Association of intrinsic pI(Cln) with volume-activated Cl- current and volume regulation in a native epithelial cell

American Journal of Physiology - Cell Physiology

Volumn 276, Issue 1 45-1, 1999, Pages

  Chen, Lixin ^a   Wang, Liwei ^a   Jacob, Tim J C ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Antisense oligonucleotides; Ciliary epithelium; Fluid transport; Ion channels; Nonpigmented ciliary epithelial cells; Secretion

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; CHLORIDE ION; CHLORIDE CHANNEL;

ANIMAL CELL; AQUEOUS HUMOR FORMATION; ARTICLE; CATTLE; CELL MEMBRANE TRANSPORT; CELL VOLUME; CHLORIDE CURRENT; CILIARY BODY EPITHELIUM; CONTROLLED STUDY; NONHUMAN; PRIORITY JOURNAL; ANIMAL; CILIARY BODY; CYTOLOGY; DRUG EFFECT; ELECTRIC CONDUCTIVITY; EPITHELIUM CELL; FLUORESCENT ANTIBODY TECHNIQUE; GENETICS; HUMAN; METABOLISM; OSMOLARITY; PHYSIOLOGY;

ANIMALS; CATTLE; CHLORIDE CHANNELS; CILIARY BODY; ELECTRIC CONDUCTIVITY; EPITHELIAL CELLS; FLUORESCENT ANTIBODY TECHNIQUE; HUMANS; OLIGONUCLEOTIDES, ANTISENSE; OSMOLAR CONCENTRATION;

EID: 0032614020     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1999.276.1.c182     Document Type: Article

References (18)

1. Anguita, J., M. L. Chalfaut, M. M. Civan, and M. Coca-Prados. Molecular cloning of the human volume-sensitive chloride conductance regulatory protein, from ocular ciliary epithelium. Biochem. Biophys. Res. Commun. 208: 89-95, 1995.
2. Arreola, J., J. E. Melvin, and T. Begenisch. Volume-activated chloride channels in rat parotid acinar cells. J. Physiol. (Lond.) 484: 677-687, 1995.
3. Cln protein forms homomeric complexes in vitro. Biochem. Biophys. Res. Commun. 218: 822-827, 1996.
4. Caprioli, J. The ciliary epithelia and aqueous humor. In: Alder's Physiology of Eye: Clinical Application, edited by R. A. Moses and W. M. Hart, Jr., St. Louis, MO: Mosby, 1987, p. 204-222.
5. Clapham, D. E. The list of potential volume-sensitive chloride currents continues to swell (and shrink). J. Gen. Physiol. 111: 623-624, 1998.
6. Cln. Am. J. Physiol. 268 (Cell Physiol. 37): C572-C579, 1995.
7. - transport by human nonpigmented ciliary epithelial cells. J. Membr. Biol. 150: 197-208, 1996.
8. Diaz, M., M. A. Valverde, C. F. Higgins, C. Rucareanu, and F. V. Sepulveda. Volume-activated chloride channels in HeLa cells are blocked by verapmil and dideoxyforskolin. Pflügers Arch. 422: 347-353, 1993.
9. Doroshenko, P., and E. Neher. Volume-sensitive conductance in bovine chromaffin cell membrane. J. Physiol. (Lond.) 449: 197-218, 1992.
10. Duan, D., C. Winter, S. Cowley, J. R. Hume, and B. Horowitz. Molecular identification of a volume-regulated chloride channel. Nature 390: 417-421, 1997.
11. Emma, F., S. Breton, R. Morrison, S. Wright, and K. Strange. Effect of cell swelling on membrane and cytoplasmic distribution of plein. Am. J. Physiol. 274 (Cell Physiol. 43): C1545-C1551, 1998.
12. Farahbakhsh, N. A., and G. L. Fain. Volume regulation of non-pigmented cells from ciliary epithelium. Invest. Ophthalmol. Vis. Sci. 28: 934-944, 1987.
13. Gill, D. R., S. C. Hyde, C. F. Higgins, M. A. Valverde, G. M. Mintenig, and F. V. Sepulveda. Separation of drug transport and chloride channel functions of the human multidrug resistance P-glycoprotein. Cell 71: 23-32, 1992.
14. Cln in neonatal rat myocytes (Abstract). J. Gen. Physiol. 111: 36a, 1997.
15. Grunder, S., A. Thiemann, M. Pusch, and T. J. Jentsch. Regions involved in the opening of ClC-2 chloride channel by voltage and cell volume. Nature 360: 759-762, 1992.
16. Gschwentner, M., U. O. Nagl, E. Woll, A. Schmarda, M. Ritter, and M. Paulmichl. Antisense oligonucleotides suppress cell-volume-induced activation of chloride channels. Pflügers Arch. 430: 464-470, 1995.
17. Hubert, M. D., I. Levitan, and S. S. Garber. Activation of volume-regulated anion current (VRAC) is dependent on ICln expression (Abstract). Biophys. J. 74: A221, 1998.
18. Ishibashi, K., S. Sasaki, S. Uchida, T. Imai, and F. Marumo. Tissue expression of mRNA of chloride channel from MDCK cells and its regulation by protein kinases. Biochem. Biophys. Res. Commun. 192: 561-567, 1993.