Optimisation and scale-up of a highly-loaded 5-ASA multi-particulate dosage form using a factorial approach

European Journal of Pharmaceutical Sciences

Volumn 45, Issue 1-2, 2012, Pages 158-168

  Di Pretoro, G ^a   Zema, L ^a   Palugan, L ^a   Wilson, D I ^b   Rough, S L ^b   Gazzaniga, A ^a  

^a Dipartimento di Scienze Farmaceutiche P Pratesi   (Italy)

^b New Museums Site ^*  (United Kingdom)

Author keywords

5 Aminosalicylic acid; Design of experiment; Extrusion spheronisation; Multi particulate dosage form; Statistical optimisation

Indexed keywords

MESALAZINE;

ARTICLE; DRUG FORMULATION; DRUG PELLET; DRUG QUALITY; DRUG SYNTHESIS; PELLET EXTRUSION; PRIORITY JOURNAL; PROCESS OPTIMIZATION; SCALE UP;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELLULOSE; DRUG COMPOUNDING; EXCIPIENTS; FEASIBILITY STUDIES; KINETICS; MESALAMINE; PARTICLE SIZE; PHYSICOCHEMICAL PHENOMENA; POWDER DIFFRACTION; SOLUBILITY; STATISTICS AS TOPIC; SURFACE PROPERTIES; TABLETS; WATER;

EID: 83655164998     PISSN: 09280987     EISSN: 18790720     Source Type: Journal    
DOI: 10.1016/j.ejps.2011.11.005     Document Type: Article

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