Two cases of everolimus-associated interstitial pneumonia in patients with renal cell carcinoma

Internal Medicine

Volumn 50, Issue 24, 2011, Pages 3013-3017

  Akata, Kentarou ^a   Yatera, Kazuhiro ^a   Ishimoto, Hiroshi ^a   Kozaki, Minako ^a   Yamasaki, Kei ^a   Nagata, Shuya ^a   Nishida, Chinatsu ^a   Yoshida, Takeshi ^a   Kawanami, Toshinori ^a   Matsumoto, Tetsuro ^a   Mukae, Hiroshi ^a  

^a UNIVERSITY OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH   (Japan)

Author keywords

Acute respiratory failure; Drug induced pneumonia; Everolimus; Interstitial pneumonia; Renal cell carcinoma

Indexed keywords

EVEROLIMUS; LEVOFLOXACIN; METHYLPREDNISOLONE; PREDNISOLONE;

ACUTE RESPIRATORY FAILURE; ADULT; AGED; ARTICLE; CASE REPORT; COMPUTER ASSISTED TOMOGRAPHY; DRUG WITHDRAWAL; DYSPNEA; FEVER; FIBEROPTIC BRONCHOSCOPY; HUMAN; INTERSTITIAL PNEUMONIA; KIDNEY CARCINOMA; LABORATORY TEST; LUNG LAVAGE; LUNG LESION; LUNG METASTASIS; LYMPHOCYTE TRANSFORMATION TEST; MALE; MEDICAL HISTORY; PHYSICAL EXAMINATION; SORE THROAT; THORAX RADIOGRAPHY;

ADRENAL CORTEX HORMONES; AGED; CARCINOMA, RENAL CELL; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KIDNEY NEOPLASMS; LUNG DISEASES, INTERSTITIAL; LUNG NEOPLASMS; MALE; MIDDLE AGED; RESPIRATORY INSUFFICIENCY; SIROLIMUS;

EID: 83755184392     PISSN: 09182918     EISSN: 13497235     Source Type: Journal    
DOI: 10.2169/internalmedicine.50.6133     Document Type: Article

References (14)

1. Garrean S, Massad MG, Tshibaka M, Hanhan Z, Caines AE, Benedetti E. Sirolimus-associated interstitial pneumonitis in solid organ transplant recipients. Clin Transplant 19: 698-703, 2005.
2. Vandewiele B, Vandecasteele SJ, Vanwalleghem L, De Vriese AS. Diffuse alveolar hemorrhage induced by everolimus. Chest 137: 456-459, 2010.
3. Bastien L, Culine S, Paule B, Ledbai S, Patard JJ, de la Taille A. Targeted therapies in metastatic renal cancer in 2009. BJU Int 103: 1334-1342, 2009.
4. Rini B, Campbell SC, Escudier B. Renal cell carcinoma. Lancet 373: 1119-1132, 2009.
5. Horiguchi A, Oya M, Uchida A, Marumo K, Murai M. Elevated Akt activation and its impact on clinicopathological features of renal cell carcinoma. J Urol 169: 710-713, 2003.
6. Motzer RJ, Escudier B, Oudard S, et al; RECORD-1 Study Group. Efficacy of everolimus in advanced renal carcinoma: a double-blind, randomized, placebo-controlled phase III trial. Lancet 372: 449-456, 2008.
7. Fervenza FC, Fitzpatrick PM, Mertz J, et al; Mayo Nephrology Collaborative Committee. Acute rapamycin nephrotoxicity in native kidneys of patients with chronic glomerulopathies. Nephrol Dial Transplant 19: 1288-1292, 2004.
8. White DA, Camus P, Endo M, et al. Noninfectious pneumonitis after everolimus therapy for advanced renal cell carcinoma. Am J Respir Crit Care Med 182: 396-403, 2010.
9. Endo M, Johkoh T, Kimura K, Yamamoto N. Imaging of gefitinibrelated interstitial lung disease: multi-institution analysis by the West Japan Thoracic Oncology Group. Lung Cancer 52: 135-140, 2006.
10. Pham PT, Pham PC, Denovitch GM, et al. Sirolimus-associated pulmonary toxicity. Transplantation 77: 1215-1220, 2004.
11. White DA, Schwartz LH, Dimitrijevic S, Scala LD, Hayes W, Gross SH. Characterization of pneumonitis in patients with advanced non-small cell lung cancer treated with everolimus (RAD 001). J Thorac Oncol 4: 1357-1363, 2009.
12. David S, Kümpers P, Shin H, Haller H, Fliser D. Everolimusassociated interstitial pneumonitis in a patient with a heart transplant. Nephrol Dial Transplant 22: 3363-3364, 2007.
13. Alexandru S, Ortiz A, Baldovi S, et al. Severe everolimusassociated pneumonitis in a renal transplant recipient. Nephrol Dial Transplant 23: 3353-3355, 2008.
14. Howard L, Gopalan D, Griffiths M, Mahadeva R. Sirolimusinduced pulmonary hypersensitivity associated with a Cd4 T-cell infiltrate. Chest 129: 1718-1721, 2006.