Potent inhibition of protein tyrosine phosphatases by copper complexes with multi-benzimidazole derivatives

BioMetals

Volumn 24, Issue 6, 2011, Pages 993-1004

  Li, Ying ^a   Lu, Liping ^a   Zhu, Miaoli ^a,c   Wang, Qingming ^a   Yuan, Caixia ^a   Xing, Shu ^b   Fu, Xueqi ^b   Mei, Yuhua ^c  

^a SHANXI UNIVERSITY   (China)

^b JILIN UNIVERSITY   (China)

^c NANJING UNIVERSITY   (China)

Author keywords

Copper complex; Fluorescence; Inhibition; Protein tyrosine phosphatases

Indexed keywords

1,1,4,7,7 PENTAKIS (1H BENZIMIDAZOL 2 YLMETHYL) 1,4,7 TRIAZAHEPTANE; 1,2 DIS(1H BENZOIMIDAZOL 2 YL)RTHANE 1,2 DIOL; BENZIMIDAZOLE DERIVATIVE; BIS(1H BENZOIMIDAZOL 2 YLMETHYL) [2 [2 [2 [BIS(1H BENZOIMIDAZOL 2 YLMETHYL)AMINO]ETHOXY]ETHOXY]ETHYL]AMINE; COPPER COMPLEX; MEGAKARYOCYTE PROTEIN TYROSINE PHOSPHATASE 2; N,N,N',N' TETRAKIS(1H BENZOIMIDAZOL 2 YLMETHYL)ETHANE; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE 2; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE 1B; PROTEIN TYROSINE PHOSPHATASE SHP 1; PROTEIN TYROSINE PHOSPHATASE SHP 2; TRIS(1H BENZOIMIDAZOL 2 YLMETHYL)AMINE; UNCLASSIFIED DRUG;

ANALYTIC METHOD; ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; ELECTROSPRAY MASS SPECTROMETRY; ELEMENTAL ANALYSIS; ENZYME BINDING; ENZYME INHIBITION; FLUORESCENCE ANALYSIS; IC 50; IN VITRO STUDY; INFRARED SPECTROSCOPY; NONHUMAN; PH; POTENTIOMETRY; RAT; ULTRAVIOLET SPECTROSCOPY;

BENZIMIDAZOLES; COPPER; ENZYME INHIBITORS; HUMANS; MOLECULAR STRUCTURE; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 1; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 11; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 2; PROTEIN TYROSINE PHOSPHATASE, NON-RECEPTOR TYPE 6; PROTEIN TYROSINE PHOSPHATASES; PROTEIN TYROSINE PHOSPHATASES, NON-RECEPTOR; SPECTRUM ANALYSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 83555174523     PISSN: 09660844     EISSN: 15728773     Source Type: Journal    
DOI: 10.1007/s10534-011-9460-3     Document Type: Article

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