Development, optimization, and anti-diabetic activity of gliclazide-loaded alginate-methyl cellulose mucoadhesive microcapsules

AAPS PharmSciTech

Volumn 12, Issue 4, 2011, Pages 1431-1441

  Pal, Dilipkumar ^a,b   Nayak, Amit Kumar ^c  

^a UNIVERSITY OF SYDNEY   (Australia)

^b IFTM UNIVERSITY   (India)

^c SEEMANTA INSTITUTE OF PHARMACEUTICAL SCIENCES   (India)

Author keywords

alginate methyl cellulose; anti diabetic activity; gliclazide; microcapsules; mucoadhesive

Indexed keywords

ALGINIC ACID; GLICLAZIDE; METHYLCELLULOSE;

ALLOXAN DIABETES MELLITUS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIDIABETIC ACTIVITY; ARTICLE; DRUG ACTIVITY; DRUG FORMULATION; DRUG RELEASE; ENCAPSULATION; GELATION; IN VITRO STUDY; IN VIVO STUDY; MICROCAPSULE; MUCOADHESION; NONHUMAN; PARTICLE SIZE; PRIORITY JOURNAL; RAT;

ADHESIVENESS; ADMINISTRATION, ORAL; ALGINATES; ANIMALS; BLOOD GLUCOSE; CALCIUM CHLORIDE; CAPSULES; CHEMISTRY, PHARMACEUTICAL; CROSS-LINKING REAGENTS; DELAYED-ACTION PREPARATIONS; DIABETES MELLITUS, EXPERIMENTAL; DRUG CARRIERS; DRUG COMPOUNDING; FEMALE; GLICLAZIDE; GLUCURONIC ACID; GOATS; HEXURONIC ACIDS; HYPOGLYCEMIC AGENTS; INTESTINAL MUCOSA; MALE; METHYLCELLULOSE; MODELS, STATISTICAL; PARTICLE SIZE; RATS; SOLUBILITY; TECHNOLOGY, PHARMACEUTICAL; TIME FACTORS;

EID: 83555174948     PISSN: None     EISSN: 15309932     Source Type: Journal    
DOI: 10.1208/s12249-011-9709-8     Document Type: Article

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