Opposite effects of interferon-beta on new B and T cell release from production sites in multiple sclerosis patients

Journal of Neuroimmunology

Volumn 240-241, Issue , 2011, Pages 147-150

  Zanotti, Cinzia ^a   Chiarini, Marco ^a   Serana, Federico ^a,b   Capra, Ruggero ^a   Rottoli, Mariarosa ^c   Rovaris, Marco ^d   Cavaletti, Guido ^e   Clerici, Raffaella ^f   Rezzonico, Monica ^g   Caimi, Luigi ^a,b   Imberti, Luisa ^a  

^a SPEDALI CIVILI   (Italy)

^b UNIVERSITY OF BRESCIA   (Italy)

^c OSPEDALI RIUNITI   (Italy)

^d IRCCS FONDAZIONE DON CARLO GNOCCHI   (Italy)

^e UNIVERSITY OF MILANO BICOCCA   (Italy)

^f VALDUCE HOSPITAL   (Italy)

^g SANT ANNA HOSPITAL   (Italy)

Author keywords

Interferon beta; K deleting recombination excision circles; Multiple sclerosis; T cell receptor excision circles

Indexed keywords

BETA1A INTERFERON; T LYMPHOCYTE RECEPTOR;

ADULT; ARTICLE; B LYMPHOCYTE; CELL ASSAY; CELL COMPARTMENTALIZATION; CELL MOTILITY; CLINICAL ARTICLE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG EFFECT; DRUG MEGADOSE; FEMALE; HUMAN; HUMAN CELL; K DELETING RECOMBINATION EXCISION CIRCLES; LOW DRUG DOSE; LYMPHOCYTE COUNT; LYMPHOCYTE SUBPOPULATION; LYMPHOCYTOPOIESIS; MALE; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; T CELL RECEPTOR EXCISION CIRCLES; T LYMPHOCYTE;

ADULT; B-LYMPHOCYTE SUBSETS; CELL DIFFERENTIATION; CELL PROLIFERATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; INTERFERON-BETA; MALE; MIDDLE AGED; MULTIPLE SCLEROSIS, RELAPSING-REMITTING; T-LYMPHOCYTE SUBSETS; YOUNG ADULT;

EID: 83555176327     PISSN: 01655728     EISSN: 18728421     Source Type: Journal    
DOI: 10.1016/j.jneuroim.2011.10.007     Document Type: Article

References (28)

1. Agenès F., Rosado M.M., Freitas A.A. Independent homeostatic regulation of B cell compartments. Eur. J. Immunol. 1997, 27:1801-1807.
2. Binder D., Fehr J., Hengartner H., Zinkernagel R.M. Virus-induced transient bone marrow aplasia: major role of interferon-alpha/beta during acute infection with the noncytopathic lymphocytic choriomeningitis virus. J. Exp. Med. 1997, 185:517-530.
3. Capra R., Sottini A., Cordioli C., Serana F., Chiarini M., Caimi L., Padovani A., Bergamaschi R., Imberti L. IFNbeta bioavailability in multiple sclerosis patients: MxA versus antibody-detecting assays. J. Neuroimmunol. 2007, 189:102-110.
4. Chen X., Barfield R., Benaim E., Leung W., Knowles J., Lawrence D., Otto M., Shurtleff S.A., Neale G.A., Behm F.G., Turner V., Handgretinger R. Prediction of T-cell reconstitution by assessment of T-cell receptor excision circle before allogeneic hematopoietic stem cell transplantation in pediatric patients. Blood 2005, 105:886-893.
5. Chiarini M., Sottini A., Ghidini C., Zanotti C., Serana F., Rottoli M., Zaffaroni M., Bergamaschi R., Cordioli C., Capra R., Imberti L. Renewal of the T-cell compartment in multiple sclerosis patients treated with glatiramer acetate. Mult. Scler. 2010, 16:218-227.
6. Douek D.C., McFarland R.D., Keiser P.H., Gage E.A., Massey J.M., Haynes B.F. Changes in thymic function with age and during the treatment of HIV infection. Nature 1998, 396:690-695.
7. Duddy M., Niino M., Adatia F., Hebert S., Freedman M., Atkins H., Kim H.J., Bar-Or A. Distinct effector cytokine profiles of memory and naive human B cell subsets and implication in multiple sclerosis. J. Immunol. 2007, 178:6092-6099.
8. Fronkova E., Muzikova K., Mejstrikova E., Kovac M., Formankova R., Sedlacek P., Hrusak O., Stary J., Trka J. B-cell reconstitution after allogeneic SCT impairs minimal residual disease monitoring in children with ALL. Bone Marrow Transplant. 2008, 42:187-196.
9. Gniadek P., Aktas O., Wandinger K.P., Bellmann-Strobl J., Wengert O., Weber A., von Wussow P., Obert H.J., Zipp F. Systemic IFN-beta treatment induces apoptosis of peripheral immune cells in MS patients. J. Neuroimmunol. 2003, 137:187-196.
10. Hartrich L., Weinstock-Guttman B., Hall D., Badgett D., Baier M., Patrick K., Feichter J., Hong J., Ramanathan M. Dynamics of immune cell trafficking in interferon-beta treated multiple sclerosis patients. J. Neuroimmunol. 2003, 139:84-92.
11. Hazenberg M.D., Otto S.A., Cohen Stuart J.W., Verschuren M.C., Borleffs J.C., Boucher C.A., Coutinho R.A., Lange J.M., Rinke de Wit T.F., Tsegaye A., van Dongen J.J., Hamann D., de Boer R.J., Miedema F. Increased cell division but not thymic dysfunction rapidly affects the T-cell receptor excision circle content of the naive T cell population in HIV-1 infection. Nat. Med. 2000, 6:1036-1042.
12. Hug A., Korporal M., Schröder I., Haas J., Glatz K., Storch-Hagenlocher B., Wildemann B. Thymic export function and T cell homeostasis in patients with relapsing remitting multiple sclerosis. J. Immunol. 2003, 171:432-437.
13. Lorenzi A.R., Patterson A.M., Pratt A., Jefferson M., Chapman C.E., Ponchel F., Isaacs J.D. Determination of thymic function directly from peripheral blood: a validated modification to an established method. J. Immunol. Methods 2008, 339:185-194.
14. McDonald W.I., Compston A., Edan G., Goodkin D., Hartung H.P., Lublin F.D., McFarland H.F., Paty D.W., Polman C.H., Reingold S.C., Sandberg-Wollheim M., Sibley W., Thompson A., van den Noor S., Weinshenker B.Y., Wolinsky J.S. Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann. Neurol. 2001, 50:121-127.
15. Naldini A., Fleischmann W.R. In vivo myelosuppression by combination interferon treatment: antagonism of MuIFN-gamma and MuIFN beta myelosuppressive effects. J. Biol. Response Mod. 1987, 6:546-555.
16. Niino M., Hirotani M., Miyazaki Y., Sasaki H. Memory and naïve B-cell subsets in patients with multiple sclerosis. Neurosci. Lett. 2009, 464:74-78.
17. Nikfar S., Rahimi R., Abdollahi M. A meta-analysis of the efficacy and tolerability of interferon-β in multiple sclerosis, overall and by drug and disease type. Clin. Ther. 2010, 32:1871-1888.
18. Puissant-Lubrano B., Viala F., Winterton P., Abbal M., Clanet M., Blancher A. Thymic output and peripheral T lymphocyte subsets in relapsing-remitting multiple sclerosis patients treated or not by IFN-beta. J. Neuroimmunol. 2008, 193:188-194.
19. Rep M.H., Hintzen R.Q., Polman C.H., van Lier R.A. Recombinant interferon-beta blocks proliferation but enhances interleukin-10 secretion by activated human T-cells. J. Neuroimmunol. 1996, 67:111-118.
20. Ribeiro R.M., Perelson A.S. Determining thymic output quantitatively: using models to interpret experimental T-cell receptor excision circle (TREC) data. Immunol. Rev. 2007, 216:21-34.
21. Rieckmann P., O'Connor P., Francis G.S., Wetherill G., Alteri E. Haematological effects of interferon-beta-1a (Rebif) therapy in multiple sclerosis. Drug Saf. 2004, 27:745-756.
22. Serana F., Sottini A., Chiarini M., Zanotti C., Ghidini C., Lanfranchi A., Notarangelo L.D., Caimi L., Imberti L. The different extent of B and T cell immune reconstitution after hematopoietic stem cell transplantation and enzyme replacement therapies in SCID patients with adenosine deaminase deficiency. J. Immunol. 2010, 185:7713-7722.
23. Sorensen P.S., Ross C., Clemmesen K.M., Bendtzen K., Frederiksen J.L., Jensen K., Kristensen O., Petersen T., Rasmussen S., Ravnborg M., Stenager E., Koch-Henriksen N., Danish Multiple Sclerosis Study Group Clinical importance of neutralising antibodies against interferon beta in patients with relapsing-remitting multiple sclerosis. Lancet 2003, 362:1184-1191.
24. Sottini A., Ghidini C., Zanotti C., Chiarini M., Caimi L., Lanfranchi A., Moratto D., Porta F., Imberti L. Simultaneous quantification of recent thymic T-cell and bone marrow B-cell emigrants in patients with primary immunodeficiency undergone to stem cell transplantation. Clin. Immunol. 2010, 136:217-227.
25. Thewissen M., Linsen L., Somers V., Geusens P., Raus J., Stinissen P. Premature immunosenescence in rheumatoid arthritis and multiple sclerosis patients. Ann. N. Y. Acad. Sci. 2005, 1051:255-262.
26. van Boxel-Dezaire A.H., Zula J.A., Xu Y., Ransohoff R.M., Jacobberger J.W., Stark G.R. Major differences in the responses of primary human leukocyte subsets to IFN-beta. J. Immunol. 2010, 185:5888-5899.
27. van Zelm M.C., Szczepanski T., van der Burg M., van Dongen J.J. Replication history of B lymphocytes reveals homeostatic proliferation and extensive antigen-induced B cell expansion. J. Exp. Med. 2007, 204:645-655.
28. Weksler M.E., Szabo P. The effect of age on the B-cell repertoire. J. Clin. Immunol. 2000, 20:240-249.