Quantification of cyproheptadine in human plasma by high-performance liquid chromatography coupled to electrospray tandem mass spectrometry in a bioequivalence study

Biomedical Chromatography

Volumn 26, Issue 1, 2012, Pages 129-136

  Mendes, Gustavo Duarte ^a,b,c   Arruda, André ^a   Chen, Lu Shi ^b   de Almeida Magalhães, José Cássio ^a,c   Alkharfy, Khalid M ^d   De Nucci, Gilberto ^a,d  

^a UNIVERSITY OF CAMPINAS   (Brazil)

^b Galeno Research Unit   (Brazil)

^c UNIVERSIDADE CAMILO CASTELO BRANCO   (Brazil)

^d KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

Cyproheptadine; Healthy volunteer; LC MS MS; Pharmacokinetic; Plasma

Indexed keywords

COLUMN CHROMATOGRAPHY; DRUG PRODUCTS; EXTRACTION; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; PLASMA (HUMAN);

AMITRIPTYLINE; BIOEQUIVALENCE STUDY; CYPROHEPTADINE; ELECTROSPRAY TANDEM MASS SPECTROMETRY; HEALTHY VOLUNTEERS; HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN PLASMAS; INTERNAL STANDARDS; LC-MS-MS; LC.MS/MS;

HIGH PERFORMANCE LIQUID CHROMATOGRAPHY;

ACETIC ACID; ACETONITRILE; AMITRIPTYLINE; COBACTIN; COBAMAMIDE; COBAVITAL; CYPROHEPTADINE; DICHLOROMETHANE; ETHER; SOLVENT; UNCLASSIFIED DRUG; WATER;

ADULT; AREA UNDER THE CURVE; ARTICLE; BIOEQUIVALENCE; CALIBRATION; CONTROLLED STUDY; CROSSOVER PROCEDURE; DRUG ABSORPTION; ELECTROSPRAY MASS SPECTROMETRY; FEMALE; FOOD AND DRUG ADMINISTRATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; LIMIT OF QUANTITATION; LIQUID LIQUID EXTRACTION; MALE; MAXIMUM PLASMA CONCENTRATION; NORMAL HUMAN; OPEN STUDY; PLASMA; RANDOMIZED CONTROLLED TRIAL; TABLET FORMULATION; TANDEM MASS SPECTROMETRY;

EID: 83555172377     PISSN: 02693879     EISSN: 10990801     Source Type: Journal    
DOI: 10.1002/bmc.1618     Document Type: Article

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