue.7
, pp. 496-505
-
-
Korhonen, H.1
Hakala, R.A.2
Helminen, A.O.3
Seppala, J.V.4
-
8
-
-
77956275002
-
Biocompatible photocrosslinked poly(ester anhydride) based on functionalized poly (-caprolactone) prepolymer shows surface erosion controlled drug release in vitro and in vivo
-
J. Mönkäre, R.A. Hakala, M.A. Vlasova, A. Huotari, M. Kilpeläinen, A. Kiviniemi, V. Meretoja, K.H. Herzig, H. Korhonen, J.V. Seppälä, and K. Järvinen Biocompatible photocrosslinked poly(ester anhydride) based on functionalized poly (-caprolactone) prepolymer shows surface erosion controlled drug release in vitro and in vivo J. Controlled Release 146 2010 349 355
-
(2010)
J. Controlled Release
, vol.146
, pp. 349-355
-
-
Mönkäre, J.1
Hakala, R.A.2
Vlasova, M.A.3
Huotari, A.4
Kilpeläinen, M.5
Kiviniemi, A.6
Meretoja, V.7
Herzig, K.H.8
Korhonen, H.9
Seppälä, J.V.10
Järvinen, K.11
-
9
-
-
0345376040
-
Recent developments in ring opening polymerization of lactones for biomedical applications
-
DOI 10.1021/bm034247a
-
A.C. Albertsson, and I.K. Varma Recent developments in ring opening polymerization of lactones for biomedical applications Biomacromolecules 4 2003 1466 1486 (Pubitemid 37460959)
-
(2003)
Biomacromolecules
, vol.4
, Issue.6
, pp. 1466-1486
-
-
Albertsson, A.-C.1
Varma, I.K.2
-
11
-
-
58149461825
-
Hydrophobicities of poly(-caprolactone) oligomers functionalized with different succinic anhydrides
-
R. Hakala, H. Korhonen, S. Holappa, and J. Seppala Hydrophobicities of poly(-caprolactone) oligomers functionalized with different succinic anhydrides Eur. Polym. J. 45 2009 557 564
-
(2009)
Eur. Polym. J.
, vol.45
, pp. 557-564
-
-
Hakala, R.1
Korhonen, H.2
Holappa, S.3
Seppala, J.4
-
12
-
-
68949177102
-
Gut hormones: Implications for the treatment of obesity
-
M. Neary, and R. Batterham Gut hormones: implications for the treatment of obesity Pharmacol. Ther. 124 2009 44 56
-
(2009)
Pharmacol. Ther.
, vol.124
, pp. 44-56
-
-
Neary, M.1
Batterham, R.2
-
13
-
-
0019310264
-
Isolation of two novel candidate hormones using a chemical method for finding naturally occurring polypeptides
-
DOI 10.1038/285417a0
-
K. Tatemoto, and V. Mutt Isolation of 2 novel candidate hormones using a chemical method for finding naturally-occurring polypeptides Nature 285 1980 417 418 (Pubitemid 10047227)
-
(1980)
Nature
, vol.285
, Issue.5764
, pp. 417-418
-
-
Tatemoto, K.1
Mutt, V.2
-
14
-
-
0037043704
-
Gut hormone PYY3-36 physiologically inhibits food intake
-
R. Batterham, M. Cowley, C. Small, H. Herzog, M. Cohen, C. Dakin, A. Wren, A. Brynes, M. Low, M. Ghatei, R. Cone, and S. Bloom Gut hormone PYY3-36 physiologically inhibits food intake Nature 418 2002 650 654
-
(2002)
Nature
, vol.418
, pp. 650-654
-
-
Batterham, R.1
Cowley, M.2
Small, C.3
Herzog, H.4
Cohen, M.5
Dakin, C.6
Wren, A.7
Brynes, A.8
Low, M.9
Ghatei, M.10
Cone, R.11
Bloom, S.12
-
15
-
-
27744584314
-
3-36 on food intake in humans
-
DOI 10.1053/j.gastro.2005.09.001, PII S0016508505017853
-
L. Degen, S. Oesch, M. Casanova, S. Graf, S. Ketterer, J. Drewe, and C. Beglinger Effect of peptide YY3-36 on food intake in humans Gastroenterology 129 2005 1430 1436 (Pubitemid 41597385)
-
(2005)
Gastroenterology
, vol.129
, Issue.5
, pp. 1430-1436
-
-
Degen, L.1
Oesch, S.2
Casanova, M.3
Graf, S.4
Ketterer, S.5
Drewe, J.6
Beglinger, C.7
-
16
-
-
0041859261
-
3-36
-
DOI 10.1056/NEJMoa030204
-
R.L. Batterham, M.A. Cohen, S.M. Ellis, C.W. Le Roux, D.J. Withers, G.S. Frost, M.A. Ghatei, and S.R. Bloom Inhibition of food intake in obese subjects by peptide YY3-36 New Engl. J. Med. 349 2003 941 948 (Pubitemid 37064767)
-
(2003)
New England Journal of Medicine
, vol.349
, Issue.10
, pp. 941-948
-
-
Batterham, R.L.1
Cohen, M.A.2
Ellis, S.M.3
Le Roux, C.W.4
Withers, D.J.5
Frost, G.S.6
Ghatei, M.A.7
Bloom, S.R.8
-
17
-
-
29044450310
-
3-36) in rabbits
-
DOI 10.1038/sj.ijo.0803067
-
A.P. Sileno, G.C. Brandt, B.M. Spann, and S.C. Quay Lower mean weight after 14 days intravenous administration peptide YY3-36 (PYY3-36) in rabbits Int. J. Obesity 30 2005 68 72 (Pubitemid 41790779)
-
(2006)
International Journal of Obesity
, vol.30
, Issue.1
, pp. 68-72
-
-
Sileno, A.P.1
Brandt, G.C.2
Spann, B.M.3
Quay, S.C.4
-
18
-
-
33644849354
-
Daily, intermittent intravenous infusion of peptide YY(3-36) reduces daily food intake and adiposity in rats
-
P.K. Chelikani, A.C. Haver, J.R. Reeve, D.A. Keire, and R.D. Reidelberger Daily, intermittent intravenous infusion of peptide YY(3-36) reduces daily food intake and adiposity in rats Am. J. Physiol-Regul. Integr. Comp. Physiol. 290 2006 R298 R305
-
(2006)
Am. J. Physiol-Regul. Integr. Comp. Physiol.
, vol.290
-
-
Chelikani, P.K.1
Haver, A.C.2
Reeve, J.R.3
Keire, D.A.4
Reidelberger, R.D.5
-
19
-
-
34249862701
-
3-36 for weight reduction in obese adults
-
DOI 10.1210/jc.2006-1806
-
I. Gantz, N. Erondu, M. Mallick, B. Musser, R. Krishna, W.K. Tanaka, K. Snyder, C. Stevens, M.A. Stroh, H.Y. Zhu, J.A. Wagner, D.J. MacNeil, S.B. Heymsfield, and J.M. Amatruda Efficacy and safety of intranasal peptide YY3-36 for weight reduction in obese adults J. Clin. Endocrinol. Metab. 92 2007 1754 1757 (Pubitemid 46997183)
-
(2007)
Journal of Clinical Endocrinology and Metabolism
, vol.92
, Issue.5
, pp. 1754-1757
-
-
Gantz, I.1
Erondu, N.2
Mallick, M.3
Musser, B.4
Krishna, R.5
Tanaka, W.K.6
Snyder, K.7
Stevens, C.8
Stroh, M.A.9
Zhu, H.10
Wagner, J.A.11
MacNeil, D.J.12
Heymsfield, S.B.13
Amatruda, J.M.14
-
20
-
-
78049440734
-
Oral administration of glucagon-like peptide 1 or peptide YY 3-36 affects food intake in healthy male subjects
-
R. Steinert, B. Poller, C. Castelli, J. Drewe, and C. Beglinger Oral administration of glucagon-like peptide 1 or peptide YY 3-36 affects food intake in healthy male subjects Am. J. Clin. Nutr. 92 2010 810 817
-
(2010)
Am. J. Clin. Nutr.
, vol.92
, pp. 810-817
-
-
Steinert, R.1
Poller, B.2
Castelli, C.3
Drewe, J.4
Beglinger, C.5
-
21
-
-
34547639141
-
Effect of subcutaneous injections of PYY1-36 and PYY3-36 on appetite, ad libitum energy intake, and plasma free fatty acid concentration in obese males
-
B. Sloth, L. Davidsen, J. Holst, A. Flint, and A. Astrup Effect of subcutaneous injections of PYY1-36 and PYY3-36 on appetite, ad libitum energy intake, and plasma free fatty acid concentration in obese males Am. J. Physiol-Endocrinol. Metab. 293 2007 E604 E609
-
(2007)
Am. J. Physiol-Endocrinol. Metab.
, vol.293
-
-
Sloth, B.1
Davidsen, L.2
Holst, J.3
Flint, A.4
Astrup, A.5
-
23
-
-
0034980298
-
Conversion and temperature profiles during the photoinitiated polymerization of thick orthopaedic biomaterials
-
DOI 10.1016/S0142-9612(00)00347-1, PII S0142961200003471
-
J.A. Burdick, A.J. Peterson, and K.S. Anseth Conversion and temperature profiles during the photoinitiated polymerization of thick orthopaedic biomaterials Biomaterials 22 2001 1779 1786 (Pubitemid 32564966)
-
(2001)
Biomaterials
, vol.22
, Issue.13
, pp. 1779-1786
-
-
Burdick, J.A.1
Peterson, A.J.2
Anseth, K.S.3
-
24
-
-
33750017278
-
Pharmacokinetics and in vitro and in vivo correlation of huperzine A loaded poly(lactic-co-glycolic acid) microspheres in dogs
-
DOI 10.1016/j.ijpharm.2006.06.032, PII S0378517306005163
-
D. Chu, X. Fu, W. Liu, K. Liu, and Y. Li Pharmacokinetics and in vitro and in vivo correlation of huperzine A loaded poly(lactic-co-glycolic acid) microspheres in dogs Int. J. Pharm. 325 2006 116 123 (Pubitemid 44573702)
-
(2006)
International Journal of Pharmaceutics
, vol.325
, Issue.1-2
, pp. 116-123
-
-
Chu, D.-F.1
Fu, X.-Q.2
Liu, W.-H.3
Liu, K.4
Li, Y.-X.5
-
26
-
-
0030213070
-
The precipitation of monomers during the erosion of a class of polyanhydrides
-
A. Gopferich, L. Schedl, and R. Langer The precipitation of monomers during the erosion of a class of polyanhydrides Polymer 37 1996 3861 3869 (Pubitemid 126692425)
-
(1996)
Polymer
, vol.37
, Issue.17
, pp. 3861-3869
-
-
Gopferich, A.1
Schedl, L.2
Langer, R.3
-
27
-
-
15244359665
-
Molecular description of erosion phenomena in biodegradable polymers
-
DOI 10.1021/ma047661r
-
M.J. Kipper, and B. Narasimhan Molecular description of erosion phenomena in biodegradable polymers Macromolecules 38 2005 1989 1999 (Pubitemid 40384618)
-
(2005)
Macromolecules
, vol.38
, Issue.5
, pp. 1989-1999
-
-
Kipper, M.J.1
Narasimhan, B.2
-
28
-
-
0042433334
-
3-36 in the mouse
-
DOI 10.1124/jpet.103.051821
-
N. Nonaka, S. Shioda, M. Niehoff, and W. Banks Characterization of blood-brain barrier permeability to PYY3-36 in the mouse J. Pharmacol. Exp. Ther. 306 2003 948 953 (Pubitemid 37025300)
-
(2003)
Journal of Pharmacology and Experimental Therapeutics
, vol.306
, Issue.3
, pp. 948-953
-
-
Nonaka, N.1
Shioda, S.2
Niehoff, M.L.3
Banks, W.A.4
-
29
-
-
56449126449
-
Pharmacokinetics and pharmacodynamic effects of oral GLP-1 and PYY3-36: A proof-of-concept study in healthy subjects
-
C. Beglinger, B. Poller, E. Arbit, C. Ganzoni, S. Gass, I. Gomez-Orellana, and J. Drewe Pharmacokinetics and pharmacodynamic effects of oral GLP-1 and PYY3-36: a proof-of-concept study in healthy subjects Clin. Pharmacol. Ther. 84 2008 468 474
-
(2008)
Clin. Pharmacol. Ther.
, vol.84
, pp. 468-474
-
-
Beglinger, C.1
Poller, B.2
Arbit, E.3
Ganzoni, C.4
Gass, S.5
Gomez-Orellana, I.6
Drewe, J.7
-
30
-
-
83955165809
-
-
US Patent Application No. US 2007/0232537 A1
-
H.R. Constantino, M.S. Kleppe, A. Stoudt Cohen, A.P. Sileno, Intranasal PYY formulations with improved transmucosal pharmacokinetics, US Patent Application No. US 2007/0232537 A1, 2007.
-
(2007)
Intranasal PYY Formulations with Improved Transmucosal Pharmacokinetics
-
-
Constantino, H.R.1
Kleppe, M.S.2
Stoudt Cohen, A.3
Sileno, A.P.4
-
31
-
-
0027503632
-
Controlled delivery systems for proteins using polyanhydride microspheres
-
DOI 10.1023/A:1018929531410
-
Y. Tabata, S. Gutta, and R. Langer Controlled delivery of systems for proteins using polyanhydride microspheres Pharm. Res. 10 1993 487 496 (Pubitemid 23113038)
-
(1993)
Pharmaceutical Research
, vol.10
, Issue.4
, pp. 487-496
-
-
Tabata, Y.1
Gutta, S.2
Langer, R.3
-
32
-
-
0030959633
-
In vitro/in vivo comparison of drug release and polymer erosion from biodegradable P(FAD-SA) polyanhydrides - A noninvasive approach by the combined use of electron paramagnetic resonance spectroscopy and nuclear magnetic resonance imaging
-
DOI 10.1023/A:1012123127330
-
K. Mäder, Y. Crémmilleux, A. Domb, J. Dunn, and H. Swartz In vitro/in vivo comparison of drug release and polymer erosion from biodegradable P(FAD-SA) polyanhydrides - a noninvasive approach by the combined use of electron paramagnetic resonance spectroscopy and nuclear magnetic resonance imaging Pharm. Res. 14 1997 820 826 (Pubitemid 27281681)
-
(1997)
Pharmaceutical Research
, vol.14
, Issue.6
, pp. 820-826
-
-
Mader, K.1
Cremmilleux, Y.2
Domb, A.J.3
Dunn, J.F.4
Swartz, H.M.5
-
33
-
-
0142217382
-
Studies on biodegradation and release of gentamicin sulphate from interpenetrating network hydrogels based on poly(acrylic acid) and gelatin: In vitro and in vivo
-
DOI 10.1016/S0142-9612(03)00466-6
-
M. Changez, V. Koul, B. Krishna, A.K. Dinda, and V. Choudhary Studies on biodegradation and release of gentamicin sulphate from interpenetrating network hydrogels based on poly(acrylic acid) and gelatin: in vitro and in vivo Biomaterials 25 2004 139 146 (Pubitemid 37324407)
-
(2004)
Biomaterials
, vol.25
, Issue.1
, pp. 139-146
-
-
Changez, M.1
Koul, V.2
Krishna, B.3
Dinda, A.K.4
Choudhary, V.5
-
34
-
-
58149145435
-
In vivo implantation of 2,2′-bis(oxazoline)-linked poly-ε-caprolactone: Proof for enzyme sensitive surface erosion and biocompatibility
-
M. Pulkkinen, M. Malin, J. Bohm, T. Tarvainen, T. Wirth, J. Seppala, and K. Jarvinen In vivo implantation of 2,2′-bis(oxazoline)-linked poly-ε-caprolactone: proof for enzyme sensitive surface erosion and biocompatibility Eur. J. Pharm. Sci. 36 2009 310 319
-
(2009)
Eur. J. Pharm. Sci.
, vol.36
, pp. 310-319
-
-
Pulkkinen, M.1
Malin, M.2
Bohm, J.3
Tarvainen, T.4
Wirth, T.5
Seppala, J.6
Jarvinen, K.7
-
35
-
-
3242888947
-
Effects of PYY[3-36] in rodent models of diabetes and obesity
-
DOI 10.1038/sj.ijo.0802696
-
R.A. Pittner, C.X. Moore, S.P. Bhavsar, B.R. Gedulin, P.A. Smith, C.M. Jodka, D.G. Parkes, J.R. Paterniti, V.P. Srivastava, and A.A. Young Effects of PYY[3-36] in rodent models of diabetes and obesity Int. J. Obes. Relat. Metab. Disord. 28 2004 963 971 (Pubitemid 38998700)
-
(2004)
International Journal of Obesity
, vol.28
, Issue.8
, pp. 963-971
-
-
Pittner, R.A.1
Moore, C.X.2
Bhavsar, S.P.3
Gedulin, B.R.4
Smith, P.A.5
Jodka, C.M.6
Parkes, D.G.7
Paterniti, J.R.8
Srivastava, V.P.9
Young, A.A.10
-
36
-
-
67349226324
-
Comparison of independent and combined chronic anti-obese effects of NPY Y2 receptor agonist, PYY(3-36), and NPY Y5 receptor antagonist in diet-induced obese mice
-
R. Moriya, S. Mashiko, A. Ishihara, T. Takahashi, T. Murai, J. Ito, Y. Mitobe, Z. Oda, H. Iwaasa, F. Takehiro, and A. Kanatani Comparison of independent and combined chronic anti-obese effects of NPY Y2 receptor agonist, PYY(3-36), and NPY Y5 receptor antagonist in diet-induced obese mice Peptides 30 2009 1318 1322
-
(2009)
Peptides
, vol.30
, pp. 1318-1322
-
-
Moriya, R.1
Mashiko, S.2
Ishihara, A.3
Takahashi, T.4
Murai, T.5
Ito, J.6
Mitobe, Y.7
Oda, Z.8
Iwaasa, H.9
Takehiro, F.10
Kanatani, A.11
-
37
-
-
0034020054
-
Lymphatic transport of proteins after subcutaneous administration
-
DOI 10.1002/(SICI)1520-6017(200003)89:3<297::AID-JPS2>3.0.CO;2-P
-
C.J.H. Porter, and S.A. Charman Lymphatic transport of proteins after subcutaneous administration J. Pharm. Sci. 89 2000 297 310 (Pubitemid 30152431)
-
(2000)
Journal of Pharmaceutical Sciences
, vol.89
, Issue.3
, pp. 297-310
-
-
Porter, C.J.H.1
Charman, S.A.2
|