Expression of CCR5 and its ligands CCL3, -4, and -5 in the tear film and ocular surface of patients with dry eye disease

Current Eye Research

Volumn 37, Issue 1, 2012, Pages 12-17

  Choi, Won ^a   Li, Zhengri ^a   Oh, Han Jin ^a   Im, Seong Kyu ^a   Lee, Seung Hyun ^a   Park, Soo Hyun ^b   You, In Cheon ^c   Yoon, Kyung Chul ^a  

^a Chonnam National University Medical School   (South Korea)

^b Chonnam National University   (South Korea)

^c Chonbuk National University Medical School   (South Korea)

Author keywords

CCL3; CCL4; CCL5; CCR5; Dry eye disease

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR CCR4; CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CCR6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; RANTES;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CONJUNCTIVA; CONTROLLED STUDY; DISEASE SEVERITY; DRY EYE; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HUMAN; MALE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TEAR FILM;

ADULT; AGED; BIOLOGICAL MARKERS; CHEMOKINE CCL3; CHEMOKINE CCL4; CHEMOKINE CCL5; CONJUNCTIVA; DRY EYE SYNDROMES; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; FOLLOW-UP STUDIES; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; PROSPECTIVE STUDIES; RECEPTORS, CCR5; SEVERITY OF ILLNESS INDEX; TEARS; YOUNG ADULT;

EID: 83655165144     PISSN: 02713683     EISSN: 14602202     Source Type: Journal    
DOI: 10.3109/02713683.2011.622852     Document Type: Article

References (32)

1. Lemp MA, Baudouin C, Baum J., et al. The definition of classification of DEDs: report of the Definition and Classification Subcommittee of the International Dry Eye WorkShop (2007). Ocul Surf. 2007;5:75-92. (Pubitemid 351902651)
2. Raphael M, Bellefqih S, Piette JC, Le Hoang P, Debre P, Chomette G. Conjunctival biopsy in Sjgren's syndrome: correlations between histological and immunohistochemical features. Histopathology. 1988;13:191-202.
3. Jones DT, Monroy D, Ji Z, Atherton SS, Pflugfelder SC. Sjgren's syndrome: cytokine and Epstein-Barr viral gene expression within the conjunctival epithelium. Invest Ophthalmol Vis Sci. 1994;35:3493-3504. (Pubitemid 24337956)
4. Pflugfelder SC, Huang AJ, Feuer W, Chuchovski PT, Pereira IC, Tseng SC. Conjunctival cytologic features of primary Sjgren's syndrome. Ophthalmology. 1990;97: 985-991. (Pubitemid 20251125)
5. Pflugfelder SC, Jones D, Ji Z, Afonso A, Monroy D. Altered cytokine balance in the tear fluid and conjunctiva of patients with Sjgren's syndrome keratoconjunctivitis sicca. Curr Eye Res. 1999;19:201-211. (Pubitemid 29500267)
6. Zheng X, de Paiva CS, Li DQ, Farley WJ, Pflugfelder SC. Desiccating stress promotion of Th17 differentiation by ocular surface tissues through a dendritic cell-mediated pathway. Invest Ophthalmol Vis Sci. 2010;51:3083-3091.
7. Pflugfelder SC, Farley W, Luo L et al. Matrix metalloproteinase- 9 knockout confers resistance to corneal epithelial barrier disruption in experimental dry eye. Am J Pathol. 2005;166:61-71. (Pubitemid 40051660)
8. Corrales RM, Stern ME, De Paiva CS, Welch J, Li DQ, Pflugfelder SC. Desiccating stress stimulates expression of matrix metalloproteinases by the corneal epithelium. Invest Ophthalmol Vis Sci. 2006;47:3293-3302. (Pubitemid 351639689)
9. Yeh S, Song XJ, Farley W, Li DQ, Stern ME, Pflugfelder SC. Apoptosis of ocular surface cells in experimentally induced dry eye. Invest Ophthalmol Vis Sci. 2003;44:124-129. (Pubitemid 36134264)
10. Lam H, Bleiden L, de Paiva CS, Farley W, Stern ME, Pflugfelder SC. Tear cytokine profiles in dysfunctional tear syndrome. Am J Ophthalmol. 2009;147:198-205. e1.
11. Yoon KC, Jeong IY, Park YG, Yang SY. Interleukin-6 and tumor necrosis factor-alpha levels in tears of patients with dry eye syndrome. Cornea. 2007;26:431-437.
12. Yoon KC, Park CS, You IC et al. Expression of CXCL9, -10, -11, and CXCR3 in the tear film and ocular surface of patients with dry eye syndrome. Invest Ophthalmol Vis Sci. 2010;51:643-650.
13. Saegusa K, Ishimaru N, Yanagi K et al. Treatment with anti-CD86 costimulatory molecule prevents the autoimmune lesions in murine Sjgren's syndrome (SS) through up-regulated Th2 response. Clin Exp Immunol. 2000;119: 354-360. (Pubitemid 30073042)
14. Kawasaki S, Kawamoto S, Yokoi N et al. Up-regulated gene expression in the conjunctival epithelium of patients with Sjgren's syndrome. Exp Eye Res. 2003;77:17-26. (Pubitemid 36776270)
15. Gulati A, Sacchetti M, Bonini S, Dana R. Chemokine receptor CCR5 expression in conjunctival epithelium of patients with dry eye syndrome. Arch Ophthalmol. 2006;124: 710-716.
16. Baudouin C, Liang H, Bremond-Gignac D et al. CCR 4 and CCR 5 expression in conjunctival specimens as differential markers of T(H)1/ T(H)2 in ocular surface disorders. J Allergy Clin Immunol. 2005;116:614-619. (Pubitemid 41267136)
17. Vitali C, Bombardieri S, Jonsson R et al.; European Study Group on Classification Criteria for Sjgren's Syndrome. Classification criteria for Sjgren's syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis. 2002;61:554-558. (Pubitemid 34539104)
18. Dogru M, Katakami C, Inoue M. Tear function and ocular surface changes in noninsulin-dependent diabetes mellitus. Ophthalmology. 2001;108:586-592. (Pubitemid 32179902)
19. Yoon KC, Heo H, Im SK, You IC, Kim YH, Park YG. Comparison of autologous serum and umbilical cord serum eye drops for dry eye syndrome. Am J Ophthalmol. 2007;144:86-92.
20. Yoon KC, Im SK, Park YG, Jung YD, Yang SY, Choi J. Application of umbilical cord serum eyedrops for the treatment of dry eye syndrome. Cornea. 2006;25: 268-272.
21. Yoon KC, De Paiva CS, Qi H et al. Expression of Th-1 chemokines and chemokine receptors on the ocular surface of C57BL/6 mice: effects of desiccating stress. Invest Ophthalmol Vis Sci. 2007;48:2561-2569. (Pubitemid 351261206)
22. Liu Z, Carvajal M, Carothers Carraway CA, Carraway KL, Pflugfelder SC. Increased expression of the type 1 growth factor receptor family in the conjunctival epithelium of patients with keratoconjunctivitis sicca. Am J Ophthalmol. 2000;129:472-480. (Pubitemid 30184918)
23. Yoon KC, De Paiva CS, Qi H et al. Desiccating environmental stress exacerbates autoimmune lacrimal keratoconjunctivitis in non-obese diabetic mice. J Autoimmun. 2008;30:212-221. (Pubitemid 351551501)
24. Yoon KC, Heo H, Kang IS et al. Effect of topical cyclosporin A on herpetic stromal keratitis in a mouse model. Cornea. 2008;27:454-460. (Pubitemid 351591484)
25. Samson M, Labbe O, Mollereau C, Vassart G, Parmentier M. Molecular cloning and functional expression of a new human CC-chemokine receptor gene. Biochemistry. 1996;35:3362-3367. (Pubitemid 26092558)
26. Sallusto F, Schaerli P, Loetscher P et al. Rapid and coordinated switch in chemokine receptor expression during dendritic cell maturation. Eur J Immunol. 1998;28:2760-2769. (Pubitemid 28425234)
27. Malesinski R, Bakunowicz-Lazarczyk A, Wysocka J. [The role of chemokines CCL3/ MIP-1 alfa and CCL4/ MIP-1 beta in pathogenesis of dry eye syndrome]. Klin Oczna. 2008;110:277-279.
28. Trnwall J, Lane TE, Fox RI, Fox HS. T cell attractant chemokine expression initiates lacrimal gland destruction in nonobese diabetic mice. Lab Invest. 1999;79:1719-1726. (Pubitemid 30013935)
29. Bacon KB, Premack BA, Gardner P, Schall TJ. Activation of dual T cell signaling pathways by the chemokine RANTES. Science. 1995;269:1727-1730.
30. Appay V, Dunbar PR, Cerundolo V, McMichael A, Czaplewski L, Rowland-Jones S. RANTES activates antigen-specific cytotoxic T lymphocytes in a mitogen-like manner through cell surface aggregation. Int Immunol. 2000;12:1173-1182. (Pubitemid 30616222)
31. Turner L, Ward SG, Westwick J. RANTES-activated human T lymphocytes. A role for phosphoinositide 3-kinase. J Immunol. 1995;155:2437-2444.
32. El Annan J, Chauhan SK, Ecoiffier T, Zhang Q, Saban DR, Dana R. Characterization of effector T cells in dry eye disease. Invest Ophthalmol Vis Sci. 2009;50:3802-3807.