Ceruloplasmin deficiency results in an anxiety phenotype involving deficits in hippocampal iron, serotonin, and BDNF

Journal of Neurochemistry

Volumn 120, Issue 1, 2012, Pages 125-134

  Texel, Sarah J ^a,b   Camandola, Simonetta ^b   Ladenheim, Bruce ^c   Rothman, Sarah M ^b   Mughal, Mohamed R ^b   Unger, Erica L ^d   Cadet, Jean Lud ^c   Mattson, Mark P ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE ON AGING   (United States)

^c NATIONAL INSTITUTE ON DRUG ABUSE   (United States)

^d PENNSYLVANIA STATE UNIVERSITY   (United States)

Author keywords

anxiety; BDNF; iron; learning and memory; norepinephrine; serotonin

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; BRAIN DERIVED NEUROTROPHIC FACTOR RECEPTOR; CERULOPLASMIN; CORTICOSTERONE; IRON; NORADRENALIN; SEROTONIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANXIETY; ARTICLE; BRAIN LEVEL; CONTROLLED STUDY; CORTICOSTERONE BLOOD LEVEL; HIPPOCAMPUS; IRON BRAIN LEVEL; IRON DEFICIENCY; IRON METABOLISM DISORDER; LEARNING DISORDER; MALE; MAZE TEST; MEMORY DISORDER; MOTOR DYSFUNCTION; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; OPEN FIELD TEST; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN EXPRESSION;

ANIMALS; ANXIETY; BRAIN CHEMISTRY; BRAIN-DERIVED NEUROTROPHIC FACTOR; CERULOPLASMIN; CORTICOSTERONE; FEAR; HINDLIMB SUSPENSION; HIPPOCAMPUS; IRON; LEARNING; MALE; MAZE LEARNING; MEMORY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOTOR ACTIVITY; POSTURAL BALANCE; PSYCHOMOTOR PERFORMANCE; REAL-TIME POLYMERASE CHAIN REACTION; RECOGNITION (PSYCHOLOGY); SEROTONIN; TRANSCRIPTION, GENETIC;

ANIMALIA; MUS;

EID: 83855165109     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2011.07554.x     Document Type: Article

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