Differential metabolism of organic nitrates by aldehyde dehydrogenase 1a1 and 2: Substrate selectivity, enzyme inactivation, and active cysteine sites

AAPS Journal

Volumn 13, Issue 4, 2011, Pages 548-555

  Tsou, Pei Suen ^a   Page, Nathaniel A ^a   Lee, Sean G ^a   Fung, Sun Mi ^a   Keung, Wing Ming ^b   Fung, Ho Leung ^a  

^a UNIVERSITY AT BUFFALO   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

Author keywords

aldehyde dehydrogenase; nitric oxide; organic nitrate; site directed mutagenesis

Indexed keywords

ALDEHYDE DEHYDROGENASE; ALDEHYDE DEHYDROGENASE 1A1; ALDEHYDE DEHYDROGENASE ISOENZYME 2; CYSTEINE; GLUTAMIC ACID; GLYCERYL TRINITRATE; ISOSORBIDE 2 NITRATE; ISOSORBIDE 5 NITRATE; ISOSORBIDE DINITRATE; MITOCHONDRIAL ENZYME; NICRORANDIL; NITRIC ACID DERIVATIVE; NITRIC OXIDE; ORGANIC COMPOUND; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOSOL; DRUG METABOLISM; ENZYME ACTIVE SITE; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME PURIFICATION; ENZYME SUBSTRATE; INCUBATION TIME; LIVER HOMOGENATE; MALE; MEDIAN EFFECTIVE CONCENTRATION; NONHUMAN; RAT; SITE DIRECTED MUTAGENESIS;

ALDEHYDE DEHYDROGENASE; BASE SEQUENCE; CYSTEINE; DNA PRIMERS; HUMANS; MUTAGENESIS, SITE-DIRECTED; NITRATES; ORGANIC CHEMICALS; SUBSTRATE SPECIFICITY;

EID: 83555173335     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-011-9295-4     Document Type: Article

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