Ginkgo biloba extract attenuates warfarin-mediated anticoagulation through induction of hepatic cytochrome P450 enzymes by bilobalide in mice

Phytomedicine

Volumn 19, Issue 2, 2012, Pages 177-182

  Taki, Yuko ^a,b   Yokotani, Kaori ^a   Yamada, Shizuo ^b   Shinozuka, Kazumasa ^c   Kubota, Yoko ^d   Watanabe, Yasuo ^d   Umegaki, Keizo ^a  

^a NATIONAL INSTITUTE OF HEALTH AND NUTRITION   (Japan)

^b UNIVERSITY OF SHIZUOKA   (Japan)

^c MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

^d NIHON PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

Adverse event; Bilobalide; Bleeding; Cytochrome P450; Ginkgo biloba; Warfarin

Indexed keywords

BILOBALIDE; CYTOCHROME P450; GINKGO BILOBA EXTRACT; GINKGOLIDE A; GINKGOLIDE B; GINKGOLIDE C; LIVER ENZYME; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; UNCLASSIFIED DRUG; WARFARIN; WARFARIN HYDROXYLASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICOAGULATION; ARTICLE; BLEEDING; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG MECHANISM; DRUG METABOLISM; ENANTIOMER; ENZYME ASSAY; ENZYME INDUCTION; HEMATOLOGICAL PARAMETERS; HERB DRUG INTERACTION; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTICOAGULANTS; BLOOD COAGULATION; COAGULANTS; CYCLOPENTANES; CYTOCHROME P-450 ENZYME SYSTEM; ENZYME INDUCTION; FURANS; GINKGO BILOBA; GINKGOLIDES; HERB-DRUG INTERACTIONS; LACTONES; LIVER; MALE; MICE; MICE, INBRED ICR; PLANT EXTRACTS; WARFARIN;

GINKGO BILOBA; MUS;

EID: 83655201440     PISSN: 09447113     EISSN: 1618095X     Source Type: Journal    
DOI: 10.1016/j.phymed.2011.06.020     Document Type: Article

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