Differential Alterations of Receptor Densities of Three Muscarinic Acetylcholine Receptor Subtypes and Current Densities of the Corresponding K + Channels in Canine Atria with Atrial Fibrillation Induced by Experimental Congestive Heart Failure

Cellular Physiology and Biochemistry

Volumn 14, Issue 1-2, 2004, Pages 31-40

  Shi, Hong ^a,d   Wang, Huizhen ^a   Li, Danshi ^a,d   Nattel, Stanley ^a,b,c   Wang, Zhiguo ^a,b  

^a MONTREAL HEART INSTITUTE   (Canada)

^b UNIVERSITÉ DE MONTRÉAL   (Canada)

^c MCGILL UNIVERSITY   (Canada)

^d BRISTOL MYERS SQUIBB   (United States)

Author keywords

Atrial fibrillation; Canine atrial myocyte; Congestive heart failure; I KACh , I KM3 , I K4AP; M 2 receptor; M 3 receptor; M 4 receptor; Muscarinic acetylcholine receptors

Indexed keywords

ACETYLCHOLINE; AMINOPYRIDINE; CHOLINE; INWARDLY RECTIFYING POTASSIUM CHANNEL; MEMBRANE PROTEIN; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; MUSCARINIC M4 RECEPTOR; MUSCARINIC RECEPTOR; POTASSIUM ION; RECEPTOR SUBTYPE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; DOG; FEMALE; HEART ATRIUM; HEART ATRIUM FIBRILLATION; HEART DEPOLARIZATION; MALE; MUSCLE CELL; NONHUMAN; PATCH CLAMP; PRIORITY JOURNAL; RECEPTOR DENSITY; WESTERN BLOTTING;

CANIS FAMILIARIS;

EID: 1442327914     PISSN: 10158987     EISSN: None     Source Type: Journal    
DOI: 10.1159/000076924     Document Type: Article

References (40)

1. Li D, Fareh S, Leung TK, Nattel S: Promotion of atrial fibrillation by heart failure in dogs: atrial remodeling of a different sort. Circulation 1999;6:87-95.
2. Li D, Petrecca K, Feng J, Wang Z, Petrecca K, Shrier A, Nattel S: The effects of experimental heart failure on atrial cellular and ionic electrophysiology. Circulation 2000;101:2631-2638.
3. Li D, Leung T, Han H, Cardin S, Wang Z, Nattel S: Effects of angiotensin-converting enzyme inhibition on the development of the atrial fibrillation substrate in dogs with ventricular tachypacing-induced congestive heart failure. Circulation 2001;104:2608-2614.
4. Maisel WH, Stevenson LW: Atrial fibrillation in heart failure: epidemiology, pathophysiology, and rationale for therapy. Am J Cardiol 2003;91:2D-8D.
5. Hynes BJ, Luck JC, Wolbrette DL, Bhatta L, Khan M, Samii S, Naccarelli GV: Atrial fibrillation in patients with heart failure. Curr Opin Cardiol 2003;18:32-38.
6. Ehrlich JR, Nattel S, Hohnloser SH: Atrial fibrillation and congestive heart failure: specific considerations at the intersection of two common and important cardiac disease sets. J Cardiovasc Electrophysiol 2002;13:399-405.
7. Hoff HE, Geddes LA: Cholinergic factor in auricular fibrillation. J Appl Physiol 1955;8:177-191.
8. Allessie MA, Lammers WJEP, Bonke FIM, Hollen J: Intra-atrial reentry as a mechanism for atrial flutter induced by acetylcholine and rapid pacing in the dog. Circulation 1984;70:123-135.
9. Wang Z, Page P, Nattel S:. The mechanism of flecainide's antiarrhythmic action in experimental atrial fibrillation. Circ Res 1992;71:271-287.
10. Wang J, Bourne GW, Wang Z, Villemaire C, Talajic M, Nattel S: Comparative mechanisms of antiarrhythmic drug action in experimental atrial fibrillation - the importance of use-dependent effects on refractoriness. Circulation 1993;88:1030-1044.
11. Kneller J, Zou R, Vigmond EJ, Wang Z, Leon LJ, Nattel S: Cholinergic atrial fibrillation in a computer model of a two-dimensional sheet of canine atrial cells with realistic ionic properties. Circ Res 2002;90:e73-e87.
12. Tomita T, Takei M, Saikawa Y, Hanaoka T, Uchikawa S, Tsutsui H, Aruga M, Miyashita T, Yazaki Y, Imamura H, Kinoshita O, Owa M, Kubo K: Role of autonomic tone in the initiation and termination of paroxysmal atrial fibrillation in patients without structural heart disease. J Cardiovasc Electrophysiol 2003;14:559-564.
13. van den Berg MP, Hassink RJ, Balje-Volkers C, Crijns HJ: Role of the autonomic nervous system in vagal atrial fibrillation. Heart 2003;89:333-335.
14. Shi H, Yang B, Xu D, Wang H, Wang Z: Electrophysiological characterization of cardiac muscarinic acetylcholine receptors: different subtypes mediate different potassium currents. Cell Physiol Biochem 2003;13:59-74.
15. Shi H, Wang H, Wang Z: Identification and characterization of multiple subtypes of muscarinic acetylcholine receptors and their physiological functions in canine hearts. Mol Pharmacol 1999;55:497-507.
16. + channel. J Membrane Biol 1999;169:55-64.
17. + current. Br J Pharmacol 1999;162:1725-1734.
18. Wang H, Han H, Zhang L, Shi H, Schram G, Nattel S, Wang Z: Expression of multiple subtypes of muscarinic receptors and cellular distribution in the human heart. Mol Pharmacol 2001;59:1029-1036.
19. Yue L, Feng J, R, Wang Z, Nattel S: Ionic remodelling underlying action potential changes in a dog model of atrial fibrillation. Circ Res 1997;81:512-525.
20. Van Wagoner DR, Pond AL, Lamorgese M, Rossie SS, McCarthy PM, Nerbonne JM: Atrial L-type Ca21 currents and human atrial fibrillation. Circ Res 1999;85:428-436.
21. Bosch RF, Zeng X, Grammer JB, Popovic K, Mewis C, Kuhlkamp V. Ionic mechanisms of electrical remodeling in human atrial fibrillation. Cardiovasc Res 1999;44:121-131.
22. Grammer JB, Bosch RF, Kuhlkamp V, Seipel L. Molecular remodeling of Kv4. 3 potassium channels in human atrial fibrillation. J Cardiovasc Electrophysiol 2000;11:626-633.
23. + current densities and Kv1.5 expression are reduced in chronic human atrial fibrillation. Circ Res. 1997;80:772-781.
24. KACh in atrial fibrillation using a mouse knockout model. J Am Coll Cardiol 2001;37:2136-2143.
25. Heidbuchel H, Vereecke J, Carmeliet E: Three different potassium channels in human atrium. Circ Res 1990;66:1277-1286.
26. Sato R, Wasserstrom J, Arentzen C, Singer D: Acetylcholine-sensitive potassium channels in human atrial myocytes. Am J Physiol 1990;259:H1730-H1735.
27. + currents in dog atrial myocytes. Am J Physiol 1994;266:C42-C51.
28. Navarro-Polanco RA, Sànchez-Chapula JA: 4-aminopyridine activates potassium currents by activation of a muscarinic receptor in feline atrial myocytes. J Physiol 1997;498:663-678.
29. + channel: A regulator of tumor cell apoptosis and proliferation. Cancer Res 2002;62: 4843-4848.
30. + channel response to acetylcholine and to G protein-mediated activation in atrial myocytes isolated from failing human hearts. Circulation 1994;90:2213-2224.
31. KACh and muscarinic receptor-mediated shortening of action potentials. Circulation 2001;104:2551-2557.
32. Mertens MJF, Batink HD, Mathy M-J, Pfaffendorf M, Van Zwieten PA: Reduced muscarinic cholinoceptor density and sensitivity in various models of experimental cardiac hypertrophy. J Auton Pharmacol 1995;15:465-474.
33. Vatner DE, Lee DL, Schwarz KR, Longabaugh JP, Fujii AM, Vatner SF, Homcy CJ: Impaired cardiac muscarinic receptor function in dogs with heart failure. J Clin Invest 1988;81:1836-1842.
34. Strasser R, Nuchter I, Rauch B, Marquetant R, Seitz H: Changes in cardiac signal transduction systems in chronic ethanol treatment preceding the development of alcoholic cardiomyopathy. Herz 1996;21:232-240.
35. Le Guludec D, Cohen-Solal A, Delforge J, Delahaye N, Syrota A, Merlet P: Increased myocardial muscarinic receptor density in idiopathic dilated cardiomyopathy: an in vivo PET study. Circulation 1997; 96:3416-3422.
36. Böhm M, Ungerer M, Erdmann E: Beta adrenoceptors and m-cholinoceptors in myocardium of hearts with coronary artery disease or idiopathic dilated cardiomyopathy removed at cardiac transplantation. Am J Cardiol 1990;66:880-882.
37. Brodde O-E, Hillman S, Kunde K, Vogelsang M, Zerkowski HR: Receptor systems affecting force of contraction in the human heart and their alterations in chronic heart failure. J Heart Lung Transplant 1992;11:S164-S174.
38. 3 muscarinic acetylcholine receptors in human atrial myocytes: Influence of chronic atrial fibrillation. Abstract of the American Heart Association Annual Meeting in 2002:776,II-154.
39. Osaka,T.; Itoh,A.; Kodama,I. Action potential remodeling in the human right atrium with chronic lone atrial fibrillation. Pacing Clin Electrophysiol 2000;23:960-965.
40. Wang Z, Feng J, Nattel S: Idiopathic atrial fibrillation in dogs: Electrophysiologic determinants and mechanism of antiarrhythmic action of flecainide. J Am Coll Cardiol 1995;26:277-286.