Interventricular differences in myofilament function in experimental congestive heart failure

Pflugers Archiv European Journal of Physiology

Volumn 462, Issue 6, 2011, Pages 795-809

  Belin, Rashad J ^a   Sumandea, Marius P ^b   Sievert, Gail A ^b   Harvey, Laura A ^b   Geenen, David L ^a   Solaro, R John ^a   De Tombe, Pieter P ^a,c,d  

^a UNIVERSITY OF ILLINOIS AT CHICAGO   (United States)

^b UNIVERSITY OF KENTUCKY   (United States)

^c LOYOLA UNIVERSITY CHICAGO   (United States)

^d LOYOLA UNIVERSITY CHICAGO   (United States)

Author keywords

Force pCa relation; Heart; Hypertrophy; Muscle mechanics; Myofilaments; Protein kinase C

Indexed keywords

CALCIUM ION; CYCLIC AMP DEPENDENT PROTEIN KINASE; PROTEIN KINASE B; PROTEIN KINASE C; TROPONIN I; TROPONIN T;

ANATOMICAL VARIATION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL FUNCTION; CELL ISOLATION; CONGESTIVE HEART FAILURE; CONTROLLED STUDY; ENZYME ACTIVATION; FEMALE; HEART INFARCTION; HEART LEFT VENTRICLE; HEART RIGHT VENTRICLE; MYOFILAMENT; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; CALCIUM; CARDIAC MYOSINS; FEMALE; HEART FAILURE; HEART VENTRICLES; HUMANS; MYOCARDIUM; MYOCYTES, CARDIAC; MYOFIBRILS; MYOSIN LIGHT CHAINS; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; RATS; RATS, SPRAGUE-DAWLEY; SIGNAL TRANSDUCTION; TROPONIN I; TROPONIN T;

EID: 83555162594     PISSN: 00316768     EISSN: 14322013     Source Type: Journal    
DOI: 10.1007/s00424-011-1024-4     Document Type: Article

References (46)

1. N Afzal NS Dhalla 1992 Differential changes in left and right ventricular SR calcium transport in congestive heart failure Am J Physiol 262 3 Pt 2 H868 H874 1313649 1:CAS:528:DyaK38Xitlejtrk%3D
2. P Anversa C Beghi Y Kikkawa G Olivetti 1986 Myocardial infarction in rats. Infarct size, myocyte hypertrophy, and capillary growth Circ Res 58 1 26 37 3943155 1:STN:280:DyaL287gs1Kgtw%3D%3D (Pubitemid 16165930)
3. RJ Belin MP Sumandea EJ Allen K Schoenfelt H Wang RJ Solaro PP de Tombe 2007 Augmented protein kinase C-alpha-induced myofilament protein phosphorylation contributes to myofilament dysfunction in experimental congestive heart failure Circ Res 101 2 195 204 17556659 10.1161/CIRCRESAHA.107. 148288 1:CAS:528:DC%2BD2sXns1Cmsb0%3D (Pubitemid 47196587)
4. RJ Belin MP Sumandea T Kobayashi LA Walker VL Rundell D Urboniene M Yuzhakova SH Ruch DL Geenen RJ Solaro PP de Tombe 2006 Left ventricular myofilament dysfunction in rat experimental hypertrophy and congestive heart failure Am J Physiol Heart Circ Physiol 291 5 H2344 H2353 16815982 10.1152/ajpheart.00541.2006 1:CAS:528:DC%2BD28Xht1Gnsb7I
5. 2+-sensitive isoforms in the failing human heart Circulation 99 384 391 9918525 1:STN:280:DyaK1M7hsleiuw%3D%3D (Pubitemid 29051264)
6. JC Braz K Gregory A Pathak W Zhao B Sahin R Klevitsky TF Kimball JN Lorenz AC Nairn SB Liggett I Bodi S Wang A Schwartz EG Lakatta AA DePaoli-Roach J Robbins TE Hewett JA Bibb MV Westfall EG Kranias JD Molkentin 2004 PKC-alpha regulates cardiac contractility and propensity towards heart failure Nat Med 10 248 254 14966518 10.1038/nm1000 1:CAS:528:DC%2BD2cXhs1Wntbk%3D (Pubitemid 38667614)
7. EM Burkart MP Sumandea T Kobayashi M Nili AF Martin E Homsher RJ Solaro 2003 Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity J Biol Chem 278 11265 11272 12551921 10.1074/jbc.M210712200 1:CAS:528:DC%2BD3sXit1Kgsbo%3D (Pubitemid 36792683)
8. MC Daniels T Naya VL Rundell PP de Tombe 2007 Development of contractile dysfunction in rat heart failure: hierarchy of cellular events Am J Physiol Regul Integr Comp Physiol 293 1 84 92 10.1152/ajpregu.00880.2006 (Pubitemid 47092186)
9. PP De Tombe T Wannenburg D Fan WC Little 1996 Right ventricular contractile protein function in rats with left ventricular myocardial infarction Am J Physiol 271 1 Pt 2 H73 H79 8760160
10. A El-Armouche L Pohlmann S Schlossarek J Starbatty YH Yeh S Nattel D Dobrev T Eschenhagen L Carrier 2007 Decreased phosphorylation levels of cardiac myosin-binding protein-C in human and experimental heart failure J Mol Cell Cardiol 43 2 223 229 17560599 10.1016/j.yjmcc.2007.05.003 1:CAS:528: DC%2BD2sXnvF2lsLo%3D (Pubitemid 47079047)
11. DS Fan T Wannenburg PP de Tombe 1997 Decreased myocyte tension development and calcium responsiviness in rat right ventricular pressure overload Circulation 95 2312 2317 9142010 1:CAS:528:DyaK2sXjtlOnt7c%3D (Pubitemid 27191010)
12. PK Ganguly KS Dhalla Q Shao RE Beamish NS Dhalla 1997 Differential changes in sympathetic activity in left and right ventricles in congestive heart failure after myocardial infarction Am Heart J 133 3 340 345 9060804 10.1016/S0002-8703(97)70230-8 1:STN:280:DyaK2s3hsVChtg%3D%3D
13. AM Gerdes JA Moore JM Hines PA Kirkland SP Bishop 1986 Regional differences in myocyte size in normal rat heart Anat Rec 215 4 420 426 3740478 10.1002/ar.1092150414 1:STN:280:DyaL283ptlOisg%3D%3D (Pubitemid 16041533)
14. PH Goldspink DE Montgomery LA Walker D Urboniene RD McKinnery DL Geenen RJ Solaro P Buttrick 2004 Protein kinase C epsilon overexpression alters myofilament properties and composition during the progression to heart failure Circ Res 95 424 432 15242976 10.1161/01.RES.0000138299.85648.92 1:CAS:528:DC%2BD2cXmsVKlu7o%3D (Pubitemid 39100461)
15. PM Janssen LB Stull MK Leppo RA Altschuld E Marbán 2003 Selective contractile dysfunction of left, not right, ventricular myocardium in the SHHF rat Am J Physiol Heart Circ Physiol 284 3 H772 H778 12424099 1:CAS:528:DC%2BD3sXisFentL4%3D
16. NM Jideama TA Noland RL Raynor GC Blobe D Fabbro MG Kazanietz PM Blumberg YA Hannun JF Kuo 1996 Phosphorylation specificities of protein kinase C isozymes for bovine cardiac troponin I and troponin T and sites within these proteins and regulation of myofilament properties J Biol Chem 271 23277 23283 8798526 10.1074/jbc.271.38.23277 1:CAS:528:DyaK28XlvVCgtbo%3D (Pubitemid 26314769)
17. EE Jweied RD McKinney LA Walker I Brodsky AS Geha MG Massad PM Buttrick PP de Tombe 2005 Depressed cardiac myofilament function in human diabetes mellitus Am J Physiol Heart Circ Physiol 289 6 H2478 H2483 16085678 10.1152/ajpheart.00638.2005 1:CAS:528:DC%2BD28XlslGmug%3D%3D (Pubitemid 41698560)
18. 2+ in myocytes from aortic-banded rats Circulation 94 2915 2922 8941121 1:CAS:528:DyaK2sXos1Cgsg%3D%3D (Pubitemid 26411760)
19. RP Kondo DA Dederko C Teutsch J Chrast D Catalucci KR Chien WR Giles 2006 Comparison of contraction and calcium handling between right and left ventricular myocytes from adult mouse heart: a role for repolarization waveform J Physiol 571 Pt 1 131 146 16357014 1:CAS:528:DC%2BD28XislKmsr4%3D
20. P Li PA Hofmann BS Li A Malhotra W Cheng EH Sonnenblick LG Meggs P Anversa 1997 Myocardial infarction alters myofilament calcium sensitivity and mechanical behavior of myocytes Am J Physiol Heart and Circ Physiol 272 H360 H370 1:CAS:528:DyaK2sXht1Wmu7o%3D
21. X Liu Q Shao NS Dhalla 1995 Myosin light chain phosphorylation in cardiac hypertrophy and failure due to myocardial infarction J Mol Cell Cardiol 27 2613 2624 8825882 10.1006/jmcc.1995.0048 1:CAS:528:DyaK28XhvVOitw%3D%3D (Pubitemid 26003190)
22. D Mann MR Bristow 2005 Mechanisms and models in heart failure: the biochemical model and beyond Circulation 111 2837 2849 15927992 10.1161/CIRCULATIONAHA.104.500546 (Pubitemid 40791557)
23. SB Marston PP de Tombe 2008 Troponin phosphorylation and myofilament Ca2+ sensitivity in heart failure: increased or decreased? J of Mol & Cell Cardiol 45 5 603 607 10.1016/j.yjmcc.2008.07.004 1:CAS:528:DC%2BD1cXhtlGhsLnJ
24. AE Messer AM Jacques SB Marston 2007 Troponin phosphorylation and regulatory function in human heart muscle: dephosphorylation of Ser23/24 on troponin I could account for the contractile defect in end-stage heart failure J Mol Cell Cardiol 42 1 247 259 17081561 10.1016/j.yjmcc.2006.08.017 1:CAS:528:DC%2BD2sXht1Cltw%3D%3D (Pubitemid 44970468)
25. DE Montgomery VL Rundell PH Goldspink D Urboniene DL Geenen PP de Tombe PM Buttrick 2005 Protein kinase C epsilon induces systolic cardiac failure marked by exhausted inotropic reserve and intact Frank-Starling mechanism Am J Physiol Heart Circ Physiol 289 H1881 H1888 15951344 10.1152/ajpheart.00454.2005 1:CAS:528:DC%2BD2MXht1Cnt7nO (Pubitemid 41507336)
26. T Noguchi Y Kihara KJ Begin JA Gorga KA Palmiter MM LeWinter P VanBuren 2003 Altered myocardial thin-filament function in the failing Dahl salt-sensitive rat heart: amelioration by endothelin blockade Circulation 107 630 635 12566378 10.1161/01.CIR.0000046267.16901.E9 1:CAS:528: DC%2BD3sXmsFCrsg%3D%3D (Pubitemid 36176816)
27. T Noguchi M Hunlich PC Camp KJ Begin M El-Zaru R Patten BJ Leavitt FP Ittleman NR Alpert MM Lewinter P Vanburen 2004 Thin filament-based modulation of contractile performance in human heart failure Circulation 110 982 987 15302786 10.1161/01.CIR.0000139334.43109.F9 (Pubitemid 39136215)
28. TA Noland RL Raynor JF Kuo 1989 Identification of sites phosphorylated in bovine cardiac troponin I and troponin T by protein kinase C and comparative substrate activity of synthetic peptides containing the phosphorylation sites J Biol Chem 264 20778 20785 2584239 1:CAS:528:DyaK3cXjtlWr (Pubitemid 20009279)
29. MC Olsson JR Patel DP Fitzsimons JW Walker RL Moss 2004 Basal myosin light chain phosphorylation is a determinant of Ca2+ sensitivity of force and activation dependence of the kinetics of myocardial force development Am J Physiol Heart Circ Physiol 287 H2712 H2718 15331360 10.1152/ajpheart.01067.2003 1:CAS:528:DC%2BD2cXhtVOmurfM (Pubitemid 39557144)
30. Perez NG, Hashimoto K, McCune S, Altschuld RA, Marbán E (1999) Origin of contractile dysfunction in heart failure: calcium cycling versus myofilaments. Circulation: 1077-1083
31. CL Perreault OH Bing WW Brooks BJ Ransil JP Morgan 1990 Differential effects of cardiac hypertrophy and failure on right versus left ventricular calcium activation Circ Res 67 707 712 2144483 1:CAS:528:DyaK3MXhtF2mt70%3D (Pubitemid 20314997)
32. BB Roman PH Goldspink E Spaite D Urboniene R McKinnery DL Geenen RJ Solaro PM Buttrick 2004 Inhibition of PKC phosphorylation of cTnI improves cardiac performance Am J Physiol Heart Circ Physiol 286 H2089 H2095 14726296 10.1152/ajpheart.00582.2003 1:CAS:528:DC%2BD2cXkvFCrtrY%3D (Pubitemid 38685221)
33. SB Scruggs LA Walker T Lyu DL Geenen RJ Solaro PM Buttrick PH Goldspink 2006 Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation J Mol Cell Cardiol 40 4 465 473 16445938 10.1016/j.yjmcc.2005.12.009 1:CAS:528:DC%2BD28XivVGqsL0%3D
34. SB Scruggs AC Hinken A Thawornkaiwong J Robbins LA Walker PP de Tombe DL Geenen PM Buttrick RJ Solaro 2009 Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation J Biol Chem 284 8 5097 5106 19106098 10.1074/jbc.M807414200 1:CAS:528:DC%2BD1MXhvVSntr4%3D
35. R Sethi V Elimban D Chapman IM Dixon NS Dhalla 1998 Differential alterations in left and right ventricular G-proteins in congestive heart failure due to myocardial infarction J Mol Cell Cardiol 30 11 2153 2163 9925353 10.1006/jmcc.1998.0778 1:CAS:528:DyaK1cXotFCitLs%3D (Pubitemid 28549968)
36. R Sethi KS Dhalla RE Beamish NS Dhalla 1997 Differential changes in left and right ventricular adenylyl cyclase activities in congestive heart failure Am J Physiol 272 2 Pt 2 H884 H893 9124452 1:CAS:528:DyaK2sXhvVWqsLs%3D
37. MP Sumandea WG Pyle T Kobayashi PP de Tombe RJ Solaro 2003 Identification of functionally critical protein kinase C phosphorylation residue of cardiac troponin T J Biol Chem 278 35135 35144 12832403 10.1074/jbc.M306325200 1:CAS:528:DC%2BD3sXntVWqtLo%3D (Pubitemid 37102277)
38. MP Sumandea S Vahebi CA Sumandea ML Garcia-Cazarin J Staidle E Homsher 2009 Impact of cardiac troponin TN-terminal deletion and phosphorylation on myofilament function Biochemistry 48 32 7722 7731 19586048 10.1021/bi900516n 1:CAS:528:DC%2BD1MXovFais70%3D
39. MP Sumandea EB Burkart T Kobayashi PP de Tombe RJ Solaro 2004 Molecular and integrated biology of thin filament protein phosphorylation in heart muscle Ann N Y Acad Sci 1015 39 52 15201148 10.1196/annals.1302.004 1:CAS:528:DC%2BD2cXmtl2mt7k%3D (Pubitemid 38879478)
40. MP Sumandea VO Rybin AC Hinken C Wang T Kobayashi E Harleton G Sievert CW Balke SJ Feinmark RJ Solaro SF Steinberg 2008 Tyrosine phosphorylation modifies protein kinase C delta-dependent phosphorylation of cardiac troponin I J Biol Chem 283 33 22680 22689 18550549 10.1074/jbc.M802396200 1:CAS:528: DC%2BD1cXpsVKmsbc%3D
41. D Urboniene FA Dias JR Peña LA Walker RJ Solaro BM Wolska 2005 Expression of slow skeletal troponin I in adult mouse heart helps to maintain the left ventricular systolic function during respiratory hypercapnia Circ Res 97 1 70 77 15961720 10.1161/01.RES.0000173849.68636.1e 1:CAS:528: DC%2BD2MXntVartbs%3D Biochemistry. 2009 Aug 18;48(32):7722-31 (Pubitemid 40982324)
42. S Vahebi A Ota M Li CM Warren PP de Tombe Y Wang RJ Solaro 2007 p38-MAPK induced dephosphorylation of alpha-tropomyosin is associated with depression of myocardial sarcomeric tension and ATPase activity Circ Res 100 3 408 415 17234967 10.1161/01.RES.0000258116.60404.ad 1:CAS:528:DC%2BD2sXhsF2rsrc%3D
43. SJ van Dijk D Dooijes C dos Remedios M Michels JM Lamers S Winegrad S Schlossarek L Carrier FJ ten Cate GJ Stienen J van der Velden 2009 Cardiac myosin-binding protein C mutations and hypertrophic cardiomyopathy: haploinsufficiency, deranged phosphorylation, and cardiomyocyte dysfunction Circulation 119 11 1473 1483 19273718 10.1161/CIRCULATIONAHA.108.838672
44. NF Voelkel RA Quaife LA Leinwand National Heart, Lung, and Blood Institute 2006 Working Group on Cellular and Molecular Mechanisms of Right Heart Failure Right ventricular function and failure: report of a National Heart, Lung, and Blood Institute working group on cellular and molecular mechanisms of right heart failure Circulation 114 17 1883 1891 17060398 10.1161/ CIRCULATIONAHA.106.632208 (Pubitemid 44673364)
45. J Wang X Liu E Sentex N Takeda NS Dhalla 2003 Increased expression of protein kinase C isoforms in heart failure due to myocardial infarction Am J Physiol Heart Circ Physiol 284 H2277 H2287 12742831 1:CAS:528: DC%2BD3sXltVehsb4%3D
46. GY Wang DT McCloskey S Turcato PM Swigart PC Simpson AJ Baker 2006 Contrasting inotropic responses to alpha1-adrenergic receptor stimulation in left versus right ventricular myocardium Am J Physiol Heart Circ Physiol 291 4 H2013 H2017 16731650 10.1152/ajpheart.00167.2006 1:CAS:528:DC%2BD28XhtFegt7bE (Pubitemid 44497712)