In vitro/in vivo comparison of drug release and polymer erosion from biodegradable P(FAD-SA) polyanhydrides - A noninvasive approach by the combined use of electron paramagnetic resonance spectroscopy and nuclear magnetic resonance imaging

Pharmaceutical Research

Volumn 14, Issue 6, 1997, Pages 820-826

  Mäder, Karsten ^a   Crémmilleux, Yannick ^b   Domb, Abraham J ^c   Dunn, Jeffrey F ^d   Swartz, Harold M ^d  

^a HUMBOLDT UNIVERSITY   (Germany)

^b UNIVERSITÉ LYON 1   (France)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

^d DARTMOUTH MEDICAL SCHOOL   (United States)

Author keywords

Biodegradable polymers; Drug delivery; EPR; In vitro in vivo correlation; MRI

Indexed keywords

3 CARBOXY 2,2,5,5 TETRAMETHYLPYRROLIDINE 1 OXYL; NITROXIDE; POLYANHYDRIDE; POLYMER;

ANIMAL EXPERIMENT; ARTICLE; DRUG RELEASE; ELECTRON SPIN RESONANCE; ENCAPSULATION; MALE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; RAT; SUBCUTANEOUS DRUG ADMINISTRATION; TABLET THICKNESS;

ANIMALS; BIOCOMPATIBLE MATERIALS; CONTRAST MEDIA; CYCLIC N-OXIDES; DECANOIC ACIDS; ELECTRON SPIN RESONANCE SPECTROSCOPY; MAGNETIC RESONANCE IMAGING; MALE; POLYMERS; RATS; RATS, WISTAR; SPIN LABELS; STEARIC ACIDS; TABLETS;

EID: 0030959633     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1012123127330     Document Type: Article

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