Threshold for toxicity from hyperammonemia in critically ill children

Journal of Hepatology

Volumn 56, Issue 1, 2012, Pages 123-128

  Ozanne, Bruno ^a   Nelson, John ^a   Cousineau, Jocelyne ^a   Lambert, Marie ^a   Phan, Véronique ^a   Mitchell, Grant ^a   Alvarez, Fernando ^a   Ducruet, Thierry ^a   Jouvet, Philippe ^a  

^a UNIVERSITY OF MONTREAL   (Canada)

Author keywords

Hyperammonemia; Liver failure; Threshold; Toxicity; Urea cycle defect

Indexed keywords

AMMONIA; DISACCHARIDE; METRONIDAZOLE; SCAVENGER;

ANTIBIOTIC THERAPY; ARTICLE; CHILD; CHILDHOOD MORTALITY; CONTROLLED STUDY; CRITICALLY ILL PATIENT; FEMALE; HOSPITAL ADMISSION; HUMAN; HYPERAMMONEMIA; INFANT; INTENSIVE CARE UNIT; LIVER FAILURE; MAJOR CLINICAL STUDY; MALE; NEWBORN; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PRESCHOOL CHILD; PRIORITY JOURNAL; RENAL REPLACEMENT THERAPY; RETROSPECTIVE STUDY; RISK ASSESSMENT; TOXICITY TESTING; UREA CYCLE DISORDER;

AMMONIA; BRAIN EDEMA; CHILD; CHILD, PRESCHOOL; CRITICAL ILLNESS; ENCEPHALOCELE; FEMALE; HUMANS; HYPERAMMONEMIA; INFANT; KAPLAN-MEIER ESTIMATE; LIVER FAILURE, ACUTE; MALE; RETROSPECTIVE STUDIES; RISK FACTORS; UREA CYCLE DISORDERS, INBORN;

EID: 83555174790     PISSN: 01688278     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jhep.2011.03.021     Document Type: Article

References (28)

1. A.E. Thompson Liver failure D.S. Wheeler, Pediatric critical care medicine 2007 Springer Verlag London 1027 1039
2. N.D. Leslie Inborn errors of metabolism D.S. Wheeler, Pediatric critical care medicine 2007 Springer Verlag London 1103 1110
3. N. Binesh, A. Huda, M.A. Thomas, N. Wyckoff, M. Bugbee, and S. Han Hepatic encephalopathy: a neurochemical, neuroanatomical, and neuropsychological study J Appl Clin Med Phys 7 2006 86 96
4. R.F. Butterworth Pathophysiology of hepatic encephalopathy: a new look at ammonia Metab Brain Dis 17 2002 221 227 (Pubitemid 36204752)
5. P.N. Bjerring, M. Eefsen, B.A. Hansen, and F.S. Larsen The brain in acute liver failure. A tortuous path from hyperammonemia to cerebral edema Metab Brain Dis 24 2009 5 14
6. J.P. Ong, A. Aggarwal, D. Krieger, K.A. Easley, M.T. Karafa, and F. Van Lente Correlation between ammonia levels and the severity of hepatic encephalopathy Am J Med 114 2003 188 193 (Pubitemid 36294003)
7. J.O. Clemmesen, F.S. Larsen, J. Kondrup, B.A. Hansen, and P. Ott Cerebral herniation in patients with acute liver failure is correlated with arterial ammonia concentration Hepatology 29 1999 648 653 (Pubitemid 29109575)
8. V. Bhatia, R. Singh, and S.K. Acharya Predictive value of arterial ammonia for complications and outcome in acute liver failure Gut 55 2006 98 104 (Pubitemid 41820642)
9. W. Bernal, C. Hall, C.J. Karvellas, G. Auzinger, E. Sizer, and J. Wendon Arterial ammonia and clinical risk factors for encephalopathy and intracranial hypertension in acute liver failure Hepatology 46 2007 1844 1852
10. G.M. Enns, S.A. Berry, G.T. Berry, W.J. Rhead, S.W. Brusilow, and A. Hamosh Survival after treatment with phenylacetate and benzoate for urea-cycle disorders N Engl J Med 356 2007 2282 2292 (Pubitemid 46849158)
11. C. Bachmann Outcome and survival of 88 patients with urea cycle disorders: a retrospective evaluation Eur J Pediatr 162 2003 410 416 (Pubitemid 36693743)
12. T. Uchino, F. Endo, and I. Matsuda Neurodevelopmental outcome of long-term therapy of urea cycle disorders in Japan J Inherit Metab Dis 21 1998 151 159
13. B. Maranda, J. Cousineau, P. Allard, and M. Lambert False positives in plasma ammonia measurement and their clinical impact in a pediatric population Clin Biochem 40 2007 531 535 (Pubitemid 46601422)
14. A. Slater, F. Shann, and G. Pearson PIM2: a revised version of the Paediatric Index of Mortality Intensive Care Med 29 2003 278 285 (Pubitemid 36384419)
15. S. Leteurtre, A. Duhamel, B. Grandbastien, J. Lacroix, and F. Leclerc Paediatric logistic organ dysfunction (PELOD) score Lancet 367 2006 897 [author reply 900-892]
16. K.D. McBryde, D.B. Kershaw, T.E. Bunchman, N.J. Maxvold, T.A. Mottes, and T.L. Kudelka Renal replacement therapy in the treatment of confirmed or suspected inborn errors of metabolism J Pediatr 148 2006 770 778 (Pubitemid 43870079)
17. D. Haussinger, and F. Schliess Pathogenetic mechanisms of hepatic encephalopathy Gut 57 2008 1156 1165
18. A. Mas, J. Rodes, L. Sunyer, L. Rodrigo, R. Planas, and V. Vargas Comparison of rifaximin and lactitol in the treatment of acute hepatic encephalopathy: results of a randomized, double-blind, double-dummy, controlled clinical trial J Hepatol 38 2003 51 58 (Pubitemid 36078524)
19. N.M. Bass, K.D. Mullen, A. Sanyal, F. Poordad, G. Neff, and C.B. Leevy Rifaximin treatment in hepatic encephalopathy N Engl J Med 362 2010 1071 1081
20. E. Strauss, R. Tramote, E.P. Silva, W.R. Caly, N.Z. Honain, and R.A. Maffei Double-blind randomized clinical trial comparing neomycin and placebo in the treatment of exogenous hepatic encephalopathy Hepatogastroenterology 39 1992 542 545 (Pubitemid 23056214)
21. M.H. Morgan, A.E. Read, and D.C. Speller Treatment of hepatic encephalopathy with metronidazole Gut 23 1982 1 7 (Pubitemid 12170168)
22. Als-Nielsen B, Gluud LL, Gluud C. Nonabsorbable disaccharides for hepatic encephalopathy. Cochrane Database Syst Rev 2004:CD003044.
23. M.L. Batshaw, R.B. MacArthur, and M. Tuchman Alternative pathway therapy for urea cycle disorders: twenty years later J Pediatr 138 2001 S46 S54 [discussion S54-45]
24. S. Sushma, S. Dasarathy, R.K. Tandon, S. Jain, S. Gupta, and M.S. Bhist Sodium benzoate in the treatment of acute hepatic encephalopathy: a double-blind randomized trial Hepatology 16 1992 138 144
25. S.K. Acharya, V. Bhatia, V. Sreenivas, S. Khanal, and S.K. Panda Efficacy of l-ornithine l-aspartate in acute liver failure: a double-blind, randomized, placebo-controlled study Gastroenterology 136 2009 2159 2168
26. N.A. Davies, G. Wright, L.M. Ytrebo, V. Stadlbauer, O.M. Fuskevag, and C. Zwingmann l-Ornithine and phenylacetate synergistically produce sustained reduction in ammonia and brain water in cirrhotic rats Hepatology 50 2009 155 164
27. L.M. Ytrebo, R.G. Kristiansen, H. Maehre, O.M. Fuskevag, T. Kalstad, and A. Revhaug l-Ornithine phenylacetate attenuates increased arterial and extracellular brain ammonia and prevents intracranial hypertension in pigs with acute liver failure Hepatology 50 2009 165 174
28. D. Zygun Non-neurological organ dysfunction in neurocritical care: impact on outcome and etiological considerations Curr Opin Crit Care 11 2005 139 143 (Pubitemid 40488613)