The C-terminus of ICln is natively disordered but displays local structural preformation

Cellular Physiology and Biochemistry

Volumn 28, Issue 6, 2011, Pages 1203-1210

  Schedlbauer, Andreas ^a   Gandini, Rosaria ^b   Kontaxis, Georg ^a   Paulmichl, Markus ^c   Furst, Johannes ^b   Konrat, Robert ^a  

^a UNIVERSITY OF VIENNA   (Austria)

^b INNSBRUCK MEDICAL UNIVERSITY   (Austria)

^c PARACELSUS MEDICAL UNIVERSITY   (Austria)

Author keywords

ICln; Intrinsic disorder; NMR; Structure

Indexed keywords

CELL PROTEIN; PROTEIN ICLN; UNCLASSIFIED DRUG;

ALPHA HELIX; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; DNA STRAND; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN STRUCTURE; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 83755206931     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000335852     Document Type: Article

References (49)

1. Gschwentner M, Nagl UO, Woll E, Schmarda A, Ritter M, Paulmichl M: Antisense oligonucleotides suppress cellvolume-induced activation of chloride channels. Pflugers Arch 1995;430:464-470.
2. Paulmichl M, Li Y, Wickman K, Ackerman M, Peralta E, Clapham D: New mammalian chloride channel identified by expression cloning. Nature 1992;356:238-241.
3. Krapivinsky G, Pu W, Wickman K, Krapivinsky L, Clapham DE: pICln binds to a mammalian homolog of a yeast protein involved in regulation of cell morphology. J Biol Chem 1998;273:10811-10814. (Pubitemid 28204911)
4. Li H, Yonekura H, Kim CH, Sakurai S, Yamamoto Y, Takiya T, Futo S, Watanabe T, Yamamoto H: Possible participation of pICln in the regulation of angiogenesis through alternative splicing of vascular endothelial growth factor receptor mRNAs. Endothelium 2004;11:293-300. (Pubitemid 40123398)
5. Larkin D, Murphy D, Reilly DF, Cahill M, Sattler E, Harriott P, Cahill DJ, Moran N: ICln, a novel integrin alphaIIbbeta3-associated protein, functionally regulates platelet activation. J Biol Chem 2004;279:27286-27293. (Pubitemid 38812568)
6. Larkin D, Treumann A, Murphy D, DeChaumont C, Kiernan A, Moran N: Compartmentalization regulates the interaction between the platelet integrin alpha IIb beta 3 and ICln. Br J Haematol 2009;144:580-590.
7. Friesen WJ, Paushkin S, Wyce A, Massenet S, Pesiridis GS, Van Duyne G, Rappsilber J, Mann M, Dreyfuss G: The methylosome, a 20S complex containing JBP1 and pICln, produces dimethylarginine-modified Sm proteins. Mol Cell Biol 2001;21:8289-8300. (Pubitemid 33108590)
8. Meister G, Eggert C, Buhler D, Brahms H, Kambach C, Fischer U: Methylation of Sm proteins by a complex containing PRMT5 and the putative U snRNP assembly factor pICln. Curr Biol 2001;11:1990-1994. (Pubitemid 33146428)
9. Pu WT, Krapivinsky GB, Krapivinsky L, Clapham DE: pICln inhibits snRNP biogenesis by binding core spliceosomal proteins. Mol Cell Biol 1999;19:4113-4120. (Pubitemid 29241985)
10. Pu WT, Wickman K, Clapham DE: ICln is essential for cellular and early embryonic viability. J Biol Chem 2000;275:12363-12366. (Pubitemid 30241374)
11. Winkler C, Eggert C, Gradl D, Meister G, Giegerich M, Wedlich D, Laggerbauer B, Fischer U: Reduced U snRNP assembly causes motor axon degeneration in an animal model for spinal muscular atrophy. Genes Dev 2005;19:2320-2330. (Pubitemid 41396909)
12. Krapivinsky GB, Ackerman MJ, Gordon EA, Krapivinsky LD, Clapham DE: Molecular characterization of a swellinginduced chloride conductance regulatory protein, pICln. Cell 1994;76:439-448.
13. Schwartz RS, Rybicki AC, Nagel RL: Molecular cloning and expression of a chloride channel-associated protein pICln in human young red blood cells: Association with actin. Biochem J 1997;327:609-616.
14. Tamma G, Procino G, Strafino A, Bononi E, Meyer G, Paulmichl M, Formoso V, Svelto M, Valenti G: Hypotonicity induces aquaporin-2 internalization and cytosol-to-membrane translocation of ICln in renal cells. Endocrinology 2007;148:1118-1130.
15. Calinisan V, Gravem D, Chen RP, Brittin S, Mohandas N, Lecomte MC, Gascard P: New insights into potential functions for the protein 4.1 superfamily of proteins in kidney epithelium. Front Biosci 2006;11:1646-1666. (Pubitemid 43253383)
16. Tang CJ, Tang TK: The 30-kD domain of protein 4.1 mediates its binding to the carboxyl terminus of pICln, a protein involved in cellular volume regulation. Blood 1998;92:1442-1447. (Pubitemid 28369059)
17. Azzouz TN, Pillai RS, Dapp C, Chari A, Meister G, Kambach C, Fischer U, Schumperli D: Toward an assembly line for U7 snRNPs: Interactions of U7-specific LSm proteins with PRMT5 and SMN complexes. J Biol Chem 2005;280:34435-34440. (Pubitemid 41504571)
18. Emma F, Sanchez-Olea R, Strange K: Characterization of pI(Cln) binding proteins: Identification of p17 and assessment of the role of acidic domains in mediating protein-protein interactions. Biochim Biophys Acta 1998;1404:321-328. (Pubitemid 28470534)
19. Furst J, Schedlbauer A, Gandini R, Garavaglia ML, Saino S, Gschwentner M, Sarg B, Lindner H, Jakab M, Ritter M, Bazzini C, Botta G, Meyer G, Kontaxis G, Tilly BC, Konrat R, Paulmichl M: ICln159 folds into a pleckstrin homology domain-like structure. Interaction with kinases and the splicing factor LSm4. J Biol Chem 2005;280:31276-31282. (Pubitemid 41291865)
20. Laich A, Gschwentner M, Krick W, Nagl UO, Furst J, Hofer S, Susanna A, Schmarda A, Deetjen P, Burckhardt G, Paulmichl M: ICln, a chloride channel cloned from kidney cells, is activated during regulatory volume decrease. Kidney Int 1997;51:477-478. (Pubitemid 27088162)
21. Musch MW, Davis-Amaral EM, Vandenburgh HH, Goldstein L: Hypotonicity stimulates translocation of ICln in neonatal rat cardiac myocytes. Pflugers Arch 1998;436:415-422. (Pubitemid 28329102)
22. Ritter M, Ravasio A, Jakab M, Chwatal S, Furst J, Laich A, Gschwentner M, Signorelli S, Burtscher C, Eichmuller S, Paulmichl M: Cell swelling stimulates cytosol to membrane transposition of ICln. J Biol Chem 2003;278:50163-50174. (Pubitemid 37548855)
23. - current and volume regulation in a native epithelial cell. Am J Physiol 1999;276:C182-192. (Pubitemid 29063581)
24. - currents in either layer of rabbit ciliary epithelium. Biochem Biophys Res Commun 1998;246:59-63. (Pubitemid 28413927)
25. Dossena S, Gandini R, Tamma G, Vezzoli V, Nofziger C, Tamplenizza M, Salvioni E, Bernardinelli E, Meyer G, Valenti G, Wolf-Watz M, Fuerst J, Paulmichl M: The molecular and functional interaction between ICln and HSPC038 modulates the regulation of cell volume. J Biol Chem 2011;286:40659-70.
26. Furst J, Botta G, Saino S, Dopinto S, Gandini R, Dossena S, Vezzoli V, Rodighiero S, Bazzini C, Garavaglia ML, Meyer G, Jakab M, Ritter M, Wappl-Kornherr E, Paulmichl M: The ICln interactome. Acta Physiol (Oxf) 2006;187:43-49. (Pubitemid 43828762)
27. Schedlbauer A, Kontaxis G, Konig M, Furst J, Jakab M, Ritter M, Garavaglia L, Botta G, Meyer G, Paulmichl M, Konrat R: Sequence-specific resonance assignments of ICln, an ion channel cloned from epithelial cells. J Biomol NMR 2003;27:399-400. (Pubitemid 37322114)
28. Furst J, Jakab M, Konig M, Ritter M, Gschwentner M, Rudzki J, Danzl J, Mayer M, Burtscher CM, Schirmer J, Maier B, Nairz M, Chwatal S, Paulmichl M: Structure and function of the ion channel ICln. Cell Physiol Biochem 2000;10:329-334. (Pubitemid 32008916)
29. Chen BP, Hai T: Expression vectors for affinity purification and radiolabeling of proteins using Escherichia coli as host. Gene 1994;139:73-75. (Pubitemid 24086741)
30. Cavanagh J, Fairbrother WJ, Palmer AG, 3rd, Skelton NJ, Rance M: Protein NMR spectroscopy, ed 2. Academic Press, 2006.
31. Delaglio F, Grzesiek S, Vuister GW, Zhu G, Pfeifer J, Bax A: NMRPipe: A multidimensional spectral processing system based on UNIX pipes. J Biomol NMR 1995;6:277-293.
32. Johnson BA, Blevins RA: NMR View: A computer program for the visualization and analysis of NMR data. J Biomol NMR 1994;4:603-614.
33. Konrat R: The protein meta-structure: A novel concept for chemical and molecular biology. Cell Mol Life Sci 2009;66:3625-3639.
34. Platzer G, Schedlbauer A, Chemelli A, Ozdowy P, Coudevylle N, Auer R, Kontaxis G, Hartl M, Miles AJ, Wallace BA, Glatter O, Bister K, Konrat R: The metastasis-associated extracellular matrix protein osteopontin forms transient structure in ligand interaction sites. Biochemistry 2011;50:6113-6124.
35. Iakoucheva LM, Kimzey AL, Masselon CD, Smith RD, Dunker AK, Ackerman EJ: Aberrant mobility phenomena of the DNA repair protein XPA. Protein Sci 2001;10:1353-1362. (Pubitemid 32568102)
36. Creamer LK, Richardson T: Anomalous behavior of bovine alpha s1-and betacaseins on gel electrophoresis in sodium dodecyl sulfate buffers. Arch Biochem Biophys 1984;234:476-486. (Pubitemid 15189102)
37. Lobley A, Swindells MB, Orengo CA, Jones DT: Inferring function using patterns of native disorder in proteins. PLoS Comput Biol 2007;3:e162.
38. Schlessinger A, Punta M, Rost B: Natively unstructured regions in proteins identified from contact predictions. Bioinformatics 2007;23:2376-2384. (Pubitemid 47423834)
39. Dunker AK, Cortese MS, Romero P, Iakoucheva LM, Uversky VN: Flexible nets. FEBS J 2005;272:5129-5148.
40. Dyson HJ, Wright PE: Intrinsically unstructured proteins and their functions. Nat Rev Mol Cell Biol 2005;6:197-208. (Pubitemid 40314921)
41. Gsponer J, Madan Babu M: The rules of disorder or why disorder rules. Prog Biophys Mol Biol 2009;99:94-103.
42. + channel modulates its interaction with scaffold proteins. Proc Natl Acad Sci USA 2007;104:13022-13027. (Pubitemid 351737586)
43. + exchanger NHE1 is intrinsically disordered: Implications for NHE1 trafficking. Biochemistry 2011;50:3469-3480.
44. Dosztanyi Z, Csizmok V, Tompa P, Simon I: IUPred: Web server for the prediction of intrinsically unstructured regions of proteins based on estimated energy content. Bioinformatics 2005;21:3433-3434. (Pubitemid 41222453)
45. Dyson HJ, Wright PE: Coupling of folding and binding for unstructured proteins. Curr Opin Struct Biol 2002;12:54-60. (Pubitemid 34142721)
46. Huber AH, Weis WI: The structure of the beta-catenin/E-cadherin complex and the molecular basis of diverse ligand recognition by beta-catenin. Cell 2001;105:391-402. (Pubitemid 32455345)
47. Grimmler M, Bauer L, Nousiainen M, Korner R, Meister G, Fischer U: Phosphorylation regulates the activity of the SMN complex during assembly of spliceosomal U snRNPs. EMBO Rep 2005;6:70-76. (Pubitemid 41710077)
48. Sanchez-Olea R, Emma F, Coghlan M, Strange K: Characterization of pICln phosphorylation state and a pIClnassociated protein kinase. Biochim Biophys Acta 1998;1381:49-60. (Pubitemid 28248115)
49. Huang X, Miller W: A time-efficient, linear-space local similarity algorithm. Adv Appl Math 1991;12:337-357.