Matrine inhibits pacing induced atrial fibrillation by modulating IKM3 and ICa-L

International Journal of Biological Sciences

Volumn 8, Issue 1, 2011, Pages 150-158

  Zhou, Yuhong ^a   Xu, Wei ^b   Han, Ruyi ^a   Zhou, Jiaying ^a   Pan, Zhenwei ^a   Rong, Huo ^a   Li, Junnan ^a   Xu, Changqing ^a   Qiao, Guofen ^a   Lu, Yanjie ^a  

^a HARBIN MEDICAL UNIVERSITY   (China)

^b THE SECOND AFFILIATED HOSPITAL OF HARBIN MEDICAL UNIVERSITY   (China)

Author keywords

Atrial fibrillation; L type calcium channel; Matrine; Potassium channel

Indexed keywords

EID: 83655181819     PISSN: 14492288     EISSN: None     Source Type: Journal    
DOI: 10.7150/ijbs.8.150     Document Type: Article

References (39)

1. Dobrev D, Nattel S. New antiarrhythmic drugs for treatment of atrial fibrillation. Lancet. 2010; 375: 1212-3.
2. Fuster V, Fuster V, Rydén LE, Cannom DS, Crijns HJ, Curtis AB, Ellenbogen KA, Halperin JL, Le Heuzey JY, Kay GN, Lowe JE, Olsson SB, Prystowsky EN, Tamargo JL & Wann S. ACC/AHA/ESC 2006 guidelines for the management of patients with atrial fibrillation - executive summary: a report of the American College of Cardiology/American Heart Association Task Force and European Society of Cardiology Committee for Practice Guidelines (Writing Committee to Revise the 2001 Guidelines for the Management of Patients with Atrial Fibrillation). Eur Heart J. 2006; 27: 1979-2030.
3. Pedersen OD, Abildstrom SZ, Ottesen MM, Rask-Madsen C, Bagger H, Køber L & Torp-Pedersen C. TRACE Study Investigators: Increased risk of sudden and non-sudden cardiovascular death in patients with atrial fibrillation flutter following acute myocardial infarction. Eur Heart J. 2006; 27: 290-5.
4. Tsang TS, Miyasaka Y, Barnes ME & Gersh BJ. Epidemiological profile of atrial fibrillation: a contemporary perspective. Prog Cardiovasc Dis. 2005; 48: 1-8.
5. Nattel S, Carlsson L. Innovative approaches to anti-arrhythmic drug therapy. Nat Rev Drug Discov. 2006; 5: 1034-49.
6. Nattel S, Opie LH. Controversies in atrial fbrillation. Lancet. 2006; 367: 262-72.
7. Schauerte P, Scherlag BJ, Pitha J, Scherlag MA, Reynolds D, Lazzara R & Jackman WM. Catheter ablation of cardiac autonomic nerves for prevention of vagal atrial fibrillation. Circulation. 2000; 102: 2774-80.
8. Zang WJ, Yu XJ, Honjo H, Kirby MS & Boyett MR. On the role of G protein activation and phosphorylation in desensitization to acetylcholine in guinea-pig atrial cells. J Physiol. 1993; 464: 649-79.
9. Shi H, Wang H, Lu Y, Yang B & Wang Z. Choline modulates cardiac membrane repolarization by activating an M3 muscarinic receptor and its coupled Kt channel. J Membr Biol. 1999; 169: 55-64.
10. Shi H, Wang H & Wang Z. Identification and characterization of multiple subtypes of muscarinic acetylcholine receptors and their physiological functions in canine hearts. Mol Pharmacol 1999; 55: 497-507.
11. + current. Br J Pharmacol 1999; 126: 1725-34.
12. Shi H, Wang H, Li D, Nattel S & Wang Z. Differential alterations of receptor densities of three muscarinic acetylcholine receptor subtypes and current densities of the corresponding Kt channels in canine atria with atrial fibrillation induced by experimental congestive heart failure. Cell Physiol Biochem. 2004; 14: 31-40.
13. Tuomi JM, Chidiac P & Jones DL. Evidence for enhanced M3 muscarinic receptor function and sensitivity to atrial arrhythmia in the RGS2-deficient mouse. Am J Physiol Heart Circ Physiol. 2010; 298: H554-H561.
14. 2+ leak promotes atrial fibrillation in mice. J Clin Invest 2009; 119: 1940-51.
15. 2+ channel KO mouse. Am J Physiol Heart Circ Physiol. 2008; 295: H2017-24.
16. Van der Velden HMW, van der Zee L, Wijffels MC, van Leuven C, Dorland R, Vos MA, Jongsma HJ & Allessie MA. Atrial fibrillation in the goat induces changes in monophasic action potential and mRNA expression of ion channels involved in repolarization. J Cardiovasc Electrophysiol 2000; 11: 1262-69.
17. Yue L, Melnyk P, Gaspo R, Wang Z & Nattel S. Molecular mechanisms underlying ionic remodeling in a dog model of atrial fibrillation. Circ Res. 1999; 84: 776-84.
18. Fareh S, Bénardeau A & Nattel S. Differential efficacy of L- and T-type calcium channel blockers in preventing tachycardia- induced atrial remodeling in dogs. Cardiovasc Res. 2001; 49: 762-70.
19. Bénardeau A, Fareh S & Nattel S. Effects of verapamil on atrial fibrillation and its electrophysiological determinants in dogs. Cardiovasc Res. 2001; 50: 85-96.
20. Zhu XH, Qiu YD, Shi MK, Wu B, Zheng XG & Ding YT. Effect of matrine on cold ischemia and reperfusion injury of sinusoidal endothelial cells in rat orthotopic liver transp lantation. Acta Pharm Acol Sin. 2003; 24: 169-74.
21. Zhang MJ, Huang J. Recent research progress of anti-tumor mechnism matrine. Zhongguo Zhong Yao Za Zhi. 2004; 29: 115-8
22. Long Y, Lin XT, Zeng KL & Zhang L. Efficacy of intramuscular matrine in the treatment of chronic hepatitis B. Hepatobiliary Pancreat Dis Int. 2004; 3: 69-72.
23. Lao Y. Clinical study of matrine injection on p reventing liver function damage of anti-tumor drugs during chemo therapy of breast cancer. J Chin Med Mater. 2005; 28: 735-7.
24. Li X, Chu W, Liu J, Xue X, Lu Y, Shan H & Yang B. Antiarrhythmic properties of long-term treatment with matrine in arrhythmic rat induced by coronary ligation. Biol Pharm Bull. 2009; 32: 1521-6.
25. Zhang Y, Zou YN, Hao DX, Lin HX & Xiao JN. Therapeutic effect of amiodarone compared with matrine and p rocainamide on ventricular arrhythmias in coronary heart disease. J Harbin Med Univ. 2005; 39: 344-8.
26. Zhou YH, Xu CX, Shan HL, Lu YJ & Yang BF. Inhibition of matrine on potassium currents in guinea pig ventricular myocytes. Chinese J Pharmacol and Toxicol. 2007; 21: 167-73.
27. Zhou YH, Shan HL, Qiao GF, Sui XH, Lu YJ & Yang BF. Inotropic Effects and Mechanisms of Matrine, a main alkaloid from Sophora flavescens Ait. Biol Pharm Bull 2008; 31: 2057-62.
28. Ling JY, Zhang GY, Cui ZJ & Zhang CK. Supercritical fluid extraction of quinolizidine alkaloids from Sophora flavescens Ait. and purification by high-speed counter-current chromatography. J Chromatogr A. 2007; 23:123-7.
29. Berul CI, Aronovitz MJ, Wang PJ & Mendelsohn ME. In vivo cardiac electrophysiology studies in the mouse. Circulation. 1996; 94: 2641-8.
30. Wakimoto H, Maguire CT, Kovoor P, Hammer PE, Gehrmann J, Triedman JK & Berul CI. Induction of atrial tachycardia and fibrillation in the mouse heart. Cardiovasc Res. 2001; 50: 463-73.
31. Morillo CA, Klein GJ, Jones DL & Guiraudon CM. Chronic rapid atrial pacing. Structural, functional, and electrophysiological characteristics of a new model of sustained atrial fibrillation. Circulation. 1995; 91: 1588-95.
32. Ausma J, Wijffels M, Thoné F, Wouters L, Allessie M & Borgers M. Structural changes of atrial myocardium due to sustained atrial fibrillation the goat. Circulation isolated canine right atrium. Circ Res. 1992; 71: 1254-67.
33. Garrey WE. The nature of fibrillary contraction of the heart: Its relation to tissue mass and form. Am J Physiol. 1994; 33: 397-414.
34. Schuessler RB, Rosenshtraukh LV, Boineau JP, Bromberg BI & Cox JL. Spontaneous itachyarrhythmias after cholinergic suppression in the isolated perfused canine right atrium. Circ Res. 1991; 69: 1075-87.
35. Schuessler RB, Grayson TM, Bromberg BI, Cox JL & Boineau JP. Cholinergically mediated tachyarrhythmias induced by a single extrastimulus in the isolated canine right atrium. Circ Res. 1992; 71: 1254-67.
36. Rosenshtraukh LV, Zaitsev AV, Fast VG, Pertsov AM & Krinsky VI. Vagally induced block and delayed conduction as a mechanism for circus movement tachycardia in frog atria. Circ Res. 1989; 64: 213-26.
37. + channel blockers: insights from mathematical models and experimental correlates. Am J Physiol Heart Circ Physiol. 2006; 295: H1489-504.
38. Cha TJ, Ehrlich JR, Chartier D, Qi XY, Xiao L & Nattel S. Kir3-based inward rectifier potassium current. Potential role in atrial tachycardia remodeling effects on atrial repolarization and arrhythmias. Circulation. 2006; 113: 1730-7.
39. Yang L, Wang BH, Zhou CH & Bi YY. Matrine induces apoptosis in angiotensin II-stimulated hyperplasia of cardiac fibroblasts: effects on Bcl-2/Bax expression and caspase-3 activation. Basic Clin Pharmacol Toxicol. 2007; 101: 1-8.