Human myeloid dendritic cells treated with supernatants of rotavirus infected Caco-2 cells induce a poor Th1 response

Cellular Immunology

Volumn 272, Issue 2, 2012, Pages 154-161

  Rodríguez, Luz Stella ^a   Narváez, Carlos F ^b   Rojas, Olga L ^c   Franco, Manuel A ^a   Ángel, Juana ^a  

^a PONTIFICIA UNIVERSIDAD JAVERIANA   (Colombia)

^b UNIVERSIDAD SURCOLOMBIANA   (Colombia)

^c UNIVERSIDAD DEL ROSARIO   (Colombia)

Author keywords

Caco 2 cells; Dendritic cells; Immunomodulators; Rotavirus; TGF 1

Indexed keywords

THYMIC STROMAL LYMPHOPOIETIN; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; CELL STRAIN CACO 2; CELLULAR IMMUNITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; HUMAN; HUMAN CELL; IMMUNOMODULATION; INTESTINE MUCOSA; MYELOID DENDRITIC CELL; PRIORITY JOURNAL; ROTAVIRUS INFECTION; SUPERNATANT; TH1 CELL; TH2 CELL; VIRUS NEUTRALIZATION;

ANTIGENS, CD86; CACO-2 CELLS; CD4-POSITIVE T-LYMPHOCYTES; CELLULAR MICROENVIRONMENT; COCULTURE TECHNIQUES; CYTOKINES; DENDRITIC CELLS; HLA-DR ANTIGENS; HUMANS; IMMUNOLOGIC FACTORS; MYELOID CELLS; RNA, MESSENGER; ROTAVIRUS; ROTAVIRUS INFECTIONS; TH1 CELLS; TH2 CELLS; TRANSFORMING GROWTH FACTOR BETA1; TUMOR CELLS, CULTURED;

ROTAVIRUS;

EID: 83955162315     PISSN: 00088749     EISSN: 10902163     Source Type: Journal    
DOI: 10.1016/j.cellimm.2011.10.017     Document Type: Article

References (37)

1. Greenberg H.B., Estes M.K. Rotaviruses: from pathogenesis to vaccination. Gastroenterology 2009, 136:1939-1951.
2. Angel J., Franco M.A., Greenberg H.B. Rotavirus vaccines: recent developments and future considerations. Nat. Rev. Microbiol. 2007, 5:529-539.
3. Franco M.A., Angel J., Greenberg H.B. Immunity and correlates of protection for rotavirus vaccines. Vaccine 2006, 24:2718-2731.
4. Mesa M.C., Gutierrez L., Duarte-Rey C., Angel J., Franco M.A. A TGF-beta mediated regulatory mechanism modulates the T cell immune response to rotavirus in adults but not in children. Virology 2010, 399:77-86.
5. Jaimes M.C., Rojas O.L., Gonzalez A.M., Cajiao I., Charpilienne A., Pothier P., Kohli E., Greenberg H.B., Franco M.A., Angel J. Frequencies of virus-specific CD4(+) and CD8(+) T lymphocytes secreting gamma interferon after acute natural rotavirus infection in children and adults. J. Virol. 2002, 76:4741-4749.
6. Rojas O.L., Gonzalez A.M., Gonzalez R., Perez-Schael I., Greenberg H.B., Franco M.A., Angel J. Human rotavirus specific T cells: quantification by ELISPOT and expression of homing receptors on CD4+ T cells. Virology 2003, 314:671-679.
7. Narvaez C.F., Angel J., Franco M.A. Interaction of rotavirus with human myeloid dendritic cells. J. Virol. 2005, 79:14526-14535.
8. Matteoli G., Mazzini E., Iliev I.D., Mileti E., Fallarino F., Puccetti P., Chieppa M., Rescigno M. Gut CD103+ dendritic cells express indoleamine 2, 3-dioxygenase which influences T regulatory/T effector cell balance and oral tolerance induction. Gut 2010, 59:595-604.
9. Rimoldi M., Chieppa M., Salucci V., Avogadri F., Sonzogni A., Sampietro G.M., Nespoli A., Viale G., Allavena P., Rescigno M. Intestinal immune homeostasis is regulated by the crosstalk between epithelial cells and dendritic cells. Nat. Immunol. 2005, 6:507-514.
10. Iliev I.D., Spadoni I., Mileti E., Matteoli G., Sonzogni A., Sampietro G.M., Foschi D., Caprioli F., Viale G., Rescigno M. Human intestinal epithelial cells promote the differentiation of tolerogenic dendritic cells. Gut 2009, 58:1481-1489.
11. Rodriguez L.S., Barreto A., Franco M.A., Angel J. Immunomodulators released during rotavirus infection of polarized caco-2 cells. Viral. Immunol. 2009, 22:163-172.
12. Livak K.J., Schmittgen T.D. Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods 2001, 25:402-408.
13. Iliev I.D., Mileti E., Matteoli G., Chieppa M., Rescigno M. Intestinal epithelial cells promote colitis-protective regulatory T-cell differentiation through dendritic cell conditioning. Mucosal. Immunol. 2009, 2:340-350.
14. Cella M., Salio M., Sakakibara Y., Langen H., Julkunen I., Lanzavecchia A. Maturation, activation, and protection of dendritic cells induced by double-stranded RNA. J. Exp. Med. 1999, 189:821-829.
15. Ohtsuka Y., Sanderson I.R. Transforming growth factor-beta: an important cytokine in the mucosal immune response. Curr. Opin. Gastroenterol. 2000, 16:541-545.
16. Li M.O., Wan Y.Y., Sanjabi S., Robertson A.K., Flavell R.A. Transforming growth factor-beta regulation of immune responses. Annu. Rev. Immunol. 2006, 24:99-146.
17. Lin J.T., Martin S.L., Xia L., Gorham J.D. TGF-beta 1 uses distinct mechanisms to inhibit IFN-gamma expression in CD4+ T cells at priming and at recall: differential involvement of Stat4 and T-bet. J. Immunol. 2005, 174:5950-5958.
18. Park I.K., Shultz L.D., Letterio J.J., Gorham J.D. TGF-beta1 inhibits T-bet induction by IFN-gamma in murine CD4+ T cells through the protein tyrosine phosphatase Src homology region 2 domain-containing phosphatase-1. J. Immunol. 2005, 175:5666-5674.
19. Barreto A., Rodriguez L.S., Rojas O.L., Wolf M., Greenberg H.B., Franco M.A., Angel J. Membrane vesicles released by intestinal epithelial cells infected with rotavirus inhibit T-cell function. Viral Immunol. 2010, 23:595-608.
20. Mileti E., Matteoli G., Iliev I.D., Rescigno M. Comparison of the immunomodulatory properties of three probiotic strains of Lactobacilli using complex culture systems: prediction for in vivo efficacy. PLoS One 2009, 4:e7056.
21. Zeuthen L.H., Fink L.N., Frokiaer H. Epithelial cells prime the immune response to an array of gut-derived commensals towards a tolerogenic phenotype through distinct actions of thymic stromal lymphopoietin and transforming growth factor-beta. Immunology 2008, 123:197-208.
22. Gibbs J.D., Ornoff D.M., Igo H.A., Zeng J.Y., Imani F. Cell cycle arrest by transforming growth factor beta1 enhances replication of respiratory syncytial virus in lung epithelial cells. J. Virol. 2009, 83:12424-12431.
23. Maillot C., Gargala G., Delaunay A., Ducrotte P., Brasseur P., Ballet J.J., Favennec L. Cryptosporidium parvum infection stimulates the secretion of TGF-beta, IL-8 and RANTES by Caco-2 cell line. Parasitol. Res. 2000, 86:947-949.
24. Holloway G., Truong T.T., Coulson B.S. Rotavirus antagonizes cellular antiviral responses by inhibiting the nuclear accumulation of STAT1, STAT2, and NF-kappaB. J. Virol. 2009, 83:4942-4951.
25. Graff J.W., Ettayebi K., Hardy M.E. Rotavirus NSP1 inhibits NFkappaB activation by inducing proteasome-dependent degradation of beta-TrCP: a novel mechanism of IFN antagonism. PLoS Pathog. 2009, 5:e1000280.
26. Zaph C., Troy A.E., Taylor B.C., Berman-Booty L.D., Guild K.J., Du Y., Yost E.A., Gruber A.D., May M.J., Greten F.R., Eckmann L., Karin M., Artis D. Epithelial-cell-intrinsic IKK-beta expression regulates intestinal immune homeostasis. Nature 2007, 446:552-556.
27. Taylor B.C., Zaph C., Troy A.E., Du Y., Guild K.J., Comeau M.R., Artis D. TSLP regulates intestinal immunity and inflammation in mouse models of helminth infection and colitis. J. Exp. Med. 2009, 206:655-667.
28. Allakhverdi Z., Comeau M.R., Jessup H.K., Yoon B.R., Brewer A., Chartier S., Paquette N., Ziegler S.F., Sarfati M., Delespesse G. Thymic stromal lymphopoietin is released by human epithelial cells in response to microbes, trauma, or inflammation and potently activates mast cells. J. Exp. Med. 2007, 204:253-258.
29. Qiao J., Li A., Jin X. TSLP from RSV-stimulated rat airway epithelial cells activates myeloid dendritic cells. Immunol. Cell Biol. 2011, 89:231-238.
30. Fontenot D., He H., Hanabuchi S., Nehete P.N., Zhang M., Chang M., Nehete B., Wang Y.H., Ma Z.M., Lee H.C., Ziegler S.F., Courtney A.N., Miller C.J., Sun S.C., Liu Y.J., Sastry K.J. TSLP production by epithelial cells exposed to immunodeficiency virus triggers DC-mediated mucosal infection of CD4+ T cells. Proc. Natl. Acad. Sci. U.S.A. 2009, 106:16776-16781.
31. Butler M., Ng C.Y., van Heel D.A., Lombardi G., Lechler R., Playford R.J., Ghosh S. Modulation of dendritic cell phenotype and function in an in vitro model of the intestinal epithelium. Eur. J. Immunol. 2006, 36:864-874.
32. Geissmann F., Revy P., Regnault A., Lepelletier Y., Dy M., Brousse N., Amigorena S., Hermine O., Durandy A. TGF-beta 1 prevents the noncognate maturation of human dendritic Langerhans cells. J. Immunol. 1999, 162:4567-4575.
33. Dong Y., Tang L., Letterio J.J., Benveniste E.N. The Smad3 protein is involved in TGF-beta inhibition of class II transactivator and class II MHC expression. J. Immunol. 2001, 167:311-319.
34. Ohtani T., Mizuashi M., Nakagawa S., Sasaki Y., Fujimura T., Okuyama R., Aiba S. TGF-beta1 dampens the susceptibility of dendritic cells to environmental stimulation, leading to the requirement for danger signals for activation. Immunology 2009, 126:485-499.
35. Biet F., Locht C., Kremer L. Immunoregulatory functions of interleukin 18 and its role in defense against bacterial pathogens. J. Mol. Med. 2002, 80:147-162.
36. Liu Y.J. IPC: professional type 1 interferon-producing cells and plasmacytoid dendritic cell precursors. Annu. Rev. Immunol. 2005, 23:275-306.
37. Dumitriu I.E., Dunbar D.R., Howie S.E., Sethi T., Gregory C.D. Human dendritic cells produce TGF-beta 1 under the influence of lung carcinoma cells and prime the differentiation of CD4+CD25+Foxp3+ regulatory T cells. J. Immunol. 2009, 182:2795-2807.